Advanced Maternal Age and Pregnancy Outcome at Manipal Teaching Hospital: Cross-sectional Analytical study

Introduction: Advanced and very advanced maternal age are associated with several adverse maternal and fetal outcome. The objective of this study was to find out the possible association between advance maternal age and adverse pregnancy outcomes at Manipal Teaching Hospital.Methods: A cross sectional analytical study conducted at department of Obstetrics and Gynecology, Manipal Teaching Hospital, Pokhara, Nepal. A total of 198 patient who were ≥30 years and >24 weeks pregnant admitted in obstetric ward were selected. These patient were divided into three groups according to their age (30-34, 35-39 and ≥ 40years). We compared the incidence of adverse maternal and perinatal outcome among these groups. We also calculated odds ratio of maternal and perinatal outcomes in 35-39 years and ≥ 40years women, compared with women aged 30-34 years.Results: Comparison of the three age groups revealed that advanced maternal age constitute a predisposing factor for malpresentation, gestational diabetes mellitus, placenta previa, fetal distress and caesarean section. Whereas, risk of non progress of labour, preterm birth, postpartum hemorrhage, perinatal death and congenital anomalies were increased in very advanced maternal age group. From these, statistical significance was reached in case of greater risk of malpresentation (p=0.01,OR=6.66), fetal distress (p=0.04, OR=2.6) and caesarean section(p=0.02,OR=2.06) in advanced age group when compared to the patients aged 30-34. Furthermore, very advanced age group were higher risk of postpartum hemorrhage (p=0.03, OR=2.47) and congenital anomalies, which were statistically significant (p=0.04, OR=29.57) when compared to the 30-34 years.Conclusion: Advanced and very advanced maternal age is associated with several adverse maternal and perinatal outcome. The risk of perinatal complication begin to increase after the age of 35 but significantly increased after 40 years.

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Pregnancy Outcome in Patients with Placenta Praevia with Delayed Child Bearing Age

TAJ Journal of Teachers Association ◽

10.3329/taj.v32i2.44899 ◽

2020 ◽

Vol 32 (2) ◽

pp. 48-55

Author(s):

Mst Shorifa Rani ◽

Shahela Jesmin ◽

Nazmun Nahar ◽

Nahid Yusuf ◽

Hamida Pervin ◽

...

Keyword(s):

Mortality Rate ◽

Caesarean Section ◽

Pregnancy Outcome ◽

Perinatal Outcome ◽

Maternal Age ◽

Advanced Maternal Age ◽

Placenta Praevia ◽

Age Group ◽

Child Bearing ◽

History Of

This is a hospital-based cross sectional descriptive study was carried out during January 2015 to June 2015 in the Department of Obstetrics and Gynaecology of Rajshahi Medical College Hospital to determine pregnancy outcome in placenta praevia cases with delayed child bearing age. Total 8107 patients were admitted during the study period and among them 82 patients were diagnosed as placenta praevia. Patients were categorized into two groups as above 35 years & below 35 years and relationship between advanced maternal age and placenta praevia was seen. Socio-demographic condition, clinical condition, course of management, maternal and perinatal outcome were observed and recorded. Proportion of placenta praevia was 1.01% during the study time. Among 82 patients of placenta praevia, 25 were advanced maternal age group (30.49%). Prevalence of placenta praevia in advanced maternal age group in comparison to below 35 years among total admitted patient was seen 9.73% and 0.73% respectively. So, incidence is more in advanced maternal age group which is statistically significant (p<0.05). Most of the patients of placenta praevia came from middle class family 42(51.21%) and most women were multi gravida 75(91.5%). 42.68% patient had history of caesarean section and 47.56% patients had history of menstrual regulation (MR), abortion & dilatation, evacuation & curettage (DE & C). Major placenta praevia was more in advanced maternal age group (64%) which is statistically significant (<0.05) and mode of delivery was caesarean section 62(75.60%). Maternal and perinatal complications were more in advanced maternal age group. Maternal mortality rate 9(10.97%) and perinatal mortality rate 14(17.07%). Advanced maternal age has a relation with placenta praevia and associated with more adverse maternal and perinatal outcome. So, pregnancy in advanced age should be considered as a risk factor for developing placenta praevia. TAJ 2019; 32(2): 48-55

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Association between very advanced maternal age and adverse pregnancy outcomes: a cross sectional Japanese study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-017-1540-0 ◽

2017 ◽

Vol 17 (1) ◽

Cited By ~ 31

Author(s):

Kohei Ogawa ◽

Kevin Y. Urayama ◽

Shinji Tanigaki ◽

Haruhiko Sago ◽

Shoji Sato ◽

...

