scholarly journals Epidemiological Surveillance over HIV-infection Including Patients Co-infected with HIV and Viral Hepatitis in the Far Eastern Federal District

2019 ◽  
Vol 18 (4) ◽  
pp. 14-24
Author(s):  
E. A. Bazykina ◽  
V. B. Turkutyukov ◽  
O. E. Trotsenko ◽  
I. O. Taenkova ◽  
L. A. Balakhontseva ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Federal District ◽  
Epidemiological Surveillance ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Infected People ◽  
Viral Hepatitis B ◽  
Far Eastern

Relevance. HIV-infection continues to be one of the unsolved issues of modern healthcare. In the Russian Federation, an annual increase in the number HIV-infected people including co-infected with HIV and viral hepatitis is registered. This is associated with common transmission mechanisms of the diseases. Objective: to conduct a retrospective analysis of the main HIV-infection epidemiological indices that included prevalence of viral hepatitis B and C among people living with HIV in the Far Eastern Federal district during years 2006–2018. Materials and methods: the conducted retrospective epidemiological analysis was based on evaluation of materials provided by AIDS prevention and control regional centers as well as in the official statistical data form № 61 «Data on HIVinfected contingents». Analysis of the obtained data included parametric and nonparametric statistics. Results. A deterioration of the epidemic situation concerning HIV-infection with and without viral hepatitis B and C was registered in the Far Eastern Federal district. The fraction of HIV-positive people aged 40 years and older increased up to 24.68 ± 0.26% in 2018. Feminization of HIV-infected population was observed. The fraction of HIV-positive women increased from 32.30 ± 0.50 % in 2006 to 36.82 ± 0.29% in 2018. The fraction of sexual transmission mechanism of the HIV has increased during the observed period of time and totaled 40.60 ± 0.30% in 2018. This fact plays a significant part in the spread of HIV in the Far Eastern Federal district. Conclusion. The revealed tendencies indicate a necessity of changing the preventive measures strategy against HIV.

scholarly journals PREVALENCE AND MOLECULAR GENETIC PECULIARITIES OF PARENTERAL VIRAL HEPATITIS B AND C AMONG HIVPOSITIVE CITIZENS OF THE FAR EASTERN FEDERAL DISTRICT, INCLUDING THOSE PERSONS SENTENCED TO DEPRIVATION OF FREEDOM

2019 ◽  
pp. 51-55
Author(s):  
E.A. Bazykina ◽  
V.B. Turkutyukov ◽  
O.E. Trotsenko ◽  
V.O. Kotova ◽  
L.A. Balakhonsteva ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Molecular Genetic ◽  
Federal District ◽  
Biological Research ◽  
Hiv Positive ◽  
Healthy Population ◽  
Genetic Characteristics ◽  
Viral Hepatitis B

We conducted a comparative analysis of the parenteral viral hepatitis B and C (HBV and HCV) prevalence and their molecular genetic characteristics among prisoners of persons diagnosed with HIV infection (41 samples), HIV-positive free citizens (187 samples) and «conditionally healthy population» with the lack of information about the presence of a diagnosis of chronic viral hepatitis of any etiology and HIV infection (231 samples). Immunological and molecular biological research methods were used. Obtained data analysis showed that the prevalence of infection markers with viruses of parenteral hepatitis was significantly higher in the groups of HIV-positive individuals (imprisoned and freemen). The HBsAg-negative form of the disease was determined among the HIV-positive free population and in the «conditionally healthy population». Over the past 10 years (2009–2018), the proportion of HIV-positive prisoners in custody of people with HCV monoinfection doubled, HBV was increased in 8.7 times. Significant decrease in the combined infection of HBV and HCV of this contingent was found. Given this decrease in the penitentiary system in HIV-positive individuals, the overall burden of HBV infection (both in mono form and coinfection with HCV) significantly (5.3 times) decreased , which can be attributed to successful widespread vaccination against hepatitis B in Russia. The most common HCV genotypes among HIV-positive individuals were 1b and 3a, genotypic structure of HBV prevailed genotype D.

