Relationship between HOMA-IR and serum vitamin D in Chinese children and adolescents

2016 ◽  
Vol 29 (7) ◽  
Author(s):  
Lingli Wang ◽  
Huiyan Wang ◽  
Huaikai Wen ◽  
Hongqun Tao ◽  
Xiaowei Zhao
Keyword(s):  
Vitamin D ◽  
Children And Adolescents ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Chinese Children ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
The Difference ◽  
Chinese Children And Adolescents

AbstractThe objective of this study was to examine the cross-sectional relationship between homeostasis model assessment for insulin resistance (HOMA-IR) and serum 25-hydroxyvitamin D (25-OHD) level in Chinese children and adolescents.Anthropometric indices, lipid metabolic profile, and serum levels of glucose, insulin and 25-OHD were determined among 278 healthy prepubertal and pubertal, normal and overweight/obese children and adolescents aged 8–18 years between March 2014 and February 2015.HOMA-IR was significantly different across vitamin D statuses (p<0.001), even after adjusting for body mass index (BMI) (p=0.035) and waist-to-height ratio (p=0.044); the difference was not significant between the vitamin D deficient and insufficient groups (p=0.120). HOMA-IR negatively correlated with serum 25-OHD level for all subjects (ROur findings supported that lower vitamin D status is strongly associated with worse HOMA-IR.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

scholarly journals Vitamin D, vitamin D binding protein, vitamin D receptor levels and cardiac dysautonomia in patients with multiple sclerosis: a cross-sectional study

2019 ◽  
Vol 77 (12) ◽  
pp. 848-854 ◽  
Author(s):  
Tülin Aktürk ◽  
Yaşar Turan ◽  
Nermin Tanik ◽  
Müjgan Ercan Karadağ ◽  
Hikmet Sacmaci ◽  
...  
Keyword(s):  
Vitamin D ◽  
Orthostatic Hypotension ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin D Binding Protein ◽  
Cross Sectional ◽  
Supine Hypertension ◽  
Serum Vitamin D

ABSTRACT Vitamin D is a pleiotropic steroid hormone that modulates the autonomic balance. Its deficiency has been described as an environmental risk factor for multiple sclerosis (MS). The aim of this study was to investigate the serum levels of vitamin D, vitamin D binding protein (VDBP) and vitamin D receptors (VDR) and to evaluate cardiac dysautonomia in MS patients due to bidirectional interaction between vitamin D and the autonomic nervous system. Methods: The current cross-sectional study was conducted on 26 patients with relapsing-remitting MS and on 24 healthy controls. Twenty-four-hour ambulatory blood pressure variability (BPV) was calculated and the participants were evaluated for orthostatic hypotension and supine hypertension. Serum levels of vitamin D, VDBP and VDR were measured. Results: The mean serum vitamin D level was significantly lower in MS patients than in controls (p = 0.044); however there was no significant difference in terms of VDR and VDBP levels between the groups. Supine hypertension and orthostatic hypotension were significant and the 24-hour systolic BPV was significantly decreased in patients with MS (p < 0.05) compared to controls. No correlation was found between vitamin D, VDBP and VDR with supine hypertension, orthostatic hypotension and systolic BPV values (p > 0.05). Also, there was a negative correlation between VDBP and the EDSS (p = 0.039, r = −0.406). Conclusion: There was no correlation between orthostatic hypotension, supine hypertension and systolic BPV values and serum vitamin D, VDBP and VDR in MS patients. Future prospective studies with large number of patients may help us to better understand the relationship between vitamin D and the autonomic nervous system.

scholarly journals Serum Levels of Vitamin D in Diabetic Patients With and Without Retinopathy

2020 ◽  
Author(s):  
Mehrdad Afarid ◽  
Naghme Ghattavi ◽  
Mohammad Karim Johari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Proliferative Retinopathy ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
25 Hydroxy Vitamin D

