scholarly journals Prevalence and Antibiotic Sensitivity Pattern of Methicillin- Resistant- Staphylococcus aureus in Kathmandu Medical College -Teaching Hospital

2013 ◽  
Vol 34 (1) ◽  
Author(s):  
S Pandey ◽  
MS Raza ◽  
CP Bhatta
Keyword(s):  
Staphylococcus Aureus ◽  
Teaching Hospital ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibiotic Sensitivity ◽  
College Teaching ◽  
Methicillin Resistant ◽  
Medical College ◽  
Sensitivity Pattern

scholarly journals Prevalence and Antibiotic Sensitivity Pattern of Methicillin- Resistant- Staphylococcus aureus in Kathmandu Medical College -Teaching Hospital

2013 ◽  
Vol 34 (1) ◽  
pp. 13-17 ◽  
Author(s):  
S Pandey ◽  
MS Raza ◽  
CP Bhatta
Keyword(s):  
Staphylococcus Aureus ◽  
Teaching Hospital ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
College Teaching ◽  
Care Hospital ◽  
Methicillin Resistant ◽  
Medical College ◽  
Sensitivity Pattern

Introduction: Staphylococcus aureus is found to be a major source of community as well as hospital acquired infection. Staphylococcal isolates from tertiary care hospital are found to be resistant to commonly used antimicrobial agents. Methicillin resistant S. aureus (MRSA) with intrinsically developed antimicrobial resistance has been associated with an increase in morbidity and mortality of the patients in the hospital. This study was undertaken to know the antibiotic sensitivity pattern of staphylococcal isolates with special reference to Methicillin resistant S. aureus. Methods: Clinical specimens received from July 2009 to July 2010 in Kathmandu Medical college-Teaching Hospital were processed and all S. aureus isolates were included in the study. The isolates were identified by standard laboratory procedure. The antibiotic susceptibility pattern of all staphylococcal strain was determined by modified Kirby Bauer antibiotic sensitivity method. Results: Of 111 S .aureus isolates 29(26.12%) were identified to be MRSA. The rate of multi drug resistance was 75.86% for MRSA and 6.09% for MSSA. All the staphylococcal isolates were resistant to penicillin. However, all strains were sensitive to vancomycin. Conclusions: This study showed a high prevalence of MRSA in tertiary care hospital of Kathmandu valley. Regular surveillance of hospital-associated infection and monitoring of antibiotic sensitivity pattern is mandatory to reduce MRSA prevalence in hospital and its spread to community as well. Present study conclusively shows that vancomycin remains the first choice of treatment for MRSA infection. To preserve its value, use of vancomycin should be limited to those cases where there are clearly needed. DOI: http://dx.doi.org/10.3126/joim.v34i1.9117 Journal of Institute of Medicine, April, 2012; 34:1 13-17

scholarly journals Prevalence of Methicillin Resistant Staphylococcus aureus and Antibiotic Susceptibility Pattern in a Tertiary Hospital in Nepal

2018 ◽  
Vol 16 (2) ◽  
pp. 172-174 ◽  
Author(s):  
Laxmi Kant Khanal ◽  
Ram Prasad Adhikari ◽  
Ankita Guragain
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibiotic Sensitivity ◽  
College Teaching ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Resistance Pattern ◽  
Cross Sectional ◽  
Methicillin Resistant ◽  
Sensitivity Pattern

Background: Methicillin resistant Staphylococcus aureus is a global health challenge nowadays creating problem in antibiotic therapy. This study was aimed to generate resistance pattern of Methicillin resistant Staphylococcus aureus to various antibiotics in order to formulate antibiotic policy for control of Methicillin resistant Staphylococcus aureus in Nepal.Methods: This was a cross-sectional study conducted at the department of Clinical Microbiology, Nepal Medical College Teaching Hospital, from April 2015 to March 2016. A total of 142 S. aureus isolated from various clinical specimens. were screened for Methicillin resistant Staphylococcus aureus by cefoxitin disc method according to Clinical and Laboratory Standards Institute guidelines.Results: Out of 142 S. aureus isolates, 30 (21.1%) were detected as Methicillin resistant Staphylococcus aureus by cefoxitin disc method. Most of the Methicillin resistant Staphylococcus aureus (25/30) were isolated from pus which were collected from OPD patients. Antibiotic sensitivity pattern showed all Methicillin resistant Staphylococcus aureus isolates were sensitive to vancomycin.Conclusions: Prevalence of Methicillin resistant Staphylococcus aureus was found to be 21.1%, and all Methicillin resistant Staphylococcus aureus appear 100% sensitive to vancomycin. Keywords: .

scholarly journals Prevalence of Methicillin-resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Hospital in Northern India