scholarly journals HIV-INFECTION AND CONSUMPTION OF PSYCHOACTIVE SUBSTANCES

2018 ◽  
Vol 23 (2) ◽  
pp. 60-67
Author(s):  
T. R. Petrosyan ◽  
Murad Z. Shakhmardanov
Keyword(s):  
Hepatitis B ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Drug Users ◽  
Specific Treatment ◽  
Chronic Viral Hepatitis ◽  
Clinical Severity ◽  
Psychoactive Substances ◽  
Social Significance ◽  
Infected People

The article describes the main trends in the incidence rate of HIV infection in the Russian Federation over the past decade. The majority of HIV-infected people was shown to be injecting drug users. The immunosuppressive effect of psychoactive substances and peculiarities of HIV infection in drug-dependent patients are characterized. The drug use is considered to be associated with a high risk of co-infection: viral hepatitis via a parenteral transmission mechanism, tuberculosis. The spread of parenteral viral hepatitis among HIV-infected consumers of psychoactive substances has acquired a huge medical and social significance: hepatitis C affects more than 90% of consumers, hepatitis B - about 70-80%. Viral hepatitis B and C are considered as a co-factor in the tanatogenesis in babies of HIV-infected pregnant females, HIV/HCV coinfection accelerates the rate of progression of the chronic viral liver disease to liver cirrhosis and hepatocellular carcinoma. Among HIV-infected patients, there was significantly increased the proportion of cases killed by chronic viral hepatitis due to lack of the antiviral therapy for specific liver damage. Psychopathological changes in comorbid HIV infection in consumers of psychoactive substances are characterized. In drug users, HIV infection was noted to change the pathological attraction to psychoactive substances. If dependence on psychoactive substance was absent, this psychopathological phenomenon can suddenly arise in patients with narcological diseases, its clinical severity increases sharply. This is due to the general change in the unfavorable side of the mental state of patients, who were informed that they have HIV infection, given the low commitment of this contingent of ART proposed algorithm of complex medical and psychological care aimed at correcting mental, behavioral disorders and specific treatment of HIV infection.

scholarly journals Clinical and laboratory features of viral hepatitis B among HIV-patients in Zambia

2019 ◽  
Vol 23 (2) ◽  
pp. 257-262
Author(s):  
L. V. Moroz ◽  
S. Ch. Soni ◽  
K. D. Chichirelo-Konstantynovych ◽  
S. M. Kulias ◽  
O. O. Popovych
Keyword(s):  
Lactate Dehydrogenase ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Alanine Aminotransferase ◽  
Hiv Positive ◽  
Hiv Patients ◽  
Laboratory Features ◽  
Viral Hepatitis B ◽  
Comparison Groups ◽  
Special Relevance

Viral hepatitis B course in HIV patients in Zambia is still bad studied. At present, the study of the influence of immunosuppression on the clinical and laboratory features of viral hepatitis B acquires a special relevance. The aim of research is to investigate clinical and laboratory features of viral hepatitis B course among HIV-patients in Zambia. Epidemiological, descriptive, serological (HBV, HIV markers), biochemical (cytolysis and cholestasis syndromes’ indicators), statistic method for determining the reliability using average errors (m), t-criterion of the probability difference of the Student) methods are used. The results show HBV/HIV-positive Zambian patients reliably differ from HBV-monoinfected ones. As well, HBV/HIV-positive patients have significantly higher indexes of asteno-vegetatic, dyspeptic syndromes, hepato- and splenomegaly, cytolysis indexes (alanine aminotransferase, lactate dehydrogenase), which are associated with increase of HIV-infection’s stage. Hepatocellular deficiency’s indicators don’t differ reliably in comparison groups. Therefore, HBV/HIV-infected patients have more severe clinical and laboratory course than HBV-monoinfected ones.

scholarly journals FACTORS ASSOCIATED WITH HEPATITIS B AND C CO-INFECTION AMONG PEOPLE LIVING WITH HUMAN IMMUNODEFICIENCY VIRUS IN VIETNAM

2019 ◽  
Vol 5 (4) ◽  
pp. 147-154
Author(s):  
Le Hieu Thuy Anh ◽  
Suchada Thaweesit
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B ◽  
Ecological Model ◽  
Theoretical Perspective ◽  
Hiv Positive ◽  
People Living With Hiv ◽  
Infected People ◽  
Factors Associated ◽  
Immunodeficiency Virus ◽  
Living With Hiv

