Adrenal Leiomyoma: a Rare Tumor Presented as an Incidentaloma in a Women with Ovarian Mature Cystic Teratoma

2019 ◽  
Vol 3 (1) ◽  
pp. 54-56
Author(s):  
Shankar Bastakoti ◽  
Nirmal Lamichhane ◽  
Sadina Shrestha ◽  
Ishan Dhungana
Keyword(s):  
Smooth Muscle ◽  
Laparoscopic Adrenalectomy ◽  
Adnexal Mass ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Immunocompromised Patients ◽  
Rare Tumor ◽  
Adrenal Incidentalomas ◽  
Ebv Infection

Adrenal leiomyoma is a rare neoplasm and usually associated with adrenal vein or its tributaries. These are benign in nature and are composed of smooth muscle cells. A sixty years Normotensive, non-HIV lady presented with right adnexal mass diagnosed as Mature Cystic Teratoma along with adrenal incidentalomas for which laparoscopic adrenalectomy was done and histopathology diagnosis was Leiomyoma. These are more common in immunocompromised patients especially HIV and or EBV infection. Adrenal incidentalomas can have a hormone secreting functions or they can be malignant tumors hence a proper evaluation and treatment should be performed.

scholarly journals Genetic Profiling of Malignant Melanoma Arising from an Ovarian Mature Cystic Teratoma: A Case Report

2021 ◽  
Vol 22 (5) ◽  
pp. 2436
Author(s):  
Kohei Nakamura ◽  
Eriko Aimono ◽  
Reika Takamatsu ◽  
Shigeki Tanishima ◽  
Tomonari Tohyama ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Homozygous Deletion ◽  
Mature Cystic Teratoma ◽  
Genetic Profiling ◽  
Improve Treatment ◽  
The Status ◽  
Genetic Mechanisms ◽  
Targeted Gene Sequencing

Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare cases, malignant tumors arise from ovarian mature cystic teratoma. A variety of tumors can arise from mature cystic teratoma, among which primary malignant melanoma (MM), for which no molecular analyses such as genomic sequencing have been reported to date, is exceedingly rare, thereby limiting possible therapeutic options using precision medicine. We used targeted gene sequencing to analyze the status of 160 cancer-related genes in a patient with MM arising from an ovarian mature cystic teratoma (MM-MCT). KRAS amplification and homozygous deletion in PTEN and RB1 were detected in tumor samples collected from the patient. No KRAS amplification has been previously reported in cutaneous MM, indicating that the carcinogenesis of MM-MCT differs from that of primary cutaneous melanomas. A better understanding of the underlying genetic mechanisms will help clarify the carcinogenesis of MM-MCT. In turn, this will enable treatment with novel targeting agents as well as the initial exploration of gene-based precision oncological therapies, which aim to improve treatment outcomes for patients with this disease.

scholarly journals Management of Adnexal Mass During Cesarean Section

2018 ◽  
Vol 12 (2) ◽  
pp. 48-51
Author(s):  
Monica Gurung ◽  
Gehanath Baral
Keyword(s):  
Retrospective Study ◽  
Cesarean Section ◽  
Adnexal Mass ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Surgical Removal ◽  
Cesarean Sections ◽  
Operation Theatre ◽  
Adnexal Masses ◽  
The Masses

Aims: To find out the prevalence of adnexal mass during Cesarean Section, its management and histological profile.Methods: This is a retrospective study conducted for 4 years from 2013 to 2017 at Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. There were 18993 Cesarean Sections out of 72263 total births screened for adnexal masses from operation theatre register and record section.Results: The incidence of adnexal mass during cesarean section was 0.31% (58 out of 18993). Among them 15.52 % diagnosed antenatally and 84.48 % were incidentally diagnosed during cesarean section. Among 58 cases, 6 (10%) were bilateral amounting to 64 adnexal masses among which 35 (54.69%) masses had cystectomy, 20 (31.25%) masses had oophorectomy, 6 (9.37%) had aspiration/ drilling done and 3(4.69 %) masses were left without intervention. Among those cases only 48 histopathological reports were available. All the masses were benign and the most common was benign mature cystic teratoma (34; 69.38 %) and the least common was fibroma (1; 2.04%).Conclusions:  Adnexal masses during cesarean section should undergo surgical removal.