2010 ◽  
Vol 2 (02) ◽  
pp. 078-081 ◽  
Author(s):  
Shilpa Arora ◽  
Pushpa Devi ◽  
Usha Arora ◽  
Bimla Devi
Keyword(s):  
Staphylococcus Aureus ◽  
Antibiotic Susceptibility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Diffusion Method ◽  
Care Hospital ◽  
Methicillin Resistant ◽  
Sensitivity Pattern

ABSTRACT Aim: The emergence of Methicillin-resistant Staphylococcus aureus (MRSA) has posed a serious therapeutic challenge. We report the prevalence and antibiotic susceptibility pattern of MRSA in the hospitals attached to GMC, Amritsar, Punjab. Materials and Methods: The study comprised of 250 coagulase-positive staphylococci (COPS) isolated from a total of 6743 clinical specimens (like pus, blood, urine, high vaginal swab, sputum, etc.) of patients admitted in hospitals attached to Government Medical College, Amritsar from January 2008−February 2009. Routine antibiotic susceptibility testing was performed and interpreted as per standard guidelines. Methicillin resistance was detected using oxacillin and cefoxitin disc diffusion method, oxacillin screen agar method, and minimum inhibitory concentration using broth macrodilution method. Results: A total of 115 (46%) strains were found to be methicillin resistant. Multidrug resistance was observed in 73% MRSA strains. However, no strain was resistant to vancomycin. Conclusion: Regular surveillance of hospital-associated infection and monitoring of antibiotic sensitivity pattern is required to reduce MRSA prevalence.

scholarly journals Prevalence of Methicillin Resistant Staphylococcus Aureus (MRSA) In A Secondary Care Hospital In North Eastern Part of India

2018 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistance ◽  
Antibiotic Sensitivity ◽  
Diffusion Method ◽  
Care Hospital ◽  
Wound Infections ◽  
Methicillin Resistant ◽  
Sensitivity Pattern ◽  
Mrsa Strains

Aim: In today’s scenario, Nosocomial infection is a foremost problem in world. Methicillin resistant staphylococcus aureus (MRSA) strains are not only resistant to several antibiotics but also, show a particular ability to spread in hospitals of many countries. The main objective of the present study is to determine the prevalence of MRSA in surgical wound infections and also to define the antimicrobial susceptibility patterns of the strains isolated. Materials and Methods: A total of 133 culture positive Staph.aureus were taken from surgical site wound infections for the study during the period from March 2016 to February 2017. Routine Antibiotic Susceptibility testing was performed and interpreted as per latest CLSI guidelines. Methicillin resistance was detected using cefoxitin disc diffusion method. Results: In total of 133 samples, 81 (60.9%) were found to be MRSA. However, no strain was resistant to Vancomycin, Linezolid or Teichoplanin. Conclusion: Vigorous antimicrobial stewardship and strengthened infection control practices are mandatory to prevent spread and reduce emergence of resistance. Customary surveillance of hospital-associated infection and monitoring of antibiotic sensitivity pattern is required to reduce MRSA prevalence.

scholarly journals Prevalence of methicillin-resistant Staphylococcus aureus in a tertiary hospital in Nepal

2021 ◽  
Vol 11 (1) ◽  
pp. 46-51
Author(s):  
P. Pradhan ◽  
P. Rajbhandari ◽  
S. B. Nagaraja ◽  
P. Shrestha ◽  
R. Grigoryan ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antibiotic Sensitivity ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Methicillin Resistant ◽  
Sensitivity Pattern ◽  
Successful Clinical Outcome ◽  
Mrsa Infection

SETTING: Patan Hospital, Lalitpur, Nepal.OBJECTIVES: To describe 1) the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and its antibiotic sensitivity pattern; 2) the demographic and clinical characteristics associated with MRSA infections; and 3) the treatment outcomes of in-patients with MRSA infection among patients with S. aureus infection between January 2018 and December 2020.DESIGN: This was a cross-sectional study using electronic and paper-based hospital records of patients with S. aureus infection.RESULTS: Of the 1,804 patients with S. aureus infection, 1,027 patients (57%, 95% CI 55–59) had MRSA. The MRSA were susceptible to vancomycin (100%), linezolid (96%), doxycycline (96%), chloramphenicol (86%) and cotrimoxazole (70%), and resistant to erythromycin (68%), clindamycin (56%), gentamycin (58%), ciprofloxacin (92%) and ofloxacin (91%). The prevalence of MRSA was higher in 2019, among out-patients, and in respiratory samples, and lower in blood samples. Of the 142 in-patients with MRSA, 93% had a successful clinical outcome (cured/improved).CONCLUSION: More than 50% of patients with S. aureus infection had MRSA that were resistant to commonly available antibiotics. This calls for strengthening surveil-lance and good infection control practices in this hospital.

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