H7N9 not only endanger human health but also hit stock marketing

Objective: This study aims to discuss the correlation between daily reported H7N9 cases and stock price indices in China. Methods: Information on daily reported H7N9 cases and stock market sectors indices between February 19, 2013 and March 31, 2014 were collected. A distributed lag non-linear model was used to describe the variation trend for the stock indices Results: The daily reported number of H7N9 cases was associated with the closing price of the Avian Influenza Sector Index (P < 0.05) and the opening price of the Shanghai Composite Index (P = 0.029). The Avian Influenza Sector Index decreased with increasing of daily reported case number when daily reported cases ? 4. Case number was associated with the opening/closing price of the Chinese Traditional Medicine Sector Index, the Biological Product Sector Index, and the Biomedicine Sector Index (P < 0.05). Conclusion: New or reemerging infectious diseases epidemic cause economic loss which is reflected in movements in stock prices.

Assessing the Level of Knowledge about Ebola Virus Disease among College Students

Objective: Ebola virus disease is becoming a public health emergency of international concern, but the study of knowledge about Ebola virus disease among college students is limited. This study aimed to assess the level of knowledge about Ebola virus disease among college students for offering the strategies to health education of Ebola virus disease. Methods: The stratified cluster sampling method was used and the investigation with self-administration and anonymous questionnaire included knowledge of Ebola virus disease and HIV/AIDS was conducted among 1200 college students who were enrolled from three colleges in Wuhu, China from May to July in 2015. Results: The correct answer rate of epidemic area of Ebola virus disease was the highest (71.37 %), the transmitting vector was the lowest (13.14 %). The average awareness rate of Ebola virus disease (0.381 ± 0.256) was significantly lower than that of HIV/AIDS (0.810 ± 0.220) (P < 0.05). The awareness rate of Ebola virus disease were significantly different in specialties, grades and registered residences (P < 0.05). And in HIV/AIDS, there were also significant differences in specialties, grades (P < 0.05). The medical students’ awareness rate of Ebola virus disease was generally higher than non-medical students’, freshmen and junior and above were higher than sophomore, and there was a decline trend in students from urban, town to rural (P < 0.05). Conclusion: The awareness rate of Ebola virus disease was lower comparing to HIV/AIDS among colleges students. It should strengthen the health education about Ebola virus disease toward different characteristics of college student.

Review of pathogenic gene prediction based on Text Mining

Background: Whether it is a single genetic disease, multiple genetic diseases or acquired genetic diseases, the discovery and prediction of disease-causing genes is a difficult problem in biomedical industry. It has also become an important research task in biomedical text mining. Methods: In the early stage of the prediction of disease-causing genes, the researchers predicted two major methods of linkage analysis and association analysis. Conclusion: The prediction of disease-causing genes can be predicted by using different prediction methods and different bioinformatics data according to the different problems of research questions and the different situations of concern. At present, the researchers have developed a number of related prediction tools to help understand, detect and predict disease-causing genes and pathogenesis of disease and other issues. Prediction of disease-causing genes is still a difficult and meaningful work.

Induced Abortion among Chinese Women with Living Child-A National Study

ABSTRACT Objective: Induced abortion is widely practiced in China. However, the information on induced abortion is limited. A national cross-sectional survey was designed to determine the risk factors of induced abortion among Chinese women with one child. Methods: We sampled 16,881 Chinese women with one living child for the study. A structured questionnaire was used to collect induced abortion and related health information. The National Research Institute for Family Planning of China conducted a cross-sectional study among women who had delivered a baby between 2006 and 2008. Information was collected in relation to demographic characteristics (age, ethnicity, region, area etc.), social economic status (education level and occupation), marriage, and the attitude towards potential child’s gender. Multi-logistic regression was used to test potential predictors for conducting abortion stratified by consistency between gender preference and current infants’ gender, and indicating adjusted estimation on selected models of risk factors for abortion. Results: The mean age of participants was 27.96 ± 4.10 years (median 27 years). Among those women, the prevalence of induced abortion was 8.13 %. In the final model, females living in rural areas (OR = 1.21, 95 %CI: 1.04-1.39), individuals ages 18-25 (OR = 0.84, 95% CI: 0.72-0.99), individuals ages 30 or older (OR = 1.63, 95% CI: 1.42-1.86), and single individuals (OR = 1.72, 95% CI: 1.05-2.83) were more likely to experience induced abortion. Wife gender preference (OR = 0.66, 95 %CI: 0.53-0.83), husband gender preference (Boy: OR = 1.33, 95 %CI: 1.10-1.63; Girl: OR = 1.5, 95% CI: 1.22-1.86), and the area where the individuals were located were significantly associated with the reporting of induced abortion. Conclusion: The prevalence of induced abortion is high among married women with child in China. There are also socio-demographic characteristics associated with induced abortion in China.

