scholarly journals An Eco-friendly Route to Synthesis of Quinolines

2012 ◽  
Vol 27 ◽  
pp. 115-119
Author(s):  
A. D. Mishra
Keyword(s):  
Aluminium Chloride ◽  
Environmentally Benign ◽  
Synthetic Method ◽  
Quinoline Derivatives ◽  
Substituted Anilines ◽  
One Step

Some 2-hydroxy-4-methyl-6- substituted quinoline derivatives have been synthesized in an environmentally benign method from easily available 4-substituted anilines and ?-Ketoesters, under ordinary conditions. The reactions were catalyzed by aluminium chloride to afford excellent amount of the products. The usage of hazardous acids, bases and solvents have been avoided in different steps of the reactions completely, which has made this synthetic method one step advance to the existing methods.DOI: http://dx.doi.org/10.3126/jncs.v27i1.6670 J. Nepal Chem. Soc., Vol. 27, 2011 115-119 

A nickel catalyzed acceptorless dehydrogenative approach to quinolines

2018 ◽  
Vol 16 (2) ◽  
pp. 274-284 ◽  
Author(s):  
Seuli Parua ◽  
Rina Sikari ◽  
Suman Sinha ◽  
Siuli Das ◽  
Gargi Chakraborty ◽  
...  
Keyword(s):  
Nickel Catalyst ◽  
Environmentally Benign ◽  
Secondary Alcohols ◽  
Quinoline Derivatives ◽  
Dehydrogenative Coupling ◽  
Earth Abundant ◽  
One Step ◽  
Macrocyclic Nickel

A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare macrocyclic nickel catalyst [Ni(MeTAA)].

In situ formation of gold/silver bi-metal nanodots on silica spheres and evaluation of their microbicidal properties

RSC Advances ◽  
2015 ◽  
Vol 5 (7) ◽  
pp. 5038-5045 ◽  
Author(s):  
Perumal Rameshkumar ◽  
Selvam Saranya ◽  
Kabilan Sujatha ◽  
Ramasamy Ramaraj
Keyword(s):  
Environmentally Benign ◽  
Silica Spheres ◽  
Synthetic Method ◽  
Gold Silver ◽  
One Step ◽  
Step Growth ◽  
In Situ Formation

An environmentally benign synthetic method of seedless and one-step growth of 2–4 nm sized gold/silver bi-metal nanodots on preformed silica spheres and their microbicidal properties with different concentrations of Au and Ag are reported.

Direct Cyclization of Alkenyl Thioester via Transition Metal‐hydrogen Atom Transfer/radical‐polar Crossover Mechanism

2019 ◽  
Author(s):  
Shiori Date ◽  
Kensei Hamasaki ◽  
Karen Sunagawa ◽  
Hiroki Koyama ◽  
Chikayoshi Sebe ◽  
...  
Keyword(s):  
Natural Products ◽  
Hydrogen Atom ◽  
Transition Metal ◽  
Hydrogen Atom Transfer ◽  
Synthetic Method ◽  
Atom Transfer ◽  
Reaction Conditions ◽  
Hydride Hydrogen ◽  
Sulfur Heterocycles ◽  
One Step

<div>We report here a catalytic, Markovnikov selective, and scalable synthetic method for the synthesis of saturated sulfur heterocycles, which are found in the structures of pharmaceuticals and natural products, in one step from an alkenyl thioester. Unlike a potentially labile alkenyl thiol, an alkenyl thioester is stable and easy to prepare. The powerful Co catalysis via a cobalt hydride hydrogen atom transfer and radical-polar crossover mechanism enabled simultaneous cyclization and deprotection. The substrate scope was expanded by the extensive optimization of the reaction conditions and tuning of the thioester unit.</div>

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

scholarly journals Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

2017 ◽  
Vol 36 (2) ◽  
pp. 223 ◽  
Author(s):  
Belgheis Adrom ◽  
Nourallah Hazeri ◽  
Malek Taher Maghsoodlou ◽  
Mojtaba Lashkari ◽  
Maryam Fatahpour
Keyword(s):  
Lactic Acid ◽  
Reaction Time ◽  
Green Synthesis ◽  
Ammonium Acetate ◽  
Simple Procedure ◽  
Environmentally Benign ◽  
Synthetic Method ◽  
Short Reaction Time ◽  
Quinazoline Derivatives ◽  
Work Up

An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.

Hyperbranched PdRu nanospine assemblies: an efficient electrocatalyst for formic acid oxidation

2018 ◽  
Vol 6 (36) ◽  
pp. 17514-17518 ◽  
Author(s):  
Hongjing Wang ◽  
Yinghao Li ◽  
Chunjie Li ◽  
Ziqiang Wang ◽  
You Xu ◽  
...  
Keyword(s):  
Formic Acid ◽  
Formic Acid Oxidation ◽  
Acid Oxidation ◽  
Synthetic Method ◽  
One Step

A very simple one-step synthetic method is developed for the fabrication of PdRu nanospine assemblies for electrocatalytic formic acid oxidation.

Invited Review. A Combinatorial Approach to the Development of Environmentally Benign Organic Chemical Preparations

1999 ◽  
Vol 52 (2) ◽  
pp. 83 ◽  
Author(s):  
Christopher R. Strauss
Keyword(s):  
Hydrogen Transfer ◽  
Aldol Condensation ◽  
Aqueous Media ◽  
Environmentally Benign ◽  
Organic Chemical ◽  
Coupling Reactions ◽  
Heck Coupling ◽  
Solvent Free Conditions ◽  
Microwave Reactors ◽  
One Step

Enabling technologies and methodologies were established and combined to afford various environmentally benign processes for laboratory-scale organic synthesis and for the production of fine chemicals, intermediates and pharmaceuticals. The technologies comprised continuous and batch microwave reactors and catalytic membranes. The methodologies included solvent-free conditions, catalysed or uncatalysed processes, the use of aqueous media at high temperature and non-extractive techniques for product isolation. Applications included Hofmann eliminations, Willgerodt and Jacobs–Gould reactions, indole transformations, aldol condensation, Rupe and Meyer–Schuster rearrangements and C–C coupling reactions (including a tandem Heck coupling–dehydrogenation). New processes for catalytic etherification, uncatalysed hydrogen transfer and a one-step arylamidation were also developed. Typical products were N-(4-hydroxyphenyl)acetamide, carvacrol, a-phenylacetamide, cinnamaldehyde, cinnamyl alcohol, acetophenone, indole, 3-hydroxy-1,2-dimethyl-4-pyridone, di(2-phenylethyl) ether, di(cyclopropylmethyl) ether, 3-methylcyclopent-2-enone and a synthetic precursor of nalidixic acid.

One-pot synthesis of bi-metallic PdRu tripods as an efficient catalyst for electrocatalytic nitrogen reduction to ammonia

2019 ◽  
Vol 7 (2) ◽  
pp. 801-805 ◽  
Author(s):  
Hongjing Wang ◽  
Yinghao Li ◽  
Chunjie Li ◽  
Kai Deng ◽  
Ziqiang Wang ◽  
...  
Keyword(s):  
Synthetic Method ◽  
One Pot ◽  
Efficient Catalyst ◽  
Nitrogen Reduction ◽  
One Pot Synthesis ◽  
One Step

A very simple one-step synthetic method is developed for fabrication of PdRu tripods for electrochemical nitrogen reduction to ammonia.

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