Effect of tear substitutes with various sodium hyaluronate levels on the condition of eye anterior segment in dry eye syndrome patients

Background. In recent years, the prevalence of allergic diseases of the anterior chamber of the eye has increased. They are often accompanied by the development of dry eye syndrome, which can complicate their course. Therefore, it is important to take a comprehensive approach to their diagnosis and treatment. The purpose was to study the effectiveness of 0.4% sodium hyaluronate (Gilays) in children with dry eye syndrome on the background of allergic diseases of the conjunctiva. Materials and methods. The study involved 42 patients (84 eyes) aged 3 to 18 years, who were examined and treated on the basis of Regional Eye Clinic. Patients were treated with local H-1 histamine blockers twice a day for 14 days, f necessary — with topical glucocorticoids by the scheme for 12 days. In the first group (21 patients, 42 eyes), the main treatment was added with the drugs containing 0.2% sodium hyaluronate, used topically 4 times a day for 14 days. In the second group (21 patients/42 eyes), 0.4% sodium hyaluronate (Gilays) was added to the treatment regimen. H-1 histamine blockers were not used systemically. Before starting therapy and 2 weeks later, the following values were evaluated: the changes in the anterior chamber of the eye using biomicroscopy, determination of lacrimal film rupture time, Schirmer 1 test, questionnaire. Conclusions. The use of sodium hyaluronate in the complex therapy of dry eye syndrome in allergic eye diseases is quite effective. The use of 0.4% sodium hyaluronate was more effective compared to the control group. It is advisable to use a questionnaire to communicate with the child, but it is necessary to refine the form of questions to eliminate as much as possible the subjectivity of the data.

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Analysis of treatment results in dry eye syndrome patients after phacoemulsification by preservative-free 0.3% sodium hyaluronate eye drops

Ophthalmology journal ◽

10.17816/ov10273-77 ◽

2017 ◽

Vol 10 (2) ◽

pp. 73-77

Author(s):

Yury I Pirogov ◽

Galina M Butina ◽

Aleksandr A Oksentjuk ◽

Ekaterina S Khromova

Keyword(s):

Dry Eye ◽

Sodium Hyaluronate ◽

Dry Eye Syndrome ◽

Surgical Trauma ◽

Eye Drops ◽

Mean Values ◽

Tear Secretion ◽

Mild Degree ◽

Patient Symptom ◽

Preservative Free

Postsurgical dry eye syndrome is found in a substantial proportion of patients after phacoemulsification. Its onset could be explained by surgical trauma and by use of preservative-containing eye drops. In some patients, it causes substantial discomfort that continues unabated after 3-4 weeks after surgery. Purpose. To investigate the results of 0.3% sodium hyaluronate instillation therapy used to treat dry eye syndrome after phacoemulsification. Materials and methods. Basal tear secretion (Schirmer II test) and tear breakup time (TBUT) test were investigated in 33 patients with symptoms characteristic of dry eye syndrome in 1 month after phacoemulsification. These patients received 0.3% preservative-free sodium hyaluronate instillations for 30 days, whereupon Schirmer II and TBUT tests were repeated. Symptom dynamics was estimated according to the OSDI questionnaire scale. Results. Mean values of basal tear secretion and TBUT tests were slightly below normal ones. In one month of treatment, the TBUT index associated with “Gilan Ultra Comfort” use became somewhat better: mean TBUT value appeared to be 9.8 ± 2.5 sec. OSDI questionnaire patient symptom score evaluation also revealed in patients a mild degree of xerosis severity. Mean score before treatment was 19.6 ± 10.0. Positive disease dynamics after “Gilan Ultra Comfort” use is confirmed by a significant decrease of OSDI score index up to 12.3 ± 6.3.

