Early Routine vs. Selective Human Milk Fortification in Extremely Preterm Infants

2020 ◽  
Author(s):  
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding

2021 ◽  
Author(s):  
Ariel A. Salas ◽  
Kent A. Willis ◽  
Waldemar A. Carlo ◽  
Nengjun Yi ◽  
Li Zhang ◽  
...  
Keyword(s):  
Human Milk ◽  
Microbial Diversity ◽  
Preterm Infants ◽  
Enteral Feeding ◽  
Gut Microbiome ◽  
Mode Of Delivery ◽  
Early Feeding ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Early Progression

Abstract Background Early progression of feeding could influence the development of the gut microbiome. Methods We collected fecal samples from extremely preterm infants randomized to receive either early (feeding day 2) or delayed (feeding day 5) feeding progression. After study completion, we compared samples obtained at three different time points (week 1, week 2, and week 3) to determine longitudinal differences in specific taxa between the study groups using unadjusted and adjusted negative binomial and zero-inflated mixed models. Analyses were adjusted for a mode of delivery, breastmilk intake, and exposure to antibiotics. Results We analyzed 137 fecal samples from 51 infants. In unadjusted and adjusted analyses, we did not observe an early transition to higher microbial diversity within samples (i.e., alpha diversity) or significant differences in microbial diversity between samples (i.e., beta diversity) in the early feeding group. Our longitudinal, single-taxon analysis found consistent differences in the genera Lactococcus, Veillonella, and Bilophila between groups. Conclusions Differences in single-taxon analyses independent of the mode of delivery, exposure to antibiotics, and breastmilk feeding suggest potential benefits of early progression of enteral feeding volumes. However, this dietary intervention does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. Trial Registration ClinicalTrials.gov identifier: NCT02915549. Impact Early progression of enteral feeding volumes with human milk reduces the duration of parenteral nutrition and the need for central venous access among extremely preterm infants. Early progression of enteral feeding leads to single-taxon differences in longitudinal analyses of the gut microbiome, but it does not appear to increase the diversity of the gut microbiome in the first 28 days after birth. Randomization in enteral feeding trials creates appealing opportunities to evaluate the effects of human milk diets on the gut microbiome.

scholarly journals Nordic study on human milk fortification in extremely preterm infants: a randomised controlled trial—the N-forte trial

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e053400
Author(s):  
Georg Bach Jensen ◽  
Fredrik Ahlsson ◽  
Magnus Domellöf ◽  
Anders Elfvin ◽  
Lars Naver ◽  
...  
Keyword(s):  
Breast Milk ◽  
Human Milk ◽  
Preterm Infants ◽  
Ethical Review ◽  
Human Breast Milk ◽  
Human Breast ◽  
Preterm Formula ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Randomised Controlled

IntroductionThe mortality rate of extremely low gestational age (ELGA) (born <gestational week 28+0) infants remains high, and severe infections and necrotising enterocolitis (NEC) are common causes of death. Preterm infants receiving human milk have lower incidence of sepsis and NEC than those fed a bovine milk-based preterm formula. Despite this, fully human milk fed ELGA infants most often have a significant intake of cow’s milk protein from bovine-based protein fortifier. The aim of this study is to evaluate whether the supplementation of human milk-based, as compared with bovine-based, nutrient fortifier reduces the prevalence of NEC, sepsis and mortality in ELGA infants exclusively fed with human milk.Methods and analysisA randomised-controlled multicentre trial comparing the effect of a human breast milk-based fortifier with a standard bovine protein-based fortifier in 222–322 ELGA infants fed human breast milk (mother’s own milk and/or donor milk). The infants will be randomised to either fortifier before reaching 100 mL/kg/day in oral feeds. The intervention, stratified by centre, will continue until the target postmenstrual week 34+0. The primary outcome is a composite of NEC, sepsis or death. Infants are characterised with comprehensive clinical and nutritional data collected prospectively from birth until hospital discharge. Stool, urine, blood and breast milk samples are collected for analyses in order to study underlying mechanisms. A follow-up focusing on neurological development and growth will be performed at 2 and 5.5 years of age. Health economic analyses will be made.Ethics and disseminationThe study is conducted according to ICH/GCP guidelines and is approved by the regional ethical review board in Linköping Sweden (Dnr 2018/193-31, Dnr 2018/384-32). Results will be presented at scientific meetings and published in peer-reviewed publications.Trial registration numberThe study was registered with ClinicalTrials.gov NCT03797157, 9 January 2019.

scholarly journals Exclusive Human Milk VS Preterm Formula: Randomized Trial in Extremely Preterm Infants

2011 ◽  
Vol 70 ◽  
pp. 4-4 ◽  
Author(s):  
E A Cristofalo ◽  
R J Schanler ◽  
C L Blanco ◽  
S Sullivan ◽  
R Trawoeger ◽  
...  
Keyword(s):  
Human Milk ◽  
Randomized Trial ◽  
Preterm Infants ◽  
Preterm Formula ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals 342 Maternal Predictors of Human Milk Intake in Extremely Preterm Infants

