scholarly journals Bacteriological profile and their antimicrobial susceptibility pattern in central venous catheter tip culture

2017 ◽  
Vol 7 (1) ◽  
pp. 1059-1061
Author(s):  
J Sapkota ◽  
B Mishra ◽  
B Jha ◽  
M Sharma
Keyword(s):  
Central Venous Catheter ◽  
Bacterial Colonization ◽  
Antibiotic Sensitivity ◽  
Venous Catheter ◽  
Blood Stream ◽  
Central Venous ◽  
Candida Spp ◽  
Gram Positive ◽  
Gram Negative ◽  
Sensitivity Pattern

Background: Bacterial colonization of central venous catheter (CVC) carries risk of developing catheter-related blood stream infections (CRBSI). The purpose of this study is to find out the frequency of colonization of CVC by different bacterial pathogens and their antibiotic sensitivity pattern.Materials and Methods: A total of 53 CVC tip were received in one-year duration for culture and antibiotic sensitivity pattern. The isolated organisms were identified by standard microbiological procedure and subjected to antimicrobial sensitivity.Results: out of 53 CVC tip sent for culture and sensitivity, 21 (39.6%) showed significant growth. Out of 21 culture positive 52.3% were gram negative bacilli, 33.3% were gram positive cocci, 4.8% were Candida spp. Acenitobacter baumannii and Staphylococcus aureus were frequent pathogens isolated. Gram negative bacteria were less sensitive to antibiotics whereas gram positive bacteria were sensitive to Vancomycin.Conclusion: Though various organisms were isolated as colonizer of CVC, Acenitobacter baumannii is the most common colonizer. Antibiotic resistance has already emerged and represents a major problem.  

scholarly journals Incidence of central venous and Foley’s catheter related bacteraemia, organisms responsible and antibiotic sensitivity pattern: in cardio-thoracic intensive theraputic unit following elective surgery, in a tertiary care hospital of Kolkata, India

2020 ◽  
Vol 7 (6) ◽  
pp. 893
Author(s):  
Swarnendu Datta ◽  
Ushnish Chakrabarty ◽  
Priyanka Chakrabarty ◽  
Plaban Mukherjee
Keyword(s):  
Blood Stream Infection ◽  
Antibiotic Sensitivity ◽  
Blood Stream ◽  
Care Hospital ◽  
Central Venous ◽  
Gram Positive ◽  
Gram Negative ◽  
Sensitivity Pattern ◽  
Culture Sensitivity ◽  
Foley’S Catheter

Background: Mortality from bacteraemia related to indwelling Central Venous Pressure (CVP) lines could be as high as 12 - 25% and that due to indwelling urinary catheters about 5%, in critically ill patients. Hence, initiation of early and aggressive antibiotic therapy, often even before the culture- sensitivity reports are available is necessary. Objectives of the study was to find out the incidence of bacteraemia  related to indwelling CVP catheters &/or Foley’s catheters in post operative patients in Cardio-thoracic  Intensive Theraputic Unit (ITU) and to understand the antibiotic sensitivity patterns against the organisms causing such bacteraemiaMethods: 48 hours after their insertion, CVP catheter tips, Foley’s catheter tips and Peripheral blood samples were collected for cultures in 50 patients who underwent elective cardiothoracic surgery, over a period of one year and results were interpreted.Results: Incidence of bacteraemia associated with indwelling CVP catheters was 8% and was caused by both - Gram positive (Staphylococcus aureus, Enterococcus faecium) and Gram negative (Acinetobacter baumanii, Pseudomonas aeruginosa) organisms. Foley’s catheter was not related to such blood stream infection.  Vancomycin and Linezolid were effective against the Gram positive organisms; while Piperacillin- Tazobactam, Meropenem, Polymyxin B and Colistin were effective against the Gram negative organisms.Conclusions: Indwelling CVP catheters were associated with blood stream infection in 4 post operative patients in our ITU. An idea about the organisms responsible, as well as their antibiogram may help in early initiation of antibiotics empirically before culture-sensitivity reports are available.

scholarly journals Central Venous Catheter Tip Culture and Sensitivity Pattern from a Tertiary Care Hospital in Jammu Region, India

