Detection of 2-Dodecylcyclobutanone in Low-Dose Irradiated (0.5 Gy) Goose Fat by Triple-Quad GC-MS/MS

Aim of this work was the development of a sensitive procedure to detect low-dose irradiation in the scale of 0.5 Gy to 20 Gy in goose fat by detection of 2-dodecylcyclobutanone (2-DCB). The general procedure to detect 2-alkylcyclobutanone (2-ACB) according to EN 1785 was optimized by using acetonitrile for extraction of 2-DCB from the lipid fraction before clean-up with silica gel. Gas chromatographic separation was realized by a 15 m TG-5 HT column, and detection was done by using a triple-quad tandem-mass spectrometer in SRM-mode. At the irradiation level of 2 Gy, the optimized procedure showed high repeatability (3.9%), a good intermediate precision (20.9%) and an acceptable recovery rate of 57.8%, with 0.25 ng 2-DCB per gram of fat. With this procedure, a reliable proof of 2-DCB was possible for the irradiation intensities 20, 5 and 2 Gy for three mass transitions; for 0.5 Gy, a proof was possible for one mass transition.

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Effects of Sodium Nitrite, Sodium Nitrate and DL, Alpha-Tocopherol on Properties of Irradiated Frankfurters

Journal of Food Protection ◽

10.4315/0362-028x-44.6.414 ◽

1981 ◽

Vol 44 (6) ◽

pp. 414-417 ◽

Cited By ~ 11

Author(s):

R. N. TERRELL ◽

F. HEILIGMAN ◽

G. C. SMITH ◽

E. WIERBICKI ◽

Z. L. CARPENTER

Keyword(s):

Sodium Nitrite ◽

Sodium Nitrate ◽

Radiation Source ◽

Low Dose ◽

Alpha Tocopherol ◽

Dose Irradiation ◽

Irradiation Level ◽

Source Use

Frankfurters were manufactured to contain certain combinations of curing ingredients (sodium nitrite, sodium nitrate and DL alpha-tocopherol). Some frankfurters were made to contain in the finished product 0% added moisture, others were made to contain 10% added moisture, some frankfurters were not irradiated (0-megarad), others were irradiated with either 0.8 or 3.2 megarads (Cobalt-60 radiation source). Use of DL, alpha-tocopherol (at a level of 206 ppm) was associated with greater processing shrinkage, more off-flavor and less overall palatability (P<0.05). The most desirable external and internal cured color and firmest texture was in frankfurters made with 50 ppm of NO2 or with 100 ppm of NO2, irrespective of irradiation level. Use of irradiation (0.8 or 3.2 megarads) on frankfurters made without nitrite or nitrate did not improve visually determined cured color but did improve this color when determined spectrophotometrically; nevertheless, cured color of irradiated frankfurters made without use of nitrite or nitrate was not comparable to that of non-irradiated or irradiated frankfurters made with 100 ppm NO2. Irrespective of added moisture or curing ingredient combinations, significant differences (P<0.05) in palatability traits were associated with increasing irradiation levels (0, 0.8 or 3.2 megarads). Off-flavor increased, texture was less firm and overall palatability was less desirable as irradiation level increased. Low-dose irradiation (⩽1 megarad) may be feasible for enhancing the palatability traits of frankfurters containing lower levels of nitrite (lower than 156 ppm) but it appears that the correct irradiation level would be lower than the 0.8 megarad used in this study.

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Inhibition of Neointimal Proliferation With Low-Dose Irradiation From a β-Particle–Emitting Stent

Circulation ◽

10.1161/01.cir.93.3.529 ◽

1996 ◽

Vol 93 (3) ◽

pp. 529-536 ◽

Cited By ~ 98

Author(s):

John R. Laird ◽

Andrew J. Carter ◽

William M. Kufs ◽

Timothy G. Hoopes ◽

Andrew Farb ◽

...

Keyword(s):

Low Dose ◽

Dose Irradiation ◽

Neointimal Proliferation

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Low-dose irradiation reduces forced swim test-induced immobility and oxidative stress in mice

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2020.12.425 ◽

2021 ◽

Vol 165 ◽

pp. 56-57

Author(s):

Shota Naoe ◽

Takahiro Kataoka ◽

Hina Shuto ◽

Junki Yano ◽

Tetsuya Nakada ◽

...

Keyword(s):

Oxidative Stress ◽

Low Dose ◽

Forced Swim Test ◽

Swim Test ◽

Dose Irradiation ◽

Forced Swim ◽

And Oxidative Stress

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Combined treatments of low dose irradiation with antimicrobials for inactivation of foodborne pathogens on fresh pork

Food Control ◽

10.1016/j.foodcont.2021.107977 ◽

2021 ◽

Vol 125 ◽

pp. 107977

Author(s):

Ziyi Hu ◽

Yingping Xiao ◽

Bingkui Wang ◽

Tony Z. Jin ◽

Wentao Lyu ◽

...

