scholarly journals The relationship between gluten free diet adherence and depressive symptoms in adults with coeliac disease: A systematic review with meta-analysis

2017 ◽  
Author(s):  
Kirby Sainsbury ◽  
Marta M Marques
Keyword(s):  
Depressive Symptoms ◽  
Coeliac Disease ◽  
Meta Analysis ◽  
Gluten Free Diet ◽  
Self Report ◽  
Gluten Free ◽  
Cross Sectional ◽  
High K ◽  
Direction Of Causation ◽  
The Relationship

Purpose: Depressive symptoms are common in patients with coeliac disease (CD) and may represent a barrier to gluten free diet (GFD) adherence. The aims of this meta-analysis were: (1) to synthesise the evidence on the relationship between depression or depressive symptoms and degree of adherence to a GFD in patients with CD who are already attempting a GFD (i.e., post-diagnosis and onset of GFD), and (2) to summarise the direction of causation of any observed relationship. Methods: A random effects meta-analysis of 8 cross-sectional studies (N=1644) was conducted. Included studies measured self-reported depressive symptoms and GFD adherence using either a dietitian interview or validated self-report questionnaire that considered unintentional gluten consumption.Results: There was a moderate association between poorer GFD adherence and greater depressive symptoms (r=0.398, 95% CI=0.321-0.469), with marked heterogeneity in the effects (I2=66.8%). A sensitivity analysis excluding studies with a moderate/high (k=1) or unclear risk of bias (k=1) did not change the results. Conclusion: The low number of studies meeting inclusion criteria limits the strength of the conclusions. Available evidence suggests there is an association between poorer GFD adherence and self-reported depressive symptoms; however, studies using longitudinal and prospective designs, and reliable measures, particularly for adherence, are needed to confirm this association. The direction of causation between depression and adherence remains unclear.

Coping Style as a Mediator of the Relationship Between Depressive Symptoms and Deliberate Self-Harm

Crisis ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 272-279 ◽  
Author(s):  
Allison S. Christian ◽  
Kristen M. McCabe
Keyword(s):  
Depressive Symptoms ◽  
Undergraduate Students ◽  
Cross Sectional Study ◽  
Self Report ◽  
Hierarchical Regression ◽  
Cross Sectional ◽  
Deliberate Self Harm ◽  
Self Blame ◽  
Self Harm ◽  
The Relationship

Background: Deliberate self-harm (DSH) occurs with high frequency among clinical and nonclinical youth populations. Although depression has been consistently linked with the behavior, not all depressed individuals engage in DSH. Aims: The current study examined maladaptive coping strategies (i.e., self-blame, distancing, and self-isolation) as mediators between depression and DSH among undergraduate students. Methods: 202 students from undergraduate psychology courses at a private university in Southern California (77.7% women) completed anonymous self-report measures. Results: A hierarchical regression model found no differences in DSH history across demographic variables. Among coping variables, self-isolation alone was significantly related to DSH. A full meditational model was supported: Depressive symptoms were significantly related to DSH, but adding self-isolation to the model rendered the relationship nonsignificant. Limitations: The cross-sectional study design prevents determination of whether a casual relation exists between self-isolation and DSH, and obscures the direction of that relationship. Conclusions: Results suggest targeting self-isolation as a means of DSH prevention and intervention among nonclinical, youth populations.

scholarly journals O papel da inflexibilidade psicológica na relação entre o stress relacionado com a infertilidade e os sintomas depressivos em mulheres com um diagnóstico de infertilidade

2021 ◽  
Vol 7 (2) ◽  
pp. 61-76
Keyword(s):  
Depressive Symptoms ◽  
Cross Sectional Study ◽  
Self Report ◽  
Psychological Inflexibility ◽  
Cross Sectional ◽  
Standardized Measures ◽  
Mediating Role ◽  
Acceptance And Commitment ◽  
Related Stress ◽  
The Relationship

