scholarly journals Mucinous Adenocarcinoma Associated with Fistula in an 87-Year-Old Managed with Neoadjuvant Chemoradiation and ELAPE at Tata Memorial Hospital, in Mumbai

2020 ◽  
pp. 1-4
Author(s):  
Avanish Saklani ◽  
Seke Manase Ephraim KAZUMA ◽  
Vivek Sukumar ◽  
Avanish Saklani
Keyword(s):  
Colorectal Cancer ◽  
Distant Metastasis ◽  
Mucinous Adenocarcinoma ◽  
Poor Prognosis ◽  
Locally Advanced ◽  
Delayed Diagnosis ◽  
Neoadjuvant Chemoradiation ◽  
Tata Memorial Hospital ◽  
The Third ◽  
Cutaneous Flap

Colorectal cancer is the third most diagnosed cancer and the fourth leading cancer-related death worldwide. Mucinous adenocarcinoma associated with anal fistula is a rare variant of adenocarcinoma, presents with delayed diagnosis, locally advanced, low nodal, and no distant metastasis. Adenocarcinoma associated with fistula (ACAF) is rare, has delayed diagnosis and poor prognosis but can be managed with neoadjuvant chemoradiation (NACRT) and complete curative resections with reconstruction by V-Y advancement cutaneous flap.

scholarly journals BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Meng Jiang ◽  
Yue Kang ◽  
Tomasz Sewastianik ◽  
Jiao Wang ◽  
Helen Tanton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Calcium Transients ◽  
Molecular Heterogeneity ◽  
Independent Function ◽  
The Third ◽  
Tumor Pathogenesis

AbstractColorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/β-catenin pathway, which plays critical roles in CRC pathogenesis. Here we have identified a β-catenin-independent function of BCL9 in a poor-prognosis subtype of CRC tumors characterized by expression of stromal and neural associated genes. In response to spontaneous calcium transients or cellular stress, BCL9 is recruited adjacent to the interchromosomal regions, where it stabilizes the mRNA of calcium signaling and neural associated genes by interacting with paraspeckle proteins. BCL9 subsequently promotes tumor progression and remodeling of the tumor microenvironment (TME) by sustaining the calcium transients and neurotransmitter-dependent communication among CRC cells. These data provide additional insights into the role of BCL9 in tumor pathogenesis and point towards additional avenues for therapeutic intervention.

scholarly journals Anorectal Melanoma - Brownish Black Mass Not Always a Hemorrhoid

2021 ◽  
Author(s):  
Jitendra Singh Nigam ◽  
Nishit . ◽  
Tarun Kumar ◽  
Avinash Singh ◽  
Prerna Tewari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
Clinical Symptoms ◽  
Delayed Diagnosis ◽  
Rare Tumor ◽  
Anorectal Melanoma ◽  
Brownish Black ◽  
Anorectal Region ◽  
Prompt Diagnosis ◽  
Uncommon Tumor

Abstract The non-specific clinical symptoms of anorectal brownish-black mass do not help to differentiate colorectal cancer, hemorrhoids, rectal ulcers which result in a delayed diagnosis or lead to inadequate management of lethal anorectal melanoma. Primary malignant melanoma of the anorectal region is an uncommon tumor, constituting approximately 1% of anal canal tumors which may be misdiagnosed clinically as hemorrhoids. Because of aggressive behavior and poor prognosis, efficient and prompt diagnosis is required in these cases. We report the 2 cases of this rare tumor.

scholarly journals Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6226
Author(s):  
Zahra Pezeshkian ◽  
Stefania Nobili ◽  
Noshad Peyravian ◽  
Bahador Shojaee ◽  
Haniye Nazari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Developing Countries ◽  
Matrix Metalloproteinases ◽  
Poor Prognosis ◽  
Critical Role ◽  
Second Cancer ◽  
The Third ◽  
Incidence And Mortality ◽  
The Family

Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis

scholarly journals Neoadjuvant chemoradiation therapy for locally advanced colorectal cancer in hypofractionation mode (case report)

2019 ◽  
Vol 9 (4) ◽  
pp. 48-56
Author(s):  
S. I. Tkachev ◽  
A. S. Abduzhapparov ◽  
V. A. Aliev ◽  
Yu. A. Barsukov ◽  
J. M. Madyarov
Keyword(s):  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Combined Treatment ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Complete Clinical Response ◽  
Locally Advanced Colorectal Cancer

This article demonstrates the experience of successful treatment of a patient with locally advanced rectal cancer, who received a combined treatment with a non-standard course of chemoradiotherapy in hypofractionation mode according to a prolonged program. After the end of a course of chemoradiation received the complete clinical response of the tumor.

TPL2 expression is correlated with distant metastasis and poor prognosis in colorectal cancer

2018 ◽  
Vol 79 ◽  
pp. 50-56 ◽  
Author(s):  
Jung-Soo Pyo ◽  
Mee Ja Park ◽  
Chang-Nam Kim
Keyword(s):  
Colorectal Cancer ◽  
Distant Metastasis ◽  
Poor Prognosis

scholarly journals EXTRAMURAL VENOUS INVASION AS A FACTOR OF DISTANT METASTASIS IN PATIENTS WITH LOCALLY ADVANCED RECTAL CANCER

2020 ◽  
Vol 66 (2) ◽  
pp. 155-159
Author(s):  
Andrey Polynovskiy ◽  
Dmitriy Kuzmichev ◽  
Zaman Mamedli ◽  
Yu. Suraeva ◽  
Zhasur Madyarov ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Distant Metastasis ◽  
Locally Advanced ◽  
Venous Invasion ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Neoadjuvant Chemoradiation ◽  
National Medical ◽  
Significant Difference ◽  
Group 2

Aim: In this article extramural venous invasion (EMVI) in patients with locally advanced rectal cancer (LARC) is evaluated as a risk factor of distant metastasis. Materials and methods: This study is based on experience made in proctological department of N.N. Blokhin National Medical Research Center of Oncology. Retrospective analysis was performed on a group of 230 patients with LARC with stage mrT3(CRM+)/T4N0-2M0. All patients underwent long course of chemoradiotherapy with capecetabine, then 2-4 courses of chemotherapy CapOx were conducted in induction and/or consolidation scheme. Results: There were no critical differences in the effect of EMVI (+) on the development of reccurences in comparison with the EMVI (-) group (p>0.05). Along with that EMVI(+) patients were significantly associated with distant metastasis (43 patients - 27,4%) then in EMVI(-) group (2 - 2,74%) (p<0,05). The positive mr-EMVI result was more likely to be present in patients with T4 then in T3 group (p<0,05). A positive EMVI status was 81,4% in patients with the III stage, which is significant higher than in patients with II stage - 55,7% (p<0,05). 3-year recurrent-free survival of patients with EMVI(+) was 64%, compared with the group of patients with EMVI (-) - 93%, which was a significant difference (HR 0.03; 95% CI, 0.08-0.19 p<0.001). Conclusion: The definition of extramural vascular invasion indicates a poor prognosis and could be used for treatment planning of neoadjuvant chemoradiation and adjuvant chemotherapy.

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