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A100-A101
Author(s):  
S. Omarsdottir ◽  
A. Adling ◽  
L. Legnevall ◽  
A. E. Bonamy ◽  
M. Vanpee
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Milk Intake ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Maternal Predictors

Intake and Macronutrient Content of Human Milk Given to Extremely Preterm Infants

2014 ◽  
Vol 30 (4) ◽  
pp. 442-449 ◽  
Author(s):  
Elisabeth Stoltz Sjöström ◽  
Inger Öhlund ◽  
Andreas Tornevi ◽  
Magnus Domellöf
Keyword(s):  
Human Milk ◽  
Preterm Infants ◽  
Macronutrient Content ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

scholarly journals Concentrated Preterm Formula as a Liquid Human Milk Fortifier at Initiation Stage in Extremely Low Birth Weight Preterm Infants: Short Term and 2-year Follow-up Outcomes

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2229 ◽  
Author(s):  
Yung-Chieh Lin ◽  
Yen-Ju Chen ◽  
Chao-Ching Huang ◽  
Chi-Chang Shieh
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Human Milk ◽  
Preterm Infants ◽  
Volume Ratio ◽  
Extremely Low Birth Weight ◽  
Improvement Project ◽  
Preterm Formula ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Human milk (HM) must be accurately fortified for extremely low birth weight (ELBW) preterm infants with human milk fortifiers (HMFs). Powdered HMF has some limitations in terms of sterilization and accuracy. A concentrated preterm formula (CPF) may serve as a safe liquid HMF to facilitate growth. Hence, we launched a quality improvement project for fortification accuracy of minute volume HM. A CPF, Similac Special Care 30 (SSC30), was newly introduced as an HMF when daily feeding reached 100 cm3/kg. CPF + HM (1:2 volume ratio), CPF + HM (1:1 volume ratio), and powdered HMF + HM (1 packet in 25 cm3) represented three fortification stages. Fortification shifted to powdered HMF while tolerable feeding reached 25 cm3/meal. The outcome was compared before (Period-I, January 2015 to June 2016, n = 37) and after the new implement (Period-II, July 2016 to December 2017, n = 36). Compared with the Period-I group, the Period-II group had significantly higher daily enteral milk intake in the first 4 weeks of life, and higher percentages of fortification in the HM-fed infants in the first 8 weeks after birth. The Period-II group also significantly increased in body weight growth in terms of z-score at term equivalent age (p = 0.04) and had better language and motor performance at 24 months old (p = 0.048 and p = 0.032, respectively). Using the liquid CPF as a strategical alternative fortification of HM might be beneficial for extremely preterm infants in terms of growth as well as neurodevelopment.

scholarly journals Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants

2018 ◽  
Vol 43 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Anders K. Nilsson ◽  
Chatarina Löfqvist ◽  
Svetlana Najm ◽  
Gunnel Hellgren ◽  
Karin Sävman ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Human Milk ◽  
Preterm Infants ◽  
Lipid Emulsions ◽  
Fatty Acid Profiles ◽  
Serum Fatty Acid ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Life expectancy of extremely preterm infants

2007 ◽  
Vol 148 (48) ◽  
pp. 2279-2284 ◽  
Author(s):  
Gabriella Vida ◽  
Ilona Sárkány ◽  
Simone Funke ◽  
Judit Gyarmati ◽  
Judit Storcz ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Preterm Infants ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Optimális esetben a 24–28. gesztációs hét közötti, igen éretlen újszülöttek olyan szülészeti intézményben születnek, ahol neonatalis intenzív centrum működik, így mind az akut, mind a hosszú távú ellátásukat magas színvonalon biztosítják. A PTE OEKK ÁOK Szülészeti és Nőgyógyászati Klinikán 2000. január 1. és 2004. december 31. között 7499 újszülött született. A koraszülési frekvencia 20% (1499/7499), ezen belül az extrém alacsony gesztációs korúak aránya (≦28. gesztációs hét) 18% (272/1499), míg a 25. gesztációs hét alattiaké 3,2% (48/1499) volt. A túlélés a gesztációs hetek emelkedésével fokozatosan javul. Az életben maradt koraszülöttek későbbi életkilátásai és társadalmi beilleszkedése függ az olyan maradandó károsodásoktól, mint a látáscsökkenés, halláskárosodás, somatomentalis fejlődés zavarai, krónikus tüdőbetegség. A klinikán vizsgált alacsony gesztációs korú csoportban az összes fogyatékkal élő betegek aránya 15,3%. Döntő többségük a 25. gesztációs hétnél korábban született koraszülöttek közül kerül ki. A 26. gesztációs héttől a koraszülöttek több mint fele tartós károsodás nélkül éli túl az extrém éretlenség társuló problémáit. Megállapították, hogy a korai koponya-ultrahangvizsgálattal, szemészeti szűréssel, otoacusticus emissio mérésével jól prognosztizálhatók a maradandó károsodások, így lehetővé válik a korai kezelés.

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