Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Cardiovascular Diseases ◽  
Ventricular Remodeling ◽  
Myocardial Hypertrophy ◽  
Cell Communication ◽  
Prognostic Indicators ◽  
Cardiovascular Protection ◽  
Heart Failure Progression ◽  
Mediate Cell ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Therapeutic Alternatives

Myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis are all influenced by cardiac exosome proteins and miRNAs, which mediate cell-to-cell communication, stimulate or inhibit target cell activities, and have an impact on myocardial hypertrophy, injury and infarction, ventricular remodeling, angiogenesis, and atherosclerosis. Circulating cardiac-specific exosome microRNAs show potential as biomarkers for early identification of acute myocardial infarction and as prognostic indicators for ischemic cardiomyopathy and congestive heart failure progression. Exosomes' function in cardiovascular protection and neovascularization implies that they might be used to treat ischemia and atherosclerotic cardiovascular diseases. Because of their biocompatibility, circulatory stability, biological barrier penetration, limited immunogenicity, and low toxicity, exosomes have the potential to deliver therapeutic pharmacologic compounds.A greater understanding of exosome composition and activity will facilitate the development of novel therapeutic alternatives for the treatment of patients with atherosclerotic cardiovascular diseases.

Cumulative prevalence of risk factors for atherosclerotic cardiovascular diseases in Iranian adolescents: IHHP-HHPC

2005 ◽  
Vol 81 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Roya Kelishadi ◽  
Gholamhossein Sadri ◽  
Ali Akbar Tavasoli ◽  
Manijeh Kahbazi ◽  
Hamid Reza Roohafza ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Atherosclerotic Cardiovascular Diseases ◽  
Cumulative Prevalence

Highlighting Exosomes' Function in Cardiovascular Diseases

2021 ◽  
Vol 17 ◽  
Author(s):  
Sidhi Laksono ◽  
Budhi Setianto ◽  
Ananta Siddhi Prawara ◽  
Bambang Dwiputra
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Prognostic Marker ◽  
Therapeutic Agent ◽  
Diagnostic Marker ◽  
Cell Communication ◽  
Surface Protein ◽  
Cardiovascular Patients

: Exosomes as one of the extracellular vesicles’ subgroups played an important role in the cell to cell communication. The cargos and surface protein of exosomes have been known to affect the cardiovascular system both positively and negatively in chronic heart failure, ischemic heart disease, and atherosclerosis. There have been several exosomes that emerged as a potential diagnostic and prognostic marker in cardiovascular patients. However, the conditions affecting the patients and the method of isolation should be considered to create a standardized normal value of the exosomes and the components. CPC-derived exosomes, ADSCs-derived exosomes, and telocyte-derived exosomes have been proven to be capable ofacting as a therapeutic agent in myocardial infarction models. Exosomes have the potential to become a diagnostic marker, prognostic marker, and therapeutic agent in cardiovascular diseases.

scholarly journals Isolation and Identification of Exosomes from Feline Plasma, Urine and Adipose-Derived Mesenchymal Stem Cells

2021 ◽  
Author(s):  
Dongsheng Li ◽  
Huina Luo ◽  
Huimin Ruan ◽  
Zhisheng Chen ◽  
Shengfeng Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Transmembrane Protein ◽  
Cell Communication ◽  
Phospholipid Bilayer ◽  
Differential Centrifugation ◽  
Isolation And Identification ◽  
Feasible Method ◽  
Transmission Electron ◽  
Mediate Cell

Abstract Background: Exosomes, internal proteins, lipids, and nucleic acids coated by phospholipid bilayer membranes, are one type of small extracellular vesicles, which can mediate cell-cell communication. In recent years, exosomes have gained considerable scientific interest due to their widely applied prospect in the diagnosis and therapeutics of human and animal diseases. In this study, we describe for the first time a feasible method designed to isolate and characterize exosomes from feline plasma, urine and adipose-derived mesenchymal stem cells. Results: Exosomes from feline plasma, urine and adipose-derived mesenchymal stem cells were successfully isolated by differential centrifugation. Quantification and sizing of exosomes were assessed by transmission electron microscopy, flow nano analysis and western blotting. Detected particles showed the normal size (30-100 nm) and morphology described for exosomes, as well as presence of the transmembrane protein (TSG101, CD9, CD63, and CD81) known as exosomal marker.Conclusions: The results suggest that differential centrifugation is a feasible method for isolation of exosomes from different types of feline samples. Moreover, these exosomes can be used to further diagnosis and therapeutics in veterinary pre-clinical and clinical studies.

CHRONIC KIDNEY DISEASE AND THE STATE OF THE CARDIOVASCULAR SYSTEM IN LOCOMOTIVE CREW WORKERS

2021 ◽  
Author(s):  
V.A. Zhmurov ◽  
◽  
D.V. Zhmurov ◽  
V.G. Yarkova
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiovascular System ◽  
Cardiovascular Events ◽  
Ventricular Remodeling ◽  
Myocardial Hypertrophy ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
Professional Activities ◽  
Ckd Stage

Abstract: 967 employees of locomotive crews (drivers and their assistants of the Sverdlovsk railway of JSC «Russian Railways») were examined. It was revealed that CKD occurs in 12, 09% of employees of locomotive crews. As the CKD stage increases, the progression of changes in the cardiovascular system was found in locomotive crew workers. A high percentage of the prognostically unfavorable variant of left ventricular remodeling - eccentric myocardial hypertrophy (25% - 39.1%, depending on the stage of CKD) was found. These changes may be a factor of adverse cardiovascular events in employees of locomotive crews, which must be taken into account when admitting to professional activities.

Investigating the growth performance, meat quality, immune function and proteomic profiles of plasmal exosomes in Lactobacillus plantarum-treated immunosuppressive broilers

2021 ◽  
Author(s):  
Huawei Liu ◽  
Fan Zhao ◽  
Kai Zhang ◽  
Jinshan Zhao ◽  
Yang Wang
Keyword(s):  
Immune Function ◽  
Growth Performance ◽  
Lactobacillus Plantarum ◽  
Meat Quality ◽  
Cell Communication ◽  
Mediate Cell

Exosomes are extracellular membranous nanovesicles that carry functional molecules to mediate cell-to-cell communication. Untile now, whether probiotics improve the immune function of broilers by plasmal exosomal cargo is unclear. In...

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