scholarly journals Non-Conservative Therapy in the Prevention of Subepithelial Fibroplasia after LASEK Hypermetropia Correction

2018 ◽  
Vol 15 (2) ◽  
pp. 200-206
Author(s):  
S. A. Korotkikh ◽  
A. E. Bogachev ◽  
A. S. Shamkin
Keyword(s):  
Dry Eye ◽  
Postoperative Period ◽  
Sodium Hyaluronate ◽  
Early Postoperative Period ◽  
Diagnostic Methods ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Study Group ◽  
Postoperative Therapy ◽  
Significant Difference

The results of observation of patients who underwent vision eximerlaser correction by the LASEK method regarding medium degree of hyperopia were analyzed.Purpose:to investigate the severity of the «dry eye» syndrome and corneal subepithelial fibroplasia in patients after laser correction of  hyperopia by the LASEK method, and their prevention by reducing  the preservative action on the eye surface.Patients and methods.The study included 40 patients (76 eyes), aged 21–46 years (32.98 ± 1.79) who underwent LASEK surgery for  moderate hyperopia (4.03 ± 0.38 D). Patients were divided into two  groups: 1) control group (20 patients, 37 eyes) — postoperative  therapy included the corneoprotector “Stilavit®” and the preparation  of hyaluronic acid “Oksial®”, containing preservatives;  2) the study group (20 patients, 39 eyes) — postoperative therapy  included the corneoprotector “Hilozar-comod®” and the artificial tear  preparation “Hilo-comod®”, which did not contain reservatives. Ophthalmic examination included, in addition to standard diagnostic  methods, the Norn test, the Schirmer test, the staining of the eye  surface with lissamine green. In addition, a questionnaire was  conducted on a modified OSDI questionnaire; there a section  characterizing the quality of vision (section B) was removed.Results.The analysis of the obtained data showed that in the study group there was less pronounced “dry eye” syndrome at 3,6,12  months after the operation. The maximum difference in the  indicators of the “dry eye” syndrome between the groups was at 3  and 6 months of the postoperative period. When evaluating corneal  subepithelial fibroplasia, maximum attention was paid to the  frequency and the intensity index. It was shown a significant  difference in the intensity of the haze between the study group and the control group by 26.1 % at 3 months, by 62.2 % at 6  months and by 65.3 % 12 months after the operation. Conclusion.Nonconservative therapy with sodium hyaluronate and  dexapanthenol in the early postoperative period and only sodium  hydrolurate allows to reduce the severity of the dry eye syndrome  after laser correction of hypermetropia and, as a result, to reduce  the intensity of haze development by 65.3 %, and its frequency on 11,5 %.

