scholarly journals Evaluation of the Relationship between Serum Vitamin D and Morbidity and Mortality in Patients with COVID-19

2021 ◽  
Vol 2 (3) ◽  
pp. 01-06
Author(s):  
Narjes Zarei jalalabadi ◽  
Hamid Khederlou ◽  
Ahmadreza Rasouli ◽  
Razieh Anari ◽  
Fahime Moeini ◽  
...  
Keyword(s):  
Vitamin D ◽  
Analytical Study ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Mediating Role ◽  
Health Authorities ◽  
Life Threatening ◽  
Underlying Diseases ◽  
The Relationship

Background: The COVID-19 can cause serious life-threatening complications. Vitamin D deficiency has been proposed to mediate the disease by some studies, however, there is a lack of sufficient data. Methods: In this descriptive-analytical study, 72 Iranian adult patients with COVID-19 were examined. At the beginning of hospitalization, serum levels of vitamin D were checked and patients were divided into four groups as vitamin D above normal, normal, insufficient, or deficient. The prognosis of patients has been evaluated based on serum levels of vitamin D and other underlying factors. Results: Only 30% of patients had normal vitamin D concentrations. Vitamin D status was associated with COVID-19 complications, but not with underlying diseases. In the multivariable logistic regression, COVID-19 prognosis was associated with being male, length of stay in an intensive care unit (ICU), need for intubation, acute respiratory disease syndrome (ARDS), and myocarditis. The serum vitamin D correlated with COVID-19 complications including ARDS, QT length, the requirement to ICU, and intubation. Conclusion: This study showed a mediating role for vitamin D in COVID-19 complications and identified the frequent complications in these patients and contributing variables exaggerating prognosis for health authorities to properly manage COVID-19 in hospitals. Further relevant examinations are highly encouraged.

scholarly journals The relationship between serum vitamin D level and COVID-19; a review study

2020 ◽  
Vol 5 (2) ◽  
pp. e34-e34
Author(s):  
Yasaman Koohshoori ◽  
Ehsan Ramanian ◽  
Nasrin Moradi ◽  
Shahrzad Shadabi ◽  
Minoo Motahhar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Length Of Hospital Stay ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Potential Effect ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Relationship

Introduction: Coronavirus disease 2019 (COVID-19) from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most important epidemiological events in the past 100 years has become, the consequences for public health and economic systems around the world. Vitamin D is an important micronutrient that has been reported to improve immunity and protect against respiratory diseases. In this study, we intend to review articles that examine the relationship between COVID-19 and vitamin D. Methods: This is a review that uses articles from studies published in 2020 on the relationship between COVID-19 and vitamin D in databases such as; Web of Science, Science Direct, SID, Magiran, Google Scholar and PubMed. Keywords used included; serum levels of 25-hydroxyvitamin D, vitamin D, COVID-19, SARS-COV-2 and coronavirus 2. With this search, 32 articles were finally selected for this purpose and their results were reviewed Results: Of the 32 studies reviewed, only three showed no association between vitamin D levels in the blood and COVID-19 disease. Other studies had a relationship between the severity of the disease, mortality rate and length of hospital stay, in different age, gender and location groups. Conclusion: It seems that the level of vitamin D in the blood has a potential effect on COVID-19 disease. Checking the serum vitamin D levels and supplementation in people with hypovitaminosis D can be a good solution to reduce the complications and problems caused by COVID-19.

Investigating the Relationship the Severity of Coronary Artery Disease with Serum Levels of Vitamin D in Men after Eliminating the Effect of Diet

2020 ◽  
Vol 16 (4) ◽  
pp. 508-513
Author(s):  
Farshad K. Birgani ◽  
Majid M. Shahi ◽  
Bahman Cheraghian ◽  
Habib Haybar
Keyword(s):  
Coronary Artery Disease ◽  
Vitamin D ◽  
Coronary Artery ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Artery Disease ◽  
The Relationship

