scholarly journals Neonatal Outcome of Antenatal Mothers with Pregnancy Induced Hypertension in Antenatal Ward of Kathmandu Medical College and Teaching Hospital

2018 ◽  
Vol 2 (3) ◽  
pp. 255-259
Author(s):  
Santoshi Shrestha Pradhan ◽  
Sabitra Paudel ◽  
Puspa Parajuli ◽  
Bina Rana Khagi
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Apgar Score ◽  
Neonatal Death ◽  
Neonatal Outcome ◽  
Pregnancy Induced Hypertension ◽  
Perinatal Morbidity ◽  
Medical College ◽  
Induced Hypertension ◽  
Perinatal Management

Introduction: Hypertensive disorders seem to complicated in approximately 5-15% of pregnancies. Pregnancy induced hypertension (PIH) increases the risk of maternal and perinatal morbidity and mortality.Objective: To assess the neonatal outcome and to identify the association between the demographic variables and outcome of Pregnancy Induced Hypertension in antenatal ward of Kathmandu Medical College and Teaching Hospital.Methodology: Prospective study design was conducted for the study in Obstetrics ward of Kathmandu Medical College Teaching Hospital. The population was the 100 antenatal mothers with pregnancy induced hypertension admitted in antenatal ward and purposive convenient sampling technique was used to collect the data. The structured questionnaire was designed and the data was collected through interview technique from 1st February 2014 to 10 March 2016. The collected data was analyzed using SPSS programme.Results: Regarding neonatal outcome the findings of the study showed that most of the babies 83% had normal weight. The most of the babies 82% had adequate for gestational age. Regarding Apgar score half of the babies 50% scored mild asphyxia at the first minute whereas most of the babies 93% scored no asphyxia at five minutes after delivery. Regarding perinatal outcome 13% babies were delivered premature, 7% had birth asphyxia, 5% were born with low birth weight and stillbirth whereas only 1% had early neonatal death. The present study revealed that there was significant association between gestational age of delivery and Apgar score at 5 minutes and there was significant association between age and perinatal management outcome, gestational age of delivery and perinatal morbidity management, grading of proteinuria and perinatal morbidity management, grading of oedema and perinatal management outcome regarding neonatal outcome of pregnancy induced hypertension.Conclusion: Pregnancy induced hypertension during pregnancy were associated with a higher risk of adverse neonatal outcomes. Women with pregnancy induced hypertension during pregnancy had a higher risk of emergency caesarean section, pre-term birth, neonatal death, low birth weight children and neonates with low Apgar score. Maternal and fetal morbidity and mortality can be reduced by early recognition and institutional management.Birat Journal of Health SciencesVol.2/No.3/Issue 4/Sep- Dec 2017, Page: 255-259

scholarly journals Risk of small for gestational age babies in preterm delivery due to pregnancy-induced hypertension

2019 ◽  
Vol 28 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Rima Irwinda ◽  
Budi Iman Santoso ◽  
Raymond Surya ◽  
Lidia Firmiaty Nembo
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Preterm Births ◽  
Secondary Data ◽  
Large For Gestational Age ◽  
Fisher Exact Test ◽  
Pregnancy Induced Hypertension ◽  
Exact Test ◽  
Induced Hypertension ◽  
The Impact

BACKGROUND Pregnancy-induced hypertension (PIH) causes high maternal morbidity and mortality worldwide. This study aims to assess the impact of PIH on fetal growth according to gestational age in preterm deliveries.METHODS A prospective cohort study using secondary data was undertaken in Ende District, East Nusa Tenggara, Indonesia from September 2014 to August 2015. The t-test was performed to compare mean birth weight based on gestational week between normotensive and PIH women, continued by linear regression. The chi-square or Fisher exact test was also conducted to determine the probability of birthing small for the gestational age (SGA) and large for gestational age (LGA) babies between normotensive and PIH women.RESULTS A total of 1,673 deliveries were recorded in Ende Hospital over the 1-year study period, among which 182 cases involved preterm births. The PIH group had lower birth weight than normotensive women at each gestational age starting from 32–35 weeks (p=0.004; 95% CI 150.84–771.36). Normotensive women at gestational ages of 32 (p=0.05; 95% CI 0.01–0.83), 34 (p=0.37; 95% CI 0.01–4.12), and 36 (p=0.31; 95% CI 0.02–2.95) weeks had a lower risk of birthing SGA babies than PIH women; LGA babies were recorded at gestational ages of 33 (p=1.00; 95% CI 0.07–37.73) and 35 (p=0.31; 95% CI 0.34–63.07) weeks.CONCLUSIONS Poor perfusion of the uteroplacental is one of the reasons behind intrauterine growth restriction, which results in SGA babies born to PIH women.