2019 ◽  
Vol 7 (4) ◽  
pp. 101-106
Author(s):  
P. Sharma Perika ◽  
S. Sudan N. Rajput ◽  
S. Gupta Y. Bhandari ◽  
R. Tomar
Keyword(s):  
Central Venous Catheter ◽  
Venous Catheter ◽  
Blood Stream ◽  
Care Hospital ◽  
Central Venous ◽  
Gram Positive ◽  
Blood Stream Infections ◽  
Gram Negative ◽  
Catheter Tip ◽  
Gram Positive Cocci

The use of Central Venous Catheters (CVC) in critically ill patients often leads to Catheter Related Blood Stream Infections (CRBSI). Blood stream infections which are associated with catheter is associated with high morbidity and mortality. Aim of the study is to find the type of organisms isolated from Central venous catheter tip and to determine their antimicrobial susceptibility pattern. A total of 100 samples were received in our laboratory over a period of one year. Samples were processed; organisms were isolated and subjected to antimicrobial sensitivity according to standard laboratory procedures. AST interpretation was done according to latest CLSI Guidelines. Of the 100 samples received in our laboratory, 11(11%) showed no growth or insignificant growth. 64% of the total samples were Gram Negative Bacilli and 23% were Gram Positive Cocci, 2% were Candida albicans. Escherichia coli and Staphylococcus aureus were the most common organisms isolated among gram negative bacilli and gram positive cocci respectively. Sensitive drugs in case of gram positive cocci were vancomycin and linezolid and in case of gram negative bacilli were Colistin and polymyxin B.

scholarly journals 183. Candidaemia in Children and Importance of Central Venous Catheter Removal

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S112-S113
Author(s):  
Kamile Arikan ◽  
Sevtap Arıkan-Akdaglı ◽  
Ates Kara
Keyword(s):  
Blood Culture ◽  
Central Venous Catheter ◽  
Blood Stream Infection ◽  
Tertiary Care ◽  
Venous Catheter ◽  
Blood Stream ◽  
Attributable Mortality ◽  
Care Hospital ◽  
Central Venous ◽  
Candida Spp

Abstract Background Candida is the most common cause of invasive fungal infection in healthcare settings and is associated with significant increases in healthcare resource utilization and attributable mortality. Methods This study was conducted in a pediatric tertiary care hospital from Turkey. We conducted a retrospective analysis in children ≤18 years with blood culture-proven candidaemia identified between December 2013 and November 2017. Sociodemographic variables,underlying condition, mortality, additional risk factors, origin of specimens were all recorded. Results A total of 236 episodes of candidaemia were identified over the study period. The median age of the patients was 600 days (4-6482). 106 specimens (44.9%) were cultured from patients under 1 year of age and 15 of 106 specimens were cultured from neonates. The most frequently isolated Candida spp. were C. albicans (42.%), followed by C. parapsilosis (30.5%), C. glabrata (7.6%), C. tropicalis (6.4%), C. krusei (2.5%), C. lusitaine (2.5%), C. dubliniensis (2.1%), C. kefir (0.8%), and C. pelliculosa (0.4%). In 11 of the 236 episodes (4.5%), two Candida spp were cultured at the same time.The most common coinfection was C. albicans and C. parapsilosis. 112 of the 236 episodes (47.5%) was due to central venous catheter-related blood stream infection. 47.5% of these patients were receiving total parenteral nutrition at the time of candidemia. Concomitant coagulase negatif staphylococcus bacteremia was present in 50 of 236 candidemia episodes (21.2%). Of 236 isolates, 74 (31.4%) was cultured from peripheral blood culture only, 95 (40.3%) from central venous catheter only, 67 (28.4%) from both peripheral and central catheter blood culture.Trombocytopenia was noted in 117 episodes (49.6%) and neutropenia in 45 episodes (19.1 Of the 112 central venous catheter-related candidemia, 35 (31.3%) resulted in death within 30 days from the onset of candidaemia (Figure 1). In 49 (45.%) episodes of central venous catheter-related candidemia, catheter was not removed and 40% of these episodes resulted as death.Catheter removal, thrombocytopenia, total parenteral nutrion were found to be associated with increased mortality in children under 1 year of age (P < 0.001). Conclusion Clinicians must be aware of candidemia in children due to high risk of mortality. Disclosures All authors: No reported disclosures.

