Twins Early Development Study: a genetically sensitive investigation into behavioural and cognitive development from infancy to emerging adulthood

2019 ◽  
Author(s):  
Kaili Rimfeld ◽  
Margherita Malanchini ◽  
Tom Spargo ◽  
Gemma Spickernell ◽  
Saskia Selzam ◽  
...  
Keyword(s):  
Emerging Adulthood ◽  
Early Development ◽  
Early Adulthood ◽  
Development Study ◽  
England And Wales ◽  
Scientific Papers ◽  
Birth Records ◽  
Longitudinal Twin Study ◽  
The Uk ◽  
First Contact

The Twins Early Development Study (TEDS) is a longitudinal twin study that recruited over 16,000 twin pairs born between 1994 and 1996 in England and Wales through national birth records. More than 10,000 of these families are still engaged in the study. TEDS was and still is a representative sample of the population in England and Wales. Rich cognitive and emotional/behavioural data have been collected from the twins from infancy to emerging adulthood with data collection at first contact and at ages 2, 3, 4, 7, 8, 9, 10, 12, 14, 16, 18 and 21, enabling longitudinal genetically sensitive analyses. Data have been collected from the twins themselves, from their parents and teachers, and from the UK National Pupil Database. Genotyped DNA data are available for 10,346 individuals (who are unrelated except for 3,320 dizygotic co-twins). TEDS data have contributed to over 400 scientific papers involving more than 140 researchers in 50 research institutions. TEDS offers an outstanding resource for investigating cognitive and behavioural development across childhood and early adulthood and actively fosters scientific collaborations.

scholarly journals Twins Early Development Study: A Genetically Sensitive Investigation into Behavioral and Cognitive Development from Infancy to Emerging Adulthood

2019 ◽  
Vol 22 (6) ◽  
pp. 508-513 ◽  
Author(s):  
Kaili Rimfeld ◽  
Margherita Malanchini ◽  
Thomas Spargo ◽  
Gemma Spickernell ◽  
Saskia Selzam ◽  
...  
Keyword(s):  
Emerging Adulthood ◽  
Early Development ◽  
Early Adulthood ◽  
Development Study ◽  
England And Wales ◽  
Scientific Papers ◽  
Birth Records ◽  
Longitudinal Twin Study ◽  
The Uk ◽  
First Contact

AbstractThe Twins Early Development Study (TEDS) is a longitudinal twin study that recruited over 16,000 twin-pairs born between 1994 and 1996 in England and Wales through national birth records. More than 10,000 of these families are still engaged in the study. TEDS was and still is a representative sample of the population in England and Wales. Rich cognitive and emotional/behavioral data have been collected from the twins from infancy to emerging adulthood, with data collection at first contact and at ages 2, 3, 4, 7, 8, 9, 10, 12, 14, 16, 18 and 21, enabling longitudinal genetically sensitive analyses. Data have been collected from the twins themselves, from their parents and teachers, and from the UK National Pupil Database. Genotyped DNA data are available for 10,346 individuals (who are unrelated except for 3320 dizygotic co-twins). TEDS data have contributed to over 400 scientific papers involving more than 140 researchers in 50 research institutions. TEDS offers an outstanding resource for investigating cognitive and behavioral development across childhood and early adulthood and actively fosters scientific collaborations.

scholarly journals Twins' Early Development Study (TEDS): A Multivariate, Longitudinal Genetic Investigation of Language, Cognition and Behavior Problems from Childhood Through Adolescence

2007 ◽  
Vol 10 (1) ◽  
pp. 96-105 ◽  
Author(s):  
Bonamy R. Oliver ◽  
Robert Plomin
Keyword(s):  
Behavior Problems ◽  
Early Development ◽  
Large Scale ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Adoption Studies ◽  
Development Study ◽  
Learning Abilities ◽  
The Uk ◽  
And Behavior

AbstractThe Twins' Early Development Study (TEDS) is a large-scale longitudinal study of twins from early childhood through adolescence. Since its conception, TEDS has had as its focus the study of problematic development within the context of normal variation, mainly in the development of language, cognitive and academic abilities and behavior problems from multivariate quantitative and molecular genetic perspectives. TEDS twins have been assessed at 2, 3, 4, 7, 9, 10 and (currently) 12 years of age, and DNA collected from more than 12,000 children. Identified from birth records of twins born in the United Kingdom between 1994 and 1996, more than 15,000 pairs of twins originally enrolled in TEDS, and well over 13,000 pairs — representative of the UK population — remain involved in the study to date. Similar to many other twin and adoption studies, TEDS data indicate that both genetic and environmental influences are important in nearly all areas of behavioral development. Multivariate genetic analyses allow researchers to go beyond this basic nature–nurture question, and TEDS results suggest that, especially in the area of learning abilities and disabilities, genes are generalists and environments are specialists. That is, genes largely contribute to similarity in performance within and between learning abilities and disabilities and across age, whereas the environment contributes to differences in performance. Quantitative genetic findings such as these chart the course for molecular genetic research. The TEDS dataset is proving valuable in genome-wide association research that tries to identify some of the many genes responsible for the ubiquitous heritability of behavior.

