scholarly journals Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships

2019 ◽  
Author(s):  
Daniel Moriarity
Keyword(s):  
Depressive Symptoms ◽  
Causal Relationship ◽  
Inflammatory Biomarkers ◽  
Causal Relationships ◽  
Blood Samples ◽  
Extant Literature ◽  
Tnf Α ◽  
Multi Level ◽  
Bidirectional Associations

There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This study separates predictors into between-person and within-person components in an attempt to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black, Mage = 16.1 years) with at least three blood draws and a total of 394 follow-up evaluations. Multi-level modeling indicated that the within-person effect of TNF-α predicted future total depressive symptoms, suggesting a potential causal relationship. Additionally, there were bidirectional, between-person effects of IL-6 on total depressive symptoms and vice-versa. Exploratory analyses examined the associations between five biomarkers and five subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistences in the extant literature as well as suggest potential causal relationships between certain biomarkers with significant within-person effects on depressive symptoms, and vice-versa.

scholarly journals Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships

2019 ◽  
Author(s):  
Daniel Moriarity
Keyword(s):  
Depressive Symptoms ◽  
Causal Relationship ◽  
Inflammatory Biomarkers ◽  
Causal Relationships ◽  
Blood Samples ◽  
Extant Literature ◽  
Tnf Α ◽  
Multi Level ◽  
Bidirectional Associations

There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This study separates predictors into between-person and within-person components in an attempt to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black, Mage = 16.1 years) with at least three blood draws and a total of 394 follow-up evaluations. Multi-level modeling indicated that the within-person effect of TNF-α predicted future total depressive symptoms, suggesting a potential causal relationship. Additionally, there were bidirectional, between-person effects of IL-6 on total depressive symptoms and vice-versa. Exploratory analyses examined the associations between five biomarkers and five subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistencies in the extant literature as well as suggest potential causal relationships between certain biomarkers with significant within-person effects on depressive symptoms, and vice-versa.

scholarly journals Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships

2020 ◽  
Vol 8 (4) ◽  
pp. 690-703 ◽  
Author(s):  
Daniel P. Moriarity ◽  
Marin M. Kautz ◽  
Naoise Mac Giollabhui ◽  
Joshua Klugman ◽  
Christopher L. Coe ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Multilevel Modeling ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Inflammatory Biomarkers ◽  
Causal Relationships ◽  
Bidirectional Associations ◽  
Factor Α ◽  
Necrosis Factor

There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-persons and within-person components to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black; mean age = 16.1 years) with at least three blood draws and a total of 394 follow-up observations. Multilevel modeling indicated that the within-persons effect of tumor necrosis factor α predicted change in total depressive symptoms, which suggests a potential causal relationship. There were no significant within-persons effects of total depressive symptoms on change in biomarkers. Exploratory analyses examined associations between inflammatory biomarkers and subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistencies in the extant literature as well as suggest potential causal relationships between certain proteins with significant within-persons effects on depressive symptoms and vice-versa.

Bidirectional Associations Between Inflammatory Biomarkers and Depression Symptoms in Adolescents: Potential Causal Relationships

2020 ◽  
Vol 87 (9) ◽  
pp. S47
Author(s):  
Lauren Alloy ◽  
Daniel Moriarity ◽  
Marin Kautz ◽  
Naoise Mac Giolalbhui ◽  
Joshua Klugman ◽  
...  
Keyword(s):  
Inflammatory Biomarkers ◽  
Depression Symptoms ◽  
Causal Relationships ◽  
Bidirectional Associations

scholarly journals Bidirectional associations between body dissatisfaction and depressive symptoms from adolescence through early adulthood

2017 ◽  
Vol 30 (4) ◽  
pp. 1447-1458 ◽  
Author(s):  
Helen Sharpe ◽  
Praveetha Patalay ◽  
Tse-Hwei Choo ◽  
Melanie Wall ◽  
Susan M. Mason ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Body Dissatisfaction ◽  
Early Adulthood ◽  
The Other ◽  
Dynamic Risk ◽  
Adverse Health Outcomes ◽  
Middle Adolescence ◽  
Bidirectional Associations ◽  
Downstream Impacts

