scholarly journals Unexplained Fatigue in an Otherwise Healthy Man Linked to Kikuchi-Fujimoto Disease, A Case Report

2021 ◽  
Vol 4 (1) ◽  
pp. 454-456
Author(s):  
Vivek Pant ◽  
Santosh Pradhan ◽  
Vijay Kumar Sharma
Keyword(s):  
Bone Marrow ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Bone Marrow Examination ◽  
Axillary Node ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supportive Treatment ◽  
Radiological Investigation ◽  
Normal Peripheral Blood ◽  
Necrotizing Lymphadenitis

Kikuchi histiocytic necrotizing lymphadenitis is a benign and self-limited illness usually characterized by cervical lymphadenopathy and fever. We present a case of a 42-year male who complained of extreme fatigue for 2 weeks. On laboratory workup, he had leucopenia and thrombocytopenia with normal peripheral blood and bone marrow examination. The radiological investigation revealed multiple enlarged lymph nodes in the left axilla and left supraclavicular region. The subsequent excisional biopsy of the axillary node clinched the diagnosis of Kikuchi- Fujimoto disease. The patient was completely recovered and laboratory parameters were normal with supportive treatment. Kikuchi- Fujimoto disease should be considered in patients with unexplained fatigue with lymphadenopathy and early biopsy prevents unnecessary investigations as well as potentially harmful treatments.

scholarly journals Kikuchi Fujimoto Disease: A Case Report with Literature Review

2021 ◽  
pp. 114-117
Author(s):  
Eshwar Rajesh ◽  
Tamilvanan Swaminathan
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymph Node ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Inappropriate Treatment ◽  
Necrotizing Lymphadenitis ◽  
Mild Fever ◽  
Shed Light

Kikuchi-Fujimoto disease (KFD), also referred to as histiocytic necrotizing lymphadenitis, is an uncommon entity, usually benign, self-limiting disease characterised by fever and regional lymphadenopathy of unexplained aetiology. There is an increase in reported cases of KFD, particularly in Asia. It is important to recognize this condition because it may be confused for systemic lupus erythematosus (SLE), tuberculosis or lymphoma. The knowledge of this condition among clinicians and pathologists can help to avoid misdiagnosis and inappropriate treatment. It must be considered among the differential diagnoses of cervical lymphadenopathy. Here, we present a case of 20-year-old male who came to the hospital with complaints of mild fever, chills, fatigue and cervical lymphadenopathy. After radiological investigations an excisional biopsy of the cervical lymph node was done and the diagnosis of KFD was confirmed. Due to the paucity of cases in literature, reporting this case may help shed light on this rare disease.

scholarly journals Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus?

2019 ◽  
Vol 57 (1) ◽  
pp. 72-77
Author(s):  
Taro Horino ◽  
Osamu Ichii ◽  
Yoshio Terada
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Clinical Entity ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Necrotizing Lymphadenitis

Abstract Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by cervical lymphadenopathy and fever. Since KFD was first reported in 1972, the validity of this clinical entity has been controversial and its aetiology remains unknown. Herein, we report a case of a patient with KFD, which was believed to be associated with systemic lupus erythematosus.

scholarly journals Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

2021 ◽  
Vol 8 (9) ◽  
pp. 1602
Author(s):  
Sushil Singla ◽  
Mohitesh Kumar ◽  
Vinod Kumar Jat ◽  
Deepika Parwan
Keyword(s):  
Lymph Node ◽  
Laboratory Test ◽  
Young Patient ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Benign Condition ◽  
Node Biopsy ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment. 

A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement

1992 ◽  
Vol 420 (3) ◽  
pp. 275-279 ◽  
Author(s):  
Yoshiaki Sumiyoshi ◽  
Masahiko Kikuchi ◽  
Kohiti Ohshima ◽  
Yuiti Masuda ◽  
Morishige Takeshita ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Skin Involvement ◽  
Necrotizing Lymphadenitis

