scholarly journals RNA-seq of a lung sample from a male COVID19 deceased patient (age 74) submitted by Icahn School of Medicine at Mount Sinai does not show the anaerobic/aerobic homeostasis disruption observed in other patient samples - an artifact of post-mortem procedures?

2020 ◽  
Author(s):  
Sandeep Chakraborty
Keyword(s):  
Atmospheric Oxygen ◽  
Anaerobic Bacteria ◽  
Rna Seq ◽  
Patient Age ◽  
School Of Medicine ◽  
Lung Sample ◽  
Obligate Anaerobic ◽  
Patient Âgé ◽  
Mount Sinai ◽  
Deceased Patient

Here, I have analyzed the RNA-seq of a lung sample from a male COVID19 deceased patient (age 74) submitted by Icahn School of Medicine at Mount Sinai (Accid:PRJNA615032). There are two replicates, which I have pooled into a single sample. The analysis (Table 1, SI/bact.txt) does not show the anaero- bic/aerobic homeostasis disruption observed in some patient samples [1–3]. Although not all samples show anaerobic/aerobic homeostasis disruption [4–6], they are possibly patients in the early phase of the disease. The findings in the current deceased patient (viral load is very low, SI/viralreads.fa) however does not align with the hypothesis [7], unless there are artifacts arising from obtaining the lung sample. Since obligate anaerobic bacteria cant tolerate more than 5% oxygen, and atmospheric oxygen is much higher, could these have been killed after atmospheric exposure? Note, anaerobic bacteria are present - its just that they don’t seem to have colonized the lung of the deceased patient.

scholarly journals Phylogenomics Suggests the Origin of Obligately Anaerobic Anammox Bacteria Correlates with the Great Oxidation Event

2021 ◽  
Author(s):  
Tianhua Liao ◽  
Sishuo Wang ◽  
Haiwei Luo
Keyword(s):  
Sequence Data ◽  
Atmospheric Oxygen ◽  
Nitrogen Loss ◽  
Anaerobic Bacteria ◽  
Anammox Bacteria ◽  
Ammonium Oxidation ◽  
Data Set ◽  
Origin And Evolution ◽  
Great Oxidation Event ◽  
Obligate Anaerobic

The anaerobic ammonium oxidation (anammox) bacteria transform ammonium and nitrite to dinitrogen gas, and this obligate anaerobic process accounts for nearly half of global nitrogen loss. Yet its origin and evolution, which may give important insights into the biogeochemistry of early Earth, remains enigmatic. Here, we compile a comprehensive sequence data set of anammox bacteria, and confirm their single origin within the phylum Planctomycetes. After accommodating the uncertainties and factors influencing time estimates with different statistical methods, we estimate that anammox bacteria originated at 2.0 - 2.6 Ga, broadly coinciding with the Great Oxidation Event (GOE) which is thought to have fundamentally changed global biogeochemical cycles. We further show that during the origin of anammox bacteria, genes involved in oxidative stress, bioenergetics and anammox granules formation were recruited, which may have contributed to their survival in an increasingly oxic Earth. Our findings suggest the rising level of atmospheric oxygen, which made nitrite increasingly available, as a potential driving force for the emergence of anammox bacteria. This is one of the first studies that link GOE to the evolution of obligate anaerobic bacteria.

Gestion orthopédique d’une ankylose de l’ATM chez l’enfant

2020 ◽  
Vol 54 (4) ◽  
pp. 407-418
Author(s):  
Pamela Villalon-Pooley ◽  
Camila Hernandez-Veliz ◽  
Maria Fernanda Pinto-Chavez ◽  
Pierre Bourdiol
Keyword(s):  
Patient Age ◽  
Patient Âgé

