Biochemical effects of low-dose whole body x-irradiation on mouse liver and the protective action of ectoine

Studies were carried out to determine the effect of X-irradiation on the uptake of chromium 51 in different organs in the mouse. Experiments were also carried out to determine whether the initial radiation effect, if any, was lessened or the return to normal chromium 51 uptake accelerated when the animal was treated with a specific radioprotective agent (serotonin) prior to exposure to X-irradiation. If the assumption is made that early disturbances in Cr51content in different organs are a measure of the effect of various treatments and the return to normal Cr51content a measure of recovery, the results obtained could be indicative of changes caused by X-irradiation and those prevented or caused by serotonin.

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Protective effect of artificially induced ‘hibernation’ against lethal doses of whole body x-irradiation in CF1 male mice

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1959.196.6.1211 ◽

1959 ◽

Vol 196 (6) ◽

pp. 1211-1213 ◽

Cited By ~ 14

Author(s):

Sondra M. Kuskin ◽

S. C. Wang ◽

Roberts Rugh

Keyword(s):

Protective Action ◽

Lethal Dose ◽

Lethal Effect ◽

The Body ◽

Whole Body ◽

Protective Mechanism ◽

Slight Reduction ◽

Male Mice ◽

Degree Of Protection ◽

X Irradiation

Hypothermia induced by the use of neuroplegic drugs such as Hydergine, chlorpromazine or promethazine, followed by refrigeration, does not significantly enhance the protective action afforded by refrigeration alone against the lethal dose of whole body x-irradiation in CF1 male mice. The neuroplegic drugs, without refrigeration, provide a slight degree of protection, probably due to the slight reduction in the body temperature. It appears that the action of hypothermia as a protective mechanism depends not on depression of metabolism alone, but on a general depression of bodily processes. Urethane, in conjunction with refrigeration, appears to augment the lethal effect of x-irradiation in the CF1 strain of male mice.

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Rapid Decrease in Brain Enkephalin Content after Low-dose Whole-body X-Irradiation of the Rat.

Journal of Radiation Research ◽

10.1269/jrr.33.11 ◽

1992 ◽

Vol 33 (1) ◽

pp. 11-15 ◽

Cited By ~ 4

Author(s):

YUKIHISA MIYACHI ◽

NORIO OGAWA ◽

AKITANE MORI

Keyword(s):

Low Dose ◽

Rapid Decrease ◽

Whole Body ◽

X Irradiation

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LATE EFFECTS OF LOW-DOSE WHOLE BODY X-IRRADIATION OF FOUR-DAY-OLD RATS

PEDIATRICS ◽

10.1542/peds.38.6.1047 ◽

1966 ◽

Vol 38 (6) ◽

pp. 1047-1056

Author(s):

Marta S. Billings ◽

James N. Yamazaki ◽

Leslie R. Bennett ◽

Baldwin G. Lamson

Keyword(s):

Life Span ◽

Low Dose ◽

Female Rats ◽

Whole Body ◽

Sprague Dawley ◽

Weight Changes ◽

F1 Hybrid ◽

Male And Female ◽

X Irradiation ◽

Total Body

1. Four-day-old male and female Long-Evans x Sprague-Dawley F1 hybrid rats were exposed to a single total body x-ray dose of 125, 25, 5, and 0 r and then were observed during their entire lifespan for weight changes, signs of morbidity and age at death. 2. There was a 10% reduction of life span in the 125 r exposed female rats. None of the male groups showed significant shortening of longevity. 3. Mean body weights were consistently lower in both male and female groups exposed to 125 r total body irradiation. 4. Female rats exposed to 25 and 125 r attained their maximum weights at a younger age than their non-irradiated controls. 5. External tumors appeared earlier in female rats. Tumor incidence was not increased by irradiation in either sex. 6. Male parentage influenced the length of life span of progeny to a greater degree than the irradiation exposure at the employed dose-level. The influence of female parentage upon longevity cannot be evaluated in this study. 7. Low dose radiation life shortening can only be demonstrated in long-lived strains. Hereditary and radiation life shortening effects are not cumulative under conditions of this study.

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The Content of α-glycerophosphate in Mouse Liver after Whole-body X-irradiation

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine ◽

10.1080/09553006814550091 ◽

1968 ◽

Vol 13 (2) ◽

pp. 187-188 ◽

Cited By ~ 2

Author(s):

Jurgen Berndt

Keyword(s):

Mouse Liver ◽

Whole Body ◽

X Irradiation

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The Effects of Whole-Body X-Irradiation on Mouse Liver Alpha-Hydroxy Acid Oxidase

Radiation Research ◽

10.2307/3572995 ◽

1969 ◽

Vol 40 (1) ◽

pp. 213

Author(s):

S. Kleinbergs ◽

I. A. Bernstein

Keyword(s):

Hydroxy Acid ◽

Mouse Liver ◽

Whole Body ◽

Acid Oxidase ◽

X Irradiation

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STIMULATIVE EFFECT OF LOW-DOSE WHOLE-BODY X-IRRADIATION ON IMMUNE CELLS

Radiation Research: A Twentieth-century Perspective ◽

10.1016/b978-0-12-168561-4.50598-9 ◽

1991 ◽

pp. 153

Author(s):

K. ISHII ◽

M. AYUZAWA ◽

J. MISONOH

Keyword(s):

Immune Cells ◽

Low Dose ◽

Whole Body ◽

X Irradiation

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THE EFFECT OF 2-AMINOETHYLISOTHIOURONIUM (AET) ON THE RESPIRATION OF MOUSE LIVER AND SPLEEN SLICES

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y60-100 ◽

1960 ◽

Vol 38 (1) ◽

pp. 819-822

Author(s):

P. V. Vittorio ◽

Wilma P. Spence

Keyword(s):

Mouse Liver ◽

Whole Body ◽

Depressing Effect ◽

Bicarbonate Buffer ◽

Liver Slices ◽

X Irradiation

The effect of AET injected in vivo on the respiration of liver and spleen slices from non-irradiated and X-irradiated mice was studied. The mice were killed 4 or 24 hours after the injection of a protective dose of AET and the livers and spleens were removed, sliced, and incubated for 3 hours in Krebs–Henseleit bicarbonate buffer containing uniformly labelled C14 glucose. In both non-irradiated and X-irradiated mice, initially, AET depressed the respiration of C14O2 from incubated liver slices but this depressing effect appeared to be overcome with time. Whole body X irradiation increased the total C14O2 respired by liver slices from mice injected with saline or AET prior to X irradiation and killed 4 or 24 hours after X irradiation. Whole body X irradiation decreased the total C14O2 respired by the spleen slices and the 24-hour samples showed the greatest decrease. In both the non-irradiated and X-irradiated mice AET did not appear to affect the total C14O2 respired by spleen slices.

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