Prematurely Born Children: Vaccination – Safety and Specific Immune Response

The analysis of safety and efficiency of vaccination of the children born before the term (61 children of 1 – 4 degree of prematurity) and children born in time (21 children – group of comparison). For vaccination and revaccination was used: DTP (20 and 15 children respectively), DTaP (22 and 4 children), pentavalentny vaccine (DTaP/IPV/Hib – 9 and 2 children) and DT (10 children of the studied group with convulsion in the anamnesis). Against measles, mumps and a rubella was immunized 47 and 20 children respectively. After immunization all clinical symptoms was analyzed and after 2 months diphtheria measles and mumps antibodies was detected.Prematurely born children has the 1 vaccination for 3 – 4 months later, then infants, with born at time. After vaccination 75.4% and 74.5% infants in both groups hadn’t any clinical symptoms. Acute respiratory infection was registered with the same frequency (25,5 – 25.0% and 24.6 – 23.8%). The antibodies titer to diphtheria, measles, mumps didn't depend on degree of prematurity.

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Replication and immune response in HAE of HCoV-HKU1 isolate from a pediatric patient with severe acute respiratory infection

Journal of Clinical Virology ◽

10.1016/j.jcv.2016.08.227 ◽

2016 ◽

Vol 82 ◽

pp. S113

Author(s):

N. Zhu ◽

R.J. Lu ◽

W.J. Tan

Keyword(s):

Immune Response ◽

Pediatric Patient ◽

Respiratory Infection ◽

Acute Respiratory Infection ◽

Severe Acute Respiratory Infection

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Frequency of Coronavirus NL63 Infection in Children with Upper Respiratory Infection by Real-Time PCR

Iranian Journal of Pediatrics ◽

10.5812/ijp.101905 ◽

2020 ◽

Vol 30 (3) ◽

Author(s):

Mahtab Mohammadi ◽

Seyed Ali Mohammad Arabzadeh ◽

Hamid Reza Mollaei ◽

Seyed Hamidreza Monavari ◽

Najmeh Nikpour

Keyword(s):

Real Time ◽

Respiratory Infection ◽

Real Time Pcr ◽

Acute Respiratory Infection ◽

Clinical Symptoms ◽

Upper Respiratory Infection ◽

Highly Sensitive ◽

Coronavirus Infection ◽

Upper Respiratory ◽

First Time

Background: Human coronavirus NL63 (HCoV-NL63) is a new respiratory virus associated with acute respiratory infection in children. Infection with this virus is usually accompanied by upper and lower infections of the respiratory tract in adults. Objectives: In a retrospective study, we investigated the incidence of coronavirus infection in children under the age of five years. Methods: We collected 138 specimens (nasal and throat swabs) from children less than five-years-old with acute respiratory infection from October 2018 to December 2019. Then, HCoV-NL63 was investigated using real-time PCR. Results: Out of 138 samples, 33 (23.9%) were positive for coronavirus NL63, including 21 (63.6%) male samples and 12 (36.4%) female samples. There was no significant correlation between gender and positivity for coronavirus infection (P > 0.05). However, the association of clinical symptoms with the virus was statistically significant (P < 0.05). Conclusions: This study was conducted for the first time in Kerman Province. In this study, the frequency of coronavirus NL63 was evaluated among children with acute respiratory infection with a highly sensitive method, real-time PCR. The prevalence of this virus was 33%, which was more frequent than in similar studies.

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