Purpose: To evaluate the levels of vitamin D in the serum of diabetic patients with and without diabetic retinopathy (DR). Methods: Thirty patients with DR and thirty diabetic patients without retinopathy were included in this cross-sectional study. Based on ophthalmic examination, patients with DR were categorized into having non-proliferative retinopathy (NPDR) and proliferative retinopathy (PDR). Patients were tested for fasting blood sugar (FBS), hemoglobin A1C (HbA1C), 25-hydroxy vitamin D (25 (OH) D), and creatinine levels in the serum, and for urine protein. Vitamin D deficiency was defined as a serum 25 (OH) D level < 20 ng/mL. Results: We found that all diabetic patients had mild vitamin D deficiency (serum 25 (OH) D level = 10–20 ng/mL). The mean serum 25 (OH) D concentration in patients with DR was lower than in those without DR (12.10 ± 14.62 ng/mL vs 15.61 ± 9.40 ng/mL, respectively, P = 0.012). Trace or more proteinuria was frequently present in patients with DR than in those without DR (56% in DR vs 30% in non-DR; P = 0.037). There were no significant differences in the FBS, HbA1C, and serum creatinine levels between patients with or without retinopathy. Conclusion: The present study demonstrated that patients with DR had lower levels of serum vitamin D compared with those without retinopathy.

scholarly journals Study of Serum Vitamin D Levels in Children with Immune Thrombocytopenic Purpura

2021 ◽  
pp. 12-18
Author(s):  
Mina Fayez Anes Karaz ◽  
Sarah Amr Hamam ◽  
Ibrahim Mohamed Badraia ◽  
Adel Abd El-Haleim Hagag
Keyword(s):  
Vitamin D ◽  
Immune Thrombocytopenic Purpura ◽  
Conventional Therapy ◽  
Serum Vitamin ◽  
Serum Levels ◽  
University Hospitals ◽  
Cross Sectional ◽  
Thrombocytopenic Purpura ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Immune thrombocytopenic purpura (ITP) is described by an immune responding versus the host’s own platelets, in recent years is progressively studied the non-calcemic roles of vitamin-D (VD) that controls immune and inflammation responding. Aim and objectives: The current work aimed to study VD-level in children with ITP and influence of VD supplementing upon the responding of the thrombopenia to conventional therapy of ITP. Subjects and methods: This study is a cross-sectional observational work which included 30 ITP-children who were attendants to Hematology and Oncology Unit, Pediatric Department, Tanta University Hospitals with ages from 2 to 16-yrs with mean ageing of 6.43 ± 3.75-yrs, for all patients and controls serum-levels of 25-hydroxyvitamin D (25[OH]D) were measured. Results: A significant change was found among the studied groups in regard to VD-levels with lower values among patients compared with controls, a statistically significant negative association was found among platelet counts and each of vitamin D level and serum Ca, the mean platelet count after conventional therapy was significantly increased in group one ITP patients. Conclusion: VD lack is very frequent in children with recently identified or chronic ITP form. Consequently, there are advantages of supplement VD in ITP-cases.

scholarly journals Follicular and serum levels of vitamin D in women with unexplained infertility and their relationship with in vitro fertilization outcome: an observational pilot study

2021 ◽  
Vol 17 (5) ◽  
pp. 1418-1422
Author(s):  
Ana Jeremic ◽  
Zeljko Mikovic ◽  
Emina Sudar-Milovanovic ◽  
Esma Isenovic ◽  
Milan Perovic
Keyword(s):  
Vitamin D ◽  
Follicular Fluid ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Unexplained Infertility ◽  
Cross Sectional ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Serum Vitamin D

IntroductionFollicular and serum vitamin D are considered potential markers of the oocyte and embryos' quality and predictors of IVF outcomes.Material and methodsThis retrospective cross-sectional study correlated vitamin D in sera and follicular fluid of women with unexplained infertility mutually and with IVF outcomes. ELISA was used for measuring Vitamin D.ResultsResults show only a positive correlation between follicular and serum levels of Vitamin D (Rho=0.615, p=0.025) and between follicular levels of Vitamin D with the percentage of embryo fragmentation (Rho=0.544; p=0.036).ConclusionsResults suggests that serum and follicular fluid vitamin D measurements could be complementary tools to the routine assessment of embryos.

