Changes in interoception after alcohol administration correlate with expectancies and subjective effects

2020 ◽  
Author(s):  
Mateo Leganes-Fonteneau ◽  
Jennifer Buckman ◽  
Shahriar Islam ◽  
Marsha Bates
Keyword(s):  
Subjective Effects ◽  
Drinking Behavior ◽  
Alcohol Expectancies ◽  
Subjective Feeling ◽  
Placebo Condition ◽  
Alcohol Administration ◽  
Interoceptive Sensitivity ◽  
Interoceptive Accuracy ◽  
Bodily States ◽  
Induced Changes

Interoceptive signals give rise to subjective feeling states that can drive motivational and behavioral responses. In the context of alcohol use behaviors, interoceptive signals may shape subjective alcohol experiences, and thereby support bio-behavioral mechanisms of drinking behavior change. This study examined the acute effects of alcohol on participants’ interoceptive sensitivity, and determined whether pharmacologically induced changes in heart beat detection correlate with subjective alcohol effects, craving and expectancies.Participants completed a two-session, double-blind placebo controlled experiment (n=31). Participants consumed a beverage containing 0.4g/kg of alcohol or a placebo. They also completed measurements of alcohol expectancies at baseline, and alcohol-induced changes in mood, craving and light-headedness. Interoceptive sensitivity was measured using the heartbeat discrimination task prior to and following beverage administration, yielding indices of interoceptive accuracy, confidence and meta-cognition. Alcohol administration increased interoceptive accuracy compared to baseline and placebo; and those changes in interoception negatively correlated with negative alcohol expectancies. Further, changes in interoception positively correlated with perceived light-headedness and positive mood after alcohol administration, whereas null effects were found for craving. In the placebo condition, null results were obtained. Alcohol is well established to change bodily states, and here we find that the extent to which alcohol increases participants’ sensitivity to bodily states impacts their subjective drinking experiences. This was observed in relation to mood and light-headedness, but also on prospective alcohol expectancies. We posit that over successive alcohol experiences, changes in bodily states may feed into the development of alcohol expectancies that could in turn predict future drinking behaviors.

An interoceptive basis for alcohol priming effects

2020 ◽  
Author(s):  
Mateo Leganes-Fonteneau ◽  
Marsha Bates ◽  
Evgeny Vaschillo ◽  
Jennifer Buckman
Keyword(s):  
Flanker Task ◽  
Cue Reactivity ◽  
Cardiovascular Responses ◽  
Attentional Biases ◽  
Double Blind ◽  
Priming Effects ◽  
Alcohol Administration ◽  
Before And After ◽  
Bodily States ◽  
Induced Changes

Background: Alcohol priming can modulate the value of rewards, as observed through the effects of acute alcohol administration on cue reactivity. However, little is known about the psychophysiological mechanisms driving these effects. Here we examine how alcohol-induced changes in bodily states shape the development of implicit attentional biases and explicit cue reactivity. Aims: To characterize the interoceptive correlates of alcohol priming effects on alcohol attentional biases and cue reactivityMethods: In a two-session double blind alcohol administration procedure, participants (n=31) were given a 0.4g/kg dose of alcohol or a placebo drink. Cardiovascular responses were measured before and after alcohol administration to observe the effects of alcohol on viscero-afferent reactivity, as indexed through changes in heart-rate variability (HRV) at or near 0.1Hz (0.1Hz HRV). Next, participants completed a modified Flanker task to examine implicit alcohol attentional biases and provided subjective valence and arousal ratings of alcohol cues to examine explicit cue reactivity. Results: We found that changes in 0.1Hz HRV after alcohol administration positively correlated with attentional biases, and negatively correlated with alcohol valence ratings; breath alcohol content was a null predictor. Conclusion: This is novel evidence that suggests alcohol-induced changes in bodily states may mediate the occurrence of alcohol priming effects, and highlights the potentially generative role of interoceptive mechanisms in alcohol-related behaviors. The differential patterns revealed by implicit biases and explicit response tendencies is considered within the context of the dissociation between wanting and liking.

scholarly journals Subjective Effects of Inhaling Kuromoji Tea Aroma

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 575
Author(s):  
Eri Matsubara ◽  
Takeshi Morikawa ◽  
Norihisa Kusumoto ◽  
Koh Hashida ◽  
Naoyuki Matsui ◽  
...  
Keyword(s):  
Core Body Temperature ◽  
Subjective Effects ◽  
Subjective Feeling ◽  
Beneficial Effects ◽  
Saliva Secretion ◽  
Subjective Assessments ◽  
Long Time ◽  
Production Areas ◽  
Core Body ◽  
Deciduous Shrub

