A Rare Case of Malignant Lung Cancer in a 20-Year-Old Patient: Possible Diagnostic Pitfalls

We present a case of a 20-year-old male with a rare form of malignant lung cancer. The patient had a long history of respiratory symptoms that have been repeatedly treated as a pulmonary infection. Despite several hints of the ineffectiveness of the therapy, the diagnosis and definitive surgical treatment were made 4 months after the onset of symptoms. Our aim is to highlight the importance of an efficient diagnostic process within multidisciplinary discussion and to warn clinicians on potential pitfalls related to unusual clinical presentation.

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SPINAL HYDATIDOSIS IN A CHILD

Hirurgiâ pozvonočnika ◽

10.14531/ss2006.1.66-71 ◽

2006 ◽

pp. 066-071

Author(s):

Aleksandr Yuryevich Mushkin ◽

Andrey Aleksandrovich Pershin ◽

Klarissa Nikolayevna Kovalenko

Keyword(s):

Surgical Treatment ◽

Natural History ◽

Rare Case ◽

Spinal Instability ◽

Social Rehabilitation ◽

History Of ◽

Diagnostic Pitfalls

A report of a rare case of the spinal hydatidosis in a child is presented. Spinal hydatidosis with a total spinal instability caused by the natural history of the disease and inadequate surgical treatment was diagnosed in a 10 year-old girl. At the department the excision of paravertebral and prevertebral hydatid cavernous masses followed by anterior L1–L5 reconstruction and posterior spinal CD-instrumentation was performed. Early post-op results are satisfactory, supporting ability of the spine is restored, that allowed physical and social rehabilitation of the child. Diagnostic pitfalls are identified and discussed.

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Jugulotympanic Paraganglioma, Mimicking Chronic Suppura tive Otitis Media

Anwer Khan Modern Medical College Journal ◽

10.3329/akmmcj.v3i2.11693 ◽

2012 ◽

Vol 3 (2) ◽

pp. 37-38

Author(s):

Sharmin Ferdousi ◽

SM Badruddoza

Keyword(s):

Otitis Media ◽

Rare Case ◽

Clinical Presentation ◽

Glomus Tumour ◽

Oval Cells ◽

Polypoid Mass ◽

Rare Tumour ◽

Suppurative Otitis Media ◽

Variable Clinical Presentation ◽

Diagnostic Pitfalls

Paraganglioma or glomus tumour are named according to their origin. Jugulotympanic paragangliomas (JTP) originates in the middle ear. There are several diagnostic pitfalls of this tumour. We now report a rare case of JTP in a 47 years old female. Pre-operative diagnosis of this case was chronic suppurative otitis media, Per-operatively it revealed an irregular somewhat polypoid mass. On histologic examination the mass composed of nests of round to oval cells surrounded by delicate vascular septae and the diagnosis was JTP. Because JTPs are rare tumour and have variable clinical presentation & different histologic findings they are easy to misdiagnose. However this case report may help to generate awareness and to avoid misinterpretation of JTPs. DOI: http://dx.doi.org/10.3329/akmmcj.v3i2.11693 AKMMC J 2012: 3(2): 37-38

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Unilateral Keratoderma in a Mother and Her Son

Journal of Cutaneous Medicine and Surgery ◽

10.1177/120347541201600413 ◽

2012 ◽

Vol 16 (4) ◽

pp. 288-290 ◽

Cited By ~ 1

Author(s):

Ashley O'toole ◽

Maureen O'malley

Keyword(s):

Case Report ◽

Clinical Features ◽

Rare Case ◽

Clinical Presentation ◽

History Taking ◽

History Of ◽

Soles Of The Feet

Background: Keratoderma is a group of conditions characterized by hyperkeratosis affecting the skin on the soles of the feet and palms of the hands bilaterally. The classification of keratodermas depends on whether it is inherited or acquired and on its clinical features, including diffuse or focal involvement of the skin and the morphology of lesions present. Case Report: We describe the rare case of a 54-year-old female who presented with a nearly 40-year history of punctate keratoderma on her right palm and sole. History taking revealed that her biologic son also has unilateral left-sided keratoderma. The clinical presentation of unilateral keratoderma has been reported only four times in the literature.

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Necrolytic erythema migrans in celiac disease

Our Dermatology Online ◽

10.7241/ourd.2022e.1 ◽

2022 ◽

Vol 13 (e) ◽

pp. e1-e1

Author(s):

Dassouli Ryme ◽

Hanane BayBay ◽

Souad Choukri ◽

Zakia Douhi ◽

Sara Elloudi ◽

...

