scholarly journals REGENERATIVE POSSIBILITIES OF RENAL STEM CELLS

2017 ◽  
pp. 39-44
Author(s):  
S. B. Geraschenko ◽  
Yu. B. Chaikovsky ◽  
O. I. Deltsova
Keyword(s):  
Stem Cells ◽  
Regenerative Therapy ◽  
Review Of Literature ◽  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Renal Stem Cells ◽  
Induced Pluripotent ◽  
Stimulation Of

Modern data about stem cells of kidney in adults are presented in the review of literature. Sources and peculiarities of stem cells structure and their niches are examined in different kidney compartments – epithelial, vascular and stromal. The aims of kidney regenerative therapy are outlined. Issues of exposure and stimulation of local stem cells, possibilities of exogenous and induced pluripotent cells transplantation and implantation of created on matrix kidney are discussed.

scholarly journals Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges

PLoS Biology ◽  
2009 ◽  
Vol 7 (2) ◽  
pp. e1000042 ◽  
Author(s):  
Katriina Aalto-Setälä ◽  
Bruce R Conklin ◽  
Bernard Lo
Keyword(s):  
Future Research ◽  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Induced Pluripotent

Regrow or Repair: An Update on Potential Regenerative Therapies for the Kidney

2021 ◽  
pp. ASN.2021081073
Author(s):  
Melissa Little ◽  
Benjamin Humphreys
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Kidney Development ◽  
Transcriptional Analysis ◽  
Cell Recruitment ◽  
Renal Stem Cells ◽  
Induced Pluripotent ◽  
Stem Cell Populations ◽  
A Site ◽  
Regenerative Therapies

Fifteen years ago, this journal published a review outlining future options for regenerating the kidney. At that time, stem cell populations were being identified in multiple tissues, the concept of stem cell recruitment to a site of injury was of great interest, and the possibility of postnatal renal stem cells was growing in momentum. Since that time, we have seen the advent of human induced pluripotent stem cells, substantial advances in our capacity to both sequence and edit the genome, global and spatial transcriptional analysis down to the single-cell level, and a pandemic that has challenged our delivery of health care to all. This article will look back over this period of time to see how our view of kidney development, disease, repair, and regeneration has changed and envision a future for kidney regeneration and repair over the next 15 years.

scholarly journals Questioned validity of Gene Expression Dysregulated Domains in Down's Syndrome

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 269 ◽  
Author(s):  
Long H. Do ◽  
William C. Mobley ◽  
Nishant Singhal
Keyword(s):  
Gene Expression ◽  
Monozygotic Twins ◽  
Recent Analysis ◽  
Ts65dn Mouse ◽  
Pluripotent Cells ◽  
Induced Pluripotent Cells ◽  
Independent Analysis ◽  
Human Ipscs ◽  
Rnaseq Data ◽  
Induced Pluripotent

Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau et al., reported the presence of a defined pattern of dysregulation within specific genomic domains they referred to as Gene Expression Dysregulated Domains (GEDDs). GEDDs were described as alternating segments of increased or decreased gene expression affecting all chromosomes. Strikingly, GEDDs in fibroblasts were largely conserved in induced pluripotent cells (iPSCs) generated from the twin’s fibroblasts as well as in fibroblasts from the Ts65Dn mouse model of DS. Our recent analysis failed to find GEDDs. We reexamined the human iPSCs RNAseq data from Letourneau et al., and data from this same research group published earlier examining iPSCs from the same monozygotic twins. An independent analysis of RNAseq data from Ts65Dn fibroblasts also failed to confirm presence of GEDDs. Our analysis questions the validity of GEDDs in DS.

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