scholarly journals Morphological, functional and structural changes in red blood cells of type 2 diabetes patients with proliferative diabetic retinopathy and different diabetes duration

2021 ◽  
Vol 94 (5) ◽  
pp. 21-27
Author(s):  
V. M. Hanyuk ◽  
◽  
O. V. Petrenko ◽  
L. V. Natrus ◽  
O. I. Prusak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Red Blood Cells ◽  
Proliferative Diabetic Retinopathy ◽  
Blood Cells ◽  
Structural Changes ◽  
Diabetes Duration ◽  
Diabetes Patients

scholarly journals National Eye Institute Visual Function Scale in Type 2 Diabetes Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Sezen Akkaya ◽  
Sinay Düzova ◽  
Özlem Şahin ◽  
Haluk Kazokoğlu ◽  
Tayfun Bavbek
Keyword(s):  
Type 2 Diabetes ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Diabetes Duration ◽  
Ophthalmological Examination ◽  
Near Vision ◽  
Snellen Visual Acuity ◽  
Clinically Significant ◽  
Diabetes Patients

Aim. To examine subscale and total scores of NEI-VFQ questionnaire of type 2 diabetes patients at different diabetic retinopathy (DRP) stages.Methods. A total number of 201 patients have been included. Prior to ophthalmological examination all patients participated in the NEI-VFQ questionnaire. The patients were divided into 5 groups according to the International Clinical Diabetic Retinopathy Disease Severity Scale (ICDRS).Results. The diabetes duration in general health scores (p=0.029); the stage (p=0.011); and clinically significant macular edema (CSME) (p=0.019) in general vision were found to be the most efficient factors. In near vision activities the most efficient factors were near vision acuity (NVA) (p=0.0001) and DRP stage (p=0.020). EDTRS visual acuity was found to be the most efficient factor in vision specific role difficulties (p=0.034) and dependency (p=0.011) whereas Snellen visual acuity was found to be among the most effective factors in distance activities (DA) (p=0.014) and total scores (p=0.026).Discussion. Difference was based not on the diabetes duration, clinically significant cataract (CSCat), CSME presence, and DRP stage but on thevisual acuitylevels of the better seeing eye of the patients.

scholarly journals Risk Factors For Diabetic Retinopathy Progression

2015 ◽  
Vol 22 (2) ◽  
pp. 159-165
Author(s):  
Mónika Deák ◽  
Monica Lasca ◽  
Ioan Andrei Vereşiu
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Smoking Status ◽  
Diabetes Duration ◽  
Diabetes Diagnosis ◽  
Number Of Patients

AbstractBackground and Aims. There is no unanimous opinion regarding the risk factors associated with progression of diabetic retinopathy (DR). We have done a retrospective analysis of risk factors and clinical features associated with DR progression.Material and Methods. This analysis included consecutive patients with moderate non-proliferative or severe retinopathy between December 1, 2013 and May 31, 2014 who had at least two eye examinations before that period. We have collected demographic, clinical and lab data.Results. 51.28% of patients were diagnosed with moderate non-proliferative diabetic retinopathy (NPDR), 24.68% with severe NPDR and 21.05% with proliferative diabetic retinopathy. In 82.16% of cases, DR had progressed. The risk factor correlated with DR progression in the whole group was anemia; hypertension, anemia and diabetes duration were risk factors in type 1 and smoking status at diabetes diagnosis in type 2 diabetes. Total cholesterol, triglycerides, diabetes control and presence of diabetic renal disease were positively but not statistically significant correlated with DR progression.Conclusions. In our study the risk factors correlated with DR progression were hypertension, anemia and diabetes duration in type 1, respectively smoking at diabetes diagnosis in type 2 diabetes. Glycemic goals were achieved in a small number of patients.

scholarly journals Development and Progression of Diabetic Retinopathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study

2021 ◽  
Author(s):  
Rose Gubitosi-Klug ◽  
Ingrid Libman ◽  
Kimberly L. Drews ◽  
Diane Uschner ◽  
Barbara A. Blodi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Treatment Options ◽  
Diabetes Duration ◽  
Fundus Photography ◽  
Dominant Factor ◽  
Fundus Photographs ◽  
Design And Methods