The impact of pregnancy-induced hypertension on birth weight by gestational age

2001 ◽  
Vol 15 (4) ◽  
pp. A37-A37
Author(s):  
X Xiong ◽  
Nn Demianczuk ◽  
Ld Saunders ◽  
Fl Wang ◽  
Wd Fraser
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
The Impact

scholarly journals PREGNANCY INDUCED HYPERTENSION AND NEONATAL GROWTH

2019 ◽  
Vol 34 (4) ◽  
pp. 915-919
Author(s):  
Elizabeta Zisovska ◽  
Lidija Madzovska ◽  
Marija Dimitrovska Ivanova
Keyword(s):  
Birth Weight ◽  
Fetal Growth ◽  
Gestational Age ◽  
White Blood Cells ◽  
Infant Growth ◽  
Late Preterm ◽  
Control Group ◽  
Pregnancy Induced Hypertension ◽  
Gynecology And Obstetrics ◽  
Induced Hypertension

Pregnancy-induced hypertension (PIH), especially preeclampsia, is a major cause of maternal and perinatal morbidity and mortality worldwide. The impact of PIH on birth outcomes has not been extensively studied. PIH has been confirmed to increase significantly the risk of low birth weight by both increasing preterm birth as well as reducing fetal growth. Low birth weight or IUGR babies have been associated with the occurrence of several chronic diseases in later life. However, to date, there have been few studies on the effects of PIH on infant growth and neonatal wellbeing. The purpose of this study was to evaluate the fetal growth and wellbeing of newborns born of mothers with confirmed pregnancy induced hypertension.Material and methods: This was prospective opservational study during the period of the last year, 1st of July 2018 up to the end of June 2019 conducted at the University Clinic for Gynecology and Obstetrics in Skopje. As pregnancy induced hypertension is defined the condition of blood pressure equal to or greater than 130/90 mmHg on more than two occasions greater than six hours apart without proteinuria after 21 weeks of gestation. All other more severe conditions are defined as pre-eclampsia or eclampsia. As outcome was considered the birth weight, gestational age and white blood cells count. IUGR was defined as birth weight below the tenth percentile of expected weight for gestational age. Also maternal age and BMI were considered as conjoined risk factor for the birth weight. Results: In this study, 4726 newborns were born at the University Clinic for Gynecology and Obstetrics, and for analysis were considered 4273 newborns who were late preterm (35 and 36 gestational weeks) or term newborns. Two groups were evaluated: control group of 200 consecutively born newborns (late preterm and term) of healthy mothers and 100 newborns (late preterm and term) consecutively born of mothers with confirmed diagnosis of PIH, which constituted the study group. Within the control group, the proportion of Small for Gestational Age-SGA was 6,3%, and in the group of mothers with PIH was 9,5% (p<0,05). The maternal mean age of the hypertensive mothers was (32.8±5.0) years while that of normotensive mothers was (26.6±3.7) years, and there was not statistical significance (p>0.05). The Body Mass Index was higher in hypertensive mothers, compared to the healthy mothers (31,3±2.02 vs. 27.8±2.8). The mean gestational age of the study group was (35.8±1.8) weeks compared to that in control group (37.4±1.2) weeks. The number of White Blood Cells (WBC) count in newborns of hypertensive mothers was 21.4±5.3x109/L compared with the control group, 18.5±3.12x109/L (p=0.005). Neonatal thrombocytopenia was found in 32% of neonates of preeclamptic mothers while it's found only in 9.5% of neonates in control group p<0,002. Discussion: The limitation of this study was the lack of data about maternal smoking, life style, etc. There is limited number of studies examining the correlation between fetal growth and PIH, and every information is of great value. The fact is that this condition can progress in more severe degree of hypertension and deleterious effects on the mother itself and on her child, if not treated on time. Conclusion: A change in infant growth of the IUGR baby itself (e.g. catch-up growth) such as in the critical early infant period may also have long-term effects on health later in life, and this change of postpartum growth may be influenced by PIH. Therefore, it is important to study postpartum infant growth patterns of babies born to mothers with PIH, and to determine if there are differences in infant growth between babies with and those without IUGR. And, the most important action is to monitor and treat pregnancy induced hypertension and prevent more severe condition of pre-eclampsia.