Teas and various herbal teas are well-known beverages and are commonly consumed around the world. In this study, we focused on kuromoji tea. Kuromoji is a deciduous shrub of the Lauraceae family, and the plucked leaves and branches have been drunk as a tea in production areas for a long time. However, no studies have investigated the subjective and physiological effects of kuromoji tea. In this study, the effects of kuromoji tea were examined on the basis of the measurements of heart rate variability and cerebral blood flow, core body temperature and subjective assessments. Moreover, the results of this study showed that a pleasant subjective feeling could be obtained by sniffing the aroma of kuromoji teas, especially tea leaves. It was also found that the aroma of kuromoji teas has the potential to stimulate saliva secretion and increase subjective and physiological excitements in the oral cavity. 1,8-Cineole, linalool, terpinen-4-ol, carvone and geraniol were determined in both kuromoji leaves and branches. In this study, the beneficial effects of kuromoji teas when drunk conventionally were investigated.

Naturalistic Follow-Up of Drinking Behavior Following Participation in an Alcohol Administration Study

1999 ◽  
Vol 17 (1-2) ◽  
pp. 159-162 ◽  
Author(s):  
Rajita Sinha ◽  
Suchitra Krishnan-Sarin ◽  
Conor Farren ◽  
Stephanie O'Malley
Keyword(s):  
Drinking Behavior ◽  
Alcohol Administration

#3083 Fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): an interoceptive predictive coding model of pain and fatigue expression

2021 ◽  
Vol 92 (8) ◽  
pp. A3.3-A4
Author(s):  
Harriet Sharp ◽  
Kristy Themelis ◽  
Marisa Amato ◽  
Andrew Barritt ◽  
Kevin Davies ◽  
...  
Keyword(s):  
Prediction Error ◽  
Predictive Coding ◽  
Chronic Fatigue ◽  
Self Report ◽  
Subjective Experiences ◽  
Double Blind ◽  
Pain Thresholds ◽  
Pressure Pain Thresholds ◽  
Interoceptive Accuracy ◽  
Bodily States

IntroductionThe aetiology and pathophysiology of fibromyalgia and ME/CFS are poorly characterised but altered inflammatory, autonomic and interoceptive processes have been implicated. Interoception has been conceptualised as a predictive coding process; where top-down prediction signals compare to bottom-up afferents, resulting in prediction error signals indicating mismatch between expected and actual bodily states. Chronic dyshomeostasis and elevated interoceptive prediction error signals have been theorised to contribute to the expression of pain and fatigue in fibromyalgia and ME/CFS.Objectives/AimsTo investigate how altered interoception and prediction error relates to baseline expression of pain and fatigue in fibromyalgia and ME/CFS and in response to an inflammatory challenge.MethodsSixty-five patients with fibromyalgia and/or ME/CFS diagnosis and 26 matched controls underwent baseline assessment: self-report questionnaires assessing subjective pain and fatigue and objective measurements of pressure-pain thresholds. Participants received injections of typhoid (inflammatory challenge) or saline (placebo) in a randomised, double-blind, crossover design, then completed heartbeat tracking task (assessing interoceptive accuracy). Porges Body Questionnaire assessed interoceptive sensibility. Interoceptive prediction error (IPE) was calculated as discrepancy between objective accuracy and subjective sensibility.ResultsPatients with fibromyalgia and ME/CFS had significantly higher IPE (suggesting tendency to over-estimate interoceptive ability) and interoceptive sensibility, despite no differences in interoceptive accuracy. IPE and sensibility correlated positively with all self-report fatigue and pain measures, and negatively with pain thresholds. Following inflammatory challenge, IPE correlated negatively with the mismatch between subjective and objective measures of pain induced by inflammation.ConclusionsThis is the first study to reveal altered interoception processes in patients with fibromyalgia and ME/CFS, who are known to have dysregulated autonomic function. Notably, we found elevated IPE in patients, correlating with their subjective experiences of pain and fatigue. We hypothesise a predictive coding model, where mismatch between expected and actual internal bodily states (linked to autonomic dysregulation) results in prediction error signalling which could be metacognitively interpreted as chronic pain and fatigue. Our results demonstrate potential for further exploration of interoceptive processing in patients with fibromyalgia and ME/CFS, aiding understanding of these poorly defined conditions and providing potential new targets for diagnostic and therapeutic intervention.

scholarly journals Interoceptive awareness is associated with acute alcohol-induced changes in subjective effects

2019 ◽  
Vol 181 ◽  
pp. 69-76 ◽  
Author(s):  
Mateo Leganes-Fonteneau ◽  
Yun Cheang ◽  
Yan Lam ◽  
Sarah Garfinkel ◽  
Theodora Duka
Keyword(s):  
Subjective Effects ◽  
Interoceptive Awareness ◽  
Induced Changes

scholarly journals Interoceptive dimensions across cardiac and respiratory axes

2016 ◽  
Vol 371 (1708) ◽  
pp. 20160014 ◽  
Author(s):  
Sarah N. Garfinkel ◽  
Miranda F. Manassei ◽  
Giles Hamilton-Fletcher ◽  
Yvo In den Bosch ◽  
Hugo D. Critchley ◽  
...  
Keyword(s):  
Internal State ◽  
The Body ◽  
Metacognitive Awareness ◽  
Self Report ◽  
Affective Processing ◽  
Organ Specific ◽  
Interoceptive Sensitivity ◽  
Interoceptive Accuracy ◽  
Future Work ◽  
Insight Into

