Inferring Mycobacterium bovis transmission between cattle and badgers using isolates from the Randomised Badger Culling Trial

Mycobacterium bovis (M. bovis) is a causative agent of bovine tuberculosis, a significant source of morbidity and mortality in the global cattle industry. The Randomised Badger Culling Trial was a field experiment carried out between 1998 and 2005 in the South West of England. As part of this trial, M. bovis isolates were collected from contemporaneous and overlapping populations of badgers and cattle within ten defined trial areas. We combined whole genome sequences from 1,442 isolates with location and cattle movement data, identifying transmission clusters and inferred rates and routes of transmission of M. bovis. Most trial areas contained a single transmission cluster that had been established shortly before sampling, often contemporaneous with the expansion of bovine tuberculosis in the 1980s. The estimated rate of transmission from badger to cattle was approximately two times higher than from cattle to badger, and the rate of within-species transmission considerably exceeded these for both species. We identified long distance transmission events linked to cattle movement, recurrence of herd breakdown by infection within the same transmission clusters and superspreader events driven by cattle but not badgers. Overall, our data suggests that the transmission clusters in different parts of South West England that are still evident today were established by long-distance seeding events involving cattle movement, not by recrudescence from a long-established wildlife reservoir. Clusters are maintained primarily by within-species transmission, with less frequent spill-over both from badger to cattle and cattle to badger.

Staying “One Step Ahead of a Racist”: Expanding Understandings of the Experiences of the Covid-19 Pandemic Among People From Minoritized Ethnic Groups Living in Britain

Covid-19 has had a disproportionate impact on those in minoritized ethnic groups. Considerable attention has been given to evidence of ethnic inequalities in rates of infection, hospitalisation, and death. But other ways in which the pandemic experience has been affected by ethnicity have received less consideration. This paper explores the lived experiences of people in different minoritized ethnic groups living in South West England, during the United Kingdom’s first pandemic lockdown, using qualitative data collected from interviews and comments provided on a survey. Perceived positive opportunities for growth were offset by anxiety and stress, which were themselves compounded by an awareness of the additional risks they experienced as members of racialised groups, and a sense that this was being ignored—or intentionally exacerbated—by the British authorities. Frustration with an incompetent and corrupt national Government was intensified by concerns regarding their racist motives. Racism in wider society undermined confidence in key public institutions, such as the NHS and the police, while also producing barriers to informal local-community pandemic responses. Only through recognition of the particular ways in which the pandemic affected those in minoritized ethnic groups, including the multiple and compounding effects of current and historical racism, will it be possible to identify avenues for transformative systemic policy change and opportunities to rebuild trust and a better post-pandemic society for all.

Primary care consultations for respiratory tract symptoms during the COVID-19 pandemic: a cohort study including 70,000 people in South West England

Background Primary care consultations for respiratory tract symptoms including identifying and managing COVID-19 during the pandemic have not been characterized. Methods A retrospective cohort analysis using routinely collected records from 70,431 adults aged 18+ in South England within the Electronic Care and Health Information Analytics (CHIA) database. Total volume and type of consultations (face-to-face, home visits, telephone, email/video, or out of hours) for respiratory tract symptoms between 1 January and 31 July 2020 (during the first wave of the pandemic) were compared with the equivalent period in 2019 for the same cohort. Descriptive statistics were used to summarize consultations by sociodemographic and clinical characteristics, and by COVID-19 diagnosis and outcomes (death, hospitalization, and pneumonia). Results Overall consultations for respiratory tract symptoms increased by 229% during the pandemic compared with the preceding year. This included significant increases in telephone consultations by 250%, a 1,574% increase in video/email consultations, 105% increase in home visits, and 92% increase in face-to-face consultations. Nearly 60% of people who presented with respiratory symptoms were tested for COVID-19 and 16% confirmed or clinically suspected to have the virus. Those with complications including pneumonia, requiring hospitalization, and who died were more likely to be seen in-person. Conclusion During the pandemic, primary care substantially increased consultations for respiratory tract symptoms to identify and manage people with COVID-19. These findings should be balanced against national reports of reduced GP workload for non-COVID care.

Knowledge exchange and the creative industries: A reflective commentary on current practice

This reflective commentary summarizes the key learnings that arose from the 2019/20 Knowledge Exchange and the Creative Industries seminar series. These seminars at the University of Bristol, UK, looked at engagement with research within the creative industries. Each seminar showcased an academic and artistic partnership from across South West England and Wales which resulted in an artistic output that could be classified as ‘immersive’, including, but not limited to, audio storytelling applications, augmented reality games, virtual reality projects, films and theatre productions. Each seminar involved collaborators sharing their experiences and thoughts on best practice, possible styles and potential pitfalls in knowledge exchange projects. My commentary provides an overview of the partnerships, which represent a snapshot of current knowledge exchange practices in the region. I summarize the common trends that emerged throughout the seminars, including methods of initiating a collaboration, the scalability of partnerships between industry and academia, the challenges surrounding process when working on multi-partner collaborations, and questions of ethics and intellectual property. I also reflect upon the processes and learnings that arose from hosting the series, to guide others who are thinking about strategies to encourage collaboration. Overall, the commentary offers a blueprint of considerations for those in both academia and the creative industries who are considering embarking upon knowledge exchange projects. By drawing attention to the lessons learned from a series of successful partnerships, the discussion paves the way for future projects of engaged research within the creative industries.

Erratum: Kadhim, I.; Abed, F.M. The Potential of LiDAR and UAV-Photogrammetric Data Analysis to Interpret Archaeological Sites: A Case Study of Chun Castle in South-West England. ISPRS Int. J. Geo-Inf. 2021, 10, 41

The authors would like to make the following corrections to the published paper [...]

Illegitimacy and its Effects on Marriage Prospects in Eighteenth and Nineteenth Century Rural England

All births, marriages and deaths that occurred in two rural parishes in south-west England in the period 1754–1914 were examined, using a wide array of source material. Records of individuals were linked together into large multi-generational family groups. There were 4,940 births, of which 319 were illegitimate. For the illegitimate cases, the rates of subsequent marriage of mothers and fathers were determined and compared with those for other people in the same parishes. Being the father of an illegitimate child did not impact the chances of subsequent marriage. Being the mother of an illegitimate child decreased the chances of subsequent marriage but only if the mother was co-resident with her children. Where the mother did not live with the illegitimate child(ren), her chances of marriage were similar to that of other women. Mothers of illegitimate children were more likely to marry their cousins and were less geographically mobile than other mothers.

Partisan Politics

New understandings of the middle order and of the post-1688 English Parliament have shifted the focus from Westminster to the constituencies in the study of eighteenth-century politics. It was the towns, and especially the smaller parliamentary boroughs, that set much of the legislative agenda and which defined partisanship. This is also where religious tension was most intense and enduring. Yet there has never been a thoroughgoing comparative study of small-town economy, religion, government and politics. Deep in the archives, the history of a clutch of towns in south-west England in the early years of the eighteenth century offers revelatory insights. Their diverse economic structure and religious divisions made these towns extraordinarily difficult to govern, while late Augustan partisanship spread into the streets and taverns, threatening urban order. This precipitated heady local realignments, with three or even four factions in each place cutting across Whig and Tory lines in the pursuit of consensus. In this intensely urban politics, government patronage was peripheral; area gentry were drawn in but had little control. The impact of this many-sided partisanship on national politics was profound. Building a clearer picture of significant change around the time of the Hanoverian accession, this book proposes a fresh approach both to the study of early modern politics and of towns far beyond its immediate region. It will be an important asset to scholars and students of both.