Effect of Maternal Hypertension on Neonatal Neutropenia and Risk of Nosocomial Infection

PEDIATRICS ◽  
1992 ◽  
Vol 90 (3) ◽  
pp. 430-435
Author(s):  
Ana Mouzinho ◽  
Charles R. Rosenfeld ◽  
Pablo J. Sanchez ◽  
Rick Risser
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Nosocomial Infection ◽  
Prospective Study ◽  
Gestational Age ◽  
Pregnancy Induced Hypertension ◽  
Increased Risk ◽  
Induced Hypertension ◽  
Maternal Hypertension ◽  
Neonatal Neutropenia

Neonatal neutropenia occurs in ∼50% of newborns delivered by women with pregnancy-induced hypertension. It is thought to be transient, independent of birth weight and gestational age, and unassociated with significant risks, including infection. It recently was suggested that neonatal neutropenia occurs primarily in smaller, younger neonates, is related to the severity of pregnancy-induced hypertension, and importantly, may be associated with an increased risk for nosocomial infection. We examined these points in a large inborn population in consecutive years, performing retrospective (n = 110, 1989) and prospective (n = 151, 1990) studies in low birth weight (≤2200 g) neonates delivered by women with pregnancy-induced hypertension. Overall, 40% to 50% of neonates studied developed neonatal neutropenia, and they were younger and smaller (P &lt; .01) than non-neutropenic neonates. In the prospective study, neutropenic neonates were more likely to have mothers with severe pregnancy-induced hypertension (P &lt; .001), and the incidence of neonatal neutropenia was primarily among neonates &lt;30 weeks of gestation and &lt;1500 g birth weight, ∼80% vs 35% to 45% in older, larger neonates or infants (P &lt; .001). Although nosocomial infection occurred more frequently among the group of neutropenic neonates in the prospective study (P &lt; .02), the incidence was similar to that in matched non-neutropenic controls delivered of normotensive women. Thrombocytopenia (&lt;100 000/mm3) was not more frequent in neutropenic neonates. Although neonatal neutropenia occurs in 40% to 50% of low birth weight neonates from pregnancies complicated by pregnancy-induced hypertension, this primarily reflects an incidence of 80% among neonates &lt;30 weeks gestation. There is no apparent increased risk for development of nosocomial infection or thrombocytopenia.

scholarly journals Effect of low dose aspirin on fetal outcome in women at risk for developing pregnancy induced hypertension

2020 ◽  
Vol 7 (4) ◽  
pp. 865
Author(s):  
Madhusmita Pradhan ◽  
Jyotiranjan Champatiray ◽  
Kishore V. S.
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Gestational Age ◽  
Low Dose ◽  
Pregnancy Induced Hypertension ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Induced Hypertension

Background: Though pregnancy induced hypertension is a worldwide problem, it is more prevalent in developing countries particularly south east Asian and African countries. It contributes to 20% of perinatal death and 40-50% of low birth weight babies in India. Fetal salvage is also an important consideration in providing quality care. Low dose aspirin given between 12 weeks to 28 weeks of gestational age in high-risk women at Developing Pregnancy Induced Hypertension (PIH) is anticipated to prevent the development of PIH and complications that arises especially those regarding maternal and fetal mortality due to PIH.Methods: This prospective randomized controlled trial was conducted in the dept of O and G, SCB MC and Hospital, Cuttack during November 2018 to October 2019. Pregnant women between the gestational age of 13 to 28 week were screened for risk factors and included in this study. Low dose aspirin of 60 mg daily till delivery was given to pregnant women who consented to be a part of study randomly with the other group taking placebo.Results: Incidence of IUGR babies in low dose aspirin treated mothers was as low as 1%. Incidence of LBW babies is lower in low dose aspirin treated mothers than with those who were not treated. Mean birth weight in cases was 2780 gm±352 gm vs control 2592 gm±483 gm. There is increased incidence of still birth in high risk group not treated with aspirin. No significant difference in reducing incidence premature deliveries between case and control.Conclusions: Low dose aspirin has a definite role in the prevention of PIH in high risk pregnancy and its complication like IUGR and low birth weight. Low dose aspirin reduces the incidence of PIH. Low dose aspirin can be considered a safe drug without any deleterious side effect for mother and the fetus. Benefits of prevention of PIH, justifies its administration in women at high risk.