Keyword(s):

Pregnancy Outcomes ◽

Maternal Age ◽

Advanced Maternal Age ◽

Adverse Pregnancy Outcomes ◽

Cross Sectional ◽

Japanese Study ◽

Adverse Pregnancy ◽

Very Advanced Maternal Age

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Postpartum Hemorrhage and Very Advanced Maternal Age [28M]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000664820.70051.60 ◽

2020 ◽

Vol 135 ◽

pp. 142S

Author(s):

H. Austinn Freeman ◽

Kirsten Salmeen ◽

Aida Shirazi ◽

Sarah Morocco

Keyword(s):

Postpartum Hemorrhage ◽

Maternal Age ◽

Advanced Maternal Age ◽

Very Advanced Maternal Age

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Re: Very advanced maternal age

The Obstetrician & Gynaecologist ◽

10.1111/tog.12732 ◽

2021 ◽

Author(s):

Maria Woolley ◽

Rhiannon George‐Carey ◽

Abha Govind ◽

Wai Yoong

Keyword(s):

Maternal Age ◽

Advanced Maternal Age ◽

Very Advanced Maternal Age

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Evaluation of Pregnancy Outcomes at Advanced Maternal Age

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.587 ◽

2019 ◽

Vol 7 (12) ◽

pp. 1951-1956 ◽

Cited By ~ 1

Author(s):

Małgorzata Radoń-Pokracka ◽

Beata Adrianowicz ◽

Magdalena Płonka ◽

Paulina Danił ◽

Magdalena Nowak ◽

...

Keyword(s):

Caesarean Section ◽

Gestational Age ◽

Maternal Age ◽

Statistical Significance ◽

Advanced Maternal Age ◽

Neonatal Outcomes ◽

University Hospital ◽

Large For Gestational Age ◽

Predisposing Factor ◽

Over 40 Years

AIM: The study aimed to investigate the association between advanced maternal age (AMA) and the risk of adverse maternal, perinatal and neonatal outcomes about parity in singleton pregnancies.METHODS: We retrospectively analysed 950 women who gave birth in the Department of Obstetrics and Perinatology of the University Hospital in Kraków for six months (between 1st January and 30th June 2018). The patients were divided into 3 groups according to their age (30-34 years old, 35-39 years old and over 40 years old). Each of these groups was subsequently subdivided into 2 groups depending on parity (primiparae and multiparae). Maternal, perinatal and neonatal outcomes were compared between the groups and the subgroups.RESULTS: Comparison of the three age groups revealed that advanced maternal age might constitute a predisposing factor for preterm birth, caesarean section and large for gestational age (LGA). From these parameters, statistical significance was reached in case of greater risk of LGA (OR = 2.17), caesarean section (OR = 2.03) and elective C-section (OR = 1.84) in women over 40 years old when compared to the patients aged 30-34. Furthermore, AMA increases the risk of postpartum haemorrhage (OR = 6.43). Additionally, there is a negative correlation between maternal age and gestational age at delivery (R = -0.106, p < 0.05).CONCLUSIONS: Advanced maternal age can undoubtedly be associated with several adverse perinatal outcomes. At the same time, the risk of perinatal complications begins to increase after the age of 35 but becomes significant in women aged ≥ 40.

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Maternal age at first cesarean delivery related to adverse pregnancy outcomes in a second cesarean delivery: a multicenter, historical, cross-sectional cohort study

BMC Pregnancy and Childbirth ◽

10.1186/s12884-021-03608-9 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shilei Bi ◽

Lizi Zhang ◽

Jingsi Chen ◽

Minshan Huang ◽

Lijun Huang ◽

...