Keyword(s):

Celiac Disease ◽

Liver Disease ◽

Clinical Picture ◽

Rare Case ◽

Clinical Presentation ◽

Erythema Migrans ◽

Lower Abdomen ◽

Intestinal Malabsorption ◽

Timely Manner ◽

History Of

Erythema migrans necrolytica is a red, blistering rash that spreads over the skin. It particularly affects the skin around the mouth and distal extremities, but can also be found on the lower abdomen, buttocks, perineum and groin. It is strongly associated with glucagonoma, a glucagon-producing tumor of the pancreas, but is also seen in a number of other conditions, including liver disease and intestinal malabsorption such as celiac disease. We present a case of a patient with a history of poorly followed celiac disease presenting with a clinical picture of ENM. This rare case adds to our understanding of the clinical presentation of NME, as well as highlights the importance of acting in a timely manner to avoid the most redoubtful complications.

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Significant predictive factors of the severity and outcomes of the first attack of acute angioedema in children

BMC Pediatrics ◽

10.1186/s12887-019-1809-8 ◽

2019 ◽

Vol 19 (1) ◽

Author(s):

Yuan-Jhen Syue ◽

Chao-Jui Li ◽

Wen-Liang Chen ◽

Tsung-Han Lee ◽

Cheng-Chieh Huang ◽

...

Keyword(s):

Hospital Admission ◽

Respiratory Symptoms ◽

Clinical Presentation ◽

Preschool Age ◽

Short Term ◽

Patient Demographics ◽

Life Threatening ◽

History Of ◽

Initial Episode

Abstract Background The initial episode of angioedema in children can be potential life-threatening due to the lack of prompt identification and treatment. We aimed to analyze the factors predicting the severity and outcomes of the first attack of acute angioedema in children. Methods This was a retrospective study with 406 children (< 18 years) who presented in the emergency department (ED) with an initial episode of acute angioedema and who had subsequent follow-up visits in the out-patient department from January 2008 to December 2014. The severity of the acute angioedema was categorized as severe (requiring hospital admission), moderate (requiring a stay in the short-term pediatric observation unit [POU]), or mild (discharged directly from the ED). The associations among the disease severity, patient demographics and clinical presentation were analyzed. Result In total, 109 (26.8%) children had severe angioedema, and the majority of those children were male (65.1%). Most of the children were of preschool age (56.4%), and only 6.4% were adolescents. The co-occurrence of pyrexia or urticaria, etiologies of the angioedema related to medications or infections, the presence of respiratory symptoms, and a history of allergies (asthma, allergic rhinitis) were predictors of severe angioedema (all p < 0.05). Finally, the duration of angioedema was significantly shorter in children who had received short-term POU treatment (2.1 ± 1.1 days) than in those who discharged from ED directly (2.3 ± 1.4 days) and admitted to the hospital (3.5 ± 2.0 days) (p < 0.001). Conclusion The co-occurrence of pyrexia or urticaria, etiologies related to medications or infections, the presence of respiratory symptoms, and a history of allergies were predictors of severe angioedema. More importantly, short-term POU observation and prompt treatment might be benefit for patients who did not require hospital admission.

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Parathyroid Cancer: A Review

Cancers ◽

10.3390/cancers11111676 ◽

2019 ◽

Vol 11 (11) ◽

pp. 1676 ◽

Cited By ~ 5

Author(s):

Machado ◽

Wilhelm

Keyword(s):

Clinical Presentation ◽

Surgical Intervention ◽

Disease Process ◽

Staging System ◽

Diagnostic Process ◽

Parathyroid Cancer ◽

En Bloc ◽

History Of ◽

General Guide

Parathyroid cancer is one of the rarest causes of primary hyperparathyroidism and tends to present with more severe symptoms than its more benign counterparts. This article details various aspects of the disease process, including epidemiology, clinical presentation, and a step-wise diagnostic process for parathyroid cancer. This includes laboratory assessments as well as a proposed staging system. The en bloc principle of surgical intervention is detailed, as well as the current role of adjuvant treatments. A general guide to surveillance and the natural history of the disease is also outlined.