<p><b>Objective</b>: The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial reported a 13.9% prevalence of diabetic retinopathy (DR) in youth with an average 4.9 ± 1.5 years of type 2 diabetes duration. After seven years of additional follow up, we report the risk factors for progression of DR in the TODAY cohort. </p> <p><b>Research Design and Methods</b>: Retinal photographs (n = 517) were obtained in 2010-2011 and again in 2017-18 (n = 420) with seven standard stereoscopic field digital fundus photography. Photographs were graded centrally using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Three hundred sixty-seven patients with gradable fundus photographs in at least one eye at both assessments were included in analyses of progression of diabetic retinopathy, defined as an increase of three or more steps on the ETDRS scale.</p> <p><b>Results</b>: With mean age of 25.4 ± 2.5 years and diabetes duration of 12.0 ± 1.5 years, participants had a 49% prevalence of any diabetic retinopathy. Prevalence by DR stage included: 39% very mild or mild non-proliferative diabetic retinopathy (NPDR); 6% moderate to severe NPDR; and 3.8% proliferative diabetic retinopathy. Compared with non-progressors, participants who progressed three or more steps had significantly lower BMI, higher HbA1c, higher blood pressure, increased triglycerides, decreased C-peptide, and higher prevalence of other comorbidities. Multivariate analysis demonstrated that HbA1c was the dominant factor impacting DR progression.</p> <p><b>Conclusions</b>: Poor glycemic control of youth-onset type 2 diabetes imparts a high risk for progression of DR, including advanced, sight-threatening disease by young adulthood. <b><u></u></b></p>

scholarly journals Erythrocyte caspase-3 and antioxidant defense is activated in red blood cells and plasma of type 2 diabetes patients at first clinical onset

Redox Report ◽  
2013 ◽  
Vol 18 (2) ◽  
pp. 56-62 ◽  
Author(s):  
Octavian Savu ◽  
Ovidiu Marius Bradescu ◽  
Cristian Serafinceanu ◽  
Liviu Iosif ◽  
Constantin Ionescu Tirgoviste ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Antioxidant Defense ◽  
Caspase 3 ◽  
Clinical Onset ◽  
Diabetes Patients

scholarly journals Development and Progression of Diabetic Retinopathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study

2021 ◽  
Author(s):  
Rose Gubitosi-Klug ◽  
Ingrid Libman ◽  
Kimberly L. Drews ◽  
Diane Uschner ◽  
Barbara A. Blodi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Treatment Options ◽  
Diabetes Duration ◽  
Fundus Photography ◽  
Dominant Factor ◽  
Fundus Photographs ◽  
Design And Methods

<p><b>Objective</b>: The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial reported a 13.9% prevalence of diabetic retinopathy (DR) in youth with an average 4.9 ± 1.5 years of type 2 diabetes duration. After seven years of additional follow up, we report the risk factors for progression of DR in the TODAY cohort. </p> <p><b>Research Design and Methods</b>: Retinal photographs (n = 517) were obtained in 2010-2011 and again in 2017-18 (n = 420) with seven standard stereoscopic field digital fundus photography. Photographs were graded centrally using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale. Three hundred sixty-seven patients with gradable fundus photographs in at least one eye at both assessments were included in analyses of progression of diabetic retinopathy, defined as an increase of three or more steps on the ETDRS scale.</p> <p><b>Results</b>: With mean age of 25.4 ± 2.5 years and diabetes duration of 12.0 ± 1.5 years, participants had a 49% prevalence of any diabetic retinopathy. Prevalence by DR stage included: 39% very mild or mild non-proliferative diabetic retinopathy (NPDR); 6% moderate to severe NPDR; and 3.8% proliferative diabetic retinopathy. Compared with non-progressors, participants who progressed three or more steps had significantly lower BMI, higher HbA1c, higher blood pressure, increased triglycerides, decreased C-peptide, and higher prevalence of other comorbidities. Multivariate analysis demonstrated that HbA1c was the dominant factor impacting DR progression.</p> <p><b>Conclusions</b>: Poor glycemic control of youth-onset type 2 diabetes imparts a high risk for progression of DR, including advanced, sight-threatening disease by young adulthood. <b><u></u></b></p>

