Umbilical Cord and Maternal Serum Levels of Mezlocillin in Term and Preterm Deliveries in Mothers Diagnosed with Chorioamnionitis

Objectives. The aim was to investigate neutrophil gelatinase-associated lipocalin (NGAL) levels in the serum and term placentas and its potential role in gestational diabetes mellitus (GDM). Methods. A total of 49 GDM subjects and 39 age-matched women with normal pregnancies were recruited. We examined serum concentrations of NGAL and tumor necrosis factor-α (TNF-α) in maternal blood and cord blood and their expression levels in the term placentas and umbilical cord. Results. Serum NGAL levels were significantly higher in GDM patients than in normal pregnant controls both in the maternal blood (4.80 ± 1.99 vs. 3.66 ± 1.13, P=0.001) and the cord blood (4.70 ± 2.08 vs. 3.85 ± 1.44, P=0.027). Moreover, serum NGAL levels exhibited a positive correlation with various parameters of insulin resistance. Maternal serum NGAL levels positively correlated with the NGAL levels found in the cord blood of the control (r = 0.399, P=0.012) and the GDM subjects (r = 0.349, P=0.014). Finally, the expression of NGAL protein levels in the placenta (1.22 ± 0.39 vs. 0.65 ± 0.23, P<0.001) and umbilical cord (0.65 ± 0.23 vs. 0.25 ± 0.10, P<0.001) were higher in GDM women than those noted in the control subjects. In the GDM group, maternal serum NGAL levels exhibited a positive correlation with placental NGAL mRNA and protein levels (r = 0.848, P=0.008; r = 0.636, P=0.011, respectively). Conclusions. NGAL may be an important adipokine involved in GDM and fetal development. The oversecretion of NGAL from the placenta may contribute to the elevated levels of serum NGAL in gestational diabetes mellitus.

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Inflammatory cytokines in newborn infants

Mediators of Inflammation ◽

10.1080/09629359890811 ◽

1998 ◽

Vol 7 (5) ◽

pp. 309-312 ◽

Cited By ~ 21

Author(s):

A. Sarandakou ◽

G. Giannaki ◽

A. Malamitsi-Puchner ◽

D. Rizos ◽

E. Hourdaki ◽

...

Keyword(s):

Immune Response ◽

Umbilical Cord ◽

Inflammatory Cytokines ◽

Environmental Changes ◽

Mode Of Delivery ◽

Newborn Infants ◽

Serum Levels ◽

Perinatal Period ◽

Maternal Serum ◽

Tnf Α

Serum levels of IL-1β, IL-6 and TNF-α were measured in 48 healthy, termed neonates on the 1st (N1), 5th (N5) and 40th (N40) day after birth, compared with those in maternal serum (MS), umbilical cord (UC) and adult controls. Cytokine values in N1 and N5 were significantly elevated, than those in UC and in controls(p<0.0001). IL-1β and IL-6 declined significantly from N1 to N40(p<0.0001), while TNF-α increased significantly from N1 to N5 and declined thereafter. MS∞IL-1β and IL-6, but not MS∞TNF-α, were significantly higher than those of controls(p<0.0001). IL-1β values depended on the mode of delivery. In conclusion, the increased concentrations of IL-1 β, IL-6 and TNF-α during the perinatal period might suggest their involvement in an inflammation like process during normal parturition, and reflect also a newborn immune response to the stress of delivery and environmental changes.

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Maternal serum levels of macrophage colony stimulating factor are related to adverse pregnancy outcome

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86461-1 ◽

1998 ◽

Vol 5 (1) ◽

pp. 132A-132A

Author(s):

J KEITHJR ◽

R PIJNENBORG ◽

C LUVTEN ◽

B SPITZ ◽

R SCHAUB ◽

...

