Prevalence of methicillin resistant Staphylococcus aureus in Lumbini Medical College and Teaching Hospital, Palpa, Western Nepal

Introduction. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of nosocomial infections. One of the potential risk factors for nosocomial staphylococcal infections is colonization of the anterior nares of healthcare workers (HCWs). Our study aimed to determine the rate of nasal carriage MRSA among HCWs at Manmohan Memorial Medical College and Teaching Hospital, Kathmandu. Methods. Two hundred and thirty-two nasal swabs were collected from HCWs of Manmohan Memorial Medical College and Teaching Hospital, Kathmandu, Nepal, within six months (February 2018–July 2018). Nasal swabs were cultured, and S. aureus isolates were subjected to the antimicrobial susceptibility test by the modified Kirby–Bauer disc diffusion method. MRSA and iMLSB (inducible macrolide lincosamide streptogramin B) resistance was screened using the cefoxitin disc (30 μg) and D-test (clindamycin and erythromycin sensitivity pattern), respectively, following CLSI (Clinical and Laboratory Standard Institute) guidelines. Risk factors for MRSA colonization were determined using the chi-square test considering the p value ˂0.05 as significant. Results. A total of 34/232 (14.7%) S. aureus were isolated, out of which 12 (35.3%) were MRSA. The overall rate of nasal carriage MRSA among HCWs was 5.2% (12/232). Colonization of MRSA was higher in males (8.7%) than in females (4.3%). MRSA colonization was found to be at peak among the doctors (11.4%). HCWs of the postoperative ward were colonized highest (18.2%). All MRSA isolates were sensitive to linezolid and tetracycline. iMLSB resistance was shown by 7(20.6%) of the isolates. MRSA strains showed higher iMLSB resistance accounting for 33.3% (4/12) in comparison to methicillin-susceptible strains with 13.6% (3/22). Smoking was found to be significantly associated with MRSA colonization ( p = 0.004 ). Conclusion. Rate of nasal carriage MRSA is high among HCWs and hence needs special attention to prevent HCW-associated infections that may result due to nasal colonization.

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Clinical- and cost-ineffectiveness of targeted methicillin-resistant Staphylococcus aureus screening of high-risk patients admitted to a low-prevalence teaching hospital

American Journal of Infection Control ◽

10.1016/j.ajic.2013.03.297 ◽

2013 ◽

Vol 41 (11) ◽

pp. 1137-1138

Author(s):

Burke A. Cunha ◽

Paul Schoch ◽

Eileen D. Abruzzo

Keyword(s):

Staphylococcus Aureus ◽

High Risk ◽

Teaching Hospital ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistant ◽

High Risk Patients ◽

Risk Patients ◽

Low Prevalence

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Virtually all methicillin-resistant Staphylococcus aureus (MRSA) infections in the largest Portuguese teaching hospital are caused by two internationally spread multiresistant strains: the ‘Iberian’ and the ‘Brazilian’ clones of MRSA

Clinical Microbiology and Infection ◽

10.1111/j.1469-0691.1998.tb00081.x ◽

1998 ◽

Vol 4 (7) ◽

pp. 373-384 ◽

Cited By ~ 41

Author(s):

D. Oliveira ◽

I. Santos-Sanches ◽

R. Mato ◽

M. Tamayo ◽

G. Ribeiro ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Teaching Hospital ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistant ◽

Multiresistant Strains

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Prevalence of Methicillin Resistant Staphylococcus Aureus In Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽

10.3329/kyamcj.v7i1.33756 ◽

2017 ◽

Vol 7 (1) ◽

pp. 673-677

Author(s):

Abdullah Akhtar Ahmed ◽

Shakhaowat Hossain ◽

Babul Aktar ◽

Nusrat Akhtar Juyee ◽

SM Ali Hasan

Keyword(s):

Staphylococcus Aureus ◽

Tract Infection ◽

Respiratory Tract ◽

Infection Control ◽

Respiratory Tract Infection ◽

Methicillin Resistant Staphylococcus Aureus ◽

Throat Swab ◽

College Hospital ◽

Methicillin Resistant ◽

Medical College

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections. To combat the challenge of life threatening MRSA remains a primary focus of most hospital infection control programs6. This study is undertaken in Khwaja Yunus Ali Medical College Hospital to identify the MRSA for determination of its prevalence and is considered a component of an infection control program in many countries5.Methods: Three hundred seventy hospitalized patients of surgery and medicine departments were studied during 2015. Clinical information of the patients and their pus, wound swab, sputum, throat swab and CSF were cultured.Results: Out of 370 patients, pus and wound swab of 217 (59%) had wound infection, sputum and throat swab of 141 had respiratory tract infection (38%) and CSF of 12 (3.2%) had meningitis were aseptically collected and cultured. Staphylococcus aureus were isolated in 51% cases and out of them MRSA was identified in 72 (73%) cases. MRSA isolated in 50% cases of meningitis, 49% cases of respiratory tract infection and 29% cases of wound infection.Conclusion: Methicillin-resistant Staphylococcus aureus appeared as a common cause of major illness and death and impose serious economic costs on patients and hospitals of our area like other developing countries. Detection of MRSA was associated with more severe clinical presentation.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 673-677

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