Prevention of Central Venous Catheter–Related Infections and Thrombotic Events in Immunocompromised Children by the Use of Vancomycin/Ciprofloxacin/Heparin Flush Solution: A Randomized, Multicenter, Double-Blind Trial

2000 ◽  
Vol 18 (6) ◽  
pp. 1269-1278 ◽  
Author(s):  
Kelly J. Henrickson ◽  
Richard A. Axtell ◽  
Susan M. Hoover ◽  
Suzanne M. Kuhn ◽  
Jodi Pritchett ◽  
...  
Keyword(s):  
Venous Catheter ◽  
Blood Stream ◽  
Double Blind Study ◽  
Central Venous ◽  
Gram Positive ◽  
Double Blind ◽  
Gram Negative ◽  
Line Infection ◽  
Positive Line ◽  
Significant Health

PURPOSE: To determine whether an antibiotic flush solution containing vancomycin, heparin, and ciprofloxacin (VHC) can prevent the majority of line infections.PATIENTS AND METHODS: A prospective double-blind study was performed comparing VHC to vancomycin and heparin (VH) to heparin alone in 126 pediatric oncology patients.RESULTS: The 153 assessable lines resulted in 36,944 line days studied. There were 58 blood stream infections (43 Gram-positive, 14 Gram-negative, and one fungal). Forty were defined as line infections (31 heparin, three VH, six VHC). The time to develop a line infection was significantly increased using either antibiotic flush (VH, P = .011; VHC, P = .036). The rate of total line infections (VH, P = .004; VHC, P = .005), Gram-positive line infections (VH, P = .028; VHC, P = .022), and Gram-negative line infections (VH, P = .006; VHC, P = .003) was significantly reduced by either VH or VHC. Sixty-two (41%) of the lines developed 119 occlusion episodes (heparin, 3.99 per 1,000 line days; VHC, 1.75 per 1,000 line days; P = .0005). Neither antibiotic could be detected after flushing, and no adverse events were detected, including increased incidence of vancomycin-resistant Enterococcus colonization or disease.CONCLUSION: The use of either VH or VHC flush solution significantly decreased the complications associated with the use of tunneled central venous lines in immunocompromised children and would save significant health care resources.

scholarly journals Epidemiology of central venous catheter related blood stream infections in pediatric patients

2006 ◽  
Vol 49 (2) ◽  
pp. 157
Author(s):  
Jung Hyun Kim ◽  
Ho Sun Eun ◽  
Kyung Min Choi ◽  
Dong Soo Kim ◽  
Dong Eun Young
Keyword(s):  
Central Venous Catheter ◽  
Pediatric Patients ◽  
Venous Catheter ◽  
Blood Stream ◽  
Central Venous ◽  
Blood Stream Infections

scholarly journals Linezolid lock prophylaxis of central venous catheter infection

2008 ◽  
Vol 57 (4) ◽  
pp. 534-535 ◽  
Author(s):  
Jérôme Patrick Fennell ◽  
Martin O'Donohoe ◽  
Martin Cormican ◽  
Maureen Lynch
Keyword(s):  
Central Venous Catheter ◽  
Hospital Admissions ◽  
Blood Stream Infection ◽  
Central Venous Access ◽  
Venous Catheter ◽  
Venous Access ◽  
Blood Stream ◽  
Central Venous ◽  
Central Venous Catheter Infection ◽  
The Impact

Central venous catheter (CVC)-related infections are a major problem for patients requiring long-term venous access and may result in frequent hospital admissions and difficulties in maintaining central venous access. CVC-related blood stream infections are associated with increased duration of inpatient stay and cost approximately \#8364;13 585 per patient [Blot, S. I., Depuydt, P., Annemans, L., Benoit, D., Hoste, E., De Waele, J. J., Decruyenaere, J., Vogelaers, D., Colardyn, F. & Vandewoude, K. H. (2005). Clin Infect Dis 41, 1591–1598]. Antimicrobial lock therapy may prevent CVC-related blood stream infection, preserve central venous access and reduce hospital admissions. In this paper, the impact of linezolid lock prophylaxis in a patient with short bowel syndrome is described.

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