Multi-Level-Chirurgie bei obstruktiver Schlafapnoe – Erweitertes Follow-up

2004 ◽  
Vol 83 (02) ◽  
Author(s):  
T Verse ◽  
A Baisch ◽  
JT Maurer ◽  
C Schroen ◽  
BA Stuck ◽  
...  
Keyword(s):  
Multi Level

scholarly journals Bidirectional Associations Between Inflammatory Biomarkers and Depressive Symptoms in Adolescents: Potential Causal Relationships

2019 ◽  
Author(s):  
Daniel Moriarity
Keyword(s):  
Depressive Symptoms ◽  
Causal Relationship ◽  
Inflammatory Biomarkers ◽  
Causal Relationships ◽  
Blood Samples ◽  
Extant Literature ◽  
Tnf Α ◽  
Multi Level ◽  
Bidirectional Associations

There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This study separates predictors into between-person and within-person components in an attempt to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black, Mage = 16.1 years) with at least three blood draws and a total of 394 follow-up evaluations. Multi-level modeling indicated that the within-person effect of TNF-α predicted future total depressive symptoms, suggesting a potential causal relationship. Additionally, there were bidirectional, between-person effects of IL-6 on total depressive symptoms and vice-versa. Exploratory analyses examined the associations between five biomarkers and five subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistences in the extant literature as well as suggest potential causal relationships between certain biomarkers with significant within-person effects on depressive symptoms, and vice-versa.

scholarly journals Non-parental care in childhood and health up to 30 years later: ONS Longitudinal Study 1971–2011

2020 ◽  
Vol 30 (6) ◽  
pp. 1121-1127
Author(s):  
Emily T Murray ◽  
Rebecca Lacey ◽  
Barbara Maughan ◽  
Amanda Sacker
Keyword(s):  
Longitudinal Study ◽  
Parental Care ◽  
Residential Care ◽  
Children And Young People ◽  
Never Married ◽  
Self Rated Health ◽  
National Statistics ◽  
Multi Level ◽  
Study Participants

Abstract Background Children who spend time in non-parental care report worse health later in life on average, but less is known about differences by type of care. We examined whether self-rated health of adults who had been in non-parental care up to 30 years later varied by type of care. Methods We used longitudinal data from the office for National Statistics Longitudinal Study. Participants were aged <18 and never-married at baseline of each census year from 1971 to 2001. Separately for each follow-up period (10, 20 and 30 years later), multi-level logistic regression was used to compare self-rated health outcomes by different care types. Results For combined census years, sample sizes were 157 896 dependent children with 10 years of follow-up, 166 844 with 20 years of follow-up and 173 801 with 30 years of follow-up. For all follow-up cohorts, longitudinal study members who had been in care in childhood, had higher odds of rating their health as ‘not good’ vs. ‘good’; with highest odds for residential care. For example, 10-year follow-up odds ratios were 3.5 (95% confidence interval: 2.2–5.6) for residential care, 2.1 (1.7–2.5) for relative households and 2.6 (2.1–3.3) for non-relative households, compared with parental households after adjustment for childhood demographics. Associations were weakest for 10-year, and strongest for 20-year, follow-up. Additional adjustment for childhood social circumstances reduced, but did not eliminate, associations. Conclusion Decades after children and young people are placed in care, they are still more likely to report worse health than children who grew up in a parental household.

scholarly journals Assessment of spino cranial angle of cervical spine sagittal balance system after multi-level anterior cervical discectomy and fusion

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zheng Wang ◽  
Zhi-Wei Wang ◽  
Xi-Wen Fan ◽  
Xian-Da Gao ◽  
Wen-Yuan Ding ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Spine ◽  
Sagittal Balance ◽  
Anterior Cervical Discectomy ◽  
Operating Characteristics ◽  
Cervical Discectomy ◽  
Multi Level ◽  
The Impact