scholarly journals Twins Early Development Study (TEDS): A Genetically Sensitive Investigation of Cognitive and Behavioral Development From Childhood to Young Adulthood

2012 ◽  
Vol 16 (1) ◽  
pp. 117-125 ◽  
Author(s):  
Claire M. A. Haworth ◽  
Oliver S. P. Davis ◽  
Robert Plomin
Keyword(s):  
Early Development ◽  
Young Adulthood ◽  
Dna Markers ◽  
Quantitative Traits ◽  
Normal Development ◽  
Behavioral Development ◽  
Development Study ◽  
Developmental Effects ◽  
Genome Wide ◽  
Birth Records

The Twins Early Development Study (TEDS) is a large longitudinal sample of twins born in England and Wales between 1994 and 1996. The focus of TEDS has been on cognitive and behavioral development, including difficulties in the context of normal development. TEDS began when multiple births were identified from birth records and the families were invited to take part in the study; 16,810 pairs of twins were originally enrolled in TEDS. More than 10,000 of these twin pairs remain enrolled in the study to date. DNA has been collected for more than 7,000 pairs, and genome-wide genotyping data for two million DNA markers are available for 3,500 individuals. The TEDS families have taken part in studies when the twins were aged 2, 3, 4, 7, 8, 9, 10, 12, 14, and 16 years of age. Data collection is currently underway to assess the adult destinations of the twins as they move from school to university and the workplace. Between January 2012 and December 2014, all of the TEDS twins will turn 18, and the study will transition to an adult sample. TEDS represents an outstanding resource for investigating the developmental effects of genes and environments on complex quantitative traits from childhood to young adulthood and beyond.

TBE in United Kingdom

2020 ◽  
Keyword(s):  
United Kingdom ◽  
Clinical Disease ◽  
England And Wales ◽  
Probable Case ◽  
The United Kingdom ◽  
South West ◽  
Louping Ill ◽  
The Uk ◽  
North And South ◽  
South West England

Until 2019, TBE was considered only to be an imported disease to the United Kingdom. In that year, evidence became available that the TBEV is likely circulating in the country1,2 and a first “probable case” of TBE originating in the UK was reported.3 In addition to TBEV, louping ill virus (LIV), a member of the TBEV-serocomplex, is also endemic in parts of the UK. Reports of clinical disease caused by LIV in livestock are mainly from Scotland, parts of North and South West England and Wales.4

HIV and other STIs in the United Kingdom: further increases

2003 ◽  
Vol 7 (48) ◽  
Author(s):  
◽  
Keyword(s):  
United Kingdom ◽  
Disease Surveillance ◽  
Communicable Disease ◽  
People Living With Hiv ◽  
Health Protection Agency ◽  
Protection Agency ◽  
England And Wales ◽  
The United Kingdom ◽  
The Uk ◽  
Living With Hiv

The Health Protection Agency Communicable Disease Surveillance Centre for England and Wales and others have reported that the number of people living with HIV in the UK has increased

Using Census Returns and the Own-Children Method to Measure Marital Fertility in Rawtenstall, 1851-1901

2017 ◽  
pp. 54-73 ◽  
Author(s):  
H.M. (Mac) Boot
Keyword(s):  
19Th Century ◽  
Marital Fertility ◽  
Cotton Textile ◽  
England And Wales ◽  
North East ◽  
Proximate Determinants ◽  
Birth Records ◽  
The 19Th Century ◽  
The Town ◽  
Fertility Estimation

The incompleteness of Victorian census returns of marriage and birth records for England and Wales, and the high costs of using civil and church records, have greatly restricted research into the timing and character of the decline in marital fertility in the second half of the 19th century. This article argues that, in spite of these limitations, the census returns provide enough data to allow the well-known the 'Own-children method of fertility estimation', when used within Bongaarts' framework for analysing the proximate determinants of fertility, to derive estimates of total and age-specific marital fertility for women 15 to 49 years of age. It uses data from the census returns for the town of Rawtenstall, a small cotton textile manufacturing town in north-east Lancashire, to generate these estimates and to test their credibility against other well respected measures of marital fertility for England and Wales.