Parmi les fractures cranio-faciales, celles affectant le condyle mandibulaire font partie des fractures les plus souvent rencontrées chez le patient en âge pédiatrique. L’évolution sans traitement peut produire une ankylose temporo-mandibulaire entraînant troubles fonctionnels et asymétrie de la croissance cranio-faciale. Le traitement traditionnellement chirurgical est d’un pronostic généralement réservé. Dans cet article est présenté le cas d’un patient, âgé de quatre ans, atteint d’ankylose fibreuse de l’articulation temporo-mandibulaire gauche, suite probable d’une fracture du col du condyle non-diagnostiquée. La libération fonctionnelle de la fibro-ankylose articulaire a été l’objectif de la première étape thérapeutique. Celle-ci a été suivie, à l’âge de sept ans, d’une distraction articulaire obtenue au moyen de butées occlusales controlatérales disposées côté droit. Ceci a produit un ajustement de la croissance dento-alvéolaire assurant à la fois un rattrapage du déficit de croissance unilatéral de départ et une néoformation condylienne par remodelage de l’articulation temporo-mandibulaire gauche. Quatre années après la mise en route de la phase orthopédique initiale, la fonction articulaire restaurée et l’équilibre facial obtenu restent stables chez ce jeune patient

Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

2012 ◽  
Vol 32 (S 01) ◽  
pp. S39-S42 ◽  
Author(s):  
S. Kocher ◽  
G. Asmelash ◽  
V. Makki ◽  
S. Müller ◽  
S. Krekeler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Frequent Change ◽  
Patient Age ◽  
Treatment Regimens ◽  
Patient Âgé ◽  
The Relationship ◽  
Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

Hämophilie-Zentrum Bonn 1980 – 2009

2011 ◽  
Vol 31 (S 01) ◽  
pp. S4-S10 ◽  
Author(s):  
I. Besmens ◽  
H.-H. Brackmann ◽  
J. Oldenburg
Keyword(s):  
Young Patients ◽  
Severe Form ◽  
Coagulation Disorder ◽  
Care Providers ◽  
Long Distance ◽  
Patient Age ◽  
Patient Âgé ◽  
Number Of Patients ◽  
Clotting Disorder ◽  
Regional Character

SummaryThe Bonn Haemophilia Care Center provides patient care on a superregional level. The centre’s large service area is, in part, due to the introduction of haemophilia home treatment and related to this the individualized prophylaxis in children and adults by Egli and Brack-mann in Bonn in the early 1970s, that represented a milestone in German haemophilia therapy. Epidemiologic patient data from the two selected time points, 1980 and 2009, are evaluated to illustrate the change in the composition of the patient clientele. In 1980 a total of 639 patients were treated at the Bonn Haemophilia Center. 529 patients exhibited a severe form and 110 a non-severe form of the respective clotting disorder. In 2009 the Bonn Haemophilia Center took care for a total of 837 patients. There were 445 patients who suffered from a severe form of the considered clotting disorder while 392 showed a non-severe course. The number of less severely affected patients has increased significantly in 2009. Patients in 1980 were predominantly suffering from a severe form and most had to travel more than 150 km from their homes to the treatment center. In 2009 the number of patients living a medium-long distance from the care provider has significantly increased while the number of patients living more than 150km from the center has decreased. Comparing 2009 to 1980 a growth of the center’s regional character becomes apparent, especially when patient age and severity of the coagulation disorder are taken into consideration. The regional character was more strongly pronounced with milder disease severity and lower patient age. Due to the existence of well established primary haemophilia care in CCCs in Germany, the trend for the recent years is that the proportion of young patients that choose haemophilia care providers closer to their homes is increasing.

scholarly journals Colonocyte metabolism shapes the gut microbiota

Science ◽  
2018 ◽  
Vol 362 (6418) ◽  
pp. eaat9076 ◽  
Author(s):  
Yael Litvak ◽  
Mariana X. Byndloss ◽  
Andreas J. Bäumler
Keyword(s):  
Gut Microbiota ◽  
Anaerobic Bacteria ◽  
Enteric Pathogens ◽  
Metabolic Reprogramming ◽  
Human Diseases ◽  
Fermentation Products ◽  
Colonic Microbiota ◽  
Obligate Anaerobic ◽  
Control Switch ◽  
Facultative Anaerobic Bacteria