scholarly journals Evaluating the Relationship Between Disease Severity and Serum Levels of Zinc, Calcium and Vitamin D in COVID-19 Patients

2021 ◽  
Author(s):  
Azam Jahangirimehr ◽  
Azam Khalighi ◽  
Elham Abdolahi Shahvali ◽  
Mostafa Labibzadeh ◽  
Nasrin Bahmanyari
Keyword(s):  
Vitamin D ◽  
Rank Order ◽  
Serum Vitamin ◽  
Serum Levels ◽  
World Health ◽  
Food Sources ◽  
Cross Sectional ◽  
Infected People ◽  
Serum Vitamin D ◽  
Severity Of The Disease

Abstract IntroductionSARS-CoV-2 is spreading rapidly worldwide these days so that it has infected people in many countries. It is a zoonotic virus and the cause of COVID-19 infectious pneumonia. The World Health Organization (WHO) declared it a pandemic on January 30, 2020. Given that no standard treatment has been found for the new coronavirus so far, the present study seeks a way to reduce the incidence and severity of the disease along with health protocols. Some of the factors possibly effective in getting less infected by the SARS-CoV-2 are|taking medication supplements such as zinc, calcium, and vitamin D.Materials and methodsThis cross-sectional study was conducted from May 13 to May 30, 2020, on 93 COVID-19 patients admitted to Khatam Al-Anbia Hospital in Shushtar in southwestern Iran. Some patients' laboratory and clinical of were collected and analyzed using the Chi-squared test, the independent t-test, the Kruskal-Wallis test, and the Spearman rank-order correlation coefficient by IBM SPSS Statistics 18.0 software.FindingsThe severity of the disease (40%) of 37 patients was severe in pulmonary involvement. Serum levels of vitamin D and zinc were lower than the average in all patients. Still, the severity of COVID-19 in patients was not significantly different from their zinc serum levels (P = 0.216). Serum vitamin D was not significantly different (P = 0.102). The severity of COVID-19 in patients was significantly different according to serum calcium levels (P = 0.005). The lower the calcium level, the more severe the disease.ConclusionGiven that the supplementation's effect in preventing COVID-19 has not been confirmed and no study has been published on the appropriate dose of these supplements in COVID-19, taking economically viable calcium-rich food sources, including dairy, is recommended.

scholarly journals Serum Vitamin D Level Associates With Handgrip Muscle Strength Among Ethiopian Schoolchildren: A Cross-Sectional Study

2017 ◽  
Vol 39 (1) ◽  
pp. 54-64 ◽  
Author(s):  
Tolassa Wakayo ◽  
Tefera Belachew ◽  
Susan J. Whiting
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Linear Regression ◽  
Handgrip Strength ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D

Background: Despite varying serum levels of 25(OH)D among schoolchildren in Ethiopia, data are lacking whether this affects their muscle function as measured by handgrip strength of these children. Handgrip strength may be used as a proxy indicator of muscle strength and function. This study evaluated the association between serum levels of 25(OH)D and handgrip strength among schoolchildren in Ethiopia. Methods: The study used a data set from a school-based cross-sectional study conducted on a total of 174 randomly selected schoolchildren from urban (N = 89) and rural (N = 85) settings of Adama Town and Adama Woreda, respectively. Handgrip strength, serum 25(OH)D levels, and anthropometry were measured for each child following standard procedures, while data on demographic characteristics of children and their parents were collected using a structured interviewer-administered questionnaire. A multivariable linear regression model was used to determine the association between serum vitamin D level and handgrip strength after adjusting for other predictors. Results: The mean handgrip muscle strength of the students was 17.6 ± 6.9 kg. The average serum 25(OH)D for the group was 54.5 ± 15.8 nmol/L. On multivariable linear regression model, serum 25(OH)D level was significantly associated with handgrip strength (β = 0.06, P = .008) of the children after controlling for potential confounders. Other variables, female gender (β = −2.20, P = .004), age (β = 1.97, P < .001), height (β = .22, P < .001), weight (β = 0.33, P < .001), and triceps skinfold thickness (β = −0.19, P = .023), were identified to have significant association with handgrip strength of schoolchildren. Conclusion: Serum 25(OH)D levels had significant positive association with handgrip strength of Ethiopian schoolchildren. The results imply the need for incorporating school nutrition education on consumption of foods rich in important nutrients including vitamin D-rich foods in the school curricula and also enhancing behavioral change communication toward exposure to sunlight in the school to produce adequate vitamin D. Further longitudinal study involving a larger sample is recommended to confirm the findings.

