scholarly journals Predictors of 1-Year Rehospitalization for Patients with Major Depressive Disorder: A Retrospective Study in a University Hospital

2021 ◽  
Vol 19 (2) ◽  
pp. 64-73
Author(s):  
Ji-Min Yoo ◽  
Sung-Min Kim ◽  
Yoo-Hyun Um ◽  
Tae-Won Kim ◽  
Ho-Jun Seo ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
University Hospital ◽  
Major Depressive

scholarly journals Repeated use of SSRIs potentially associated with an increase on serum CK and CK-MB in patients with major depressive disorder: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shengwei Wu ◽  
Yufang Zhou ◽  
Zhengzheng Xuan ◽  
Linghui Xiong ◽  
Xinyu Ge ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Major Depressive Disorder ◽  
Retrospective Study ◽  
Depressive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Cardiac Injury ◽  
First Episode ◽  
Cardiovascular Risks ◽  
Major Depressive ◽  
Depressive Patients

AbstractThere is a large amount of evidence that selective serotonin reuptake inhibitors (SSRIs) are related to cardiovascular toxicity, which has aroused concern regarding their safety. However, few studies have evaluated the effects of SSRIs on cardiac injury biomarkers, such as creatine kinase (CK) and creatine kinase isoenzyme (CK-MB). The purpose of our study was to determine whether SSRIs elevated CK and CK-MB levels of prior medicated depressive patients (PMDP) compared to first-episode drug-naïve depressive patients (FDDPs). We performed an observational and retrospective study involving 128 patients with major depressive disorder. Patients who had never used any type of antidepressant were designated FDDP; patients who had used only one type of SSRI but were not treated after a recent relapse were designated PMDP. Serum CK and CK-MB levels were measured before and after using SSRIs for a period of time. The duration of current treatment in the FDDP and PMDP groups was 16.200 ± 16.726 weeks and 15.618 ± 16.902 weeks, respectively. After SSRI treatment, levels of serum CK in the PMDP group were significantly higher than in the FDDP group. Univariate ANCOVA results revealed that PMDP was 22.313 times more likely to elevate CK (OR 22.313, 95% CI 9.605–35.022) and 2.615 times more likely to elevate CK-MB (OR 2.615, 95% CI 1.287–3.943) than FDDP. Multivariate ANCOVA revealed an interaction between the group and sex of CK and CK-MB. Further pairwise analysis of the interaction results showed that in female patients, the mean difference (MD) of CK and CK-MB in PMDP was significantly greater than that in FDDP (MD = 33.410, P = 0.000, 95% CI 15.935–50.886; MD = 4.613, P = 0.000, 95% CI 2.846–6.381). Our findings suggest that patients, especially females, who had previously used SSRI antidepressants were more likely to have elevated CK and CK-MB, indicators of myocardial muscle injury. Use of SSRIs should not be assumed to be completely safe and without any cardiovascular risks.

Major Depressive Disorder: Recurrence Risk Factors

2017 ◽  
Vol 41 (S1) ◽  
pp. S139-S139
Author(s):  
R. Ben Soussia ◽  
S. Khouadja ◽  
I. Marrag ◽  
S. Younes ◽  
M. Nasr
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Age At Onset ◽  
Recurrence Risk ◽  
University Hospital ◽  
Major Depressive ◽  
Residual Symptoms ◽  
Time To Recurrence ◽  
Depressive Episodes

IntroductionIn spite of the frequency and the gravity of the depressive episodes, the major depressive disorder (MDD) is diagnosed and treated today insufficiently and the risk factors of its recurrence are little approached.Aims of the studyDescribe the socio–demographic, clinical and therapeutic characteristics of patients with MDD and identify the factors involved in the recurrence risk.MethodologyThis is a retrospective study carried out in the university hospital of Mahdia, Tunisia during two years. We have included patients with a follow up for at least two years and diagnosed with MDD, isolated episode or MDD, recurrent episode according to the DSM-IV-TR criteria. Data collection was performed using two pre-established questionnaires respectively with 51 and 92 items. We have estimated the time to recurrence with the Kaplan-Meier estimator.ResultsWe have collected 150 patients. The time to recurrence was 109 months. Five factors were associated with recurrence: early age at onset of the disorder, family history of mood disorders, severity of the index major depressive episode, persistent residual symptoms and ceasing treatment.ConclusionDepression is a very common mental illness that is highly recurrent in individuals. There is great interest in the development of strategies that might reduce the recurrence of depression.

scholarly journals The association between alexithymia and two dimensions of major depressive disorder: cognitive and somatic-affective

2020 ◽  
Vol 57 (1) ◽  
pp. 39-52
Author(s):  
Maja Vilibić ◽  
Anita Dostal ◽  
Dalibor Karlović
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
False Discovery Rate ◽  
Target Population ◽  
Two Dimensions ◽  
University Hospital ◽  
Major Depressive ◽  
Cross Sectional ◽  
Cognitive Dimension ◽  
False Discovery