scholarly journals Maternal And Fetal Outcome Following Severe Anaemia In Pregnancy: Results From Nobel Medical College Teaching Hospital, Biratnagar, Nepal.

2013 ◽  
Vol 2 (1) ◽  
pp. 22-26
Author(s):  
Ram Hari Ghimire ◽  
Sita Ghimire
Keyword(s):  
Birth Weight ◽  
Postpartum Haemorrhage ◽  
Fetal Death ◽  
Severe Anaemia ◽  
Exposed Group ◽  
Intrauterine Fetal Death ◽  
Pregnancy Induced Hypertension ◽  
Medical College ◽  
Induced Hypertension ◽  
In Pregnancy

Background: anaemia is a major contributor to maternal death in developing countries. Since it reduces resistance to blood loss, death may occur from bleeding associated with normal delivery. Objective: To explore the association between anaemia and maternal and perinatal complications. Study Design: Retrospective cohort study. Materials and Methods: 100 pregnant women admitted for delivery and having severe anaemia were studied and compared with 100 non anaemic women matched for age, parity, and gestational age. Adverse outcomes analysed were: pregnancy induced hypertension, Postpartum haemorrhage hypertension, Abruptio Placenta,, Infection, Maternal Mortality, Low Birth Weight, and Perinatal mortality. Results : Compared to nonexposed women, exposed women had an increased risk of pregnancy induced hypertension with odds ratio of 5.06 . Postpartum haemorrhage, incidence of wound infection,Intermediate care unit admission were statistically significant in exposed group .However there was no significant difference in maternal mortality among study group.APGAR score <7 in 5 minutes was 18%in exposed group and 5% in non exposed group (p=0.0039). Intrauterine fetal death was 6% in cases and none of respondants from control group had Intrauterine fetal death (p=0.0128). Frequency of low birth weight was 22% in exposed group and 9% in non exposed group(p=0.011). Conclusions: The burden of anemia in pregnant population is still high in eastern region of Nepal. Severe anemia in pregnancy carries significant risk to mother and fetus. Hence preventive measures need to be implemented at community level. Public awareness regarding pre-pregnancy hemoglobin status and importance of antenatal checkup relating with maternal and fetal adverse pregnancy outcome should be initiated. Journal of Nobel Medical College Vol. 2, No.1 Issue 3 Nov.-April 2013 Page 22-26 DOI: http://dx.doi.org/10.3126/jonmc.v2i1.7668

The impact of pregnancy-induced hypertension on birth weight by gestational age

2008 ◽  
Vol 15 (4) ◽  
pp. A37-A37
Author(s):  
X Xiong ◽  
Nn Demianczuk ◽  
Ld Saunders ◽  
Fl Wang ◽  
Wd Fraser
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
The Impact

scholarly journals A defined grey zone with in fetal growth curves for predicting adverse neonatal morbidity in fetuses being small for their gestational age at term in uncomplicated pregnancies

2019 ◽  
Author(s):  
Mefkure Eraslan Sahin ◽  
Ilknur Col Madendag ◽  
Erdem Sahin ◽  
Yusuf Madendag ◽  
Fatma Ozdemir ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Birth Weight ◽  
Gestational Age ◽  
Apgar Score ◽  
Neonatal Sepsis ◽  
Neonatal Death ◽  
Neonatal Morbidity ◽  
Grey Zone ◽  
Increased Risk ◽  
Significant Difference