Background: Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are the leading causes of death from infectious diseases. Because of sharing same transmission routes, the co-infection of HIV with HBV or HCV is common. And the co-infections make HIV infected persons have higher morbidity and mortality than those who infected only with HIV. This study aims to investigate factors that may have influence on the co-infections of HBV or HCV among HIV positive individuals.Objective: The goals of this study were to identify factors associated with the co-infection of HBV or HCV among people living with HIV. Methods: Quantitative research method was applied in this study to examine factors associated with HBV or HCV co-infection among HIV infected people. A total of 250 HIV infected individuals in Khanh Hoa province, Vietnam were the sample of this study. It employed the Social Ecological Model (SEM) as a theoretical perspective that focused on multiple levels of factors. Descriptive statistic was used to describe the general characteristics of the respondents. And Binary logistic regression was carried out to measure the influence of factors on the co-infection. Results: The multivariate analysis of this study showed that HIV-HBV co-infection was associated significantly with residents of Nha Trang (OR= 7.179). Regarding HIV-HCV co-infection, being men (OR= 7.617), unemployed (OR= 4.013), a resident of Nha Trang (OR=10.894) and an injecting drug user (OR= 16.688) were risk factors of the co-infection.Conclusions: This study recommended that intervention strategies to prevent HIV-positive individuals from co-infection with either HBV or HCV should focuses on altering individuals’ risk behaviors and their socio-economic environments. Also, specific preventing programs should be implemented and focus on unemployed populations, injecting drug users, men in general, as well as people living in particular areas, especially cities having a large number of people living with HIV.

scholarly journals PARENTERAL VIRAL HEPATITISES IN THE IRKUTSK REGION

2018 ◽  
Vol 3 (5) ◽  
pp. 148-153 ◽  
Author(s):  
E. D. Savilov ◽  
N. N. Chemezova ◽  
V. A. Astafev ◽  
I. V. Malov ◽  
S. I. Malov ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Federal District ◽  
Disease Rates ◽  
Irkutsk Region ◽  
Viral Hepatitis C ◽  
Viral Hepatitis B ◽  
Epidemiological Risk ◽  
Epidemiological Situation

From all group of infectious pathology viral hepatitises, from which the most priority are the parenteral hepatitises B and С, are essential for health of mankind, also the Irkutsk region isn’t an exception.The aim of the study:to assess an epidemiological situation in sharp and chronic forms of the viral hepatitises B and С in the territory of the Irkutsk region for the long-term period.Materials and methods. The retrospective analysis of an epidemiological situation on viral hepatitises B and C in Russia, Siberian Federal District and in the Irkutsk region for 2008–2016 is carried out.Results.The expressed decrease in incidence of acute viral hepatitis B is noted, at a chronic form of this disease rates of decrease had less expressed character that can be connected with carrying out by mass vaccinal prevention. The carried-out ranged distribution of territories for all forms of viral hepatitis B and viral hepatitis C in the Irkutsk region has allowed to reveal territories of risk.Conclusion.Parenteral viral hepatitises (sharp and chronic forms) are widespread in the territory of the Irkutsk region. From 43 administrative territories of the area, 24 belong to unsuccessful on incidences from which five are to territories of high epidemiological risk: cities of Irkutsk, Angarsk and Ust-Ilimsk and also Katangsky and Shelekhovsky districts.

scholarly journals LETHALITY OF TB PATIENTS, COMBINED WITH THE VIRAL HEPATITIS AND HIV INFECTION IN SAINT-PETERSBURG

2019 ◽  
Vol 11 (2) ◽  
pp. 42-47
Author(s):  
A. K. Ivanov ◽  
V. V. Nechaev ◽  
L. N. Pozhidayeva ◽  
V. B. Musatov ◽  
V. S. Belyakov ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Fatal Outcome ◽  
Chronic Viral Hepatitis ◽  
Unknown Etiology ◽  
Saint Petersburg ◽  
Viral Hepatitis B ◽  
High Level

