The effect of deactivated phospholipids on joints lubrication: Osteoarthritis and lubricating properties

2021 ◽  
Vol 3 (6) ◽  
pp. 01-03
Author(s):  
Z. Pawlak
Keyword(s):  
Articular Cartilage ◽  
Joint Inflammation ◽  
Phospholipid Content ◽  
Lubrication Mechanism ◽  
Hydration Mechanism ◽  
Synovial Joints ◽  
Lamellar Phases ◽  
Supportive Role ◽  
Synovial Fluids ◽  
Lubricating Properties

PLs bilayers coating the major synovial joints such as knees and hips as the lubricant are responsible for the lubrication of articular cartilage. Lamellar-repulsive effect has been considered as a lubrication mechanism but it is likely that lubricin and hyaluronan with PLs participate in the lubrication process. The molecules of lubricin and hyaluronan adsorbed by PLs have a supportive role and provide the efficient lubrication of synovial joints via the hydration mechanism (~ 80% water content). Lipid profiles of injured and healthy knees’ synovial fluids show significant differences. The phospholipid content in synovial fluid (SF) during joint inflammation, osteoarthritis is significantly higher (2 to 3 times) above the normal concentration of PL, and has a poor boundary-lubricating ability because of deactivated PL molecules. Deactivated PL molecule has no ability to form bilayers, lamellar phases, and liposomes.

On the Natural Lubrication of Synovial Joints: Normal and Degenerate

1977 ◽  
Vol 99 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Joseph M. Mansour ◽  
Van C. Mow
Keyword(s):  
Articular Cartilage ◽  
Solid Phase ◽  
Articular Surface ◽  
Moving Load ◽  
Frictional Resistance ◽  
Elastic Solid ◽  
Surface Load ◽  
Two Phase ◽  
Tissue Properties ◽  
Synovial Joints

Fluid flow and mass transport mechanisms associated with articular cartilage function are important biomechanical processes of normal and pathological synovial joints. A three-layer permeable, two-phase medium of an incompressible fluid and a linear elastic solid are used to model the flow and deformational behavior of articular cartilage. The frictional resistance of the relative motion of the fluid phase with respect to the solid phase is given by a linear diffusive dissipation term. The subchondral bony substrate is represented by an elastic solid. The three-layer model of articular cartilage is chosen because of the known histological, ultrastructural, and biomechanical variations of the tissue properties. The calculated flow field shows that for material properties of normal healthy articular cartilage the tissue creates a naturally lubricated surface. The movement of the interstitial fluid at the surface is circulatory in manner, being exuded in front and near the leading half of the moving surface load and imbibed behind and near the trailing half of the moving load. The flow fields of healthy tissues are capable of sustaining a film of fluid at the articular surface whereas pathological tissues cannot.

scholarly journals Formation of synovial joints and articular cartilage

2013 ◽  
Vol 72 (3) ◽  
pp. 181-187 ◽  
Author(s):  
S. Moskalewski ◽  
A. Hyc ◽  
E. Jankowska-Steifer ◽  
A. Osiecka-Iwan
Keyword(s):  
Articular Cartilage ◽  
Synovial Joints

Joints and connective tissue—structure and function

2020 ◽  
pp. 4379-4385
Author(s):  
Thomas Pap ◽  
Adelheid Korb-Pap ◽  
Christine Hartmann ◽  
Jessica Bertrand
Keyword(s):  
Articular Cartilage ◽  
Biochemical Properties ◽  
Structure And Function ◽  
Physical Interaction ◽  
Connective Tissues ◽  
Inflammatory Joint Diseases ◽  
Synovial Joints ◽  
Key Features ◽  
And Function ◽  
Connective Tissue Structure