Background: Coronary artery disease (CAD) is one of the most common cardiovascular diseases that can lead to mortality, inability, and lower productivity levels. Objective: The aim of this study was to determine the relationship between serum vitamin D level and cardiovascular risk factors and the severity of CAD after determining and eliminating the confounding effects of dietary patterns in male patients undergoing angiography. Methods: This descriptive-analytic study was carried out on 132 men undergoing angiography during 2017 and 2018. To this end, food frequency questionnaire (FFQ) and physical activity questionnaire (PAQ) were completed for the patients. Fasting blood sugar (FBS), triglyceride, total cholesterol, HDL-C, LDL-C and vitamin D levels were also investigated. Results: Serum vitamin D levels significantly decreased with an increase in CAD severity (p=0.001). Also, low serum levels led to the highest severity of CAD (p=0.005). However, there was no significant difference between patients with vitamin D deficiency with different degrees of CAD (p=0.084). Also, the highest percentage of individuals with normal serum levels of vitamin D was observed in the group without any blocked blood arteries (normal) (p=0.023). Conclusion: This study shows an inverse relationship between serum 25(OH) D level and the severity of CAD. Our data show that vitamin D plays an important role in preventing CAD. These findings could help design prospective studies and clinical trials on a wider scale to investigate the effects of vitamin D interventions in preventing the development of CAD.

scholarly journals The Relationship Between Serum Vitamin D Level and Severity of Bronchiolitis in Infants Being Referred to in Bandar Abbas Children’s Hospital, Iran

2020 ◽  
Vol 9 (3) ◽  
pp. 96-100
Author(s):  
Mohammad Bagher Rahmati ◽  
Mehran Ahmadi ◽  
Seyed Alireza Sobhani ◽  
Morteza Bakhshi ◽  
Hosein Hamadiyan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Children's Hospital ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children’S Hospital ◽  
The Mean ◽  
Bandar Abbas ◽  
The Relationship

Background: The present study aimed to investigate the relationship between the serum vitamin D level and the severity of bronchiolitis in infants. Materials and Methods: The population of this descriptive-analytical study included all infants within the age range of 1 month to 24 months old with bronchiolitis hospitalized in Bandar Abbas children’s hospital in 2018-2019. According to the exclusion and inclusion criteria, patients were entered in the study and diagnosed with bronchiolitis by a pediatric infectious disease specialist. Then, their serum levels of vitamin D were measured as well. Results: Of the 85 patients, 62.4% and 37.6% were males and females, respectively. The mean serum level of vitamin D was 29.74±13.44 ng/mL. In addition, the mean age in groups with mild-, moderate-, and severe-intensity was 9.27±4.52 months, 5.12±3.95 months, and 3.16±1.16 months (P<0.001), respectively. Further, the Spearman’s correlation between age and serum vitamin D levels was r = 0.05 (P<0.001). Based on the results, there was a statistically significant difference between the mean age in the two study groups (P<0.001). Finally, a statistically significant association was found between the severity of bronchiolitis and vitamin D status (P=0.007). Conclusion: According to the results of the present study, more than half of the infants admitted to the diagnosis of bronchiolitis had insufficient serum levels of vitamin D. There was also a significant association between the severity of bronchiolitis and serum vitamin D levels.

scholarly journals The relationship of serum vitamin D, calcium, and phosphorus levels of mothers with growth indices of their newborns in pregnant women admitted to Hajar hospital of Shahrekord in 2016

2019 ◽  
Vol 21 (5) ◽  
pp. 237-243
Author(s):  
Sheida Shabanian ◽  
Neda Neyazi ◽  
Abolfazl Khoshdel ◽  
Soleyman Kheiri ◽  
Mohammad Saleh Ghafari
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Analytical Study ◽  
Phosphorus Deficiency ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Calcium And Phosphorus ◽  
Relationship Of ◽  
The Relationship ◽  
Phosphorus Levels

Background and aims: Vitamin D deficiency is a known pandemic problem which has thousands of bad health outcomes. The aim of the current study was to investigate the effect of maternal vitamin D, Ca, and PO4 levels on growth indexes of newborns at birth and 1 month and 3 months after delivery in pregnant women admitted to Hajar hospital of Shahrekord, Iran in 2016. Materials and Methods: This descriptive-analytical study was conducted on 196 pregnant women admitted to the hospital. During pregnancy, 5 mL of mother’s blood and 5 mL of umbilical cord blood were taken. Serum calcium and phosphorus levels were determined immediately after sampling and then centrifuged. After collecting the samples, 25-OHD levels were measured by ELISA method. Neonatal growth indexes such as weight, height, and head circumference atbirth,1 month, and 3 months were measured. Data were analyzed using independent samples t test, ANOVA, and correlation coefficient by SPSS version 16.0. Results: Deficiency of vitamin D, phosphorus, and calcium was observed in 76%, 1%, and 25% of women, respectively. Moreover, deficiency of vitamin D, phosphorus, and calcium was reportedin56.1%, 15.8%, and 9.2% of newborns, respectively. There was a significant relationship between calcium level in newborns and their weight and height at birth, one month, and three months of age ( P<0.05). Levels of vitamin D, calcium and phosphorus of mother and newborns were significantly correlated ( P<0.05). Conclusion: More than two-thirds of mothers and more than half of the newborns were deficient in vitamin D. There was also a lack of calcium in one third of mothers and 9.2% of newborns, and phosphorus deficiency was observed only in 1% of mothers and 15.8% of newborns. Due to the low intake of these materials through nutrition, the supplementation of these substances, especially vitamin D and calcium, is required during pregnancy.

