scholarly journals A study on assessment of HbA1c level as a diagnostic criterion of type 2 diabetes mellitus

2015 ◽  
Vol 7 (1) ◽  
pp. 49-52
Author(s):  
Agnibha Dutta ◽  
Ashish P Dudhe ◽  
Subhasish Deb ◽  
Somnath Dasgupta ◽  
Amit Sarkar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Predictive Value ◽  
Newly Diagnosed ◽  
Eastern India ◽  
Medical Sciences ◽  
Time Period ◽  
Diagnostic Criterion

Aims and Objectives: We compared performance of HbA1c in diagnosis of type 2 diabetes mellitus with that of fasting plasma glucose and tried to determine cut off point of HbA1c for optimum sensitivity and specificity in a population of eastern India both from urban and rural background.Materials and Methods: The analysis was conducted in persons aged between 40 and 80 years, visiting our institution, who are newly diagnosed as diabetic and non-diabetic attending hospital for some other reason, who underwent FPG and HbA1c testing, in the time period January 2013 to August 2014.Results: From 100 individuals (mean age 54.6 years) HbA1c ? 6.5% produced sensitivity of 90% and specificity of 72%, positive predictive value 76.27% and negative predictive value 87.80% when compared to FPG ? 126 mg% as standard. By ROC curve, optimum cut off point for HbA1c was found to be 7.05% for diagnosis of diabetes.Conclusion: Using a cut off value of HbA1c of 7% may optimise detection of diabetes mellitus and ensure proper patient care.Asian Journal of Medical Sciences Vol.7(1) 2015 49-52

Circulating Netrin-1 as a Novel Biomarker for Impaired Fasting Glucose and Newly Diagnosed Type 2 Diabetes Mellitus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1535-P ◽  
Author(s):  
HYE-IN JUNG ◽  
JAEHYUN BAE ◽  
EUGENE HAN ◽  
GYURI KIM ◽  
JI-YEON LEE ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Newly Diagnosed

scholarly journals Effect of Sitagliptin on Serum Irisin Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

2021 ◽  
Vol 12 (4) ◽  
pp. 1029-1039
Author(s):  
Qiu Wang ◽  
Lirong Ma ◽  
Yuanying Zhang ◽  
Lin Zhang ◽  
Yu An ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Newly Diagnosed

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Yangyang Cheng ◽  
Xiaohui Du ◽  
Bilin Zhang ◽  
Junxia Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lower Extremity ◽  
Interleukin 6 ◽  
Atherosclerotic Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diabetic Patients ◽  
Newly Diagnosed

Abstract Background Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear. Methods 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Patients were divided into two groups, LEAD group (n=100) and control group (n=74). Anthropometric parameters, blood pressure and some biochemical parameters were obtained. Body composition was detected by bioelectrical impedance analysis (BIA). Levels of serum insulin were determined by radioimmunoassay. Serum WISP1 and interleukin 6 (IL-6) levels were determined using an enzyme-linked immunosorbent assay. Results It was shown that serum WISP1 levels in diabetic patients with LEAD were higher than those without LEAD (P<0.001). Serum WISP1 levels were positively related with waist circumference (r=0.237, P=0.003), waist-hip ratio (r=0.22, P=0.006), visceral fat area (r=0.354, P<0.001), serum creatinine (r=0.192, P=0.012), interleukin 6 (r=0.182, P=0.032), c-reactive protein (r=0.681, P<0.001), triglycerides (r=0.119, P<0.001), fasting glucose (r=0.196, P=0.011), glycated hemoglobin (r=0.284, P<0.001), and HOMA-IR (r=0.285, P<0.026). Compared with the lowest tertile, the odds ratio of the middle tertile for LEAD incidence was 3.27 (95% CI, 1.24–8.64) and 4.46 (95% CI, 1.62–12.29) for the highest tertile after adjusting confounding factors. Conclusion The results suggest that increased serum WISP1 levels independently contribute to the incidence of LEAD in patients with newly diagnosed T2DM.

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