A hemochromatosis-causing mutation C282Y is a risk factor for proliferative diabetic retinopathy in Caucasians with type 2 diabetes

2004 ◽  
Vol 137 (6) ◽  
pp. 1171-1172
Author(s):  
B. Peterlin ◽  
M. Globočnik Petrovič ◽  
J. Makuc ◽  
M. Hawlina ◽  
D. Petrovič
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Risk Factor ◽  
Proliferative Diabetic Retinopathy

scholarly journals Correction: Prevalence and Progression Rate of Diabetic Retinopathy in Type 2 Diabetes Patients in Correlation with the Duration of Diabetes

2018 ◽  
Vol 126 (09) ◽  
pp. e2-e2
Author(s):  
Margarete Voigt ◽  
Sebastian Schmidt ◽  
Thomas Lehmann ◽  
Benjamin Köhler ◽  
Christof Kloos ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Progression Rate ◽  
Duration Of Diabetes ◽  
Diabetes Patients

scholarly journals Serum levels of mac-2 binding protein are associated with diabetic microangiopathy and macroangiopathy in people with type 2 diabetes

2020 ◽  
Vol 8 (1) ◽  
pp. e001189
Author(s):  
Yoshitaka Hashimoto ◽  
Masahide Hamaguchi ◽  
Ayumi Kaji ◽  
Ryosuke Sakai ◽  
Noriyuki Kitagawa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Liver Fibrosis ◽  
Proliferative Diabetic Retinopathy ◽  
Binding Protein ◽  
Protein Glycosylation ◽  
Diabetic Microangiopathy ◽  
Alcoholic Fatty Liver ◽  
Increased Risk

IntroductionNon-alcoholic fatty liver disease is reportedly associated with type 2 diabetes and progressive liver fibrosis, as evaluated by transient elastography, and has been linked with micro- and macroangiopathy in people with type 2 diabetes. The purpose of this cross-sectional study was to investigate the association between serum mac-2 binding protein glycosylation isomer (M2BPGi) levels and diabetic complications in people with type 2 diabetes.Research design and methodsSerum M2BPGi levels were measured in terms of cut-off index (C.O.I.) units. Urinary albumin excretion (UAE) was calculated and nephropathy was graded as normoalbuminuria, microalbuminuria, or macroalbuminuria. Retinopathy was divided into three groups: no-diabetic retinopathy (NoDR), non-proliferative-diabetic retinopathy (NPDR), or proliferative-diabetic retinopathy (PDR) .ResultsThe mean age for the 363 studied subjects (212 males) was 66.4±10.6 years, the median serum M2BPGi level was 0.77 (0.57–1.04) C.O.I., and the median UAE was 22 (9–82.1) mg/g creatinine. M2BPGi levels in microalbuminuria (0.83 (0.61 to 1.18) C.O.I.) and macroalbuminuria (0.88 (0.67 to 1.22) C.O.I.) cases were higher than those in normoalbuminuria cases (0.71 (0.54 to 0.92) C.O.I.). M2BPGi levels in NPDR (0.93 (0.68 to 1.28) C.O.I.) and PDR (0.95 (0.71 to 1.31) C.O.I.) cases were higher than in cases with NoDR (0.73 (0.56 to 0.99) C.O.I.). Furthermore, M2BPGi levels in subjects with a history of cardiovascular diseases were higher than in those with no such history (0.82 (0.65 to 1.22) vs 0.76 (0.55 to 1.03) C.O.I., p=0.019). The logarithm of (M2BPGi+1) was associated with the logarithm of UAE values after adjusting for covariates (standardized β=0.107, p=0.031).ConclusionsThis study reveals a close association between serum M2BPGi levels and diabetic microangiopathy and macroangiopathy in people with type 2 diabetes. The results also show that liver fibrosis, evaluated by M2BPGi, is independently associated with an increased risk of albuminuria.

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