Stimuli-responsive hydrogels in drug delivery and tissue engineering

Stimuli-responsive hydrogels are becoming increasingly important for controlled drug delivery, biosensing, and tissue engineering. It would be much advantageous for intelligent hydrogels if they exhibit superior mechanical performances.

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Hydrogel Nanoparticle as a Functional Coating Layer in Biosensing, Tissue Engineering, and Drug Delivery

Coatings ◽

10.3390/coatings10070663 ◽

2020 ◽

Vol 10 (7) ◽

pp. 663

Author(s):

Heejoo Cho ◽

Sumin Jeon ◽

Junghyeok Yang ◽

Song Yi Baek ◽

Doeun Kim

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Local Environment ◽

Stimuli Responsive ◽

Functional Coating ◽

Coating Materials ◽

Hydrogel Particles ◽

Cross Links ◽

Smart Coating ◽

Responsive Hydrogels

The development of functional coating materials has resulted in many breakthroughs in the discovery of energy, environmental, and biomedical applications. Responsive polymeric hydrogels are an example of smart coating materials due to their stimuli-responsive characteristics upon changes in their local environment. This review focuses on the introduction of hydrogel nanoparticles and their applications in functional layers as responsive coating materials. Hydrogels are explained by the composition of cross-links and monomers used for preparation. In particular, an important class of responsive hydrogels, that is, nanosized hydrogel particles (nanogels), are described for thee synthesis, modification, and application in assembly of functional coating layers. Finally, nanogel functional layers for biological applications will be discussed with recent advances in biosensing, tissue engineering, and drug delivery.

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Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽

10.1039/d1sm00780g ◽

2021 ◽

Author(s):

Michael Meleties ◽

Priya Katyal ◽

Bonnie Lin ◽

Dustin Britton ◽

Jin Kim Montclare

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Self Assembly ◽

Coiled Coil ◽

Stimuli Responsive ◽

Tunable Properties ◽

Stimuli Sensitive ◽

Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

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Stimuli-responsive hydrogels for intratumoral drug delivery

Drug Discovery Today ◽

10.1016/j.drudis.2021.04.012 ◽

2021 ◽

Author(s):

Ana C. Marques ◽

Paulo J. Costa ◽

Sérgia Velho ◽

Maria H. Amaral

Keyword(s):

Drug Delivery ◽

Stimuli Responsive ◽

Responsive Hydrogels ◽

Intratumoral Drug Delivery

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Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

Applied Sciences ◽

10.3390/app112311369 ◽

2021 ◽

Vol 11 (23) ◽

pp. 11369

Author(s):

Ashni Arun ◽

Pratyusha Malrautu ◽

Anindita Laha ◽

Hongrong Luo ◽

Seeram Ramakrishna

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Solubility ◽

Stimuli Responsive ◽

Preparation Methods ◽

Nanoparticle Preparation ◽

Responsive Behavior ◽

Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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Utilization of L-serinyl derivate to preparing triple stimuli-responsive hydrogels for controlled drug delivery

Journal of Polymer Research ◽

10.1007/s10965-019-1976-1 ◽

2019 ◽

Vol 26 (12) ◽

Cited By ~ 3

Author(s):

Chun Hui Luo ◽

Xin Xin Sun ◽

Feng Wang ◽

Ning Wei ◽

Fa Liang Luo

Keyword(s):

Drug Delivery ◽

Controlled Drug Delivery ◽

Stimuli Responsive ◽

Responsive Hydrogels

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Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

International Journal of Molecular Sciences ◽

10.3390/ijms21134724 ◽

2020 ◽

Vol 21 (13) ◽

pp. 4724 ◽

Cited By ~ 1

Author(s):

Sofia Municoy ◽

María I. Álvarez Echazú ◽

Pablo E. Antezana ◽

Juan M. Galdopórpora ◽

Christian Olivetti ◽

...

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Smart Materials ◽

Controlled Drug Release ◽

Stimuli Responsive ◽

Responsive Materials ◽

Stimuli Responsive Polymers ◽

Responsive Polymers ◽

Stimuli Response ◽

Materials Used

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery

Journal of Materials Chemistry B ◽

10.1039/c5tb00864f ◽

2015 ◽

Vol 3 (27) ◽

pp. 5560-5568 ◽

Cited By ~ 31

Author(s):

Krishnamoorthy Lalitha ◽

Y. Siva Prasad ◽

C. Uma Maheswari ◽

Vellaisamy Sridharan ◽

George John ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Renewable Resource ◽

Stimuli Responsive ◽

Composite Gel ◽

Drug Delivery Applications ◽

Responsive Hydrogels

We report coumarin-tris based hydrogel and curcumin encapsulated composite gel for stimuli responsive drug delivery applications.

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Multi-stimuli-responsive hydrogels and their medical applications

New Journal of Chemistry ◽

10.1039/d1nj02260a ◽

2021 ◽

Author(s):

Ali Pourjavadi ◽

Rozhin Heydarpour ◽

Zahra Mazaheri Tehrani

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Medical Applications ◽

Self Healing ◽

Stimuli Responsive ◽

Antibacterial Materials ◽

Responsive Hydrogels

This review highlights the medical applications of multi-stimuli-responsive hydrogels as self-healing hydrogels, antibacterial materials and drug-delivery systems.

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