Abstract Background To analyze the impact of spino cranial angle (SCA) on alteration of cervical alignment after multi-level anterior cervical discectomy fusion (ACDF) and explore the relationship between SCA and health-related quality of life (HRQOL) scores. Material and methods In total, 49 patients following multi-level ACDF for multi-level cervical spondylotic myelopathy (MCSM) with more than 2 years follow-up period were enrolled. Radiographic data including SCA were measured. Receiver operating characteristics (ROC) curve analysis was applied to confirm the optimal cut-off values of SCA for predicting sagittal balance. Patients were divided into two groups on the basis of the cut-off value of preoperative SCA. Correlation coefficients were analyzed between SCA and HRQOL scores. Results Optimal cut-off values for predicting sagittal balance was SCA of 88.6°. Patients with higher SCA, no matter preoperatively, postoperatively and at follow-up, got lower T1-Slope (T1s), C2–C7 lordosis angle (CA) and higher △SCA (pre vs post: p = 0.036, pre vs F/U: p = 0.022). Simultaneously, pre-SCA, post-SCA, and F/U-SCA in the high SCA group were positively correlated with the pre-NDI, post-NDI, and F/U-NDI scores respectively (pre: p < 0.001, post: p = 0.015, F/U: p = 0.003). However, no correlation was performed in the low SCA group. Conclusion An excessive SCA can be considered to cause poorer clinical outcomes at preoperative and better correction after surgery. The SCA could be used as a new reference value to determine sagittal balance parameters of the cervical spine and to assess the quality of life.

scholarly journals Self-administered multi-level pregnancy tests in simplified follow-up of medical abortion in Tunisia

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Rasha Dabash ◽  
Tara Shochet ◽  
Selma Hajri ◽  
Héla Chelli ◽  
Anne-Emmanuele Hassairi ◽  
...  
Keyword(s):  
Medical Abortion ◽  
Multi Level

scholarly journals Evaluation of a multi-level intervention to improve postpartum intrauterine device services in Rwanda

2019 ◽  
Vol 2 ◽  
pp. 38
Author(s):  
Rosine Ingabire ◽  
Julien Nyombayire ◽  
Alexandra Hoagland ◽  
Vanessa Da Costa ◽  
Amelia Mazzei ◽  
...  
Keyword(s):  
Family Planning ◽  
Unintended Pregnancy ◽  
Intrauterine Device ◽  
Intervention Development ◽  
Health Centers ◽  
Labor And Delivery ◽  
African Countries ◽  
Government Clinic ◽  
Multi Level

Background. The copper intrauterine device is one of the most safe, effective, and cost-effective methods for preventing unintended pregnancy. It can be used postpartum irrespective of breastfeeding to improve birth spacing and reduce unintended pregnancy and maternal-child mortality. However, this method remains highly underutilized. Methods. We developed a multi-level intervention to increase uptake of the postpartum intrauterine device (PPIUD, defined as insertion up to six weeks post-delivery) in Kigali, Rwanda. High-volume hospitals and health centers were selected for implementation of PPIUD counseling and service delivery. Formative work informed development of a PPIUD counseling flipchart to be delivered during antenatal care, labor and delivery, infant vaccination visits, or in the community. Two-day didactic counseling, insertion/removal, and follow-up trainings were provided to labor and delivery and family planning nurses followed by a mentored practicum certification process. Counseling data were collected in government clinic logbooks. Insertions and follow-up data were collected in logbooks created for the implementation. Data were collected by trained government clinic staff and abstracted/managed by study staff. Stakeholders were involved from intervention development through dissemination of results. Results. Two hospitals (and their two associated health centers) and two additional health centers were selected. In 6-months prior to our intervention, 7.7 PPIUDs/month were inserted on average at the selected facilities. From August 2017-July 2018, we trained 83 counselors and 39 providers to provide PPIUD services. N=9,020 women received one-on-one PPIUD counseling after expressing interest in family planning who later delivered at a selected health facility. Of those, n=2,575 had PPIUDs inserted (average of 214.6 insertions/month), a 29% uptake. Most PPIUDs (62%) were inserted within 10 minutes of delivery of the placenta. Conclusions. This successful, comprehensive intervention has the potential to make a significant impact on PPIUD uptake in Rwanda. The intervention is scalable and adaptable to other sub-Saharan African countries.

scholarly journals Sleep disorders predict the one-year onset, persistence, but not remission of psychotic experiences in 10-11 year old children: a longitudinal analysis of the ABCD cohort data