scholarly journals Ovarian Lymphangioma with Mature Cystic Teratoma

2019 ◽  
Vol 17 (01) ◽  
pp. 128-130
Author(s):  
Karishma Malla Vaidya ◽  
Bigya Shrestha
Keyword(s):  
Benign Tumor ◽  
Histological Analysis ◽  
Adnexal Mass ◽  
Histopathological Examination ◽  
Cystic Teratoma ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Mature Cystic Teratoma ◽  
Long Time ◽  
Slow Growing

Lymphangiomas are slow-growing tumors that remain asymptomatic for a long time, with the tumor being identified incidentally during histopathological examination after excision. Mature cystic teratoma is benign tumor consisting of mature tissue derived from two or three germ layers. We have 47-year-old woman who underwent total abdominal hysterectomy for right adnexal mass. As her ultrasound report revealed a right adnexal mass with solid and cystic components. The histological analysis along with immunohistochemistry (D2-40) maker confirmed the diagnosis of lymphangioma of the ovary coexisting with mature cystic teratoma. There is paucity of reported case of co-existing these two tumors in same tissue.Keywords: D2-40; lymphangioma; mature cystic teratoma; ovary.

scholarly journals Ovarian Germ Cell Tumor – Histopathological and statistical analysis

2013 ◽  
Vol 3 (6) ◽  
pp. 441-446
Author(s):  
A Ghosh ◽  
D Magar Gharti ◽  
B Sathian ◽  
R Narasimhan ◽  
Op Talwar
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Malignant Tumors ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Cell Tumor ◽  
Ovarian Tumors ◽  
Mature Cystic Teratoma ◽  
Age Group ◽  
Malignant Germ Cell Tumors

Background: Ovarian cancers are common among females. The ovarian tumors are classified according to its histogenesis. In the present study, we analyzed the germ cell ovarian tumors reported in our institute. Materials and Methods: This study was a hospital based retrospective study. All ovarian germ cell tumor reported from Jan 2001 to Feb 2013 were retrieved and analyzed. The specimens were routinely processed and the slides were stained with H&E and special stains wherever required. Results: A total of 340 cases of ovarian tumors were reported and 150 cases (44%) were of germ cell origin. We had 137 cases of benign and 13 cases of malignant germ cell tumors. Most common subtype was mature cystic teratoma comprising 125 cases. Among the malignant cases, the most common was immature teratoma (5 cases). Age range in our series was from 8 to 82 years (mean 28 years). The most common age group affected was 21-30 years. Most of the malignant cases (76.9%) were in less than 30 years. Among the malignant cases majority (84.6%) were more than 10 cm in size. None of the malignant germ cell tumors were bilateral. Conclusion: Among germ cell tumors of ovary, mature cystic teratoma is the most common tumor and malignant subtypes are uncommon. Malignant tumors tend to occur in younger age group. DOI: http://dx.doi.org/10.3126/jpn.v3i6.8990 Journal of Pathology of Nepal (2013) Vol. 3, 441-446

scholarly journals Histopathological diagnosis of ovarian mass

2018 ◽  
Vol 8 (1) ◽  
pp. 1261-1264
Author(s):  
Shahali Shadab ◽  
Tadayon Tadayon
Keyword(s):  
Malignant Tumors ◽  
Histopathological Examination ◽  
Age Groups ◽  
Germ Cell Tumors ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Hospital Data ◽  
Ovarian Masses

Background:  Ovarian cysts are common forms of gynecological problems that can be range from physiological cysts to highly aggressive neoplastic lesions. The purpose of this study was to investigate prevalence and frequency of different histopathological patterns of ovarian lesions and their correlation with various parameters in Ahvaz, Iran.Materials and Methods: This is the retrospective study of patients with the ovarian masses at Ahvaz Imam Khomeini Hospital from 2010 - 2015. The relevant clinical details about the patient were retrieved from hospital data. Clinical characteristics of patients such as patient's age, presenting signs and symptoms, histopathological diagnosis, mass type, mass subtype, size of cysts and ovary which is involved were noted. Results: Two hundred sixty seven specimens of ovarian tumor obtained for histopathological examination. Of these, 163(61.0%) were tumor like, 96(36.0%) were benign tumor and 8(3.0%) were malignant. The most common tumor like conditions was Corpus luteum cyst (43.4% cases), among benign and malignant tumors, mature cystic teratoma (17.2% of total) and Epithelial tumors (n=4) were most common. There is a statistically significant positive relation between age and various ovarian masses. (P= 0.002). Histopathological diagnosis wasn't correlated with ovarian involvement.Conclusion: Benign tumors are more common than malignant tumors in all age groups. Germ cell tumors followed by surface epithelial cell tumors are the commonest tumor. Mature cystic teratoma was the most common tumor. Unilaterality is more frequently seen in ovarian tumors and various tumors are seen in various age groups.

