scholarly journals The dynamical signature of anhedonia in Major Depressive Disorder: Positive emotion dynamics, reactivity, and recovery

2018 ◽  
Author(s):  
Vera Ellen Heininga ◽  
Egon Dejonckheere ◽  
Marlies Houben ◽  
Jasmien obbels ◽  
Pascal Sienaert ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Positive Emotion ◽  
Multilevel Models ◽  
Daily Life ◽  
Major Depressive ◽  
Daily Lives ◽  
Emotion Dynamics ◽  
Almost All ◽  
Ecological Momentary

Background: Major Depressive Disorder (MDD) is the leading cause of disability worldwide. The cardinal features of MDD are depressed mood and anhedonia. Anhedonia is defined as a “markedly diminished interest or pleasure in all, or almost all, activities of the day”, yet has never been investigated in the daily life of patients diagnosed with MDD. We address this gap in knowledge by means of Ecological Momentary Assessments (EMA). Methods: We sampled Positive Affect (PA) and reward experiences on 10 semi-random time points a day, for seven days in the daily lives of 47 MDD patients with anhedonia, and 40 controls. Results: Multilevel models showed that anhedonia was associated to low PA, but not to differences in PA dynamics, nor reward frequency in daily life. In reaction to rewards, MDD patients with anhedonia showed no difference in their increase in PA (i.e., PA reactivity), and showed no signs of a faster return to baseline thereafter (i.e., PA recovery). Conclusion: Our results suggest that the dynamical signature of anhedonia in MDD can be described best as a lower average level of PA, and “normal” in terms of PA dynamics, daily reward reactivity and reward recovery. Preregistration doi: 10.17605/osf.io/gjaze; Data and Materials: osf.io/8gxrw.

scholarly journals The dynamical signature of anhedonia in major depressive disorder: positive emotion dynamics, reactivity, and recovery

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Vera E. Heininga ◽  
Egon Dejonckheere ◽  
Marlies Houben ◽  
Jasmien Obbels ◽  
Pascal Sienaert ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Positive Emotion ◽  
Major Depressive ◽  
Emotion Dynamics

scholarly journals An investigation of emotion dynamics in major depressive disorder patients and healthy persons using sparse longitudinal networks

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178586 ◽  
Author(s):  
Stijn de Vos ◽  
Klaas J. Wardenaar ◽  
Elisabeth H. Bos ◽  
Ernst C. Wit ◽  
Mara E. J. Bouwmans ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Emotion Dynamics ◽  
Healthy Persons

scholarly journals Brain Responses to Emotional Stimuli after Eicosapentaenoic Acid and Docosahexaenoic Acid Treatments in Major Depressive Disorder: Toward Personalized Medicine with Anti-Inflammatory Nutraceuticals

2020 ◽  
Vol 10 (4) ◽  
pp. 283
Author(s):  
Cheng-Hao Tu ◽  
Chun-Ming Chen ◽  
Chuan-Chih Yang ◽  
Piotr Gałecki ◽  
Kuan-Pin Su
Keyword(s):  
Major Depressive Disorder ◽  
Personalized Medicine ◽  
Docosahexaenoic Acid ◽  
Depressive Disorder ◽  
Eicosapentaenoic Acid ◽  
Positive Emotion ◽  
Emotional Stimuli ◽  
Major Depressive ◽  
Brain Responses ◽  
Anti Inflammatory

N-3 polyunsaturated fatty acid supplements improve the symptoms of major depressive disorder (MDD) in randomized-controlled trials and meta-analyses, with the higher efficacy from anti-inflammatory eicosapentaenoic acid (EPA) than brain-dominant docosahexaenoic acid (DHA). To investigate the specific brain mechanisms of the anti-inflammatory anti-depressant nutraceutical compounds, we recruited 24 MDD subjects in this double-blind, head-to-head study with a 12-week EPA or DHA treatment (clinical trial registration number: NCT03871088). The depression severity was assessed by Hamilton depression rating scale (HAM-D). Brain responses to emotional stimuli were measured by a 3-Tesla MRI. The correlation between HAM-D scores and brain responses also were tested. Compared to 18 healthy controls, the brain responses of untreated 24 MDD patients mainly revealed hypoactivity in the regions associated with emotion perception and emotion control when processing positive emotion. After treatment, more remitted MDD patients have been observed in the EPA as compared to the DHA groups. In addition, the EPA, but not DHA, treatment revealed increased activity in the regions associated with emotion perception and cognitive control when processing positive emotion. The correlation analysis further revealed negative correlation between HAM-D scores and brain responses in cognitive control regions. The results of this study may imply the compensatory brain responses of cognitive and emotion controls by EPA but not DHA and underpin personalized medicine with anti-inflammatory nutraceuticals toward depression treatments.

scholarly journals Predicting response to treatment and discriminating bipolar and depression symptoms using Hamilton Depression Rating Scale

2017 ◽  
Vol 66 (3) ◽  
pp. 125-130 ◽  
Author(s):  
Adriana Munhoz Carneiro ◽  
André Cavalcanti ◽  
Lucas de Francisco Carvalho ◽  
Ricardo Alberto Moreno
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rating Scale ◽  
Response To Treatment ◽  
Depression Symptoms ◽  
Type I ◽  
Major Depressive ◽  
Bipolar Type ◽  
The Difference ◽  
Almost All

ABSTRACT Objective The present study aims to compare the diagnostic ability of the HAMD 17 items with shorter versions of 7 and 6 items. Methods A total of 133 patients from a 6 month clinical trial diagnosed with mood disorders (60.2% with Major Depressive Disorder and 39.8% with bipolar type I disorder) were recruited. Results The 17 items HAMD scale showed similar results as compared with shorter versions. Furthermore, almost all patients’ diagnosed with Major Depressive Disorder scored more compared to Bipolar Disorder, but the difference was not significant. Conclusion This study allows that the use of a shorter version of HAMD might be an adequate possibility, and also that depressive symptoms were similar among groups.

Sign in / Sign up

Export Citation Format

Share Document