Background and Aim: Introduction: Infertility is a medical and social condition that impacts people’s lives at the marital, family, social and financial levels. Several studies point to comorbidity between psychopathology and infertility, and people facing the demands of infertility may use maladaptive mechanisms of emotion regulation translated into psychological inflexibility. Objectives: This current study aimed to explore the mediating role of infertility-related psychological inflexibility in the relationship between infertility-related stress and depressive symptoms in women presenting an infertility diagnosis and pursuing infertility medical treatment. In addition, as a secondary aim, the associations between the time since diagnosis and the study variables were examined. Methods: A cross-sectional study was conducted on a sample of 96 women recruited with the support of the Portuguese Fertility Association. Participants filled in online a set of self-report instruments. Sociodemographic and clinical data were collected, and standardized measures of infertility-related stress, depressive symptoms, and infertility-related psychological inflexibility were used. Results: The results demonstrated that the effect of infertility-related stress on depressive symptoms was .46, being totally mediated by infertility-related psychological inflexibility. Discussion: Difficulty in achieving a pregnancy is a painful life event that interferes with the goals and plans for building a family, which can lead to stress and depressive symptoms. The relationship between these symptoms seems to be influenced by the mechanism of infertility-related psychological inflexibility. Therefore, interventions such as Acceptance and Commitment Therapy and the Mindfulness-Based Program for Infertility may be particularly suitable for this population by integrating psychological inflexibility as a therapeutic target.

scholarly journals Determinants of adherence to gluten-free diet in Greek children with coeliac disease: a cross-sectional study

2013 ◽  
Vol 67 (6) ◽  
pp. 615-619 ◽  
Author(s):  
D Charalampopoulos ◽  
J Panayiotou ◽  
G Chouliaras ◽  
A Zellos ◽  
E Kyritsi ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Cross Sectional Study ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Sectional Study ◽  
Cross Sectional

Are the Changes of Mood in Children with Coeliac Disease Due to Abnormal Serotonin Metabolism?

1987 ◽  
Vol 5 (3-4) ◽  
pp. 145-152 ◽  
Author(s):  
D. N. Challacombe ◽  
E. E. Wheeler
Keyword(s):  
Coeliac Disease ◽  
Biogenic Amine ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Serotonin Metabolism ◽  
Mood Changes ◽  
Humoral Agent ◽  
The Relationship ◽  
The Brain

Children with untreated coeliac disease are characteristically unhappy and after a few days of treatment with a gluten-free diet their mood improves. This improvement in mood can be rapidly reversed by introducing gluten into their diet again which suggests that a humoral agent could be involved in this process. As serotonin is a neurotransmitter in the brain and abnormalities of serotonin metabolism have been reported in coeliac disease, this biogenic amine could be the humoral agent that mediates the changes of mood in coeliac disease. In this review the relationship between the mood changes in coeliac disease and serotonin metabolism will be further examined.

P–475 The mediator role of infertility-related psychological inflexibility in the relationship between infertility-stress domains and psychopathological symptoms

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
N Carolino ◽  
B Monteiro ◽  
M Cunha ◽  
A Galhardo
Keyword(s):  
Depressive Symptoms ◽  
Anxiety Symptoms ◽  
Self Report ◽  
Psychological Inflexibility ◽  
Cross Sectional ◽  
Psychopathological Symptoms ◽  
Related Stress ◽  
The Impact ◽  
The Relationship ◽  
Stress Domains

Abstract Study question Does infertility-related psychological inflexibility play a role in the relationship between infertility-related stress domains and psychopathological symptoms (depression, anxiety)? Summary answer Infertility-related psychological inflexibility mediated the relationship between infertility-related stress domains and depression. There were no effects between infertility-related stress domains and anxiety symptoms. What is known already The emotional impact of infertility may include anxiety and depressive symptoms and these seem to be related to stress. Beliefs about the importance of parenthood (need for parenthood) and rejection of a childfree lifestyle, as well as the impact of infertility in several life areas (social, sexual, and relationship) are conceptually considered two infertility-related stress domains. Although the relationship between infertility-related stress and psychopathological symptoms has been previously recognized, the mechanism underlying this relationship remains undetermined. Psychological inflexibility has been pointed as a core transdiagnostic process contributing to the development and maintenance of several psychological difficulties. Study design, size, duration Cross-sectional study. Participants were recruited through the Associação Portuguesa de Fertilidade (patients’ association). Inclusion criteria were age (18 years or older) and an infertility medical diagnosis. Data were collected online through self-report instruments between June and December 2019. Participants/materials, setting, methods: A sample comprising 287 women pursuing infertility medical treatment (at different stages) completed online a sociodemographic questionnaire, the depression and anxiety subscales of the Depression, Anxiety and Stress Scales (DASS – 21), the Psychological Inflexibility Scale - Infertility (PIS-I), and the Fertility Problem Inventory (FPI). Descriptive and correlational analyses were computed through SPSS v. 26, and path analyses were estimated in AMOS (v. 24) with bootstrap procedures (2000 samples). Main results and the role of chance Correlation analyses revealed that FPI domains (importance of parenthood and impact on life domains), depressive and anxiety symptoms were significantly and positively associated with PIS-I. A mediation analysis was conducted to examine whether PIS-I mediated the effect of FPI domains on depressive and anxiety symptoms. Paths showing not to be statistically significant were removed. This model showed a good fit to the empirical data: χ2(4) = 1.59, p = .810, CMIN/DF = .40; TLI = 1.00; CFI = 1.00; RMSEA = .00, 95% CI = .00 to .06. The effect of the importance of parenthood on depressive symptoms revealed to be both direct (b = .03; SEb = .01; Z = 2.46; p = .014; β= .15) and partially mediated by the PIS-I (b = .31, 95% CI = .24 to .37, p = .018). The effect of the impact of infertility in several life areason depressive symptoms was fully mediated by PIS-I (b = .15, 95% CI = .10 to .21, p = .008). This model explained 43% of the total variance of depressive symptoms. No significant effects were found for anxiety symptoms. Limitations, reasons for caution Participants were at different stages of their fertility treatment. Data collection was completed online and this tends to recruit participants with more access to online platforms. Results rely on cross-sectional and self-report data. Wider implications of the findings: Results suggest the relevance of targeting processes encompassing psychological inflexibility, such as cognitive fusion, experiential avoidance, conceptualized self, conceptualized past and future, lack of values clarity, and inability to commit with values-driven actions, in psychological interventions designed for women with infertility. Trial registration number N/A.