Сombination of tuberculosis and viral hepatitis have been registered 2525 newly identified patients in Saint-Petersburg for the period 2006–2017. Some of these patients have been infected with HIV. Fatal outcome in 625 (24,7%) was noted. Patients with tuberculosis and chronic viral hepatitis have had a combination of viral hepatitis B and C in 36% of cases. Patients with combination tuberculosis and chronic hepatitis of unknown etiology experienced a more frequent death (60%) than patients with combination tuberculosis and other chronic viral hepatitis. In patients with concurrent tuberculosis, chronic viral hepatitis and HIV infection, patients infected viral hepatitis B and C were 31,6%. In 160 patients with fatal outcomes had a combination of infections (tuberculosis, viral hepatitis and HIV infection), the mortality rate of persons with hepatitis of unknown etiology was the lowest (42%), compared with a group of individuals affected by viral hepatitis B and C simultaneously (83%). Among patients with tuberculosis, chronic hepatitis and HIV infection, the highest incidence of tuberculosis of the intrathoracic lymph nodes and disseminated pulmonary tuberculosis was registered. Lethal outcomes most often occur in individuals with advanced tuberculosis, in whom the secretion of mycobacteria tuberculosis into the external environment has not been established. Given the high level of mortality in patients with simultaneous defeat of tuberculosis, viral hepatitis and HIV infection, it is necessary to establish their centralized registration in order to study the epidemiological patterns and clinical features of co-infections.

scholarly journals A clinical case of Kaposi sarcoma in a patient with TB/HIV co-infection

2020 ◽  
Vol 98 (7) ◽  
pp. 63-68
Author(s):  
N. V. Kuzmina ◽  
N. V. Nelidova
Keyword(s):  
Hepatitis B ◽  
Hiv Infection ◽  
Viral Hepatitis ◽  
Clinical Case ◽  
Kaposi Sarcoma ◽  
Antiretroviral Drugs ◽  
T Cell Immunity ◽  
Adherence To Treatment ◽  
Cell Immunity ◽  
Viral Hepatitis B

The article describes a clinical case of Kaposi sarcoma in a patient with concurrent tuberculosis, HIV infection with severely compromised T-cell immunity, viral hepatitis B and C, and substances and alcohol abuse. Also, the patient had low adherence to treatment with anti-tuberculosis and antiretroviral drugs.

Current Issues of Epidemiological Surveillance of Chronic Viral Hepatitis B, C, D and Hepatocellular Carcinoma at the Regional Level

2021 ◽  
pp. 76-84
Author(s):  
EV Khorkova ◽  
LV Lyalina ◽  
OM Mikailova ◽  
AYu Kovelenov ◽  
YuV Ostankova ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Epidemiological Surveillance ◽  
Leningrad Region ◽  
Hepatitis D ◽  
Viral Hepatitis B

Introduction. To achieve the goal of eliminating viral hepatitis by 2030, it is necessary to assess the real situation, improve epidemiological surveillance and prevention of these infections. Objectives: To evaluate the results of epidemiological surveillance of chronic viral hepatitis B, C, D and hepatocellular carcinoma in order to optimize the surveillance system at the regional level. Materials and methods: We analyzed the incidence of viral hepatitis B, C and liver cancer in the regions of the Northwestern and Central Federal Districts of the Russian Federation over the past 10 years. We also studied the prevalence of hepatitis B, C, D, and hepatitis C virus genotypes (6,020 cases), and examined 465 case histories of patients with hepatocellular carcinoma in the Leningrad Region using techniques of epidemiological analysis, ELISA, PCR, and statistical methods. Results: We established a tendency towards a decrease in the incidence of chronic hepatitis B and C in all study areas. In 2020, high rates of hepatitis B (26.2 and 9.1) and hepatitis C (49.2 and 39.2) were registered in St. Petersburg and Moscow per 100,000 population, respectively. The prevalence of hepatitis D in the Leningrad Region was 6.3 per 100,000 population. Hepatitis C virus genotypes 1 and 3 prevailed (48.9 % and 43.9 %, respectively). A high incidence of liver cancer was established in St. Petersburg, the Pskov and Novgorod Regions. Conclusions: Our findings prove the efficiency of the surveillance system and prevention of chronic hepatitis B and C. The main objectives are to further reduce the incidence rate, screen all patients with chronic hepatitis B for hepatitis D, and use the results of molecular genetic studies and cancer registries for epidemiological surveillance purposes.

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