ASSOCIATION OF SERUM VITAMIN D LEVELS IN CHRONIC RHINOSINUSITIS (CRS)

2021 ◽  
pp. 4-6
Author(s):  
Saranya Chithra Cheruvu ◽  
Prasanna Kumar Saravanam ◽  
Vivekanandan Balakumar ◽  
Srinivasan Venkataraman
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Review Of Literature ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objective: To assess the levels of Vitamin D in patients with Chronic Rhinosinusitis (CRS) and its correlation with disease severity Methods: The study is an analytical cross -sectional study of patients with Chronic Rhinosinusitis (CRS) and the serum levels of Vitamin D in them.Controls have been used to compare the level of Vitamin D in healthy versus diseased population Results: There is an inverse correlation between severity of chronic rhinosinusitis and serum Vitamin D levels amongst the various subtypes of CRS. Conclusion: This study has observed that Vitamin D levels may have a denitive role in pathogenesis and severity of Chronic Rhinosinusitis. On review of literature, it was noted that very few Studies have discussed this issue.

scholarly journals Association between serum vitamin D level and tuberculosis in children

2016 ◽  
Vol 48 (6) ◽  
pp. 350 ◽  
Author(s):  
Ahmad Zaeni Syafii ◽  
Abdurachman Sukadi ◽  
Budi Setiabudiawan
Keyword(s):  
Vitamin D ◽  
Positive Response ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
The Other ◽  
Sectional Study ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
The Difference ◽  
Tuberculosis In Children

Background A possible association between vitamin 0 andtuberculosis has been described. In adult, vitamin 0 is consideredto have a role in protecting tuberculosis. On the other hand,tuberculosis infection can decrease serum vitamin 0 level.Objective To find out the difference between serum vitamin 0level in children with and without tuberculosis, and to find theassociation of serum vitamin 0 level with tuberculosis.Methods A cross sectional study was conducted in Cibabat Hospital,Ban dung from July to October 2007. We selected children :S 14years, diagnosed as tuberculosis, and had positive response aftertwo month treatment; for control we selected randomly siblingsor neighbors who didn't have tuberculosis. We excluded childrenwith liver abnormalities and immunocompromized children.Mann-Whitney test and OR method with 95% confidence intervalwas used to analyze the data.Results Thirty-nine children with tuberculosis (21 boys, 18 girls)and 39 children without tuberculosis (19 boys, 20 girls) as wereenrolled. Mean serum vitamin 0 level of children with and withoutTB were 4 7 (SO 25) pmol/L and 125 (SO 3 7) pmol/L, respectively(P=O.OOl). All children without tuberculosis had normal vitamin0 level while of those with tuberculosis, 14 children had normallevel and 25 children were deficient (corrected OR: 139, 95%CI8 to 238).Conclusion Serum vitamin 0 level is low in children withtuberculosis.

Relationship Between Nutrient Intake and Vitamin D Status in Osteoporotic Women

2007 ◽  
Vol 77 (6) ◽  
pp. 376-381 ◽  
Author(s):  
de Souza Genaro ◽  
de Paiva Pereira ◽  
de Medeiros Pinheiro ◽  
Szejnfeld ◽  
Araújo Martini
Keyword(s):  
Vitamin D ◽  
Mineral Metabolism ◽  
Sodium Intake ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Dietary Records

Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (≥ 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 μ g/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.

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