scholarly journals Tear Film Osmolarity of the Eye after Cataract Surgery. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Ēriks Elksnis ◽  
Keyword(s):  
Cataract Surgery ◽  
Postoperative Period ◽  
Ocular Surface ◽  
Tear Film ◽  
Visual Outcome ◽  
Early Postoperative Period ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Almost every cataract surgeon has encountered a situation during the postoperative period when, even though, the primary goal – improvement of visual acuity – has been achieved, yet the patient felt frustrated because of subjective discomfort in the operated eye. Sometimes this issue is more disturbing for the patient than the hope for a perfect visual outcome. Although it has been established that the ocular surface is affected during the postoperative period, there is still no generally accepted opinion about the changes in tear osmolarity after cataract surgery despite several studies dedicated to evaluation of these changes. The present study was designed to elucidate the effect of cataract surgery on the characteristic feature of ocular surface homeostasis – tear film osmolarity in the early postoperative period. Aim. The aim of the study was to evaluate the changes in tear film osmolarity after a cataract surgery in a healthy ocular surface. Methods. For this purpose two examination groups were formed. The study group included voluntary patients undergoing cataract surgery not having any complaints about subjective symptoms typical of dry eye disease. In order to correspond to the criteria of healthy ocular surface, the study group excludes the following types of patients and conditions: contact lens wearers, patients with diabetes, pseudoexfoliation, pterygia and eye drop users. The eye that has not undergone the surgery was classified as the control group. This single–center, prospective study was held at Ophthalmology department of Pauls Stradins Clinical university hospital. All cataract surgeries were done by the same surgeon. The tear osmolarity tests were evaluated with TearLab Osmolarity System (TearLab Corporation, San Diego, CA, the USA) before surgery, in the next morning, one week and one month after the surgery. Results. No statistically significant difference was observed between the groups before operation when comparing the mean tear osmolarity – in the study group it was 296.87 mOsm/L, and in the control group it was 297.27 mOsm/L (p = 0.84). The tear osmolarity results changed significantly during early postoperative period in the study group (p < 0.001), while in non–operated eye no significant tear film osmolarity changes were observed (p = 0.86). Significant changes were recognized on the next day after the surgery – the tears became hypoosmolar (< 275 mOsm/L). One week later the tear osmolarity increased significantly, and the tears became hyperosmolar (312.64 mOsm/L). Over the course of one month, the test values for the study and control groups equalized (297.87 in the study group and 298.93 in the control group (p = 0.66)), when compared to preoperative tear osmolarity results. Conclusion. The results achieved lead towards a more detailed understanding of the changes in the ocular surface homeostasis after a cataract surgery. The obtained data indicate that tear osmolarity changes considerably during the first postoperative month after a cataract surgery. Also, there is a huge difference in measurements between operated and non–operated eye on the next day and one week after the surgery. One month after the surgery tear osmolarity returns to preoperative test results, and there is no difference determined between the eyes.

Optimization of postoperative management of patients undergoing functional endoscopic sinus surgery

2018 ◽  
pp. 26-31
Author(s):  
Sergey Bezshapochny ◽  
Andrey Loburets ◽  
Valery Loburets
Keyword(s):  
Nasal Cavity ◽  
Postoperative Period ◽  
Sodium Hyaluronate ◽  
Sinus Surgery ◽  
Control Group ◽  
Nasal Breathing ◽  
Traditional Therapy ◽  
Significant Difference ◽  
Water Salt ◽  
Experimental Group

Topicality: The result of surgical treatment depends largely on the chosen method of management of the postoperative period, the main purpose of which is to reduce the effects of surgical trauma. Despite the wide variety of drugs for local and systemic use, the question of pharmacotherapy of the operated sinus remains open to this day. The main properties that a modern drug should possess are safety and high clinical efficacy. Aim: to study the clinical efficacy of topical application of a complex preparation based on a saline solution containing sodium hyaluronate and dexpanthenol in patients with chronic sinusitis after functional endoscopic sinus surgery (FESS). Materials and Methods: Clinical and laboratory studies were conducted on 47 patients with chronic rhinosinusitis who underwent surgery using the FESS technique. Patients were divided into 2 groups according to the principle of the postoperative period. Patients of research group (n=21), except for traditional therapy, was used locally NASOMER (a preparation based on a water-salt solution containing sodium hyaluronate and dexpanthenol); to the control group (n=26) patients entered, in the postoperative period received traditional therapy. Traditional therapy included a toilet of the nasal cavity, the use of short-course topical decongestants, irrigation of the nasal cavity with water-salt solutions. Criteria of clinical effectiveness: data of endoscopy of the nasal cavity, rhinomanometry, activity of the mucociliary transport system. The effectiveness of functional research methods in the postoperative period was determined on the 7th and 14th day of treatment. Results: On the 3rd day of the study, an increase in the swelling of the nasal cavity was observed in patients of both clinical groups, correlated with difficulty in nasal breathing. On the 7th day, a decrease in edema was observed in patients of both groups, but in the experimental group, the index of nasal breathing, according to rhinomanometry, was significantly (p<0.05) different from the control group, and was respectively 1.54±0.14 and 2.04±0.19 kPa/l*s. On the 14th day of the study, no significant difference was observed between these indicators. When studying the activity of the ciliated epithelium of the mucous membrane of the nasal cavity, it was proved that patients of the experimental group on day 7 after surgery showed a statistically significant difference in this indicator compared to the control group (17.8±1.0 and 22.7±2.1 min. respectively). Conclusions: The use of NASOMER after surgical intervention in patients with chronic rhinosinusitis contributes to more effective treatment compared with traditional therapy, as evidenced by the rapid recovery of the main functional parameters according to active posterior rhinomanometry and mucociliary clearance. Based on the results of the studies performed, the use of NASOMER for pharmacotherapy in the postoperative period is recommended for patients who have undergone rhinosurgical interventions with the aim of reducing the period of postoperative rehabilitation as an effective anti-inflammatory and wound-healing agent.