Keyword(s):

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Serum Levels ◽

Maternal Serum ◽

Colony Stimulating Factor ◽

Macrophage Colony Stimulating Factor ◽

Adverse Pregnancy ◽

Macrophage Colony ◽

Stimulating Factor

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Interleukin-6 and Malondialdehyde in Women with Preterm Birth

Current Immunology Reviews ◽

10.2174/1573395515666191026140006 ◽

2019 ◽

Vol 15 (2) ◽

pp. 207-212

Author(s):

Vinita Verma ◽

Hina Oza ◽

Riddhi Thaker ◽

Sunil Kumar

Keyword(s):

Oxidative Stress ◽

Preterm Birth ◽

Interleukin 6 ◽

Critical Role ◽

Serum Levels ◽

Maternal Serum ◽

Full Term ◽

Mortality And Morbidity ◽

Term Birth ◽

Weak Negative Correlation

Background: Preterm Birth (PTB) is one of the main causes of neonatal death and infant mortality and morbidity. The pro-inflammatory cytokine interleukin-6 (IL-6) is a major proinflammatory mediator of the host response to infection and malondialdehyde (MDA) is a marker of oxidative stress. Objective : To evaluate potential associations between IL-6 and MDA levels in women with preterm birth. Method: A total of 150 women (66 with full-term and 84 with PTB) were enrolled in this case-control study. Predesigned performas were filled through questionnaire interviews to collect data on personal, demographic, occupational, lifestyle and reproductive history. Blood samples were collected within 36 hours of delivery. Serum concentrations of IL-6 and MDA were determined in mothers with full-term and preterm birth. Results: The mean age was marginally higher; whereas BMI was slightly lower in cases (PTB) as compared to controls (full-term) subjects. Serum IL-6 and MDA levels were significantly higher in subjects with PTB than full-term birth. The data were further analyzed with respect to underweight, normal and overweight/obese BMI. In all the BMI categories, the levels of IL-6 and MDA were higher in PTB cases. Among the PTB categories, the levels of IL-6 and MDA were highest in moderate to late preterm birth. A significant positive correlation was found between IL-6 and MDA levels. There was a weak negative correlation between either IL-6 or MDA and the number of gestational weeks. Conclusion : Elevated maternal serum levels of Interleukin-6 and Malondialdehyde in preterm as compared to full-term birth might suggest that inflammation and oxidative stress play a critical role in PTB.

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Serum levels of caffeine in umbilical cord and apnea of prematurity

Jornal de Pediatria ◽

10.2223/jped.1990 ◽

2010 ◽

Vol 86 (2) ◽

pp. 137-142 ◽

Cited By ~ 4

Author(s):

Cláudia Regina Hentges ◽

Renata Rostirola Guedes ◽

Rita C. Silveira ◽

Renato S. Procianoy

Keyword(s):

Umbilical Cord ◽

Serum Levels ◽

Apnea Of Prematurity

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Resistin in pregnancy: analysis of determinants in pairs of umbilical cord blood and maternal serum

Cytokine X ◽

10.1016/j.cytox.2021.100052 ◽

2021 ◽

pp. 100052

Author(s):

Anne FLOECK ◽

Nina FERRARI ◽

Christine JOISTEN ◽

Maria T. PUTH ◽

Brigitte STRIZEK ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Maternal Serum ◽

In Pregnancy

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Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review

Journal of Clinical Medicine ◽

10.3390/jcm9010183 ◽

2020 ◽

Vol 9 (1) ◽

pp. 183 ◽

Cited By ~ 1

Author(s):

Katarzyna Kosinska-Kaczynska ◽

Magdalena Zgliczynska ◽

Szymon Kozlowski ◽

Lukasz Wicherek

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Serum Levels ◽

Maternal Serum ◽

Placental Growth Factor ◽

Cochrane Library ◽

Original Research ◽

Multiple Gestation ◽

Soluble Endoglin ◽

Twin Pregnancies

Multiple gestation is one of the key risk factors for the occurrence of preeclampsia (PE). Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of PE. The aim of the review was to summarize available data on maternal serum levels of the above-mentioned factors and their usefulness in predicting PE in twin pregnancies. Only original research articles written in English were considered eligible. Reviews, chapters, case studies, conference papers, experts’ opinions, editorials, and letters were excluded from the analysis. No publication date limitations were imposed. The systematic literature search using PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases identified 338 articles, 10 of which were included in the final qualitative analyses. The included studies showed significant differences in maternal serum levels of the discussed factors between women with twin pregnancies with PE and those who did not develop PE, and their promising performance in predicting PE, alone or in combination with other factors. The identification of the most effective algorithms, their prompt introduction to the clinical practice, and further assessment of the real-life performance should become a priority.

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