The PD-1/PD-L1 pathway in murine hair cycle transition: a potential anagen phase regulator

2021 ◽  
Author(s):  
Lijuan Zhou ◽  
Liang Wen ◽  
Youyu Sheng ◽  
Jinghao Lu ◽  
Ruiming Hu ◽  
...  
Keyword(s):  
Hair Cycle ◽  
Anagen Phase

scholarly journals CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

Genes ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 297 ◽  
Author(s):  
Yuxin Xu ◽  
Hongmei Liu ◽  
Huilin Pan ◽  
Xinyue Wang ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Hair Growth ◽  
Negative Regulator ◽  
Fibroblast Growth ◽  
Hair Cycle ◽  
Ideal Model ◽  
Anagen Phase ◽  
Hematoxylin And Eosin ◽  
Scanning Electron

Hair growth and morphology are generally regulated by the hair cycle in mammals. Fibroblast Growth Factor 5 (FGF5), which is a hair cycle regulator, has a role in regulating the hair cycle during the transition from the anagen phase to the catagen phase, and a hereditary long hair phenotype has been widely reported when FGF5 is mutated in humans and other species. However, there has been no such report in rabbits. Thus, the first exon of rabbit FGF5 was disrupted by the CRISPR/Cas9 system, and the phenotype of FGF5-/- rabbits was characterized while using hematoxylin and eosin (H&E) staining, immunohistochemistry, quantitative PCR, scanning electron microscopy, and western blotting. The results showed a significant and systemic long hair phenotype in the FGF5-/- rabbits, which indicated that FGF5 is a negative regulator of hair growth. In addition, a decreased diameter of the fiber and a higher area proportion of hair follicle clusters were determined in FGF5-/- rabbits as compared with the WT rabbits. Further investigation verified that prolonging the anagen phase in rabbits, with decreased BMP2/4 pathway signaling and increased VERSICAN pathway signaling, caused the systemic long hair phenotype. Taken together, these results indicate a systemic long hair phenotype by prolonging anagen in FGF5-/- rabbits, which could be widely used for Fur production and an ideal model for studying the mechanism of long hair in the future.

scholarly journals Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

2020 ◽  
Vol 6 (30) ◽  
pp. eaba1685 ◽  
Author(s):  
Shiqi Hu ◽  
Zhenhua Li ◽  
Halle Lutz ◽  
Ke Huang ◽  
Teng Su ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Hair Cycle ◽  
Paracrine Signaling ◽  
Hair Regrowth ◽  
Study Results ◽  
Anagen Phase ◽  
Hair Follicle Cycle

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results revealed that DP spheroids are effective at inducing the progression of the hair follicle cycle from telogen to anagen compared with just DP cell or minoxidil treatment. Because of the importance of paracrine signaling in this process, secretome and exosomes were isolated from DP cell culture, and their therapeutic efficacies were investigated. We demonstrated that miR-218-5p was notably up-regulated in DP spheroid–derived exosomes. Western blot and immunofluorescence imaging were used to demonstrate that DP spheroid–derived exosomes up-regulated β-catenin, promoting the development of hair follicles.

Pro-inflammatory cytokine interleukin-1α is downregulated during anagen phase of hair cycle in vivo

2003 ◽  
Vol 33 (3) ◽  
pp. 195-198 ◽  
Author(s):  
Kazuto Hamada ◽  
Sachiyo Hirotsu ◽  
Hideyo Uchiwa ◽  
Shunsuke Yamazaki ◽  
Keiko Suzuki
Keyword(s):  
Inflammatory Cytokine ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Interleukin 1Α

scholarly journals What Can Complex Dietary Supplements Do for Hair Loss and How Can It Be Validly Measured—A Review

2020 ◽  
Vol 10 (14) ◽  
pp. 4996
Author(s):  
Nicole Braun ◽  
Ulrike Heinrich
Keyword(s):  
Hair Follicle ◽  
Dietary Supplements ◽  
Hair Loss ◽  
Hair Growth ◽  
Hair Cycle ◽  
Active Growth ◽  
Widespread Occurrence ◽  
Non Invasive ◽  
Anagen Phase