AbstractBody dissatisfaction and depressive symptoms are commonly experienced during adolescence and increase the risk of adverse health outcomes, especially eating disorders. However, the dominant temporal associations between these two experiences (i.e., whether one is a risk factor for the other or the two are mutually reinforcing) has yet to be fully explored. We examined the associations between body dissatisfaction and depressive symptoms assessed at baseline and 5- and 10-year follow-up in younger (M age = 12.9 years at baseline, 56% female, n = 577) and older (M age = 15.9 years at baseline, 57% female, n = 1,325) adolescent cohorts assessed as part of Project Eating Among Teens and Young Adults. Associations between body dissatisfaction and depressive symptoms were examined using cross-lagged models. For females, the dominant directionality was for body dissatisfaction predicting later depressive symptoms. For males, the picture was more complex, with developmentally sensitive associations in which depressive symptoms predicted later body dissatisfaction in early adolescence and early adulthood, but the reverse association was dominant during middle adolescence. These findings suggest that interventions should be tailored to dynamic risk profiles that shift over adolescence and early adulthood, and that targeting body dissatisfaction at key periods during development may have downstream impacts on depressive symptoms.

scholarly journals 329 - A psychological needs-based intervention to reduce depression in newly admitted nursing home residents

2020 ◽  
Vol 32 (S1) ◽  
pp. 88-88
Author(s):  
Tanya E. Davison ◽  
Marita P. McCabe ◽  
Lucy Busija ◽  
Annette Graham
Keyword(s):  
Nursing Home ◽  
Depressive Symptoms ◽  
Nursing Homes ◽  
Nursing Home Residents ◽  
Psychological Needs ◽  
Term Care ◽  
Symptoms Of Depression ◽  
Multi Level ◽  
Facility Staff

Background:Depression is common in nursing homes, with newly admitted residents at a particularly high risk. Current prevention and treatment approaches have failed to impact on the high rates of depression and new approaches are required. We have developed a novel intervention that addresses individual psychological needs in newly admitted residents, which is implemented in collaboration with residents and facility staff. The Program to Enhance Adjustment to Residential Living (PEARL) is a 5-session intervention based on Self-Determination Theory that aims to tailor care to enhance residents’ autonomy, competence and relations.Methods:A cluster randomised controlled trial was conducted to determine the effectiveness of PEARL in reducing depression in newly admitted nursing home residents, compared to a treatment as usual control condition. A total of 216 residents with normal cognition or mild-moderate cognitive impairment, living in 42 nursing homes in Melbourne, Australia, participated in the study. The sample included 76 men and 140 women, aged 62-99 years (M = 85.5, SD = 7.3). The primary outcome was level of depressive symptoms, assessed using the Cornell Scale for Depression in Dementia at baseline and at 8, 16 (primary endpoint), and 31 weeks follow-up. Multi-level modelling, accounting for within-facility clustering and repeated assessments, was used to determine the effectiveness of the intervention, employing an intention-to-treat approach.Results:At 16-weeks, fewer symptoms of depression were observed among those in the intervention group (M = 7.0, SD = 5.6) than in the control group (M = 8.6, SD = 6.5). Multi-level modelling of unadjusted data showed a significant condition (intervention, control) by time (T1, T2, T3) interaction (p = .021), indicating that the PEARL intervention led to a reduction in the occurrence of depressive symptoms. The treatment effect was maintained at 31 weeks follow-up (p = .004).Discussion:This study provides evidence that an intervention designed to address newly admitted residents’ individual psychological needs reduced symptoms of depression in subsequent months. This brief, simple intervention may be suitable for broad implementation across long-term care settings. However, future research to determine if the intervention can be implemented by trained facility staff in situ is warranted.