scholarly journals Usage of 0.4% sodium hyaluronate in complex treatment of pediatric patients with dry eye syndrome against the background of allergic diseases of the organ of vision

2021 ◽  
Vol 9 (2) ◽  
pp. 21-24
Author(s):  
L.S. Vasilyeva ◽  
O.V. Nesterenko ◽  
K.A. Rylkova
Keyword(s):  
Anterior Chamber ◽  
Dry Eye ◽  
Pediatric Patients ◽  
Sodium Hyaluronate ◽  
Allergic Diseases ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Film Rupture ◽  
Topical Glucocorticoids

Background. In recent years, the prevalence of allergic diseases of the anterior chamber of the eye has increased. They are often accompanied by the development of dry eye syndrome, which can complicate their course. Therefore, it is important to take a comprehensive approach to their diagnosis and treatment. The purpose was to study the effectiveness of 0.4% sodium hyaluronate (Gilays) in children with dry eye syndrome on the background of allergic diseases of the conjunctiva. Materials and methods. The study involved 42 patients (84 eyes) aged 3 to 18 years, who were examined and treated on the basis of Regional Eye Clinic. Patients were treated with local H-1 histamine blockers twice a day for 14 days, f necessary — with topical glucocorticoids by the scheme for 12 days. In the first group (21 patients, 42 eyes), the main treatment was added with the drugs containing 0.2% sodium hyaluronate, used topically 4 times a day for 14 days. In the second group (21 patients/42 eyes), 0.4% sodium hyaluronate (Gilays) was added to the treatment regimen. H-1 histamine blockers were not used systemically. Before starting therapy and 2 weeks later, the following values were evaluated: the changes in the anterior chamber of the eye using biomicroscopy, determination of lacrimal film rupture time, Schirmer 1 test, questionnaire. Conclusions. The use of sodium hyaluronate in the complex therapy of dry eye syndrome in allergic eye diseases is quite effective. The use of 0.4% sodium hyaluronate was more effective compared to the control group. It is advisable to use a questionnaire to communicate with the child, but it is necessary to refine the form of questions to eliminate as much as possible the subjectivity of the data.

Comparative analysis of incidence of dry eye syndrome after ReLEx SMILE and FemtoLASIK keratorefractive surgeries

2021 ◽  
pp. 192-196
Author(s):  
A.D. Pilipenko ◽  
◽  
R.A. Burya ◽  
A.V. Romanova ◽  
E.L. Sorokin ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Refractive Surgery ◽  
Photorefractive Effect ◽  
Study Groups ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Significant Difference ◽  
Negative Effect ◽  
Breakup Time

