Application of traditional Chinese medicine preparation in targeting drug delivery system

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Because of the possibilities of various clinical applications, the properties and administration of these bioactive glycosides deserve further investigation. Their promising treatment effects, however, are hindered by their poor solubility, poor stability and rapid elimination. Therefore, it is necessary that we improve the therapeutic efficacy of bioactive glycosides by overcoming these problems. Meanwhile, some practical design strategies and novel drug delivery vehicles based on drug delivery systems provide favorable support in clinical practice for these active ingredients. This review summarizes diverse pharmacological activities of bioactive glycosides and focuses on recent advances in delivery system for these active constitutes; in particular, some glycol glycosides can effectively cure intractable diseases through targeted drug delivery. This review elucidates some design strategies for drug delivery system that are mainly based on two methods (avoiding physical barriers by changing dosage forms and enhancing the ability to bind to receptors or proteins after administration) and indicate the current challenges during the combination of delivery vehicles and these glycosides in hopes of promoting the process of receiving ideal therapeutic efficacy of them in future studies.

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Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)

Chinese Herbal Medicines ◽

10.1016/j.chmed.2020.08.001 ◽

2020 ◽

Author(s):

Ruo-ning Wang ◽

Hua-cong Zhao ◽

Jian-yu Huang ◽

Hong-lan Wang ◽

Jun-song Li ◽

...

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Drug Delivery System ◽

Delivery System ◽

Salviae Miltiorrhizae ◽

Salviae Miltiorrhizae Radix ◽

Challenges And Strategies

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Construction of evaluation systems for traditional Chinese medicine multiple drug delivery system on basis of component level

China Journal of Chinese Materia Medica ◽

10.4268/cjcmm20121734 ◽

2012 ◽

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Drug Delivery System ◽

Delivery System ◽

Multiple Drug ◽

Component Level ◽

Evaluation Systems ◽

Multiple Drug Delivery

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Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2020.111072 ◽

2021 ◽

Vol 133 ◽

pp. 111072

Author(s):

Yukun Zhang ◽

Peng Lu ◽

Huan Qin ◽

Yuelin Zhang ◽

Xinru Sun ◽

...

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Drug Delivery System ◽

Delivery System ◽

Therapeutic Potential ◽

Pulmonary Drug Delivery

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Preparation of a micro/nanotechnology based multi-unit drug delivery system for a Chinese medicine Niuhuang Xingxiao Wan and assessment of its antitumor efficacy

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2015.07.023 ◽

2015 ◽

Vol 492 (1-2) ◽

pp. 244-247 ◽

Cited By ~ 7

Author(s):

Feng Shi ◽

Yongtai Zhang ◽

Gang Yang ◽

Teng Guo ◽

Nianping Feng

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Drug Delivery System ◽

Delivery System ◽

Antitumor Efficacy

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Phytochemical and Pharmacological Review of Da Chuanxiong Formula: A Famous Herb Pair Composed ofChuanxiong RhizomaandGastrodiae Rhizomafor Headache

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/425369 ◽

2013 ◽

Vol 2013 ◽

pp. 1-16 ◽

Cited By ~ 6

Author(s):

Lu Wang ◽

Jinming Zhang ◽

Yanlong Hong ◽

Yi Feng ◽

Meiwan Chen ◽

...

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Drug Delivery System ◽

Chronic Headache ◽

Chinese Herb ◽

Blood Stasis ◽

Long Time ◽

Gastrodiae Rhizoma ◽

Chemical Characters

Chronic headache such as migraine and nervous headache has become one of the most common locations of pain and one of the most difficult diseases to recover due to its numerous causes and inconvenience to keep acesodyne administration for a long time. However, there are a series of treatment theories and herbal formulas for this disease in traditional Chinese medicine (TCM), in which Da Chuanxiong formula (DCXF), a herb pair composed ofChuanxiong Rhizoma(CR), Chuanxiong in Chinese, andGastrodiae Rhizoma(GR) called as Tianma in China, is a greatly classic representative. This formula has been used for headaches via dispelling wind pathogen and dissipating blood stasis for many years in TCM. In recent years, the efficiency and representativeness of DCXF have garnered many researchers’ attention. To reveal the compatibility mechanism and develop innovative Chinese herb, herein ethnopharmacological relevance, chemical characters, and pharmacological actions of DCXF are detailed. It is expected to give a comprehensive interpretation of DCXF, namely, Chuanxiong Tianma herb pair (CTHP), to inherit the essence of herb pair and innovate drug delivery system of this prescription.

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