scholarly journals Feasibility of MR guided Lung Cancer ablation using saline flooded lung

2018 ◽  
Author(s):  
Thomas Lesser ◽  
Frank Wolfram
Keyword(s):  
Lung Cancer ◽  
Mr Imaging ◽  
Surgical Resection ◽  
Ultrasound Guided ◽  
Air Content ◽  
Hifu Ablation ◽  
Fundamental Information ◽  
Lung Flooding ◽  
Tumor Entity ◽  
Cancer Ablation

Lung cancer is the most mortal tumor entity, which is preferably treated by surgical resection. Alternative ablation methods (rf, litt) haven't been clinically established by their invasivity. HIFU is not considered as an treatment option in lung due to the air content. Lung flooding generates gas free saline parenchyma compound without damaging the lung. Recently our work showed the usability of ultrasound guided lung cancer hifu ablation. In contrast to ultrasound, MRg-FUS would improve the radically of treatment. Toward the first human pilot, the lung flooding process needs to be optimized for operating in MR environment. Further the usability of MR imaging and thermometry in flooded lung haven't been investigated so far. This research project is aimed to provide fundamental information describing the usability and limitations of MRg-FUS treatment of lung cancer using lung flooding.

scholarly journals Metabolic Changes in Early-Stage Non–Small Cell Lung Cancer Patients after Surgical Resection

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3012
Author(s):  
Naseer Ahmed ◽  
Biniam Kidane ◽  
Le Wang ◽  
Zoann Nugent ◽  
Nataliya Moldovan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Surgical Resection ◽  
Cell Lung Cancer ◽  
Early Stage ◽  
Small Cell ◽  
Resonance Spectroscopy ◽  
Small Cell Lung ◽  
Serum Samples ◽  
Post Surgery

Metabolic alterations in malignant cells play a vital role in tumor initiation, proliferation, and metastasis. Biofluids from patients with non–small cell lung cancer (NSCLC) harbor metabolic biomarkers with potential clinical applications. In this study, we assessed the changes in the metabolic profile of patients with early-stage NSCLC using mass spectrometry and nuclear magnetic resonance spectroscopy before and after surgical resection. A single cohort of 35 patients provided a total of 29 and 32 pairs of urine and serum samples, respectively, pre-and post-surgery. We identified a profile of 48 metabolites that were significantly different pre- and post-surgery: 17 in urine and 31 in serum. A higher proportion of metabolites were upregulated than downregulated post-surgery (p < 0.01); however, the median fold change (FC) was higher for downregulated than upregulated metabolites (p < 0.05). Purines/pyrimidines and proteins had a larger dysregulation than other classes of metabolites (p < 0.05 for each class). Several of the dysregulated metabolites have been previously associated with cancer, including leucyl proline, asymmetric dimethylarginine, isopentenyladenine, fumaric acid (all downregulated post-surgery), as well as N6-methyladenosine and several deoxycholic acid moieties, which were upregulated post-surgery. This study establishes metabolomic analysis of biofluids as a path to non-invasive diagnostics, screening, and monitoring in NSCLC.

scholarly journals Cure of Lung Cancer from Incomplete Surgical Resection

BMJ ◽  
1971 ◽  
Vol 2 (5761) ◽  
pp. 563-565 ◽  
Author(s):  
R. A. Smith
Keyword(s):  
Lung Cancer ◽  
Surgical Resection

scholarly journals C2-06: Integrated PET/CT versus 3T whole body MR imaging: efficacy comparison in non-small cell lung cancer staging

2007 ◽  
Vol 2 (8) ◽  
pp. S363-S364
Author(s):  
Kyung-Min Shin ◽  
Chin A. Yi ◽  
Kyung Soo Lee ◽  
Byung-Tae Kim ◽  
Hojoong Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mr Imaging ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Cancer Staging ◽  
Small Cell ◽  
Whole Body ◽  
Small Cell Lung ◽  
Pet Ct

Results of surgical resection of patients with primary lung cancer: a retrospective analysis of 1,905 cases

2001 ◽  
Vol 72 (4) ◽  
pp. 1155-1159 ◽  
Author(s):  
Dekang Fang ◽  
Dawei Zhang ◽  
Guojun Huang ◽  
Rugang Zhang ◽  
Liangjun Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Retrospective Analysis ◽  
Surgical Resection ◽  
Primary Lung Cancer

Radiotherapy for the Second Lung Mass after Surgical Resection of the First Lung Cancer

2010 ◽  
Vol 78 (3) ◽  
pp. S520
Author(s):  
K. Miyagi ◽  
A. Nakajima ◽  
Y. Kawaguchi ◽  
O. Suzuki ◽  
S. Nakamura ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Lung Mass
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