The main factor in pathogenesis of postoperative dry eye syndrome (DES) is damage to subbasal nerve plexus and stromal nerve endings. Taking into account the different principles of photorefractive effect on cornea of FemtoLASIK and ReLEx SMILE technologies, we decided on our own clinical experience to evaluate incidence of this undesirable complication. Purpose. Comparative study of frequency and timing of relief of postoperative DES after FemtoLASIK and ReLEx SMILE in patients with myopia. Material and methods. The study involved 32 patients (64 eyes) with varying degrees of myopia. The patients were divided into 2 groups: 1st group - 17 patients (34 eyes) after FemtoLASIK surgery, 2nd group - 15 people (30 eyes) after ReLEx SMILE procedure. Control group consist of 15 patients with comparable myopia who had not undergone refractive surgery was also observed. Patients underwent an assessment of the OSDI index, Norn and Schirmer tests, as well as degree of staining of anterior ocular surface 1, 6 and 12 months after refractive surgery. Results. There was statistically significant difference in total tear production, in tear breakup time (TBUT) and in the OSDI index between study groups 1 month after surgery in favor of ReLEx SMILE procedure. After 6 months, TBUT after FemtoLASIK significantly differed from control values. 12 months after surgery, studied parameters did not differ significantly from control. Conclusion. According to our datas, ReLEx SMILE procedure has lower negative effect on ocular surface compared to FemtoLASIK technique, which is manifested by less pronounced subjective symptoms of DES, as well as their faster relief. Key words: dry eye syndrome, ReLEx SMILE, FemtoLASIK.

A Clinical Study of Acupuncture and SSP (Silver Spike Point) Electro-therapy for Dry Eye Syndrome

2006 ◽  
Vol 34 (02) ◽  
pp. 197-206 ◽  
Author(s):  
Kuo-Lieh Tseng ◽  
Hsu-Jan Liu ◽  
Kam-Yuen Tso ◽  
Lin-Chung Woung ◽  
Yi-Chang Su ◽  
...  
Keyword(s):  
Dry Eye ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Artificial Tears ◽  
Schirmer Test ◽  
Analog Scale ◽  
Treatment Groups ◽  
Significant Difference ◽  
Before And After ◽  
The Right

The present study was designed as a clinical trial to assess the efficacy of acupuncture and silver spike point (SSP) electro-therapy on dry eye syndrome. A total of 43 dry eye syndrome patients participated in the present study. Subjects were divided into control, acupuncture and SSP electro-therapy groups. The three groups were all given artificial tears treatment. Patients in the treatment groups were given two 20-minute treatments of either acupuncture or SSP. Assessment was carried out using the Basal Schirmer test, tear break-up time (BUT), visual analog scale (VAS) and an overall score of eye condition. After four weeks of treatment, both the acupuncture and SSP treatment groups showed improvements over the control group, in Schirmer tests of the left eye and average tearing of both eyes. After 8 weeks of treatment, both treatment groups showed improvements over the control group both in Schirmer tests and VAS. For the right eye, treatment groups showed significant improvements in Schirmer test and VAS versus the control group averages for both eyes. There was no significant difference in BUT at any time. Comparing scores before and after treatment, the acupuncture and SSP groups showed a significant improvement compared to the control group. The acupuncture group showed a greater 8-week improvement in Schirmer tests scores compared to the SSP group. However, the SSP group patients used fewer applications of artificial tears. Acupuncture and SSP electro-therapy were effective in increasing tear secretion in patients with dry eye syndrome. The SSP electro-therapy not only alleviated dry eye syndrome, but also reduced the number of applications of artificial tears necessary.

scholarly journals The possibility of using skeletal muscle electrical stimulation in the rehabilitation of patients after cardiac surgery

2020 ◽  
Vol 8 (4S) ◽  
pp. 70-81
Author(s):  
A. N. Sumin ◽  
P. A. Oleynik ◽  
A. V. Bezdenejnykh
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Period ◽  
Clinical Status ◽  
Early Postoperative Period ◽  
Muscle Performance ◽  
Control Group ◽  
Study Group ◽  
Six Minute Walk Test ◽  
Lower Extremity Muscle ◽  
Minute Walk