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Bilateral vertex extradural hematomas: A case report

Indian Journal of Neurotrauma ◽

10.1016/s0973-0508(08)80010-x ◽

2008 ◽

Vol 05 (02) ◽

pp. 109-111 ◽

Cited By ~ 5

Author(s):

SGS Datta

Keyword(s):

Case Report ◽

Head Injury ◽

Clinical Features ◽

Rare Case ◽

Clinical Presentation ◽

Rare Form ◽

Excellent Outcome ◽

Intra Cranial Pressure

AbstractBilateral vertex extra dural hematomas (EDH) are a rare form of extra dural hematomas with many unique features. We report one such case of bilateral vertex extra dural hematoma. A young house wife had a fall in the bathroom and sustained head injury. She showed clinical features of progressive raised intra cranial pressure. Neuroimaging revealed bilateral vertex EDH. The larger left sided hematoma was evacuated surgically while the smaller right sided hematoma was managed non operatively, with excellent outcome. This case report presents this rare case and briefly reviews the literature. Vertex EDH has a special uniqueness as to their etiopathology, clinical presentation, diagnosis & management principles.

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The Effect of Surgical Treatment on the Natural History of Lung Cancer

American Review of Respiratory Disease ◽

10.1164/arrd.1983.127.1.1 ◽

1983 ◽

Vol 127 (1) ◽

pp. 1-1 ◽

Cited By ~ 12

Author(s):

Wilmot C. Ball

Keyword(s):

Lung Cancer ◽

Surgical Treatment ◽

Natural History ◽

History Of

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SARS-CoV-2 infection in 86 healthcare workers in two Dutch hospitals in March 2020

10.1101/2020.03.23.20041913 ◽

2020 ◽

Cited By ~ 25

Author(s):

Marjolein F.Q. Kluytmans-van den Bergh ◽

Anton G.M. Buiting ◽

Suzan D. Pas ◽

Robbert G. Bentvelsen ◽

Wouter van den Bijllaardt ◽

...

Keyword(s):

Healthcare Workers ◽

Respiratory Symptoms ◽

Clinical Presentation ◽

Case Definition ◽

Northern Italy ◽

Teaching Hospitals ◽

Local Spread ◽

Clinical Presentations ◽

High Prevalence ◽

History Of

ABSTRACTBackgroundOn February 27, 2020, the first patient with COVID-19 was reported in the Netherlands. During the following weeks, nine healthcare workers (HCWs) were diagnosed with COVID-19 in two Dutch teaching hospitals, eight of whom had no history of travel to China or Northern-Italy. A low-threshold screening regimen was implemented to determine the prevalence and clinical presentation of COVID-19 among HCWs in these two hospitals.MethodsHCWs who suffered from fever or respiratory symptoms were voluntarily tested for SARS-CoV-2 by real-time reverse-transcriptase PCR on oropharyngeal samples. Structured interviews were conducted to document symptoms for all HCWs with confirmed COVID-19.FindingsThirteen-hundred fifty-three (14%) of 9,705 HCWs employed were tested, 86 (6%) of whom were infected with SARS-CoV-2. Most HCWs suffered from relatively mild disease and only 46 (53%) reported fever. Eighty (93%) HCWs met a case definition of fever and/or coughing and/or shortness of breath. None of the HCWs identified through the screening reported a travel history to China or Northern Italy, and 3 (3%) reported to have been exposed to an inpatient known with COVID-19 prior to the onset of symptoms.InterpretationWithin two weeks after the first Dutch case was detected, a substantial proportion of HCWs with fever or respiratory symptoms were infected with SARS-CoV-2, probably caused by acquisition of the virus in the community during the early phase of local spread. The high prevalence of mild clinical presentations, frequently not including fever, asks for less stringent use of the currently recommended case-definition for suspected COVID-19.RESEARCH IN PERSPECTIVEEvidence before this studyThis study was conducted in response to the global spread of SARS-CoV-2, and the detection of eight healthcare workers (HCWs) in two Dutch teaching hospitals within two weeks after the first patient with COVID-19 was detected in the Netherlands who had no history of travel to China or Northern-Italy, raising the question of whether undetected community circulation was occurring.Added value of this studyTo the best of our knowledge, this report is the first to describe the prevalence, the clinical presentation and early outcomes of COVID-19 in HCWs, which may be helpful for others seeking to identify HCWs suspected for COVID-19 in an outbreak situation.Implications of all the available evidenceWe describe that within two weeks after the first Dutch case was detected, a substantial proportion of HCWs with fever or (mild) respiratory symptoms were infected with SARS-CoV-2, probably caused by acquisition of the virus in the community during the early phase of local spread. The high prevalence of mild clinical presentations, frequently not including fever, asks for less stringent use of the currently recommended case-definition for suspected COVID-19.

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