Meta-analysis of Effect on HIV/AIDS Intervention in Comprehensive Commercial Sex Work in China

Objective: In recent 5 years, to evaluate the effect of an intervention or preventing HIV/AIDS in commercial sex workers, to provide foundations for preventing HIV/AIDS in commercial sex workers in future. Methods: A computerized literature searching Was carried out in PubMed, springer, China Info, VIP, CNKI databases to collect articles published between 2008 and 2009 concerning the effect of AHIV/AIDS education intervention in commercial sex workers. The type was self-control intervention study, the method was Comprehensive intervention, according to the KABP Model and comprehensive factors, we choose five indicators about the HIV/AIDS knowledge and behavior for Meta analysis by Stata12.0 software. We use RD (rate difference) as Effect Size and make consistency check for included studies, then choose fixed effect model or random effect model to do Comprehensive quantitative analysis. Results: the analysis that the RD for knowing the sexual transmission route of HIV, the RD for knowing the effect of condoms for HIV prevention, the RD for knowing the Maternal and child route of HIV, the RD for using condom in the latest month, and the RD for consistently using condom in the latest month were increased by 23.8 % (0.143, 0.180), 19.5 % (0.139, 0.251), 19.0 % (0.100, 0.281) , 23.5 % (0.160, 310) and 25.8 % (0.068, 0.448), respectively. Conclusion: Comprehensive intervention for preventing HIV/AIDS is effective in changing knowledge and action in commercial sex workers, in China.

Analysis of 10-Year Physical Health Trends amongMedical College Freshmen

Purpose: This study was aimed at exploring the trends of health status of medical college freshmen in 10 years (2005-2014), as a guide for improving the physical health conditions of University students. Methods: Freshman physical test data from 2005 to 2014 were collected, and their height, body mass index (BMI), lung capacity and long distance running times were analyzed. Results: Mean height of male students increased significantly from 172.08±5.56 cm in 2005 to 159.36±5.27 cm in 2014 (t=26.028,P<0.001), while that of female students increased significantly from 175.11±5.50 cm in 2005 to 162.66±5.03 cm in 2014 (t=28.291,P<0.001). BMI of male students increased significantly (t=6.224,P<0.001) within the same period, in contrast to that of the female students (t=7.458,P<0.001). In addition, mean BMI of male students were higher than that of female students (Z=29.760,P<0.001). Lung capacity showed a decline for both groups (male: t=12.944,P<0.001; female: t=29.489,P<0.001). Long–distance running times increased (male: t=21.833,P<0.001; female: t=18.717,P<0.001). The percentage of overweight and obese male students was significantly higher than that in female students (male: 12.73%; female: 4.84%), and both showed increasing trends (male: Z=9.056,P<0.001; female: Z=3.643,P<0.001). Non-compliance of lung capacity with long-distance running time increased over the years (male: Z=12.892,P<0.001; female: Z=19.148,P<0.001; male: Z=14.596,P<0.001; female: Z=8.209,P<0.001). Conclusion: Height of college freshmen showed an upward trend, but their physical health condition showed a downtrend within the period of study.

The serum level of Cystatin c in different gender and its influence factors

Objective: To investigate the serum level of Cystatin c and its influence factors. Methods: A cross-sectional study was performed among 322 population who came to physical examination center of one hospital and had a physical examination during march 2012 to august 2012, a questionnaire survey was carried out and some biochemical criterions were detected. The formula of modification of diet in renal disease (MORD) was used to estimate glomerular filtration rate (eGFR). Results: The average serum level of Cystatin c was 1.05±0.13 mg/L,and the level in male was higher than that in female and the difference had statistical significance(t=4.353, P=0.000). Multiple stepwise linear regression analysis showed that the increase of age, uric acid, urea nitrogen and weekly meat intake and the decrease of estimated glomerular filtration rate related with a higher serum level of Cystatin c in male, and the increase of age, uric acid, urea nitrogen, systolic blood pressure and monthly bean products intake and the decrease of estimated glomerular filtration rate related with a higher serum level of Cystatin c in female. Conclusions: The serum level of Cystatin c is different in different gender. The increase of age and the serum level of uric acid, urea nitrogen, and the decrease of estimated glomerular filtration rate related with a higher level of Cystatin c both in male and female, however, it still exists some differences that the weekly meat intake only increase the serum level of Cystatin c in male and the monthly bean products intake only increase the serum level of Cystatin c in female.