Aim. To evaluate the effectiveness of electrical muscle stimulation (EMS) in patients with the complicated early postoperative period after cardiac surgery.Methods. 61 patients (44 men and 17 women) aged 52-70 years with the complicated early postoperative period after cardiac surgery were included in the study. The complications included prolonged length of stay in the intensive care unit and prolonged mechanical ventilation. The initial muscle performance of the lower extremities was measured with the carpal and isokinetic dynamometer in all patients. The six-minute walk test was performed in all patients after they had been transferred to the department of cardiac surgery.Results. Patients in the study group had reduced lower extremity muscle strength at baseline, compared with the control group. After the EMS sessions, the study group patients demonstrated pronounced improvements in muscle performance as compared to the control group. Both knee-joint extension values increased during the isometric contraction as compared to those in the control group (38.8% and 40.0% versus 8.1% and 8.4%, p <0.001), similarly to right knee-joint flexion (23.7% versus 10.1%, p = 0.008), left ankle joint (18.6 versus 4.3%, p = 0.010), right-hand grip strength (18.3 versus 11.1%, p = 0.042). In addition, the six-minute walk test results improved in the EMS group (119.72% (293 meters) and 87.13% (315 meters)) as compared to the control group (p = 0.079).Conclusion. The EMS sessions did not affect the clinical status of cardiac surgical patients with the complicated postoperative period. Moreover, it appeared to be beneficial in terms of the improved lower extremity muscle strength that was more pronounced in the study group than in the control group. Therefore, the effects of EMS on the clinical status of these patients require the further investigation.

Evaluation of the intraoperative monitoring effectiveness during intramedullary tumors surgery in the early postoperative period

2015 ◽  
Vol 9 (2) ◽  
pp. 0-0
Author(s):  
Федин ◽  
P. Fedin ◽  
Шахпаронова ◽  
N. Shakhparonova ◽  
Гуща ◽  
...  
Keyword(s):  
Postoperative Period ◽  
Intraoperative Monitoring ◽  
Early Postoperative Period ◽  
Activity Level ◽  
Successful Outcome ◽  
Control Group ◽  
Study Group ◽  
Motor Score ◽  
Preoperative Level ◽  
Intramedullary Tumors

Purpose: On the grounds of comprehensive assessment of the 2 groups of patients after intramedullary tumors surgery compare a neurological outcome in the early postoperative period. The first group was operated with intraoperative monitoring and the second group was operated before the introduction of neurophysiological control. During the monitoring try to identify predictors of successful outcome for patients after intramedullary tumors surgery. The study included 48 patients with intramedullary tumors of cervical and thoracic localization. Complex neurological examination was performed before surgery and 2 weeks after surgery and included: as-sessment of neurological status on McCormick Scale, functional outcome rated on SCIM III Scale, the total mobility was evaluated on Rivermid Index mobility and paresis we rated on the ASIA Motor Score scale. The study group consisted of 26 patients operated with intraoperative monitoring and control group consisted of 22 patients operated before the introduction of intraoperative monitoring in neurosurgical practice. The trial comprised patients with a functional status I-III rated on McCormick Scale. After assessing the 2 groups according the SCIM III scale it was found out the persistence of the level in the study group (p=0,044) and a decrease of the final score in the control group. Comparing the activity level on a Rivermid scale we identified improvement in the study group (р=0,034) and retention of activity in the control group. We detected that in the study group where we used intraoperative monitoring, the level of paresis accord-ing to ASIA Motor Score preserve at the preoperative level, and the growth of paresis level in the control group (p&#60;0,05). Preservation of MEP amplitude &#62; 50% at the end of the operation is a predictor of saving muscle strength at the preoperative level. Patients, who underwent surgery with the use of intraoperative monitoring are more active and indepen-dent from outside help in the early postoperative period.

