Economic consequence of switching to citalopram after its generic entry for adult patients with major depressive disorder (MDD) treated with escitalopram: a 6-month retrospective study

2010 ◽  
Vol 13 (4) ◽  
pp. 599-609
Author(s):  
Andrew P. Yu ◽  
Jipan Xie ◽  
Arielle Bensimon ◽  
Kejal Parikh ◽  
Eric Q. Wu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
Adult Patients ◽  
Economic Consequence ◽  
Major Depressive ◽  
Generic Entry

scholarly journals Repeated use of SSRIs potentially associated with an increase on serum CK and CK-MB in patients with major depressive disorder: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shengwei Wu ◽  
Yufang Zhou ◽  
Zhengzheng Xuan ◽  
Linghui Xiong ◽  
Xinyu Ge ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Cardiac Injury ◽  
First Episode ◽  
Cardiovascular Risks ◽  
Major Depressive ◽  
Depressive Patients

AbstractThere is a large amount of evidence that selective serotonin reuptake inhibitors (SSRIs) are related to cardiovascular toxicity, which has aroused concern regarding their safety. However, few studies have evaluated the effects of SSRIs on cardiac injury biomarkers, such as creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether SSRIs elevated CK and CK-MB levels of prior medicated depressive patients (PMDP) compared to first-episode drug-naïve depressive patients (FDDPs). We performed an observational and retrospective study involving 128 patients with major depressive disorder. Patients who had never used any type of antidepressant were designated FDDP; patients who had used only one type of SSRI but were not treated after a recent relapse were designated PMDP. Serum CK and CK-MB levels were measured before and after using SSRIs for a period of time. The duration of current treatment in the FDDP and PMDP groups was 16.200 ± 16.726 weeks and 15.618 ± 16.902 weeks, respectively. After SSRI treatment, levels of serum CK in the PMDP group were significantly higher than in the FDDP group. Univariate ANCOVA results revealed that PMDP was 22.313 times more likely to elevate CK (OR 22.313, 95% CI 9.605–35.022) and 2.615 times more likely to elevate CK-MB (OR 2.615, 95% CI 1.287–3.943) than FDDP. Multivariate ANCOVA revealed an interaction between the group and sex of CK and CK-MB. Further pairwise analysis of the interaction results showed that in female patients, the mean difference (MD) of CK and CK-MB in PMDP was significantly greater than that in FDDP (MD = 33.410, P = 0.000, 95% CI 15.935–50.886; MD = 4.613, P = 0.000, 95% CI 2.846–6.381). Our findings suggest that patients, especially females, who had previously used SSRI antidepressants were more likely to have elevated CK and CK-MB, indicators of myocardial muscle injury. Use of SSRIs should not be assumed to be completely safe and without any cardiovascular risks.

scholarly journals Predictors of 1-Year Rehospitalization for Patients with Major Depressive Disorder: A Retrospective Study in a University Hospital

2021 ◽  
Vol 19 (2) ◽  
pp. 64-73
Author(s):  
Ji-Min Yoo ◽  
Sung-Min Kim ◽  
Yoo-Hyun Um ◽  
Tae-Won Kim ◽  
Ho-Jun Seo ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
University Hospital ◽  
Major Depressive

scholarly journals Childhood Adversity Impairs Theory of Mind Abilities in Adult Patients With Major Depressive Disorder

2019 ◽  
Vol 10 ◽  
Author(s):  
Maria Simon ◽  
Nándor Németh ◽  
Mónika Gálber ◽  
Elza Lakner ◽  
Eszter Csernela ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Theory Of Mind ◽  
Depressive Disorder ◽  
Childhood Adversity ◽  
Adult Patients ◽  
Major Depressive

scholarly journals Major depressive disorder is associated with subsequent adult-onset asthma: a population-based cohort study

2016 ◽  
Vol 26 (6) ◽  
pp. 664-671 ◽  
Author(s):  
T-C. Shen ◽  
C-L. Lin ◽  
C.H. Liao ◽  
C-C. Wei ◽  
F-C. Sung ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Proportional Hazards ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Adult Patients ◽  
Major Depressive ◽  
Significant Difference ◽  
Receptor Blockers

Aim.To examine the incidence of asthma in adult patients with major depressive disorder (MDD).Methods.From the National Health Insurance database of Taiwan, we identified 30 169 adult patients who were newly diagnosed with MDD between 2000 and 2010. Individuals without depression were randomly selected four times and frequency matched for sex, age and year of diagnosis. Both cohorts were followed-up for the occurrence of asthma up to the end of 2011. Adjusted hazard ratios (aHRs) of asthma were estimated using the Cox proportional hazards method.Results.The overall incidence of asthma was 1.91-fold higher in the MDD cohort than in the non-depression cohort (7.55 v. 3.96 per 1000 person-years), with an aHR of 1.66 (95% confidence interval (CI) 1.55–1.78). In both cohorts, the incidence of asthma was higher in patients and controls who were female, aged, with comorbidities and users of aspirin or beta-adrenergic receptor blockers. No significant difference was observed in the occurrence of asthma between patients with MDD treated with selective serotonin reuptake inhibitors (SSRIs) and those treated with non-SSRIs (SSRIs to non-SSRIs aHR = 1.03, 95% CI 0.91–1.17).Conclusion.Adult patients with MDD are at a higher risk of asthma than those without depression are.

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