scholarly journals What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

2020 ◽  
Vol 10 (14) ◽  
pp. 4996
Author(s):  
Nicole Braun ◽  
Ulrike Heinrich
Keyword(s):  
Hair Follicle ◽  
Dietary Supplements ◽  
Hair Loss ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
Widespread Occurrence ◽  
Non Invasive ◽  
Anagen Phase

Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

The effect of plucking hairs during different phases of the follicular cycle

Development ◽  
1964 ◽  
Vol 12 (3) ◽  
pp. 465-474
Author(s):  
Elizabeth Johnson ◽  
F. J. Ebling
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
The Dead

Hair growth is intermittent; periods of activity when the follicle is producing the hair alternating with periods of rest when the dead hair is retained. In the rat, hair growth occurs in a series of waves which start ventrally and pass over the flanks to the back (Dry, 1926; Butcher, 1934; Johnson, 1958). It has long been known (Collins, 1918; David, 1934) that if hairs are pulled out of resting follicles activity is induced. To explain this phenomenon, Chase (1955) put forward the view that an inhibitor accumulates in the hair follicle during active growth and is dissipated during the resting stage. Plucking during the resting stage removes this inhibitor along with the club hair, so that activity recommences. Preliminary observations on rats with plucked follicles indicated that the response to plucking varied at different stages of the hair cycle. A detailed study seemed desirable, therefore, in order to test more closely than hitherto the validity of the inhibitor hypothesis.

scholarly journals Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

2020 ◽  
Vol 6 (30) ◽  
pp. eaba1685 ◽  
Author(s):  
Shiqi Hu ◽  
Zhenhua Li ◽  
Halle Lutz ◽  
Ke Huang ◽  
Teng Su ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Hair Cycle ◽  
Paracrine Signaling ◽  
Hair Regrowth ◽  
Study Results ◽  
Anagen Phase ◽  
Hair Follicle Cycle

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

scholarly journals Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4360
Author(s):  
Kristelle Hughes ◽  
Raimana Ho ◽  
Stéphane Greff ◽  
Edith Filaire ◽  
Edwige Ranouille ◽  
...  
Keyword(s):  
Hair Loss ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Cycle ◽  
Bidens Pilosa ◽  
Dermal Papilla Cells ◽  
Qpcr Analysis ◽  
Chemical Content ◽  
Growth Activity ◽  
Gene Expression Levels

Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

scholarly journals Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 466 ◽  
Author(s):  
Pietro Gentile ◽  
Simone Garcovich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Hair Follicle ◽  
Hair Loss ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Regrowth ◽  
Hair Follicle Development

The use of stem cells has been reported to improve hair regrowth in several therapeutic strategies, including reversing the pathological mechanisms, that contribute to hair loss, regeneration of hair follicles, or creating hair using the tissue-engineering approach. Although various promising stem cell approaches are progressing via pre-clinical models to clinical trials, intraoperative stem cell treatments with a one-step procedure offer a quicker result by incorporating an autologous cell source without manipulation, which may be injected by surgeons through a well-established clinical practice. Many authors have concentrated on adipose-derived stromal vascular cells due to their ability to separate into numerous cell genealogies, platelet-rich plasma for its ability to enhance cell multiplication and neo-angiogenesis, as well as human follicle mesenchymal stem cells. In this paper, the significant improvements in intraoperative stem cell approaches, from in vivo models to clinical investigations, are reviewed. The potential regenerative instruments and functions of various cell populaces in the hair regrowth process are discussed. The addition of Wnt signaling in dermal papilla cells is considered a key factor in stimulating hair growth. Mesenchymal stem cell-derived signaling and growth factors obtained by platelets influence hair growth through cellular proliferation to prolong the anagen phase (FGF-7), induce cell growth (ERK activation), stimulate hair follicle development (β-catenin), and suppress apoptotic cues (Bcl-2 release and Akt activation).

scholarly journals CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 297 ◽  
Author(s):  
Yuxin Xu ◽  
Hongmei Liu ◽  
Huilin Pan ◽  
Xinyue Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Negative Regulator ◽  
Fibroblast Growth ◽  
Hair Cycle ◽  
Ideal Model ◽  
Anagen Phase ◽  
Hematoxylin And Eosin ◽  
Scanning Electron

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has been widely reported when FGF5 is mutated in humans and other species. However, there has been no such report in rabbits. Thus, the first exon of rabbit FGF5 was disrupted by the CRISPR/Cas9 system, and the phenotype of FGF5-/- rabbits was characterized while using hematoxylin and eosin (H&E) staining, immunohistochemistry, quantitative PCR, scanning electron microscopy, and western blotting. The results showed a significant and systemic long hair phenotype in the FGF5-/- rabbits, which indicated that FGF5 is a negative regulator of hair growth. In addition, a decreased diameter of the fiber and a higher area proportion of hair follicle clusters were determined in FGF5-/- rabbits as compared with the WT rabbits. Further investigation verified that prolonging the anagen phase in rabbits, with decreased BMP2/4 pathway signaling and increased VERSICAN pathway signaling, caused the systemic long hair phenotype. Taken together, these results indicate a systemic long hair phenotype by prolonging anagen in FGF5-/- rabbits, which could be widely used for Fur production and an ideal model for studying the mechanism of long hair in the future.