An imbalance in the colonic microbiota might underlie many human diseases, but the mechanisms that maintain homeostasis remain elusive. Recent insights suggest that colonocyte metabolism functions as a control switch, mediating a shift between homeostatic and dysbiotic communities. During homeostasis, colonocyte metabolism is directed toward oxidative phosphorylation, resulting in high epithelial oxygen consumption. The consequent epithelial hypoxia helps to maintain a microbial community dominated by obligate anaerobic bacteria, which provide benefit by converting fiber into fermentation products absorbed by the host. Conditions that alter the metabolism of the colonic epithelium increase epithelial oxygenation, thereby driving an expansion of facultative anaerobic bacteria, a hallmark of dysbiosis in the colon. Enteric pathogens subvert colonocyte metabolism to escape niche protection conferred by the gut microbiota. The reverse strategy, a metabolic reprogramming to restore colonocyte hypoxia, represents a promising new therapeutic approach for rebalancing the colonic microbiota in a broad spectrum of human diseases.

Predictors of Lymph Node Metastasis in T1 Breast Carcinoma, Stratified by Patient Age

2002 ◽  
Vol 8 (6) ◽  
pp. 349-355 ◽  
Author(s):  
Amila Orucevic ◽  
Vijaya B. Reddy ◽  
Kenneth J. Bloom ◽  
Pincas Bitterman ◽  
Cristina Magi-Galluzzi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Lymph Node Metastasis ◽  
Patient Age ◽  
Node Metastasis ◽  
Patient Âgé

scholarly journals How do specialist surgeons treat the atrophic tooth gap? A vignette-based study among maxillofacial and oral surgeons

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Michael Korsch ◽  
Winfried Walther ◽  
Bernt-Peter Robra ◽  
Aynur Sahin ◽  
Matthias Hannig ◽  
...  
Keyword(s):  
Decision Making ◽  
Treatment Decision ◽  
Bisphosphonate Therapy ◽  
Bone Block ◽  
Patient Anxiety ◽  
Patient Age ◽  
Endocarditis Prophylaxis ◽  
Therapy Decision ◽  
Patient Âgé ◽  
Case Vignettes

Abstract Background There is little information available regarding the decision-making process of clinicians, especially in the choice of therapy for a severely atrophic tooth gap. The aim of this research was to use case vignettes to determine the influence of possible factors on the decision making of maxillofacial and oral surgeons. Methods A total of 250 maxillofacial (MFS) and oral (OS) surgeons in southern Germany were surveyed for atrophic single- or multiple-tooth gap with the help of case vignettes. The influence of different determinants on the therapy decision was investigated. Two case vignettes were designed for this purpose: vignette 1 with determinants “patient age” and “endocarditis prophylaxis” and vignette 2 with determinants “anxiety” and “bisphosphonate therapy”. Furthermore, the specialist designation was assessed for both. The options available to achieve a sufficient implant site were "bone split", "bone block", "augmentation with bone substitute material" and "bone resection". Therapy was either recommended or rejected based on principle. Results A total of 117 participants returned the questionnaire: 68 (58%) were OS and 49 (42%) MFS. “Patient age” and “patient anxiety” were not significantly associated with any therapy decision. However, required “endocarditis prophylaxis” led to significantly higher refusal rates for "bone split", "bone block" and "bone replacement material" and to higher rates of general refusal of a therapy. “Bisphosphonate therapy” was significantly associated with general refusal of therapy, but with no significant correlation with different therapy options. In vignette 1, OS refused therapy significantly more often than MFS, though there was no association with the specialist designation for other therapy modalities. In vignette 2, specialty was not significantly associated with the therapy decision. Conclusion “Patient age” as well as “patient anxiety” appear to have no or little influence on the treatment decision for severely atrophic single- or multiple-tooth gap by specialist surgeons. Surgeons more often refuse treatment for patients with endocarditis prophylaxis and bisphosphonate therapy.

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