scholarly journals COVID-19 in patients with chronic kidney disease stage 5

2021 ◽  
pp. 38-47
Author(s):  
I. Dudar ◽  
E. Krasyuk ◽  
A. Shymova ◽  
Y. Hryhorieva ◽  
M. Malasaiev ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Dialysis Patients ◽  
Duration Of Treatment ◽  
Dialysis Treatment ◽  
Patients With Diabetes

The study aimed to determine the frequency of COVID-19, specific of process and the mortality rate among dialysis patients with COVID-19. Materials and methods: The retrospective study included 764 patients with CKD VD, who received dialysis treatment at the Kyiv City Center for Nephrology and Dialysis, which is the clinical base of the Institute of Nephrology of the National Academy of  Medical  Sciences since September 1, 2020. until December 31, 2020. 155 patients were diagnosed with coronavirus disease. The study was conducted in two stages. In the first stage, dialysis patients with coronavirus disease were divided into groups depending on the severity of the disease. The second stage of the study was determined the influence of age, duration of dialysis treatment, gender, cause of chronic kidney disease VD, obesity, diabetes mellitus and cardiovascular pathology on the course of coronavirus disease, as well as complications and mortality from COVID-19  among the dialysis population. Results: 155 cases of COVID-19 were registered among 764 dialysis patients. Mild coronavirus disease was diagnosed in 38 (24.5%) patients, moderate and severe in 64 (41.3%) and 53 (34.2%) patients, respectively. Oxygen support was required for 76 patients (79%), and artificial lung ventilation was used for 17 (10.9%) patients. Factors associated with severe coronavirus disease in this category of patients were found to be obesity (BMI> 30 kg / m2), diabetes mellitus, concomitant cardiovascular disease, and the need for oxygen support.  In this category of patients, obesity (BMI>30 kg/m2), cardiovascular disease, diabetes mellitus and require supplement oxygen are associated with severe Coronavirus disease COVID-19. There was no significant effect on the severity of coronavirus disease in the age of patients and duration of dialysis treatment. The duration of treatment in patients with diabetes was significantly higher (p <0.05), a direct strong correlation between BMI and duration of treatment was demonstrated. Survival was significantly higher in the group of patients who did not require oxygen support (78% vs. 56%) and had a BMI <30 kg / m2 (87% vs. 37%). Conclusions: the incidence of coronavirus disease among the dialysis cohort was 20.2% of cases. Patients treated with peritoneal dialysis had a significantly lower incidence. Severe coronavirus disease has been associated with obesity, cardiovascular disease, and the need for oxygen support. Men were more likely to have COVID-19 than women. There is no connection between the severe course of coronavirus disease with the age of patients and the duration of dialysis treatment. The duration of treatment of Coronavirus disease in the group of patients with diabetes and high BMI was longer. The following complications predominated in patients with COVID-19: thrombosis of arteriovenous fistula and atrial fibrillation.  During the study period, 20 (12.9%) deaths were registered. Patient survival was higher in the group of patients without oxygen support and with a lower BMI.

scholarly journals Intravenous neurotropic vitamin b injection in chronic kidney disease patients on dialysis: patient’s perspective

2020 ◽  
Vol 11 (SPL4) ◽  
Author(s):  
Rizaldy Taslim Pinzon ◽  
Radian Adhiputra Antonius
Keyword(s):  
Diabetes Mellitus ◽  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Daily Activity ◽  
Treatment Quality ◽  
Vitamin B ◽  
Dialysis Patients ◽  
Risk Of Mortality ◽  
Intravenous Vitamin

Chronic kidney disease is characterized by a decrease in glomerular filtration rate and lasts over 3 months. Meanwhile, patient perspectives include patient compliance in treatment and care programs. Vitamin B combination plays a role in reducing the risk of mortality for cardiovascular disease. This study aims in measuring perspective on patients with chronic kidney disease undergoing hemodialysis to intravenous vitamin B injection. This is a cohort retrospective study of patients on dialysis that were injected with intravenous vitamin B two times a week after dialysis. The subjects studied were chronic kidney disease patients who underwent hemodialysis at Bethesda Hospital Yogyakarta and Panti Rapih Hospital Yogyakarta, Indonesia. This study involved 58 patients, comprising 38 male (65.5%) and 20 females (34.5%). Total 41 patients (70.7%) with age under 60 years. The most common comorbidities were hypertension (86.2%), diabetes mellitus (25.9%), and cardiovascular disease (20.7%). Patients' perspectives on improvement of fatigue symptoms are higher in patients with hypertension comorbidity (88.9%), sleep quality higher in diabetes mellitus comorbidity (80%), daily activity higher in patients with other comorbidity (84.6%) and mood higher in other comorbidity (88.9%). Overall, most of the patients were satisfied with the treatment (98.3%), satisfied that it reduced fatigue (96.6%), said no side effects appeared (91.4%), were confident in the treatment (94.8%), considered it resulted in greater benefit than costs (84.5%). Patients' perspectives in the treatment of intravenous vitamin B combination injections for chronic dialysis patients have satisfactory treatment quality.