scholarly journals Molecular Pathways Involved in Promoting Activity of Timosaponin BII on Hair Growth in C57BL/6 Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Lei Xiao ◽  
Xia Zhang ◽  
Zhiyi Chen ◽  
Jianhua Li ◽  
Bing Li ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Immunohistochemical Analysis ◽  
Hair Follicles ◽  
Common Disease ◽  
Male Mice ◽  
High Concentration ◽  
Anagen Phase ◽  
Approved Drugs ◽  
Anemarrhena Asphodeloides

Hair loss is a common disease in dermatology, while the approved drugs may have unpredictable side effects. In this study, the effect of timosaponin BII extracted from Anemarrhena asphodeloides on hair growth of C57BL/6 mice was investigated by measuring the hair follicle morphology, hair growth length and area in C57BL/6 male mice, and the immunohistochemical analysis of β-catenin, Wnt3a, and Wnt10b in the dorsal skins of mice after topical application with minoxidil and timosaponin BII for 15 days. The decrease in skin brightness, the increase in the regrowing area of hair and hair follicles numbers, and the improvement of hair follicle morphology in the group applied with 0.5% timosaponin BII indicated an induction of the anagen phase in telogenic mice skin, which were comparative to the 2% minoxidil treatment. The immunohistochemical analysis detected an increase in the expression of β-catenin and Wnt10b, supporting the theory of the activation of the β-catenin/Wnt pathway was one of the pathways that are related to anagen phase induction. Anemarrhena asphodeloides is a herb commonly used for metabolic disorders in China. The present study is the first to show that the timosaponin BII, which is present at a high concentration in A. asphodeloides, promotes hair growth in C57BL/6 male mice. The results indicate that timosaponin BII may be a potential promoting agent for hair growth.

scholarly journals HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition

2020 ◽  
Vol 21 (12) ◽  
pp. 4553
Author(s):  
Sung Min Kim ◽  
Jung-Il Kang ◽  
Hoon-Seok Yoon ◽  
Youn Kyung Choi ◽  
Ji Soo Go ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Cell Cycle Progression ◽  
Dermal Papilla ◽  
Follicle Cell ◽  
Hair Shaft ◽  
Promoting Effect ◽  
Dermal Papilla Cells ◽  
Anagen Phase

The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer’s disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells from apoptosis. This study was performed to investigate the promoting effect and action mechanisms of HNG on hair growth. HNG significantly increased DPC proliferation. HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture. In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice. Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs. This means that HNG could induce the anagen phase longer by up-regulating VEGF, which is a Stat3 target gene and one of the anagen maintenance factors. HNG stimulated the anagen phase longer with VEGF up-regulation, and it prevented apoptosis by activating Erk1/2, Akt, and Stat3 signaling.

Reconstitution of Hair Follicle Development In Vivo: Determination of Follicle Formation, Hair Growth, and Hair Quality by Dermal Cells

1993 ◽  
Vol 100 (3) ◽  
pp. 229-236 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Linda V. Goodman ◽  
Carmen George ◽  
David L. Morgan ◽  
Steve Ledbetter ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Follicle Development ◽  
Hair Follicle Development ◽  
Dermal Cells

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

2014 ◽  
Vol 23 (7) ◽  
pp. 486-491 ◽  
Author(s):  
Jing Jing ◽  
Xian-jie Wu ◽  
Yun-ling Li ◽  
Sui-Qing Cai ◽  
Min Zheng ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Hair Follicle Cycle ◽  
Cycle Dependence

Hair Loss in Children

1981 ◽  
Vol 3 (3) ◽  
pp. 85-90
Author(s):  
James E. Rasmussen
Keyword(s):  
Cross Section ◽  
Hair Loss ◽  
Human Hair ◽  
Shape Change ◽  
Hair Color ◽  
Random Pattern ◽  
Active Growth ◽  
Anagen Phase ◽  
Straight Hair ◽  
Histologic Changes

PHYSIOLOGY OF NORMAL HAIR1,2 Unlike the hair of most animals, human hair usually follows a random pattern of growth, rest, and shedding, followed by the growth and emergence of a new hair from the follicle. This cycle is related to histologic changes in the follicle: The anagen phase involves active growth (long follicle); the telogen phase is resting (short follicle); and the catagen phase is a transition between anagen and telogen. The duration of the growing phase (anagen) determines the ultimate length of the hair: normally longest on the scalp, followed in descending order of length by the hairs of the beard, pubis, axillae, body, eyebrows, and eyelid margins. Longer hair is associated with a higher ratio (10:1) of anagen to telogen follicles. Hair plucking is the most rapid, convenient path to examine this relationship: anagen hairs have a glistening, cylindrical proximal sheath, approximately 3 mm long (Fig 1) whereas the telogen follicle yields a hair with a short, 1-mm knob, appropriately called a club (Fig 2). The shape and color of hair are usually determined genetically. Straight hair is round in cross section, with curly and kinky (spiral) varieties becoming progressively more ellipsoid. Hair color may normally darken and shape change for the first five to ten years of life; this tendency is most commonly seen in the transformation of a curly haired blond child into a tow-headed or brunette adolescent.

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