Non-invasive Near-infrared Spectroscopy (NIRS) Versus Invasive Licox Intracranial Pressure

Author(s):  
2019 ◽  
Vol 40 (11) ◽  
pp. 2304-2314 ◽  
Author(s):  
Alexander Ruesch ◽  
Samantha Schmitt ◽  
Jason Yang ◽  
Matthew A Smith ◽  
Jana M Kainerstorfer

Intracranial pressure (ICP) is typically measured invasively through a sensor placed inside the brain or a needle inserted into the spinal canal, limiting the patient population on which this assessment can be performed. Currently, non-invasive methods are limited due to lack of sensitivity and thus only apply to extreme cases of increased ICP, instead of use in general clinical practice. We demonstrate a novel application for near-infrared spectroscopy (NIRS) to accurately estimate ICP changes over time. Using a non-human primate (Rhesus Macaque) model, we collected optical data while we induced ICP oscillations at multiple ICP levels obtained by manipulating the height of a fluid column connected via a catheter to the lateral ventricle. Hemodynamic responses to ICP changes were measured at the occipital pole and compared to changes detected by a conventional intraparenchymal ICP probe. We demonstrate that hemoglobin concentrations are highly correlated with induced ICP oscillations and that this response is frequency dependent. We translated the NIRS data into non-invasive ICP measurements via a fitted non-parametric transfer function, demonstrating a match in both magnitude and time alignment with an invasively measured reference. Our results demonstrate that NIRS has the potential for non-invasive ICP monitoring.


Biosensors ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 389
Author(s):  
Kogulan Paulmurugan ◽  
Vimalan Vijayaragavan ◽  
Sayantan Ghosh ◽  
Parasuraman Padmanabhan ◽  
Balázs Gulyás

Functional Near-Infrared Spectroscopy (fNIRS) is a wearable optical spectroscopy system originally developed for continuous and non-invasive monitoring of brain function by measuring blood oxygen concentration. Recent advancements in brain–computer interfacing allow us to control the neuron function of the brain by combining it with fNIRS to regulate cognitive function. In this review manuscript, we provide information regarding current advancement in fNIRS and how it provides advantages in developing brain–computer interfacing to enable neuron function. We also briefly discuss about how we can use this technology for further applications.


2021 ◽  
Vol 22 (18) ◽  
pp. 9940
Author(s):  
Soo-In Sohn ◽  
Subramani Pandian ◽  
Young-Ju Oh ◽  
John-Lewis Zinia Zaukuu ◽  
Hyeon-Jung Kang ◽  
...  

Near-infrared spectroscopy (NIRS) has become a more popular approach for quantitative and qualitative analysis of feeds, foods and medicine in conjunction with an arsenal of chemometric tools. This was the foundation for the increased importance of NIRS in other fields, like genetics and transgenic monitoring. A considerable number of studies have utilized NIRS for the effective identification and discrimination of plants and foods, especially for the identification of genetically modified crops. Few previous reviews have elaborated on the applications of NIRS in agriculture and food, but there is no comprehensive review that compares the use of NIRS in the detection of genetically modified organisms (GMOs). This is particularly important because, in comparison to previous technologies such as PCR and ELISA, NIRS offers several advantages, such as speed (eliminating time-consuming procedures), non-destructive/non-invasive analysis, and is inexpensive in terms of cost and maintenance. More importantly, this technique has the potential to measure multiple quality components in GMOs with reliable accuracy. In this review, we brief about the fundamentals and versatile applications of NIRS for the effective identification of GMOs in the agricultural and food systems.


Meat Science ◽  
2017 ◽  
Vol 126 ◽  
pp. 29-35 ◽  
Author(s):  
M. Isabel Campos ◽  
M. Luisa Mussons ◽  
Gregorio Antolin ◽  
Luis Debán ◽  
Rafael Pardo

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