Hair plays a major role in perception within a society. It provides information about gender, age, health, and social status. It is therefore not surprising that those affected are exposed to great suffering due to the widespread occurrence of hair loss. As a result, the demand for new products to remedy this problem is not diminishing. Hair grows in cycles, and a hair follicle goes through several phases called the hair cycle. The active growth phase (anagen phase) lasts 2–6 years. In this state a hair follicle shows a growth of about 1 cm per month. In order to improve the existing hair status, hair should be kept in the active anagen phase as long as possible, or the transition to anagen should be stimulated. A number of reviews already describe the influence of individual active ingredients on hair growth. However, the following review describes existing studies of complex dietary supplements with their experimental weaknesses and strengths and their influence on hair loss. Also, for the determination of hair loss, it is important to use a valid method with high acceptance by the test persons. In this context, the TrichoScale® is a validated and non-invasive tool for quantifying hair loss/hair growth. Thus, it is an ideal measuring instrument to objectively quantify the effectiveness of a hair loss treatment.

Alopecia of IFN-γ Knockout Mouse as a Model for Disturbance of the Hair Cycle: A Unique Arrest of the Hair Cycle at the Anagen Phase Accompanied by Mitosis

2002 ◽  
Vol 22 (9) ◽  
pp. 935-945 ◽  
Author(s):  
Ryuichiro Hirota ◽  
Sadao Tajima ◽  
Yukio Yoneda ◽  
Takumi Tamayama ◽  
Masahito Watanabe ◽  
...  
Keyword(s):  
Knockout Mouse ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Ifn Γ

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

2014 ◽  
Vol 23 (7) ◽  
pp. 486-491 ◽  
Author(s):  
Jing Jing ◽  
Xian-jie Wu ◽  
Yun-ling Li ◽  
Sui-Qing Cai ◽  
Min Zheng ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Hair Follicle Cycle ◽  
Cycle Dependence

scholarly journals De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle

2010 ◽  
Vol 130 (11) ◽  
pp. 2664-2666 ◽  
Author(s):  
Woo Y. Chi ◽  
David Enshell-Seijffers ◽  
Bruce A. Morgan
Keyword(s):  
De Novo ◽  
Dermal Papilla ◽  
Hair Cycle ◽  
Dermal Papilla Cells ◽  
Anagen Phase

A new Gsdma3 mutation affecting anagen phase of first hair cycle

2007 ◽  
Vol 359 (4) ◽  
pp. 902-907 ◽  
Author(s):  
Shigekazu Tanaka ◽  
Masaru Tamura ◽  
Aya Aoki ◽  
Tomoaki Fujii ◽  
Hiromitsu Komiyama ◽  
...  
Keyword(s):  
Hair Cycle ◽  
Anagen Phase

scholarly journals Selective Elimination of NG2-Expressing Hair Follicle Stem Cells Exacerbates the Sensitization Phase of Contact Dermatitis in a Transgenic Rat Model

2020 ◽  
Vol 21 (18) ◽  
pp. 6922
Author(s):  
Yasuhisa Tamura ◽  
Kumi Takata ◽  
Asami Eguchi ◽  
Yosky Kataoka
Keyword(s):  
Stem Cells ◽  
Immune System ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Hair Cycle ◽  
Anagen Phase ◽  
Hair Follicle Stem Cells ◽  
Sensitization Phase ◽  
Allergic Contact ◽  
Follicle Stem Cells

The hair cycle consists of three different phases: anagen (growth), catagen (regression), and telogen (resting). During the anagen phase, hair follicle stem cells (HFSCs) in the bulge and the secondary hair germ proliferate and generate the outer and inner root sheath cells and the hair shafts. We previously identified NG2-immunoreactive (NG2+) cells as HFSCs in both regions of the hair follicles. Recently, the interaction between the hair cycle and the cutaneous immune system has been re-examined under physiological and pathological conditions. However, the roles of NG2+ HFSCs in the skin’s immune system remain completely elucidated. In the present study, we investigated whether the elimination of NG2+ HFSCs affects the induction of allergic contact dermatitis, using a herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) suicide gene system. When the GCV solution was applied to the skin of NG2-HSVtk transgenic (Tg) rats during the depilation-induced anagen phase, NG2+ HFSCs in the Tg rat skin induced apoptotic cell death. Under exposure of a hapten, the selective ablation of NG2+ HFSCs during the anagen phase aggravated the sensitization phase of allergic contact dermatitis. These findings suggest that NG2+ HFSCs and their progeny have immunosuppressive abilities during the anagen phase.

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