scholarly journals Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation

2009 ◽  
Vol 45 (2) ◽  
pp. 219-226 ◽  
Author(s):  
Takahiro Kataoka ◽  
Masaaki Yoshimoto ◽  
Shinya Nakagawa ◽  
Yuko Mizuguchi ◽  
Takehito Taguchi ◽  
...  
Author(s):  
D. E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
Joann Stevenson ◽  
S. Black

The response of spermatogonial cells to X-irradiation is well documented. It has been shown that there is a radiation resistent stem cell (As) which, after irradiation, replenishes the seminiferous epithelium. Most investigations in this area have dealt with radiation dosages of 100R or more. This study was undertaken to observe cellular responses at doses less than 100R of X-irradiation utilizing a system in which the tissue can be used for light and electron microscopy.Brown B6D2F1 mice aged 16 weeks were exposed to X-irradiation (225KeV; 15mA; filter 0.35 Cu; 50-60 R/min). Four mice were irradiated at each dose level between 1 and 100 rads. Testes were removed 3 days post-irradiation, fixed, and embedded. Sections were cut at 2 microns for light microscopy. After staining, surviving spermatogonia were identified and counted in tubule cross sections. The surviving fraction of spermatogonia compared to control, S/S0, was plotted against dose to give the curve shown in Fig. 1.


1985 ◽  
Vol 8 (6) ◽  
pp. 517-522 ◽  
Author(s):  
T. J. FitzGerald ◽  
C. Daugherty ◽  
K. Kase ◽  
L. A. Rothstein ◽  
M. McKenna ◽  
...  

1998 ◽  
Vol 11 (3) ◽  
pp. 223-230 ◽  
Author(s):  
Hassen Ben Abdennebi ◽  
Jean-Paul Steghens ◽  
Jacqueline Margonari ◽  
Silvina Ramella-Virieux ◽  
Alain Barbieux ◽  
...  

1961 ◽  
Vol 200 (5) ◽  
pp. 1039-1042 ◽  
Author(s):  
Bernard D. Newsom ◽  
Donald J. Kimeldorf

A lethal dose of X irradiation can be made sublethal by the fractionation of a dose into a series of smaller doses separated by adequate time intervals. The results reported here demonstrate how an environmental stress, such as cold, may affect this mitigating action of dose fractionation. Rats were maintained at 6 C while receiving a total dose of 600 r in one or eight exposures with various intervals between exposures. A greater interval was required between radiation exposures at 6 C than at 23 C to reduce the lethal response following irradiation. From the results of the food consumption measurements, it appears that cold exposure emphasizes the consequence of the reduced food intake which follows daily doses of 75 r in the rat. The irradiated rat was able to increase the amount of food consumed during cold exposure; however, the increase was not sufficient for adaptation. The lowered consumption which followed eight daily 75-r exposures was sufficient to cause death in pair-fed rats maintained at 6 C, but not at 23 C.


2016 ◽  
Vol 80 ◽  
pp. 82-90 ◽  
Author(s):  
Amandeep Kaur ◽  
Neha Singla ◽  
D.K. Dhawan
Keyword(s):  
Low Dose ◽  

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