Funding Local Political Parties in England and Wales: Donations and Constituency Campaigns

2007 ◽  
Vol 9 (3) ◽  
pp. 365-395 ◽  
Author(s):  
Ron Johnston ◽  
Charles Pattie
Keyword(s):  
Political Parties ◽  
England And Wales ◽  
Liberal Democrats ◽  
Using Data ◽  
The Uk ◽  
The Impact

The funding of political parties is an issue of considerable contemporary concern in the UK. Although most attention has been paid to the situation regarding national parties, the new funding regime introduced in 2001 also applies to constituency parties, and some concerns have been raised regarding the limits on spending and expenditure there. Using data released by the Electoral Commission on all donations above a specified minimum to constituency parties, this article looks at the pattern of donations over the period 2001–05. It then analyses the impact of spending on the 2005 constituency campaigns, showing that for the Conservatives and Liberal Democrats substantial donations enhanced their vote-winning performances in seats where their candidates were challengers whereas for Labour substantial donations aided its performance in marginal seats that it was defending.

scholarly journals Fruit and vegetable intake: change with age across childhood and adolescence

2017 ◽  
Vol 117 (5) ◽  
pp. 759-765 ◽  
Author(s):  
Viviana Albani ◽  
Laurie T. Butler ◽  
W. Bruce Traill ◽  
Orla B. Kennedy
Keyword(s):  
Vegetable Intake ◽  
Early Adulthood ◽  
Childhood And Adolescence ◽  
Nutrition Survey ◽  
Average Intake ◽  
Eating Fruit ◽  
Important Health ◽  
Food Diaries ◽  
The Uk

AbstractEating fruit and vegetables (FV) offers important health benefits for children and adolescents, but their average intake is low. To explore if negative trends with age exist as children grow, this study modelled differences in FV consumption from childhood to young adulthood. A pseudo-panel was constructed using years 1–4 (combined) of the Rolling Programme of the UK National Diet and Nutrition Survey (NDNS) (2008/2009–2011/2012). Intake of FV in the NDNS was recorded using 4-d unweighted food diaries. The data consisted of 2131 observations of individuals aged 2–23 years. Age-year-cohort decomposition regression analyses were used to separate age effects from year and cohort effects in the data. Total energy intake was included to account for age differences in overall energy consumption. Fruit intake started to decrease from the age of 7 years for boys and girls, and reached its lowest level during adolescence. By 17 years, boys were consuming 0·93 (P=0·037) less fruit portions compared with the age of 2 years. By 15 years, girls were consuming 0·8 fruit portions less (P=0·053). Vegetable intake changed little during childhood and adolescence (P=0·0834 andP=0·843 for change between 7 and 12 years, boys and girls, respectively). There was unclear evidence of recovery of FV intakes in early adulthood. Efforts to improve FV intake should consider these trends, and focus attention on the factors influencing intake across childhood and adolescence in order to improve the nutritional quality of diets during these periods.

Trust, efficacy and ethicacy when testing prisoners for COVID-19

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Steve Lambert ◽  
Dean Wilkinson
Keyword(s):  
Large Scale ◽  
Current System ◽  
Epidemiological Studies ◽  
Careful Consideration ◽  
Power Relationships ◽  
England And Wales ◽  
Content Type ◽  
Large Scale Testing ◽  
The Uk ◽  
The Impact

Purpose The outbreak of the severe acute respiratory syndrome coronavirus 2 virus and subsequent COVID-19 illness has had a major impact on all levels of society internationally. The extent of the impact of COVID-19 on prison staff and prisoners in England and Wales is unknown. Testing for COVID-19 both asymptomatic and symptomatic, as well as for antibodies, to date, has been minimal. The purpose of this paper is to explore the widespread testing of COVID-19 in prisons poses philosophical and ethical questions around trust, efficacy and ethicacy. Design/methodology/approach This paper is both descriptive, providing an overview of the widespread testing of COVID-19 in prisoners in England and Wales, and conceptual in that it discusses and argues the issues associated with large-scale testing. This paper provides a discussion, using comparative studies, of the issues associated with large-scale testing of prisoners across the prison estate in England and Wales (120 prisons). The issues identified in this paper are contextualised through the lens of COVID-19, but they are equally transferrable to epidemiological studies of any pandemic. Given the prevalence of COVID-19 globally and the lack of information about its spread in prisons, at the time of writing this paper, there is a programme of asymptomatic testing of prisoners. However, there remains a paucity of data on the spread of COVID-19 in prisons because of the progress with the ongoing testing programme. Findings The authors argue that the widespread testing of prisoners requires careful consideration of the details regarding who is included in testing, how consent is gained and how tests are administered. This paper outlines and argues the importance of considering the complex nuance of power relationships within the prison system, among prisoner officers, medical staff and prisoners and the detrimental consequences. Practical implications The widespread testing of COVID-19 presents ethical and practical challenges. Careful planning is required when considering the ethics of who should be included in COVID-19 testing, how consent will be gained, who and how tests will be administered and very practical challenges around the recording and assigning of COVID-19 test kits inside the prison. The current system for the general population requires scanning of barcodes and registration using a mobile number; these facilities are not permitted inside a prison. Originality/value This paper looks at the issues associated with mass testing of prisoners for COVID-19. According to the authors’ knowledge, there has not been any research that looks at the issues of testing either in the UK or internationally. The literature available details countries’ responses to the pandemic rather and scientific papers on the development of vaccines. Therefore, this paper is an original review of some of the practicalities that need to be addressed to ensure that testing can be as successful as possible.

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