Effect of Probiotics Supplementation on Blood Glucose: a Meta-analysis of Randomized Controlled Trials

Purpose: Thisstudy was carried out as a meta-analysis to assess whether probiotics supplementation can reduce blood glucose (BG) levels in Type 2 diabetes mellitus (T2DM) patients. Methods: The analysis included 1005 subjects from 15 probiotics supplementation randomized trials in which changes in BG were reported as one of the end points. Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were obtained by using random-effect models. Meta-regression and sub-group analyses were performed to identify sources of heterogeneity. Results: Probiotics supplementation was associated with significant decreases in BG levels (WMD: -0.29 mmol/L; 95% CI: -0.56, -0.02; P = 0.038), particularly in subjects with T2DM (WMD: -1.11 mmol/L; 95% CI: -1.54, -0.68; P< 0.001), and in trials carried out in Iran (-0.74 mmol/L; 95% CI: -1.30, -0.18; P = 0.009). Baseline BG levels were positively related to magnitude of effect (P< 0.001). Greater bene?cial effects were consistently seen in trials with baseline BG levels ? 7.0 mmol/L (WMD: -0.881 mmol/L; 95% CI: -1.357, -0.405; P < 0.001). However, in the corresponding comparison groups, magnitudes of effect were attenuated and non-signi?cant. Conclusion: These results indicate that probiotics supplementation is effective in reducing the BG levels in subjects with T2DM and in trials with higher baseline BG levels.

Association between Vitamin D Receptor Gene Polymorphism and Susceptibility to Tuberculosis (TB): a Meta Analysis

Objective: The study was carried out to comprehensively evaluate association between Vitamin D receptor gene polymorphism and susceptibility to TB, using meta-analysis. Methods: Literature on controlled case studies on association between vitamin D receptor gene polymorphism and TB were collected through online database (Pubmed, Chinese CNKI, VIP database, Wanfang database and Google search). Odd ratio (OR) of all the studies were collected depending on the result of their heterogeneity tests. Publication bias was assessed by using a funnel plot and Egger’s test. Results: Eight papers were selected based on study criteria. Meta analysis results showed that the combined OR values (95%CI) of dominant model and recessive model were 0.51(0.40,0.65) and0.72(0.61, 0.85), They were both statistically significant (P<0.001). Significant associations were observed for Fok? polymorphisms among Chinese. Conclusion: The results suggest that Vitamin D receptor gene polymorphism was significantly associated with TB in China. Our findings support the hypothesis that vitamin D deficiency might play a role in TB infection and development of associated risk factors.

Meta-Analysis of the Relationship Between HLA-DRB1*07and HLA-DRB1*13 Gene Polymorphisms, and Chronic Hepatitis B in Chinese Han Population

Objective:To assess the relationship of HLA-DRB1*07 and HLA-DRB1*13 gene polymorphisms with chronic hepatitis B (CHB) in Chinese Han population Methods: A comprehensive search for articles from 2000 to 2015 was conducted from China National Knowledge Infrastructure (CNKI), VIP and Medline databases. Ten epidemiological case-control studies on the relationship between gene polymorphisms of HLA-DRB1*07 and HLA-DRB1*13, and CHB were subjected to meta analysis. Potential publication bias was analyzed with Review Manager 5.3 software and stata software. Results: A total of 838 patients with CHB and 1181 uninfected healthy controls were included from the ten studies. HLA-DRB1*07 alleles were the risk factors of CHB, with pooled odds ratio of 2.09 (95% CI=1.26~3.47;Z=2.86,P<0.01). HLA-DRB1*13 alleles were the protection factors against CHB, and the value of pooled odds ratio was 0.32 (95% CI=0.19~0.57;Z=3.94,P<0.01) Conclusion: CHB is associated with gene polymorphism of HLA-DRB1 in Chinese Han population. HLA-DRB1*07 alleles were the risk factors of CHB, while HLA-DRB1*13 alleles were the protection factors against the disease.