Comparative Analysis of Magnetic Resonance Imaging and X-ray Examination on Knee Degenerative Osteoarthrosis

2019 ◽  
Vol 9 (8) ◽  
pp. 1760-1764
Author(s):  
Siyu Liu ◽  
Yuan Gao ◽  
Yu Liu ◽  
Jiabing Xiang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Soft Tissue ◽  
Detection Rate ◽  
Diagnostic Methods ◽  
Control Group ◽  
Study Group ◽  
Resonance Imaging ◽  
X Ray ◽  
Significant Difference

Objective: To compare the diagnostic effect of magnetic resonance imaging (MRI) and X-ray in degenerative osteoarthritis of knee joint. Methods: 107 patients with degenerative osteoarthrosis of the knee were selected as study subjects. They were divided into study group (53 cases) and control group (54 cases) according to different diagnostic methods. The study group underwent MRI examination for diagnosis, and the control group underwent X-ray examination for diagnosis. The diagnostic criteria of arthroscopic surgery were used as the gold standard to compare the diagnostic accuracy of patients with knee degenerative osteoarthrosis. Result: There was no significant difference in the detection rate of joint space stenosis and bone hyperplasia between the two groups (P > 0.05). Compared with the control group, the positive rate of synovial thickening, soft tissue swelling and meniscus degeneration was higher in the study group, and the difference was statistically significant (P < 0.05). Discussion: The progression of knee degenerative osteoarthrosis is very slow, and the clinical symptoms are not specific and inconspicuous. Especially in the early stage, knee cartilage injury and degeneration are not obvious. X-ray examination is used to diagnose the misdiagnosis. The rate is relatively high, and MRI, as a non-invasive examination method, has the advantages of high tissue resolution, multiazimuth imaging and multi-parameter imaging, which can clearly show the knee meniscus, articular cartilage, bone, ligament and other soft tissue injuries. The diagnosis is remarkable. Conclusion: The application of MRI in the diagnosis of degenerative osteoarthrosis of the knee is significant, which can further improve the diagnostic detection rate, and it is worthy of promotion and application in the diagnosis.

scholarly journals Comparative analysis of treatment of patients with chronic dacryocystitis in early and late postoperative periods

2021 ◽  
pp. 20-32
Author(s):  
Oleksii O. Minaiev
Keyword(s):  
Postoperative Period ◽  
Early Postoperative Period ◽  
Small Sample ◽  
Lower Percentage ◽  
Control Group ◽  
Endoscopic Dacryocystorhinostomy ◽  
Chronic Dacryocystitis ◽  
Significant Difference ◽  
The Difference ◽  
Late Postoperative Period