Aim: To explore the association between alexithymia and two dimensions of major depressive disorder (MDD): cognitive and somatic-affective. Patients and methods. Unicentric, cross-sectional study included consecutive sample of 63 patients at the Department of Psychiatry (DoP), Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia. Target population included outpatients with diagnosed MDD (F32 and F33, according to ICD-10). Inclusion criteria were: confirmed MDD diagnosis, age between 18 and 65 years, both genders, outpatient treatment at the DoP. The main outcome was the association between alexithymia, measured by total score on 20-item Toronto-Alexithymia scale (TAS-20), with two dimensions of MDD, cognitive and somatic-affective, measured by Beck Depression Inventory-II (BDI-II). Results: Both dimensions of BDI-II and the total severity of MDD symptoms were statistically significantly, although low, associated with alexithymia, and the differences between these two correlations were not (statistically) significant. However, in the multivariable model, the cognitive dimension (b = 0.64; β = 0.48; p = 0.002; statistically significant at the false discovery rate of 0.05) was primarily associated with alexithymia, and the somatic-affective was not, after all cognitive aspects were controlled for (b = -0.19; β = 0-0.14; p = 0.491; not statistically significant, with the false discovery rate of 0.05). Conclusion: Alexithymia is primarily associated with a pure cognitive dimension of MDD after somatic-affective elements are excluded. Somatic-affective dimension of MDD is not associated with alexithymia after the cognitive elements were controlled for. Both dimensions, as well as the overall severity of MDD, are associated with alexithymia, but this association is relatively low.

Electroencephalogram Source Connectivity in the Prediction of Electroconvulsive Therapy Outcome in Major Depressive Disorder

2019 ◽  
Vol 51 (1) ◽  
pp. 10-18 ◽  
Author(s):  
Alexandra Kirsten ◽  
Erich Seifritz ◽  
Sebastian Olbrich
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
University Hospital ◽  
Major Depressive ◽  
First Line Therapy ◽  
Eeg Connectivity ◽  
Brain Tomography ◽  
Eeg Alpha

Objectives. Major depressive disorder (MDD) is a common and potentially lethal disorder affecting up to 14% of all persons worldwide. However, one-third to thwo-thirds of patients are nonresponders to first-line therapy. Even the electroconvulsive therapy (ECT) as the option of choice in therapy-resistant MDD still shows a high proportion of nonresponders. In case of a predicted nonresponse to ECT, for example, by means of electrophysiological electroencephalogram (EEG) parameters, other therapies of MDD (eg, augmentation, polypharmacy etc) could be chosen. Methods. In this study, we retrospectively analyzed 2-minute resting state EEGs from patients with MDD who underwent ECT (6-12 sessions with 3 sessions per week) between 2006 and 2015 at the University Hospital of Zurich. Following several lines of evidence, we hypothesized altered linear EEG connectivity within the alpha band being predictive for treatment outcome. We used a network-based statistics (NBS) approach to compare connectivity measures between responders and nonresponders. Source estimates and connectivity measures were mapped using low-resolution brain tomography (LORETA). As the main outcome parameter served the retrospectively assessed efficacy index (CGI-E) from the Clinical Global Impression (CGI) rating scale. Results. Responders in comparison with non-responders showed a significant lower linear lagged connectivity in widespread cortical areas within the EEG alpha 2 band. Additionally, there were strong correlations between CGI ratings and connectivity strength mainly within frontal cortices. Conclusions. Pretreatment EEG-connectivity within the alpha 2 band has a predictive value for the efficacy of ECT treatment.

scholarly journals Diagnostic Stability of Major Depressive Disorder in hospitalized patients in a University Hospital: a Brief Report

2021 ◽  
Vol 5 (3) ◽  
pp. 141-144
Author(s):  
Enrique De Doménico ◽  
João Mauricio Castaldelli-Maia ◽  
Antonio Ventriglio ◽  
Julio Torales
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Hospital Admission ◽  
Mentally Ill ◽  
University Hospital ◽  
Major Depressive ◽  
Cross Sectional ◽  
Diagnostic Stability ◽  
Probabilistic Sampling ◽  
National University

Introduction: There may be a discordance between diagnoses at admission and discharge of mentally ill patients with major issues regarding their diagnostic stability. The objective of this brief report was to determine the diagnostic stability of major depressive disorder at patients’ discharge and if the diagnosis of their hospital admission had been retained. Methodology: This was a pilot, descriptive, cross-sectional, and retrospective observational study. A non-probabilistic sampling of consecutive cases was used.  We reviewed the medical records, at admission and discharge, of patients with an initial diagnosis of major depressive disorder, hospitalized in the Department of Psychiatry of the ‘Hospital de Clínicas’ of the National University of Asunción, Paraguay, during the months of October to December 2020. Results: Fifty-three patients with a diagnosis of major depression on their hospital admission were included in the study (mean age = 35.7 ± 16.5 years). 79.2 % were women, 52.8 % were single, and 37.7 % were from the Central province of Paraguay. The most frequent diagnosis at discharge was borderline personality disorder, in 35.8% of cases. Major depressive disorder was confirmed in 15.1% of cases. No significant relationship was found between any discharge diagnosis and sociodemographic data. Conclusion: The results of this study, although preliminary, described the trajectories of diagnoses in the Psychiatry Department of a University hospital, but confirmatory studies are needed.

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