scholarly journals A score that verifies adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life

2012 ◽  
Vol 108 (10) ◽  
pp. 1884-1888 ◽  
Author(s):  
Federico Biagi ◽  
Paola Ilaria Bianchi ◽  
Alessandra Marchese ◽  
Lucia Trotta ◽  
Claudia Vattiato ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Villous Atrophy ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Cross Sectional ◽  
Simple Method ◽  
Endomysial Antibodies ◽  
Dietary Interview

A dietary interview performed by expert personnel is the best method to check whether patients with coeliac disease follow a strict gluten-free diet (GFD). We previously developed a score based on four fast and simple questions that can be administered even by non-expert personnel. The aim of the present study is to verify the reliability of our questionnaire in a new cohort of patients. The questionnaire has a five-level score. From March 2008 to January 2011, the questionnaire was administered to 141 coeliac patients on a GFD, who were undergoing re-evaluation. The score obtained was compared with persistence of both villous atrophy and endomysial antibodies (EMA). The rate of lower scores was higher among the patients with persistence of either villous atrophy (Fisher's exact, P < 0·001; test for trend, P < 0·001) or positive EMA (Fisher's exact, P = 0·001; test for trend, P = 0·018). Given that the coeliac patients have been well instructed on what a GFD means and on how to follow it, our questionnaire is a reliable and simple method to verify compliance to a GFD.

scholarly journals The rise and fall of gluten!

2015 ◽  
Vol 74 (3) ◽  
pp. 221-226 ◽  
Author(s):  
Imran Aziz ◽  
Federica Branchi ◽  
David S. Sanders
Keyword(s):  
Coeliac Disease ◽  
Agricultural Production ◽  
Clinical Symptoms ◽  
Gluten Free Diet ◽  
Gluten Sensitivity ◽  
Gluten Free ◽  
Western Asia ◽  
Fertile Crescent ◽  
Gluten Sensitive Enteropathy ◽  
The Relationship

Mankind has existed for 2·5 million years but only in the last 10 000 years have we been exposed to wheat. Wheat was first cultivated in the Fertile Crescent (South Western Asia) with a farming expansion that lasted from about 9000BC to 4000BC. Thus it could be considered that wheat (and gluten) is a novel introduction to man's diet! Prior to 1939 the rationing system had already been devised. This led to an imperative to try to increase agricultural production. Thus it was agreed in 1941 that there was a need to establish a Nutrition Society. The very roots of the society were geared towards necessarily increasing the production of wheat. This goal was achieved and by the end of the 20th century, global wheat output had expanded 5-fold. Perhaps as a result the epidemiology of coeliac disease (CD) or gluten sensitive enteropathy has changed. CD is a state of heightened immunological responsiveness to ingested gluten in genetically susceptible individuals. CD now affects 1 % or more of all adults, for which the treatment is a strict lifelong gluten-free diet. However, there is a growing body of evidence to show that a far greater proportion of individuals without coeliac disease are taking a gluten-free diet of their own volition. This clinical entity has been termed non-coeliac gluten sensitivity (NCGS), although the condition is fraught with complexities due to overlap with other gluten-based constituents that can also trigger similar clinical symptoms. This review will explore the relationship between gluten, the rising prevalence of modern coeliac disease, and the new entity of NCGS along with its associated uncertainties.

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