Interoception refers to the sensing of signals concerning the internal state of the body. Individual differences in interoceptive sensitivity are proposed to account for differences in affective processing, including the expression of anxiety. The majority of investigations of interoceptive accuracy focus on cardiac signals, typically using heartbeat detection tests and self-report measures. Consequently, little is known about how different organ-specific axes of interoception relate to each other or to symptoms of anxiety. Here, we compare interoception for cardiac and respiratory signals. We demonstrate a dissociation between cardiac and respiratory measures of interoceptive accuracy (i.e. task performance), yet a positive relationship between cardiac and respiratory measures of interoceptive awareness (i.e. metacognitive insight into own interoceptive ability). Neither interoceptive accuracy nor metacognitive awareness for cardiac and respiratory measures was related to touch acuity, an exteroceptive sense. Specific measures of interoception were found to be predictive of anxiety symptoms. Poor respiratory accuracy was associated with heightened anxiety score, while good metacognitive awareness for cardiac interoception was associated with reduced anxiety. These findings highlight that detection accuracies across different sensory modalities are dissociable and future work can better delineate their relationship to affective and cognitive constructs. This article is part of the themed issue ‘Interoception beyond homeostasis: affect, cognition and mental health’.

scholarly journals Drinking Motives, Alcohol Expectancies, Self-Efficacy, and Drinking Patterns

2005 ◽  
Vol 35 (2) ◽  
pp. 147-166 ◽  
Author(s):  
Rutger C. M. E. Engels ◽  
Reinout Wiers ◽  
Lex Lemmers ◽  
Geertjan Overbeek
Keyword(s):  
Self Efficacy ◽  
Multivariate Analyses ◽  
Drinking Behavior ◽  
Alcohol Expectancies ◽  
Self Report ◽  
Drinking Motives ◽  
Drinking Patterns ◽  
Adolescents And Adults ◽  
Positive Expectancies ◽  
And Gender

The current study focused on the associations between drinking motives, alcohol expectancies, self-efficacy, and drinking behavior in a representative sample of 553 Dutch adolescents and adults. Data were gathered by means of self-report questionnaires and a 14-days drinking diary. A model was postulated in which negative expectancies and self-efficacy were directly associated with drinking, and in which drinking motives mediated the associations between positive expectancies, and drinking. The findings of multivariate analyses showed that drinking motives were related to general indicators of drinking and to drinking levels in specific situations. Furthermore, self-efficacy was moderately related to all drinking variables. Negative expectancies were related to general drinking variables but hardly to drinking in specific situations. Positive expectancies were hardly related to drinking in multivariate analyses and therefore mediation models could not be tested. No systematic moderator effects were apparent for age and gender on the associations between drinking motives, alcohol expectancies, self-efficacy, and drinking.

scholarly journals Alcohol Expectancy, Drinking Behavior, and Sexual Victimization Among Female and Male College Students

2015 ◽  
Vol 32 (15) ◽  
pp. 2298-2322 ◽  
Author(s):  
Kimberly A. Tyler ◽  
Rachel M. Schmitz ◽  
Scott A. Adams
Keyword(s):  
College Students ◽  
Sexual Assault ◽  
Sexual Victimization ◽  
Drinking Behavior ◽  
Heavy Drinking ◽  
Alcohol Expectancies ◽  
Hooking Up ◽  
Alcohol Expectancy ◽  
Housing Type ◽  
The Relationship

College students have high rates of heavy drinking, and this dangerous behavior is strongly linked to sexual victimization. Although research has examined risk factors for sexual assault, few studies have simultaneously studied the various pathways through which risks may affect sexual assault and how these pathways may be uniquely different among females and males. As such, the current study uses path analyses to examine whether alcohol expectancies mediate the relationship between social factors (e.g., hooking up, amount friends drink) and drinking behavior and experiencing sexual victimization, and whether drinking behavior mediates the relationship between alcohol expectancies and sexual victimization among a college sample of 704 males and females from a large Midwestern university. For both females and males, sexual victimization was positively associated with child sexual abuse, hooking up more often, and heavier drinking, whereas greater alcohol expectancies were associated with sexual victimization only for females. Several mediating pathways were found for both females and males. Gender comparisons revealed that some of the pathways to sexual victimization such as hooking up, amount friends drink, and housing type operated differently for females and males.

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