scholarly journals A D3-vitamin-szint és a betegség súlyossága közötti kapcsolat vizsgálata herediter angioödémában

2019 ◽  
Vol 160 (25) ◽  
pp. 987-993
Author(s):  
Beáta Visy ◽  
Tamás Szilágyi ◽  
Kinga Viktória Kőhalmi ◽  
Nóra Veszeli ◽  
Lilian Varga ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Serum Levels ◽  
C1 Inhibitor ◽  
C1 Inhibitor Deficiency ◽  
Serum Vitamin D ◽  
Need For Treatment ◽  
Significant Difference ◽  
The Given ◽  
The Relationship

Abstract: Introduction: In recent years, many papers analyzed the relationship between serum vitamin D3 level and the frequency and activity of various diseases at least partially attributed to immune mechanisms. Aim: We looked for correlations among the number and location of edematous episodes occurring in patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and the quantity of the C1-inhibitor used for supplementation as well as the vitamin D3 levels of patients. Method: We measured vitamin D3 levels in 118 of the 175 C1-INH-HAE patients of the National Angioedema Reference Center during the winter–spring (n = 111) and the summer–autumn periods (n = 105) in 2013–2014. Complement levels and clinical data were extracted from the National Angioedema Registry and from patient diaries. Results: The proportion of vitamin D3 deficient patients (serum level <20 ng/ml) was approximately 59.5% during winter–spring, 27.6% in summer–autumn, and 23.5% during both periods. There was a significant difference between vitamin D3 serum levels measured in the winter–spring or in the summer–autumn months (p<0.0001). The same applies to the number of the vials of C1-inhibitor concentrate administered as acute treatment for angioedema attacks (p = 0.01). In any season, vitamin D3 level did not correlate with the number of attacks experienced by the patients during the given period or of the vials of C1-inhibitor concentrate administered. Conclusions: We could not demonstrate a relationship between vitamin D3 level and the frequency or location of edematous episodes in HAE patients. The need for treatment (as reflected by the number of the vials administered) was higher in the winter–spring period. As vitamin D3 deficiency was more severe than expected in our patients, supplementation is clearly necessary. Orv Hetil. 2019; 160(25): 987–993.

Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents

2016 ◽  
Vol 29 (7) ◽  
Author(s):  
Lingli Wang ◽  
Huiyan Wang ◽  
Huaikai Wen ◽  
Hongqun Tao ◽  
Xiaowei Zhao
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Chinese Children ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
The Difference ◽  
Chinese Children And Adolescents

AbstractThe objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents.Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8–18 years between March 2014 and February 2015.HOMA-IR was significantly different across vitamin D statuses (p<0.001), even after adjusting for body mass index (BMI) (p=0.035) and waist-to-height ratio (p=0.044); the difference was not significant between the vitamin D deficient and insufficient groups (p=0.120). HOMA-IR negatively correlated with serum 25-OHD level for all subjects (ROur findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.

scholarly journals No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

2017 ◽  
Vol 75 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Tarso Adoni ◽  
Soniza Vieira Alves-Leon ◽  
Samira L. Apostolos-Pereira ◽  
Walter Oleschko Arruda ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Large Population ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Serum Vitamin D ◽  
Control Subjects ◽  
Vitamin D Levels ◽  
The Mean ◽  
25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

scholarly journals Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

2020 ◽  
Author(s):  
Daniel R Drodge ◽  
Ashley Budu-Aggrey ◽  
Lavinia Paternoster
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Strong Relationship ◽  
Reverse Direction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Standard Deviations ◽  
The Relationship ◽  
Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

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