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Non-Conservative Therapy in the Prevention of Subepithelial Fibroplasia after LASEK Hypermetropia Correction

Ophthalmology in Russia ◽

10.18008/1816-5095-2018-2-200-206 ◽

2018 ◽

Vol 15 (2) ◽

pp. 200-206

Author(s):

S. A. Korotkikh ◽

A. E. Bogachev ◽

A. S. Shamkin

Keyword(s):

Dry Eye ◽

Postoperative Period ◽

Sodium Hyaluronate ◽

Early Postoperative Period ◽

Diagnostic Methods ◽

Dry Eye Syndrome ◽

Control Group ◽

Study Group ◽

Postoperative Therapy ◽

Significant Difference

The results of observation of patients who underwent vision eximerlaser correction by the LASEK method regarding medium degree of hyperopia were analyzed.Purpose:to investigate the severity of the «dry eye» syndrome and corneal subepithelial fibroplasia in patients after laser correction of hyperopia by the LASEK method, and their prevention by reducing the preservative action on the eye surface.Patients and methods.The study included 40 patients (76 eyes), aged 21–46 years (32.98 ± 1.79) who underwent LASEK surgery for moderate hyperopia (4.03 ± 0.38 D). Patients were divided into two groups: 1) control group (20 patients, 37 eyes) — postoperative therapy included the corneoprotector “Stilavit®” and the preparation of hyaluronic acid “Oksial®”, containing preservatives; 2) the study group (20 patients, 39 eyes) — postoperative therapy included the corneoprotector “Hilozar-comod®” and the artificial tear preparation “Hilo-comod®”, which did not contain reservatives. Ophthalmic examination included, in addition to standard diagnostic methods, the Norn test, the Schirmer test, the staining of the eye surface with lissamine green. In addition, a questionnaire was conducted on a modified OSDI questionnaire; there a section characterizing the quality of vision (section B) was removed.Results.The analysis of the obtained data showed that in the study group there was less pronounced “dry eye” syndrome at 3,6,12 months after the operation. The maximum difference in the indicators of the “dry eye” syndrome between the groups was at 3 and 6 months of the postoperative period. When evaluating corneal subepithelial fibroplasia, maximum attention was paid to the frequency and the intensity index. It was shown a significant difference in the intensity of the haze between the study group and the control group by 26.1 % at 3 months, by 62.2 % at 6 months and by 65.3 % 12 months after the operation. Conclusion.Nonconservative therapy with sodium hyaluronate and dexapanthenol in the early postoperative period and only sodium hydrolurate allows to reduce the severity of the dry eye syndrome after laser correction of hypermetropia and, as a result, to reduce the intensity of haze development by 65.3 %, and its frequency on 11,5 %.

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A new approach to the treatment of dry eye syndrome against the background of chronic peripheral uveitis

Modern technologies in ophtalmology ◽

10.25276/2312-4911-2021-2-154-157 ◽

2021 ◽

pp. 154-157

Author(s):

E.B. Tatarnikova ◽

◽

O.I. Krivosheina ◽

Keyword(s):

Conservative Treatment ◽

Dry Eye ◽

Comparison Group ◽

Anterior Segment ◽

Main Group ◽

Dry Eye Syndrome ◽

Laser Coagulation ◽

Complex Method ◽

Anti Inflammatory

Aim. To study the clinical and functional effectiveness of a complex method of treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus. Materials and methods. The study was performed among 98 patients who made up 2 follow-up groups: the main group (78 people) and the comparison group (20 people). All patients underwent OSDI questionnaires, visometry, pneumotonometry, biomicroscopy of the anterior segment of both eyes, binocular ophthalmoscopy with sclerocompression, and the Schirmer I test. In the main group, along with conservative treatment, laser coagulation of the extreme periphery of the retina was performed, in the comparison group - conservative treatment. The follow-up period was 3 months. Results and discussion. The use of a complex method of treatment of «dry eye» syndrome against the background of chronic peripheral uveitis significantly reduces the number of complaints according to the OSDI questionnaire, improves the condition of the eye surface (reducing the overhang of the conjunctival fold, the severity of «sluggish» hyperemia of the conjunctiva of the eyelids and transitional folds, reducing the amount of conjunctival discharge). The indicator of total tear production in the main group after 3 months. it increases by 1,5 times in comparison with the initial data, and in 100% of cases, stable relief of inflammation of the chorioretinal structures on the extreme periphery of the fundus is provided. Conclusion. A new effective method for the treatment of dry eye syndrome against the background of chronic peripheral uveitis, including local tear-replacement and anti-inflammatory therapy in combination with laser retinal coagulation on the extreme periphery of the fundus, has been developed and introduced into clinical practice. The use of this method provides stable clinical and functional results in the long-term period and can be recommended for the treatment of «dry eye» syndrome of mild to moderate severity against the background of chronic peripheral uveitis. Key words: dry eye syndrome, chronic peripheral uveitis, laser coagulation of the extreme periphery of the retina.