Synovial joints are complex functional elements of the vertebrate body that provide animals with motion capabilities and hence the ability for locomotion and direct physical interaction with their environment. They are composed of different connective tissues structures that are derived from the same developmental structures in the embryo but have distinct cellular and biochemical properties. Articular cartilage and synovial membrane are key components of synovial joints and show several peculiarities that makes them different from other tissues. An in-depth knowledge of these features is important not only for understanding key features of articular function, but also providing explanations for important characteristics of both degenerative and inflammatory joint diseases. This chapter reviews the structure, biochemical composition, and function of articular cartilage and synovium, and points to important links between physiology and pathologic conditions, particularly arthritis.

scholarly journals Expression of Natural Peptide Antibiotics in Human Articular Cartilage and Synovial Membrane

2001 ◽  
Vol 8 (5) ◽  
pp. 1021-1023 ◽  
Author(s):  
Friedrich Paulsen ◽  
Thomas Pufe ◽  
Wolf Petersen ◽  
Bernhard Tillmann
Keyword(s):  
Articular Cartilage ◽  
Antimicrobial Peptides ◽  
Synovial Membrane ◽  
Rare Event ◽  
Joint Inflammation ◽  
Human Articular Cartilage ◽  
Peptide Antibiotics ◽  
Invasive Procedures ◽  
Articular Joint ◽  
Natural Peptide

ABSTRACT In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.

Inflammatory and Noninflammatory Synovial Fluids Exhibit New and Distinct Tribological Endotypes

2020 ◽  
Vol 142 (11) ◽  
Author(s):  
Elizabeth Feeney ◽  
Devis Galesso ◽  
Cynthia Secchieri ◽  
Francesca Oliviero ◽  
Roberta Ramonda ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Synovial Fluid ◽  
Inflammatory Arthritis ◽  
Tribological Behavior ◽  
Friction Coefficients ◽  
Low Concentrations ◽  
Synovial Fluids ◽  
Erratic Behavior ◽  
Lubricating Properties

Abstract Inferior synovial lubrication is a hallmark of osteoarthritis (OA), and synovial fluid (SF) lubrication and composition are variable among OA patients. Hyaluronic acid (HA) viscosupplementation is a widely used therapy for improving SF viscoelasticity and lubrication, but it is unclear how the effectiveness of HA viscosupplements varies with arthritic endotype. The objective of this study was to investigate the effects of the HA viscosupplement, Hymovis®, on the lubricating properties of diseased SF from patients with noninflammatory OA and inflammatory arthritis (IA). The composition (cytokine, HA, and lubricin concentrations) of the SF was measured as well as the mechanical properties (rheology, tribology) of the SF alone and in a 1:1 mixture with the HA viscosupplement. Using rotational rheometry, no difference in SF viscosity was detected between disease types, and the addition of HA significantly increased all fluids' viscosities. In noninflammatory OA SF, friction coefficients followed a typical Stribeck pattern, and their magnitude was decreased by the addition of HA. While some of the IA SF also showed typical Stribeck behavior, a subset showed more erratic behavior with highly variable and larger friction coefficients. Interestingly, this aberrant behavior was not eliminated by the addition of HA, and it was associated with low concentrations of lubricin. Aberrant SF exhibited significantly lower effective viscosities compared to noninflammatory OA and IA SF with typical tribological behavior. Collectively, these results suggest that different endotypes of arthritis exist with respect to lubrication, which may impact the effectiveness of HA viscosupplements in reducing friction.

scholarly journals Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Jun Yamada ◽  
Kunikazu Tsuji ◽  
Kazumasa Miyatake ◽  
Yu Matsukura ◽  
Kahaer Abula ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Proinflammatory Cytokines ◽  
Synovial Membrane ◽  
Joint Inflammation ◽  
Cartilage Degeneration ◽  
Decoy Receptor ◽  
Arthritis Model ◽  
Cartilage Homeostasis ◽  
Articular Cartilage Degeneration ◽  
And Cartilage

Activins are proinflammatory cytokines which belong to the TGFβsuperfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model. Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin. Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin. In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage. These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis. Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration.

Sign in / Sign up

Export Citation Format

Share Document