A Study of Lipid Profile in Chronic Kidney Disease Patients

2021 ◽  
Vol 15 (9) ◽  
pp. 3087-3090
Author(s):  
Muhammad Rizwan ◽  
Muhammad Taha Lodhi ◽  
Asim Maqsood ◽  
Tahir Mukhtar Sayed
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Lipid Profile ◽  
Chronic Kidney Disease Stage ◽  
Inverse Correlation ◽  
Lipid Profiles ◽  
Kidney Damage ◽  
Disease Stage ◽  
Dialysis Patients ◽  
Ckd Stage

Background and Aim: Chronic kidney disease patients are more likely to develop cardiovascular diseases caused by atherosclerosis accelerated rate and variety of other factors, of which they exhibit the abnormality of lipid profile atherogonic characteristics. The current study aim was to investigate the lipid profile abnormalities pattern in non-diabetic chronic kidney disease patients and to evaluate the association between the lipid profile alteration extent and renal impairment degree. Methods: This cross-sectional study was carried out on 118 chronic disease patients in the Department of Nephrology, Shaikh Zayed Hospital Lahore during the period, from August 2020 to May 2021. All the patients were carefully chosen based on their eligibility criteria. A history was taken, clinical investigation was performed, and biochemical tests were conducted. Blood was drawn for lipid profile analysis after 9 hours abstaining. The Institutional Ethical Committee approved the study and informed consent was taken from each individual. Chronic Kidney Disease as defined by the KDOQI Criteria Kidney damage for three months, defined as functional kidney abnormalities with or without decreased GFR, manifested by either: Pathological abnormalities; kidney damage markers such as changes in blood or urine composition, or abnormalities in imaging tests. GFR of less than 60 mL/min/1.73m2 for 3 months, with or without kidney damage. SPSS version 20 was used for data analysis. Results: The study included 118 patients, 79 (66.9%) of whom were males and 39 (33.1%) were females. The mean age of patients was 49.46 + 9.35 years with an age range of 28 to 78 years. Stage 5CKD patients were 23 who underwent dialysis. Chronic kidney disease patients had lower HDL and higher levels of triglyceride whereas, with chronic kidney disease stage progression, the HDL and TGL levels increased. In both stages 4 and 5 CKD, there is a positive correlation between triglyceride levels and serum phosphorous and TGL and calcium had inverse correlation. Dialysis patients' lipid profiles do not differ from those of non-dialysis patients. Conclusion: Our study found that patients with non-diabetic CKD have high triglyceride levels, low HDL, and had LDL and total cholesterol unchanged levels. As the CKD stage advances and GFR declines, triglyceride increases, and HDL decreases. TGL and serum phosphorous had a positive association in chronic kidney disease stage 4 and 5 whereas TGL and serum calcium had an inverse correlation in stages 4 and 5. Moreover, no significant difference between dialysed and non-dialysed chronic kidney disease patients’ lipid profiles was observed. Keywords: Chronic Kidney Disease; Lipid Profile; Lipid Profile Abnormalities

scholarly journals Study of correlation between adequacy of dialysis and glycemic control in patients of type 2 diabetes mellitus with chronic kidney disease stage 5

2020 ◽  
Vol 8 (4) ◽  
pp. 1366
Author(s):  
Samrat Mitra ◽  
Sanghita Barui
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Kidney Disease ◽  
Glycemic Control ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Random Blood Sugar

Background: The adequacy of haemodialysis in patients of type 2 diabetes mellitus with chronic kidney disease stage 5 depends on several clinical as well as laboratory parameters. Previous studies from Western literature have identified several clinical and laboratory markers for predicting adequacy of dialysis. There is a dearth of literature regarding the same in Indian patient populace. Authors aimed to find correlation, if any, between glycemic control and adequacy of dialysis in this cohort of patients.Methods: A set of 200 patients of type 2 diabetes mellitus who have undergone hemodialysis at a tertiary care hospital were included in the study. Random blood sugar (RBS), Glycated hemoglobin (HbA1c) were measured at admission. After 4 hours of dialysis, the urea reduction ratio (URR) and Kt/V was measured for each patient. The correlation coefficient as well as linear equation of the association between these variables were calculated. Standard statistical method and software were used in the process.Results: The study revealed a linear negative correlation between the variables RBS, HbA1c and URR as well as Kt/V. This suggests the importance of pre dialysis glycemic control in patients undergoing hemodialysis.Conclusions: Authors formulate the hypothesis that glycated hemoglobin and random blood sugar at admission correlate well with the outcome and adequacy of dialysis in patients of stage 5 chronic kidney disease undergoing haemodialysis.  Good glycemic control (HbA1c <6.5 % and RBS <120 mg/dL) have shown to be important predictive markers of adequate dialysis. The hypothesis needs to be tested with a larger study.