scholarly journals Oligodendroglioma Arising in Mature Cystic Teratoma

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
Betül Ünal ◽  
Faruk Güleç ◽  
Murat Şedele
Keyword(s):  
Adnexal Mass ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Germ Layers ◽  
Neuroepithelial Tumors ◽  
Tumoral Lesion ◽  
Round Nucleus

Background.Development of neuroepithelial tumors from mature cystic teratoma is very rare. We present a case of oligodendroglioma developing inside mature cystic teratoma.Case.Eighteen-years-old female, right adnexal mass with solid and cystic areas was detected. Sections showed all three germ layers. Also, a tumoral lesion was observed in a glial fibrillary matrix. Tumor was composed of monotonous, uniform cells which have oval-round nucleus, perinuclear halo, and indistinct cytoplasm. GFAP, EGFR, P53 were positive.Conclusions.We diagnosed oligodendroglioma arising from mature cystic teratoma. There was no recurrence at the end of 13 months followup. The number of cases which have been reported in the literature is only a few.

scholarly journals Squamous cell carcinoma arising in ovarian mature cystic teratoma: report of three cases

1970 ◽  
Vol 2 (3) ◽  
pp. 248-250 ◽  
Author(s):  
R Bashyal ◽  
MC Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Postmenopausal Women ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Malignant Tumors ◽  
Cystic Teratoma ◽  
Squamous Cell Carcinomas ◽  
Mature Cystic Teratoma ◽  
First Case

Malignant transformation of mature cystic teratoma of the ovary is rare. A wide variety of malignant tumors may arise within benign mature cystic teratoma. The most common form of malignant transformation of a mature cystic teratoma is squamous cell carcinoma. We report a series of three cases that developed squamous cell carcinoma in a benign ovarian cystic teratoma. Two of the carcinomas occurred in postmenopausal women: 51-year-old (case # 2) and 60 year-old (case # 3). The first case occurred in a 33-year-old woman. Histologically, all three cases were moderately differentiated squamous cell carcinomas and were confined to the ovaries. The aim of this study was to review our experience with this disease and to review the literature. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6032 JPN 2012; 2(3): 248-250

scholarly journals Primary malignant melanoma arising from ruptured ovarian mature cystic teratoma with elevated serum CA 19–9: a case report and review of literature

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Won Ku Choi ◽  
Dong Hyun Lee ◽  
Dong Hyu Cho ◽  
Kyu Yun Jang ◽  
Kyoung Min Kim
Keyword(s):  
Malignant Melanoma ◽  
Malignant Tumors ◽  
Elevated Serum ◽  
Cystic Teratoma ◽  
Surgical Excision ◽  
Mature Cystic Teratoma ◽  
Primary Malignant Melanoma ◽  
Cystic Masses ◽  
Strong Immunoreactivity ◽  
Pleomorphic Cells

Abstract Background Ovarian mature cystic teratomas comprise tissues derived from all three germ layers. In rare incidences, malignant tumors may arise from ovarian mature cystic teratoma, which occurs in 0.2–1.8% of cases. A variety of tumors can arise within mature cystic teratoma, among which malignant melanoma is exceedingly rare. Case presentation A 42-year-old woman presented with abdominal pain. Transvaginal ultrasonography showed mixed echogenic cystic masses in both ovaries. Her serum cancer antigen (CA19–9) level was elevated at 29,770 U/ml. Surgical excision was performed. Histologic examination showed infiltrating nests of pleomorphic cells with prominent nucleoli and black pigments in the background of a mature cystic teratoma. These pleomorphic cells showed strong immunoreactivity for Melan-A and HMB-45. The patient was re-evaluated and the possibility of a melanoma at any other site was ruled out. Based on these findings, we concluded that the malignant melanoma originated from the ovarian mature cystic teratoma. Conclusion We report a rare case of primary malignant melanoma derived from an ovarian mature cystic teratoma.

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