2021 ◽  
Author(s):  
Sarah Reeve ◽  
Vaughan Bell
Keyword(s):  
Sleep Disorder ◽  
Regression Models ◽  
Sleep Problems ◽  
Stimulant Medication ◽  
Psychotic Experiences ◽  
Multi Level ◽  
One Year ◽  
The One ◽  
The Relationship

AbstractSleep problems have been reliably associated with psychotic experiences in adults and have been suggested as target for intervention. However, the relationship between sleep disorder and psychotic experiences in children has not been extensively studied despite the potential for guiding intervention. The Adolescent Brain Cognitive Development (ABCD) dataset, containing baseline and one-year follow-up data of over 11,000 10-11 year olds, was utilised to investigate this relationship. More specifically, a set of pre-registered multi-level regression models were applied to test whether a) baseline sleep disorder predicts baseline psychotic experiences cross-sectionally; b) baseline sleep disorder predicts psychotic experiences one year later; c) the persistence of sleep disorder predicts the persistence psychotic experiences at one year; d) the remission of sleep disorder predicts the remission of psychotic experiences. After controlling for potential confounders, sleep disorder was associated with psychotic experiences cross-sectionally (OR=1.40, 95% CI 1.20-1.63), at one-year follow-up (OR=1.32, 95% CI 1.11-1.57), and the persistence of sleep disorder predicted the persistence of psychotic experiences (OR=1.72, 95% CI 1.44-2.04). However, remission of sleep problems did not predict remission of psychotic experiences (OR=1.041, 95% CI 0.80-1.35). In all models where an association was found, sleep was one of the two strongest predictors of psychotic experiences (with stimulant medication being the other). The results indicate that sleep problems in children are common and strongly associated with psychotic experiences but the lack of co-remission raises questions about the mechanism of association. However given existing evidence in adults, further investigation and interest in sleep as a preventative mental health intervention in this age group is warranted.

scholarly journals Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression

BMC Medicine ◽  
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Xiumeng Hua ◽  
Yin-Ying Wang ◽  
Peilin Jia ◽  
Qing Xiong ◽  
Yiqing Hu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular ◽  
Enzyme Linked Immunosorbent Assay ◽  
Transcriptomic Data ◽  
Network Analyses ◽  
Qrt Pcr ◽  
Healthy Donors ◽  
Potential Biomarker ◽  
Multi Level

Abstract Background Heart failure (HF) has been recognized as a global pandemic with a high rate of hospitalization, morbidity, and mortality. Although numerous advances have been made, its representative molecular signatures remain largely unknown, especially the role of genes in HF progression. The aim of the present prospective follow-up study was to reveal potential biomarkers associated with the progression of heart failure. Methods We generated multi-level transcriptomic data from a cohort of left ventricular heart tissue collected from 21 HF patients and 9 healthy donors. By using Masson staining to calculate the fibrosis percentage for each sample, we applied lasso regression model to identify the genes associated with fibrosis as well as progression. The genes were further validated by immunohistochemistry (IHC) staining in the same cohort and qRT-PCR using another independent cohort (20 HF and 9 healthy donors). Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma level in a validation cohort (139 HF patients) for predicting HF progression. Results Based on the multi-level transcriptomic data, we examined differentially expressed genes [mRNAs, microRNAs, and long non-coding RNAs (lncRNAs)] in the study cohort. The follow-up functional annotation and regulatory network analyses revealed their potential roles in regulating extracellular matrix. We further identified several genes that were associated with fibrosis. By using the survival time before transplantation, COL1A1 was identified as a potential biomarker for HF progression and its upregulation was confirmed by both IHC and qRT-PCR. Furthermore, COL1A1 content ≥ 256.5 ng/ml in plasma was found to be associated with poor survival within 1 year of heart transplantation from heart failure [hazard ratio (HR) 7.4, 95% confidence interval (CI) 3.5 to 15.8, Log-rank p value < 1.0 × 10− 4]. Conclusions Our results suggested that COL1A1 might be a plasma biomarker of HF and associated with HF progression, especially to predict the 1-year survival from HF onset to transplantation.

Sign in / Sign up

Export Citation Format

Share Document