Keyword(s):

Risk Factor ◽

Cohort Study ◽

Cesarean Delivery ◽

Maternal Age ◽

Reference Group ◽

Multivariate Logistic Regression Analysis ◽

Advanced Maternal Age ◽

Adverse Outcomes ◽

Cross Sectional ◽

Singleton Pregnancies

Abstract Background To determine the effects of maternal age at first cesarean on maternal complications and adverse outcomes of pregnancy with the second cesarean. Methods This was a multicenter, historical, cross-sectional cohort study involving singleton pregnancies ≥28 gestational weeks, with a history of 1 cesarean delivery, and who underwent a second cesarean between January and December 2017 at 11 public tertiary hospitals in 7 provinces of China. We analyzed the effects of maternal age at first cesarean on adverse outcomes of pregnancy in the second cesarean using multivariate logistic regression analysis. Results The study consisted of 10,206 singleton pregnancies. Women were at first cesarean between 18 and 24, 25–29, 30–34, and ≥ 35 years of age; and numbered 2711, 5524, 1751, and 220 cases, respectively. Maternal age between 18 and 24 years at first cesarean increased the risk of placenta accreta spectrum (aOR, 1.499; 95% CI, 1.12–2.01), placenta previa (aOR, 1.349; 95% CI, 1.07–1.70), intrahepatic cholestasis of pregnancy (aOR, 1.947; 95% CI, 1.24–3.07), postpartum hemorrhage (aOR, 1.505; 95% CI, 1.05–2.16), and blood transfusion (aOR, 1.517; 95% CI, 1.21–1.91) in the second cesarean compared with the reference group (aged 25–29 years). In addition, maternal age ≥ 35 years at first cesarean was a risk factor for premature rupture of membranes (aOR, 1.556; 95% CI, 1.08–2.24), placental abruption (aOR, 6.464, 95% CI, 1.33–31.51), uterine rupture (aOR, 7.952; 95% CI, 1.43–44.10), puerperal infection (aOR, 6.864; 95% CI, 1.95–24.22), neonatal mild asphyxia (aOR, 4.339; 95% CI, 1.53–12.32), severe asphyxia (aOR, 18.439; 95% CI, 1.54–220.95), and admission to a neonatal intensive care unit (aOR, 2.825; 95% CI, 1.54–5.17) compared with the reference group (aged 25–29 years). Conclusions Maternal age between 18 and 24 years or advanced maternal age at first cesarean was an independent risk factor for adverse maternal outcomes with the second cesarean. Advanced maternal age at the first cesarean specifically increased adverse neonatal outcomes with the second. Therefore, decisions as to whether to perform a first cesarean at a young or advanced maternal age must be critically evaluated.

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Pregnancy outcomes in very advanced maternal age women

American Journal of Obstetrics & Gynecology MFM ◽

10.1016/j.ajogmf.2021.100491 ◽

2021 ◽

pp. 100491

Author(s):

Sarah D Smithson ◽

Naomi H Greene ◽

Tania F Esakoff

Keyword(s):

Pregnancy Outcomes ◽

Maternal Age ◽

Advanced Maternal Age ◽

Very Advanced Maternal Age

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CONSANGUINITY AND MATERNAL AGE;

The Professional Medical Journal ◽

10.29309/tpmj/2017.24.04.1458 ◽

2017 ◽

Vol 24 (04) ◽

pp. 511-515

Author(s):

Nayyab Zehra ◽

Ahmed Hassaan Malik ◽

Zahabia Khalid ◽

Misha Sabir ◽

Simra Tanvir ◽

...

Keyword(s):

Family History ◽

Gestational Age ◽

Maternal Age ◽

Sampling Technique ◽

Reproductive Age ◽

Military Hospital ◽

Age Group ◽

Spontaneous Abortions ◽

Cross Sectional ◽

History Of

Objectives: To determine the frequency of risk factors i.e. consanguinity andmaternal age associated with spontaneous abortions in Pakistan and to propose ways toreduce them. Study design: Cross sectional descriptive study. Place of study: Gynecologydepartment of Military Hospital and Combined Military Hospital, Rawalpindi. Duration ofstudy: 6 months (September 2015 to February 2016). Sampling technique: Non probabilityconvenient sampling. Methodology: 150 married female patients in reproductive age group(15-49 years), who were confirmed cases of pregnancy and presented with abortions, wereinterviewed and responses were filled in a structured questionnaire after written consent.The collected data was then entered and analyzed by SPSS 20.0. Results: The major bulkof spontaneous abortions occurred in the maternal age group of 25-35 years (55.3%). A totalof 53.3% of abortions occurred in the gestational age of less than 12 weeks. Around 54.7% offemales had family history of spontaneous abortions and 65.3% had consanguineous marriage.Conclusion: Spontaneous abortions occur more frequently in the females of 25-35 yearsage group and among the fetuses with gestational age less than 12 weeks (1st trimester ofpregnancy). Family history of spontaneous abortions and consanguinity are associated withspontaneous abortions.

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