Cathartic Effect of Suicide Attempts Not Limited to Depression

Crisis ◽  
2003 ◽  
Vol 24 (2) ◽  
pp. 73-78 ◽  
Author(s):  
Yves Sarfati ◽  
Blandine Bouchaud ◽  
Marie-Christine Hardy-Baylé
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Personality Traits ◽  
Rating Scales ◽  
Suicide Attempts ◽  
World Health ◽  
Life Questionnaire ◽  
Short Term

Summary: The cathartic effect of suicide is traditionally defined as the existence of a rapid, significant, and spontaneous decrease in the depressive symptoms of suicide attempters after the act. This study was designed to investigate short-term variations, following a suicide attempt by self-poisoning, of a number of other variables identified as suicidal risk factors: hopelessness, impulsivity, personality traits, and quality of life. Patients hospitalized less than 24 hours after a deliberate (moderate) overdose were presented with the Montgomery-Asberg Depression and Impulsivity Rating Scales, Hopelessness scale, MMPI and World Health Organization's Quality of Life questionnaire (abbreviated versions). They were also asked to complete the same scales and questionnaires 8 days after discharge. The study involved 39 patients, the average interval between initial and follow-up assessment being 13.5 days. All the scores improved significantly, with the exception of quality of life and three out of the eight personality traits. This finding emphasizes the fact that improvement is not limited to depressive symptoms and enables us to identify the relative importance of each studied variable as a risk factor for attempted suicide. The limitations of the study are discussed as well as in particular the nongeneralizability of the sample and setting.

Multi-Level-Chirurgie bei obstruktiver Schlafapnoe – Erweitertes Follow-up

2004 ◽  
Vol 83 (02) ◽  
Author(s):  
T Verse ◽  
A Baisch ◽  
JT Maurer ◽  
C Schroen ◽  
BA Stuck ◽  
...  
Keyword(s):  
Multi Level

The bidirectional association between Internet addiction and depression: a large-sample longitudinal study among Chinese university students (Preprint)

2020 ◽  
Author(s):  
Wan-Jun Guo ◽  
Xia Yang ◽  
Yu-Jie Tao ◽  
Ya-Jing Meng ◽  
Hui-Yao Wang ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Internet Addiction ◽  
Causal Effects ◽  
Causal Relationships ◽  
Depression Severity ◽  
Large Sample ◽  
Panel Model ◽  
Bidirectional Association ◽  
Predictive Effect

BACKGROUND Evidence indicates that Internet addiction (IA) is associated with depression, but longitudinal studies have rarely been reported, and no studies have yet investigated potential common vulnerability or a possible specific causal relationship between these disorders. OBJECTIVE To overcome these gaps, the present 12-month longitudinal study based on a large-sample employed a cross-lagged panel model (CLPM) approach to investigate the potential common vulnerability and specific cross-causal relationships between IA and CSD (or depression). METHODS IA and clinically-significant depression (CSD) among 12 043 undergraduates were surveyed at baseline (as freshmen) and in follow-up after 12 months (as sophomores). Application of CLPM revealed two well-fitted design between IA and CSD, and between severities of IA and depression, adjusting for demographics. RESULTS Rates of baseline IA and CSD were 5.47% and 3.85%, respectively; increasing to 9.47% and 5.58%, respectively at follow-up. Among those with baseline IA and CSD, 44.61% and 34.48% remained stable at the time of the follow-up survey, respectively. Rates of new-incidences of IA and CSD over 12 months were 7.43% and 4.47%, respectively. Application of a cross-lagged panel model approach (CLPM, a discrete time structural equation model used primarily to assess causal relationships in real-world settings) revealed two well-fitted design between IA and CSD, and between severities of IA and depression, adjusting for demographics. Models revealed that baseline CSD (or depression severity) had a significant net-predictive effect on follow-up IA (or IA severity), and baseline IA (or IA severity) had a significant net-predictive effect on follow-up CSD (or depression severity). CONCLUSIONS These correlational patterns using a CLPM indicate that both common vulnerability and bidirectional specific cross-causal effects between them may contribute to the association between IA and depression. As the path coefficients of the net-cross-predictive effects were significantly smaller than those of baseline to follow-up cross-section associations, vulnerability may play a more significant role than bidirectional-causal effects. CLINICALTRIAL Ethics Committee of West China Hospital, Sichuan University (NO. 2016-171)

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