Chronic dacryocystitis (CD) is a common pathology of the lacrimal ducts. The search for the optimal method of endonasal endoscopic dacryocystorhinostomy (EEDCR), which would give a quick, high-quality and lasting effect, as well as a lower percentage of disease relapses, remains relevant. The aim: to analyze the effectiveness of treatment of patients with chronic dacryocystitis in the early and late postoperative periods with the use of various modifications of EEDCR. Materials and methods: The study group (1st group) consisted of 45 patients with CD, who underwent EED-CR according to the developed method, the comparison group (2nd group) included 36 patients who, after performing the developed EEDCRa polyvinyl chloride (PVC) conductor was installed in the area of the dacryorhinostoma. The control group (3rd group) included 28 patients who underwent EEDCR according to the generally accepted method: with preservation and plastic placement of mucous flaps and with the installation of a PVC conductor. Patients of 1stand 2nd groups were divided into 2 subgroups: 1A and 2A included patients who underwent computed tomography of the lacrimal ducts in the preoperative period according to the developed method, and patients of subgroups 1B and 2B – according to the traditional algorithm. In the postoperative period, the severity of lacrimation was assessed according to the Munk scale, the degree of visualization of the dacryorhinostoma was determined, and the lacrimal function was investigated by advanced West nasolacrimal test under endoscopic control. The final treatment efficacy was assessed 1 year after surgery. Results: The best results when tested according to the Munk scale were recorded in subgroups 1A and 1B with a statistically significant difference from subgroups 2A, 2B and 3rd group throughout the early postoperative period and 1 month after surgery (p<0.05).During the observation period of 3, 6 and 12 months, that is, after the removal of the implant from the lacrimal ducts, there was an improvement in the results in patients of subgroups 2A, 2B and 3rd group, and the difference from subgroups 1A and 1B was statistically insignificant (p>0.05).In the early postoperative period, visualization of the dacryorhinostoma was good in all patients. In the late postoperative period, the best results were in subgroup 1A, the worst in 3rd group, but without a statistically significant difference due to a small sample of patients (p>0.05).Reliably better results of the lacrimal function were obtained in subgroups 1A and 1B already from the 3rd day after surgery, as well as in the subsequent periods of the early postoperative period and 1 month after surgery (p<0.05).In subsequent periods of the late postoperative period, this indicator worsened in all clinical groups, the best results were in subgroup 1A, the worst in 3rd group, but due to a small sample of patients, there was no statistically significant difference (p>0.05).The maximum paces of deterioration in visualization of dacryorhinostoma and lacrimal function were observed from the 3rd to 6th months after the operation. The proportion of positive treatment results in 1st group was 97.8%, in 2nd group – 94.4%, and in 3rd group – 85.7%, while the difference between groups 1 and 3 was statistically significant (p<0,05). Conclusions: The developed technique of endonasal endoscopic dacryocystorhinostomy allows achieving stable remission in 97.8% of patients with chronic dacryocystitis, and the use of CT of the lacrimal ducts according to the developed technique allows to improve the results of surgical treatment.

scholarly journals Trehalose efficacy in dry eye syndrome treatment after phacoemulsification

2016 ◽  
Vol 9 (4) ◽  
pp. 79-89 ◽  
Author(s):  
Sergey Yu Astakhov ◽  
Natalia V Tkachenko
Keyword(s):  
Dry Eye ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Conjunctival Hyperemia ◽  
Special Investigation ◽  
Postoperative Therapy ◽  
Treatment Tolerance ◽  
Confocal Tomography ◽  
Test Result

Purpose to estimate the efficacy of “artificial tear” preparation on the trehalose base in dry eye syndrome treatment in cataract patients after phacoemulsification.Materials and methods: in 40 patients with incipient cataract phacoemulsification with IOL implantation was performed. During 1 week, all patients received eye gel with dexpanthenol in addition to postoperative therapy. Then, all patients were divided into two groups (randomization using envelopes): in the main group, the gel was replaced by Thealoz®, in the control group, the gel was discontinued. Special investigation tests (OSDI score, TBUT test, conjunctival hyperemia, corneal confocal tomography) were performed before surgery, in one week and one month after it. Statistical analysis was performed using SAS 9.4 program.Results: all investigated parameters had significant differences with time and between groups (р < 0.001). TBUT test result decreased in one week after surgery from 7.4 ± 2.1 to 4.6 ± 1.9 sec in the main group and from 7.5 ± 2.3 to 4.4 ± 2 sec in the control group. Return to baseline results in the control group was slowed down and made 6.4 ± 2.8 sec (compared with 7.9 ± 2.4 sec in the main one). In the trehalose group, OSDI score ameliorated from 35.1 ± 8.7 (in one week) to 14.2 ± 5.3 (in one month), in the control group, from 40.1 ± 11.5 to 24.8 ± 9. Conjunctival hyperemia was also less pronounced in the main group in one month after surgery: 0.45 ± 0.6 (1.6 ± 0.7 in one week), in the control group, these indices were equal to 1.7 ± 0.5 (in one week) and 1.3 ± 0.7 (in one month).Conclusions: Thealoz® use as a part of combined postoperative therapy helps to effectively fight against dry eye syndrome main signs and enhances treatment tolerance.

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