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Hialid®/Hyalein® (sodium hyaluronate) ophthalmic solution in dry eye syndrome: a profile of its use

Drugs & Therapy Perspectives ◽

10.1007/s40267-018-0540-0 ◽

2018 ◽

Vol 34 (9) ◽

pp. 405-410

Author(s):

Kate McKeage ◽

Katherine A. Lyseng-Williamson

Keyword(s):

Dry Eye ◽

Sodium Hyaluronate ◽

Ophthalmic Solution ◽

Dry Eye Syndrome

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A randomised, crossover, multicentre study to compare the performance of 0.1% (w/v) sodium hyaluronate with 1.4% (w/v) polyvinyl alcohol in the alleviation of symptoms associated with dry eye syndrome

Eye ◽

10.1038/sj.eye.6700169 ◽

2002 ◽

Vol 16 (5) ◽

pp. 601-607 ◽

Cited By ~ 44

Author(s):

C C McDonald ◽

S B Kaye ◽

F C Figueiredo ◽

G Macintosh ◽

C Lockett

Keyword(s):

Polyvinyl Alcohol ◽

Multicentre Study ◽

Dry Eye ◽

Sodium Hyaluronate ◽

Dry Eye Syndrome

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Comprehensive Treatment of Dry Eye Syndrome in Patients with Sjogren’s Syndrome by Using Preservative-Free Drops Containing 0.4 % Sodium Hyaluronate and a Complex of Nutraceuticals

International scientific-practical journal Ophthalmology ◽

10.30702/ophthalmology27082021-14.3.08-17/002.1-022 ◽

2021 ◽

pp. 8-17

Author(s):

Oleksandra V. Zborovska ◽

Ilijna S. Horyanova ◽

Victoria V. Kolesnichenko

Keyword(s):

Sjögren’S Syndrome ◽

Dry Eye ◽

Sjögren's Syndrome ◽

Sodium Hyaluronate ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Dry Eye Syndrome ◽

Comprehensive Treatment ◽

Preservative Free ◽

Sjögren‘S Syndrome

The aim. To increase the effectiveness of treatment of dry eye syndrome in patients with Sjogren’s syndrome with preservative-free drops which contain 0.4 % sodium hyaluronate and nutraceutical complexes nutraceuticals. Materials and methods. The study was conducted on the basis of the Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine. The study included 64 patients aged 34 to 58 years (128 eyes) with dry eye syndrome accompanied by Sjogren’s syndrome. Examination of patients included: assessment of complaints, visometry, refractometry, bacterial culture of the conjunctiva and nasopharynx, biomicroscopy, ophthalmoscopy, Schirmer and Norn tests, assessment of "comfort of application of drops" on the questionnaire. This study is an extension of the study previously conducted at the premises of the Filatov Institute of Eye Diseases and Tissue Therapy of The National Academy of Medical Sciences of Ukraine on the effectiveness of preservative-free eye drops containing 0.4 % hyaluronic acid in the treatment of Sjogren’s syndrome. Results. Prior to the appointment of comprehensive treatment with instillations, the Norn test showed 6.55 s (SD 1.57) with a minimum of 3 s, a maximum of 9 s, and a median of 6.5 s. After 3 months of treatment the Norn test score in the 1st group averaged 14.66 (SD 1.07) vs. 13.86 (SD 1.07) in the 2nd group, but the difference was not statistically significant (p=1.0). The mean number of required instillations per day was 4.1 (SD 1.04) in the 1st group and 5.27 (SD 1.11) in the 2nd group. Conclusion. Instillations of preservative-free drops containing sodium hyaluronate 0.4 % (in a bottle with an innovative ophthalmic squeeze dispenser (OSD)) in combination with a nutraceutical complex in the treatment of dry eye syndrome in patients with Sjogren’s syndrome is effective and allows achieving a stable and long-term effect. Keywords: Sjogren’s syndrome, hyaluronic acid, nutraceuticals, artificial tear, Schirmer test, Norn test, dry eye syndrome, tear film.

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