scholarly journals Kikuchi-Fujimoto Disease: A Report of 3 Cases

2007 ◽  
Vol 86 (7) ◽  
pp. 412-413 ◽  
Author(s):  
Eimear Phelan ◽  
Emer Lang ◽  
Peter Gormley ◽  
John Lang
Keyword(s):  
Weight Loss ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Accurate Diagnosis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Node Biopsy ◽  
Night Sweats ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Cervical lymphadenopathy has many underlying etiologies. One of its rare causes is Kikuchi-Fujimoto disease (Kikuchi's disease, histiocytic necrotizing lymphadenitis). We discovered such a cause in a 37-year-old woman who had presented with malaise, night sweats, and weight loss in addition to cervical lymphadenopathy. We based our diagnosis on excisional lymph node biopsy. We also review 2 other cases of Kikuchi's disease that were diagnosed by others at our institution. Clinically and histologically, Kikuchi's disease is very similar to lymphoma, and distinguishing the two is difficult. However, despite the fact that Kikuchi's disease is benign, an accurate diagnosis is important because misdiagnosis might lead to unnecessary surgery and/or chemotherapy.

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

scholarly journals A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

scholarly journals Case Report: Kikuchi-Fujimoto Disease: A case of supraclavicular lymphadenopathy

F1000Research ◽  
2021 ◽  
Vol 8 ◽  
pp. 1652
Author(s):  
Shiza Sarfraz ◽  
Hamza Rafique ◽  
Hassam Ali ◽  
Syed Zawahir Hassan
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
Tuberculous Lymphadenitis ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supraclavicular Lymph Nodes ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare cause of cervical lymphadenopathy. Patients usually present with localized lymphadenopathy, fever and fatigue. Because of the poorly understood etiology, it can be mistaken for an infectious disease or even malignance. Here we discuss a case of KFD that initially presented with left sided cervical lymphadenopathy that later progressed to left supraclavicular lymph nodes. Due to its characteristic overlap with other disorders like tuberculous lymphadenitis and lymphoma, KFD remains an arduous diagnosis for physicians. Therefore, one should be made aware of symptoms that can lead to misdiagnosis in patients.

scholarly journals PHENYTOIN-ASSOCIATED LYMPHOADENOPATHY MIMICKING A PERIPHERAL T-CELL LYMPHOMA

2010 ◽  
Vol 2 (2) ◽  
pp. e2010028 ◽  
Author(s):  
Mark E. Johns ◽  
Lynn C. Moscinski ◽  
Lubomir Sokol
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
T Cell ◽  
Cell Population ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Whole Body ◽  
Cervical Lymph Nodes

We report a case of phenytoin-induced pseudolymphoma in a 28-year-old male with a history of autism and seizure disorder.  The patient presented with bilateral cervical lymphadenopathy that was shown to be moderately to markedly FDG-avid on a whole body PET/CT scan.  Flow cytometry analysis of peripheral blood and bone marrow mononuclear cells detected identical T cell population with aberrant immunophenotype.  Additionally, a TCR beta gene was found to be clonally rearranged in both peripheral blood and bone marrow supporting a clonal origin of atypical T cells. However, no such clonal population of T-cells could be detected in a pathologic specimen obtained from an excisional biopsy of one of the patient’s cervical lymph nodes. After discontinuing the patient’s phenytoin, his lymphadenopathy has nearly completely resolved and circulation clonal T cell population disappeared with 12 months of follow-up.

Histiocytic Necrotizing Lymphadenitis With Autoimmune Phenomena and Meningitis in a 14-Year-Old Girl

PEDIATRICS ◽  
1996 ◽  
Vol 98 (1) ◽  
pp. 130-133 ◽  
Author(s):  
Jason S. Debley ◽  
David J. Rozansky ◽  
Michael L. Miller ◽  
Ben Z. Katz ◽  
Marianne E. Greene
Keyword(s):  
United States ◽  
Weight Loss ◽  
Lymph Nodes ◽  
Cervical Lymphadenopathy ◽  
The United States ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Common Presentation ◽  
Necrotizing Lymphadenitis ◽  
Autoimmune Phenomena

Histiocytic necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a disorder of lymph nodes originally described by Kikuchi1 and Fujimoto2 in 1972. Since 1982 this disorder has been increasingly recognized in the United States and worldwide, with the most extensive analyses of the disease presented by Dorfman et al.3-5 There has been little discussion of this entity in the pediatric literature. The most common presentation of necrotizing lymphadenitis includes fever and painless cervical lymphadenopathy. Patients may also present with weight loss, nausea, vomiting, diarrhea, chills, or diaphoresis. On occasion, myalgias, arthralgias, malar or butterfly rash, hepatomegaly, and splenomegaly have been noted.3

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