scholarly journals Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260417
Author(s):  
Sasha S. Bjergfelt ◽  
Ida M. H. Sørensen ◽  
Henrik Ø. Hjortkjær ◽  
Nino Landler ◽  
Ellen L. F. Ballegaard ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Coronary Arteries ◽  
Carotid Plaque ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Arterial Calcification ◽  
Carotid Plaques ◽  
Computed Tomography Scanning

Background Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with cardiovascular disease and severity of calcification in the carotid and coronary arteries. Methods The study group consisted of 200 patients with chronic kidney disease stage 3 from the Copenhagen Chronic Kidney Disease Cohort and 121 age- and sex-matched controls. cPTmax was assessed by ultrasound and arterial calcification by computed tomography scanning. Results Carotid plaques were present in 58% of patients (n = 115) compared with 40% of controls (n = 48), p = 0.002. Among participants with plaques, cPTmax (median, interquartile range) was significantly higher in patients compared with controls (1.9 (1.4–2.3) versus 1.5 (1.2–1.8) mm), p = 0.001. Cardiovascular disease was present in 9% of patients without plaques (n = 85), 23% of patients with cPTmax 1.0–1.9 mm (n = 69) and 35% of patients with cPTmax >1.9 mm (n = 46), p = 0.001. Carotid and coronary calcium scores >400 were present in 0% and 4%, respectively, of patients with no carotid plaques, in 19% and 24% of patients with cPTmax 1.0–1.9 mm, and in 48% and 53% of patients with cPTmax >1.9 mm, p<0.001. Conclusions This is the first study showing that cPTmax is increased in patients with chronic kidney disease stage 3 compared to controls and closely associated with prevalent cardiovascular disease and severity of calcification in both the carotid and coronary arteries.

487-P: AI Prediction of Chronic Kidney Disease Stage Progression Combinations for Type 2 Diabetes Mellitus

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 487-P
Author(s):  
KOHTAROH MIYAMOTO ◽  
AKIRA KOSEKI ◽  
MICHIHARU KUDO ◽  
MASAKI MAKINO ◽  
ATSUSHI SUZUKI
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Stage Progression

scholarly journals ERBP guideline on management of patients with diabetes and chronic kidney disease stage 3B or higher. Metformin for all?

2017 ◽  
Vol 37 (6) ◽  
pp. 567-571
Author(s):  
Alberto Martínez-Castelao ◽  
José Luis Górriz ◽  
Alberto Ortiz ◽  
Juan F. Navarro-González
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Patients With Diabetes

scholarly journals Association between serum magnesium levels and abdominal aorta calcification in patients with pre-dialysis chronic kidney disease stage 5

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0253592
Author(s):  
Mayumi Ito ◽  
Makoto Yamaguchi ◽  
Takayuki Katsuno ◽  
Hironobu Nobata ◽  
Shiho Iwagaitsu ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Abdominal Aorta ◽  
Serum Magnesium ◽  
Chronic Kidney Disease Stage ◽  
Magnesium Level ◽  
Disease Stage ◽  
Serum Magnesium Level ◽  
The Relationship

Background Several studies have revealed the relationship between serum magnesium levels and vascular calcification in chronic kidney disease patients. Despite excellent predictability of abdominal aorta calcification for cardiovascular disease events, the relationship between serum magnesium levels and abdominal aorta calcification, as evaluated by quantitative methods, in pre-dialysis patients remains unclear. This study aimed to determine the abdominal aorta calcification volume using computerized tomography and its association with serum magnesium levels in pre-dialysis chronic kidney disease stage 5 patients. Methods This single-center cross-sectional study included 100 consecutive patients with pre-dialysis chronic kidney disease stage 5 between January 2016 and May 2020 at Aichi Medical University Hospital, Japan. The relationships between serum magnesium levels and the abdominal aorta calcification volume were assessed using multiple linear regression models after adjusting for clinically relevant factors. We also assessed clinical factors that affect serum magnesium levels. Results The mean serum magnesium level was 2.0 mg/dL (interquartile range, 1.8 to 2.3). Multivariate analyses revealed that a higher serum magnesium level (stand. β = -0.245, p = 0.010) was significantly associated with a reduced abdominal aorta calcification volume, and that a history of cardiovascular disease (stand. β = 0.3792, p < 0.001) and older age (stand. β = 0.278, p = 0.007) were significantly associated with an increased abdominal aorta calcification volume. Moreover, multivariate analysis showed that the use of proton pump inhibitor or potassium-competitive acid blocker was significantly associated with lower serum magnesium levels (stand. β = -0.246, p = 0.019). Conclusions The present study revealed that the higher Mg level was significantly associated with lower volume of abdominal aorta calcification in pre-dialysis chronic kidney disease stage 5 patients. Further studies should be undertaken to determine the appropriate magnesium level to suppress vascular calcification.

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