Keyword(s):

Foodborne Pathogens ◽

Low Dose ◽

Combined Treatments ◽

Dose Irradiation

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Primary Explants of Human Uroepithelium Show an Unusual Response to Low-Dose Irradiation with Cobalt-60 Gamma Rays

Radiation Research ◽

10.2307/3579027 ◽

1995 ◽

Vol 142 (2) ◽

pp. 181 ◽

Cited By ~ 26

Author(s):

C. Mothersill ◽

J. Harney ◽

F. Lyng ◽

D. Cottell ◽

K. Parsons ◽

...

Keyword(s):

Gamma Rays ◽

Low Dose ◽

Dose Irradiation ◽

Primary Explants

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Low-dose irradiation promotes Rad51 expression by down-regulating miR-193b-3p in hepatocytes

Scientific Reports ◽

10.1038/srep25723 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 5

Author(s):

Eon-Seok Lee ◽

Yeo Jin Won ◽

Byoung-Chul Kim ◽

Daeui Park ◽

Jin-Han Bae ◽

...

Keyword(s):

Low Dose ◽

Dose Irradiation

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Chiral analysis of amphetamines in hair by liquid chromatography-tandem mass spectrometry: compliance-monitoring of attention deficit hyperactivity disorder (ADHD) patients under Elvanse® therapy and identification after controlled low-dose application

Drug Testing and Analysis ◽

10.1002/dta.2208 ◽

2017 ◽

Vol 10 (2) ◽

pp. 254-261 ◽

Cited By ~ 7

Author(s):

Tina M. Binz ◽

Elena Williner ◽

Petra Strajhar ◽

Patrick C. Dolder ◽

Matthias E. Liechti ◽

...

Keyword(s):

Mass Spectrometry ◽

Attention Deficit Hyperactivity Disorder ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Low Dose ◽

Tandem Mass ◽

Compliance Monitoring ◽

Hyperactivity Disorder ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Letter to the Editor In vitro radiation-induced apoptosis and tumour response to radiotherapy: a prospective study in patients with non-Hodgkin lymphomas treated by low-dose irradiation

International Journal of Radiation Biology ◽

10.1080/095530097142924 ◽

1997 ◽

Vol 72 (6) ◽

pp. 759-760 ◽

Cited By ~ 8

Author(s):

B Dubray C Breton J Delic J Klijanien

Keyword(s):

Prospective Study ◽

Low Dose ◽

Tumour Response ◽

Dose Irradiation ◽

Letter To The Editor ◽

Radiation Induced ◽

Induced Apoptosis ◽

A Prospective Study

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Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice

Blood ◽

10.1182/blood.v97.2.557 ◽

2001 ◽

Vol 97 (2) ◽

pp. 557-564 ◽

Cited By ~ 41

Author(s):

Peter J. Quesenberry ◽

Suju Zhong ◽

Han Wang ◽

Marc Stewart

Keyword(s):

Low Dose ◽

Great Majority ◽

Cd40 Ligand ◽

Third Party ◽

Whole Body ◽

Spleen Cells ◽

Graft Versus Host ◽

Dose Irradiation ◽

Unique Model ◽

High Level

Abstract We have previously shown that the keys to high-level nontoxic chimerism in syngeneic models are stem cell toxic, nonmyelotoxic host treatment as provided by 100-cGy whole-body irradiation and relatively high levels of marrow stem cells. This approach was unsuccessful in H-2 mismatched B6.SJL to BALB/c marrow transplants, but with tolerization, stable multilineage chimerism was obtained. Ten million B6.SJL spleen cells were infused intravenously into BALB/c hosts on day −10 and (MR-1) anti-CD40 ligand monoclonal antibody (mAb) injected intraperitoneally at varying levels on days −10, −7, −3, 0, and +3 and the BALB/c mice irradiated (100 cGy) and infused with 40 million B6.SJL/H-2 mismatched marrow cells on day 0. Stable multilineage chimerism at levels between 30% to 40% was achieved in the great majority of mice at 1.6 mg anti-CD40 ligand mAb per injection out to 64 weeks after transplantation, without graft-versus-host disease. The transplanted mice were also tolerant of donor B6.SJL, but not third-party CBA/J skin grafts at 8 to 9 and 39 to 43 weeks after marrow transplantation. These data provide a unique model for obtaining stable partial chimerism in H-2 mismatched mice, which can be applied to various clinical diseases of man such as sickle cell anemia, thalassemia, and autoimmune disorders.

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