Abstract Background: “Small for gestational age” (SGA) is a term used to define an important risk factor for both neonatal morbidity and mortality. Our hypothesis suggests that adverse neonatal morbidity (ANM) in fetuses can occur when the birth weight is closer to 10th percentile. For example, although a fetus with a birth weight within the 11th or 12th percentile is appropriate for gestational age (AGA), it is difficult to clearly distinguish these fetuses from SGA fetuses for ANM; therefore we suggest defining a transition zone, or “grey zone”, for ANM. The aim of the present study was to examine ANM frequency in fetuses using this newly defined grey-zone percentile. Methods: This retrospective analysis comprised 7,817 pregnant women with uncomplicated pregnancies and single deliveries between 37 0/7 and 41 6/7 gestational weeks. The babies were divided into groups according to birth weight percentiles as follows: (1) SGA, (2) 10–20 percentile, and 21–90 percentile. The primary outcome was ANM, defined as any of the following: Apgar score <4 at 5 min; respiratory distress; mechanical ventilation; intraventricular hemorrhage, grade III or IV; necrotizing enterocolitis, stage 2 or 3; neonatal sepsis, stillbirth or neonatal death. Results: Demographic and obstetric characteristics of the mothers were similar among the groups. ANM rates were 10.7% in the SGA group, 6.8% in the 10–20 percentile group, and 2.1% in the 21–90 percentile group, a significant difference. ANM was 5-fold higher in the SGA group and 3.2-fold higher in the 10–20 percentile group than in the 21–90 percentile group. Delivery induction or augmentation, cesarean delivery for non-reassuring fetal heart rate or fetal distress, apgar score <4 at 5 min, mechanical ventilation, neonatal sepsis, stillbirth, or neonatal death significantly increased in the 10–20 percentile group compared with those in the 21–90 percentile group. Conclusion: In uncomplicated pregnancies, ANM for SGA fetuses born at term are significantly worse than that for AGA fetuses. Fetuses with a birth weight within the 10–20 percentile (grey zone) had a significant increased risk of ANM than those within the 21–90 percentile.

scholarly journals The association of pregnancy-induced hypertension and neonatal hypospadias.

2021 ◽  
Author(s):  
Yi Wang ◽  
Lin Wang ◽  
Zeyong Yang ◽  
Fang Chen ◽  
Zhiwei Liu
Keyword(s):  
Regression Analysis ◽  
Birth Weight ◽  
Gestational Age ◽  
Occurrence Rate ◽  
Multiple Birth ◽  
Control Group ◽  
Hypertensive Disorder ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
In Pregnancy

Background: The prevalence of hypertensive disorder in pregnancy has been well-documented worldwide. In Chinese newborns, the risk of hypospadias in women with hypertension during pregnancy remains ambiguous. This study aimed to evaluate the relationship between hypertension in pregnancy and neonatal hypospadias based on a large sample of Chinese people. Methods: A retrospective cohort study was conducted at our hospital from 2015 to 2019. Mothers who delivered male infants with hypospadias or those without any malformations were enrolled. Factors such as hypertension, placenta previa, thyroid diseases, hepatitis B, obesity, multiple birth, amniotic fluid, gestational age, birth weight, and in vitro fertilization were collected to establish a regression analysis to assess risk factors for hypospadias. Results: In total, 41,490 mothers and 42,244 male infants were enrolled. The overall incidence of hypospadias was 0.23%. The occurrence rate of hypospadias in pregnancy-induced hypertension (PIH) group was higher than control group (0.944% vs. 0.186%, RR 5.08), whereas the occurrence rate in chronic hypertension group was 0%. Potential exposure factors were screened for hypospadias, and PIH, multiple birth, hyperthyroidism, preterm delivery, low birth weight, and small for gestational age (SGA) were found to have higher proportion of hypospadias in offspring. After adjustment for potential confounders in the multivariate regression analysis, PIH (OR: 2.437, 95% CI: 1.478–4.016, P<0.01), birth weight (OR: 0.852, 95% CI: 0.795–0.912, P<0.01), and SGA (OR: 3.282, 95% CI: 1.644–6.549, P<0.01) showed a significant relationship with hypospadias. Conclusion: Women with PIH had higher risks of hypospadias in offspring. Lower birth weight, SGA and hyperthyroidism were also statistically associated with hypospadias.

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