Clinical efficacy of free androgen index, a surrogate hallmark of circulating free testosterone level, in male patients with HCV-related chronic liver disease

Objectives: To determine the frequency of sexual dysfunction in the patientssuffering from chronic liver disease. Period: 1 year from June 2013 to May 2014. Study Design:An observational study. Setting: Asian Institute of Medical Sciences. Methodology: 150 casesof chronic liver disease including patients of both genders at Asian Institute of medical scienceswho had suggestive history and signs /symptoms of sexual dysfunction. Results: Study found51.3% of total patients were suffering with sexual dysfunction. Out of all participating females,52.2% were affected and among the total male patients 51% males were suffering from sexualdysfunction. Hepatitis C virus (HCV) and Hepatitis B virus (HBV) were positive in 76.7% and11.3%, respectively. Conclusion: Sexual dysfunction is a common complication in the patientssuffering from chronic liver disease.

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Abstract TP323: Does Serum Level Of Sex Hormones Before Rehabilitation Predict Functional Recovery In Elderly Post-stroke Patients?

Stroke ◽

10.1161/str.44.suppl_1.atp323 ◽

2013 ◽

Vol 44 (suppl_1) ◽

Author(s):

Ryo Momosaki ◽

Masahiro Abo ◽

Wataru Kakuda

Keyword(s):

Serum Level ◽

Sex Hormones ◽

Functional Recovery ◽

Testosterone Level ◽

Free Testosterone ◽

Serum Levels ◽

Stroke Patients ◽

Post Stroke ◽

Male Patients ◽

Free Testosterone Level

Background: Sex hormone is recognized as a critical factor affecting physical function in the elderly. However, the influence of these hormones on functional recovery after stroke has not been studied in elderly patients. The objective of the study was to examine whether serum level of sex hormones before rehabilitation can predict clinical outcome in elderly post-stroke patients. Subjects and Methods: Seventy-on post-stroke hemiparetic patients who were hospitalized to our rehabilitation ward in their subacute-chronic phase, were subjected (age: 78 ± 6 years, period between onset and admission: 47 ± 31 days). On their admission, serum levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone (only in male patients) were measured after an overnight fast. As functional measures, NIHSS and functional Independence Measure (FIM) were evaluated at their admission and discharge. We assessed the correlation between changes in serum levels of measured hormones and functional changes during hospitalization. Results: Neither DHEA-S nor free testosterone levels at admission correlated with the severity of stroke at admission. In male patients, significant positive correlation was found between free testosterone level at admission and FIM at discharge (r=0.31, p<0.05), although there was not significant correlation between DHEA-S level at admission and FIM change. Furthermore, the results of multivariate analysis showed that free testosterone level at admission significantly predicted the rate of FIM change during hospitalization in male patients. Conclusions: Serum level of free testosterone at the admission to rehabilitation ward can be a predictor of functional recovery in elderly male patients after stroke.

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High testosterone level in Chronic Liver Disease

Endocrine Abstracts ◽

10.1530/endoabs.41.ep695 ◽

2016 ◽

Author(s):

Nawal Ibraheem ◽

Ibrahim Shahbuddin ◽

Ravi Gouni ◽

Emily Mudenha

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Testosterone Level ◽

Chronic Liver ◽

High Testosterone Level

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Clinical efficacy and safety of sulbactam/ampicillin in patients suffering from chronic liver disease

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/19.4.527 ◽

1987 ◽

Vol 19 (4) ◽

pp. 527-532 ◽

Cited By ~ 1

Author(s):

D. Galante ◽

S. Esposito ◽

D. Barba ◽

M. P. Ruffilli

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Clinical Efficacy ◽

Chronic Liver ◽

Efficacy And Safety

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CHRONIC LIVER DISEASE (CLD);

The Professional Medical Journal ◽

10.29309/tpmj/2012.19.03.2136 ◽

2012 ◽

Vol 19 (03) ◽

pp. 351-355

Author(s):

SHAHZAD ALAM KHAN ◽

TARIQ MUHAMMAD KHAN TAREEN ◽

IJAZ-UL- HAQUE TASEER ◽

SOHAIL Safdar

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Upper Gastrointestinal Bleeding ◽

Case Series ◽

Personal Data ◽

Chronic Liver ◽

Upper Gi ◽

Male Patients ◽

Gi Bleed ◽

Upper Gastrointestinal

Objective: To determine the frequency of chronic liver disease in patients presenting with upper gastrointestinal bleeding(UGIB) at Nishtar Hospital, Multan. Study Design: Descriptive case series. Duration of study: Six months from August 2009 to January 2010.Setting: Department of Internal Medicine, Nishtar Hospital Multan. Methodology: A total of 88 patients with upper GI bleed were registered.Prior permission was taken from Institutional Ethical Committee to conduct this study. Informed consent was taken from each patient. Upper GIEndoscopy was done to find out the source of bleeding. For identification of each patient, personal data was collected. All the data collectedwere entered and analyzed using SPSS-10. Results: Mean age was 41.64±13.56 years with 49 (55.70%) male patients and 39 (44.30%)female patients. Majority of the patients 38(43.18%) were between 36-50 years of age. In our series frequency of chronic liver disease was56.82%. Conclusions: Chronic liver disease is the most common cause of upper GI bleeding in our setting.

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The Risk of Depression in Patients with Pemphigus: A Nationwide Cohort Study in Taiwan

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17061983 ◽

2020 ◽

Vol 17 (6) ◽

pp. 1983

Author(s):

Yi-Min Hsu ◽

Hsin-Yu Fang ◽

Cheng-Li Lin ◽

Shwn-Huey Shieh

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Proportional Hazards ◽

Cox Proportional Hazards ◽

Chronic Liver ◽

Autoimmune Response ◽

Control Group ◽

Research Database ◽

Increased Risk ◽

Male Patients

Pemphigus is a chronic dermatological disorder caused by an autoimmune response and is associated with a high proportion of comorbidities and fatalities. The aim of this study was to investigate the risk of depression in patients with pemphigus. Data were derived from the National Health Insurance Research Database recorded during the period 2000–2010 in Taiwan. Multivariate Cox proportional hazards regression models were used to analyze the data and assess the effects of pemphigus on the risk of depression after adjusting for demographic characteristics and comorbidities. Patients with pemphigus were 1.98 times more likely to suffer from depression than the control group (pemphigus, adjusted HR: 1.99, 95% CI = 1.37–2.86). People aged ≥65 years were 1.69 times more likely to suffer from depression than those aged 20–49 years (≥65 years, adjusted HR: 1.42, 95% CI = 0.92–2.21). Female and male patients with pemphigus were respectively 2.02 and 1.91 times more likely to suffer from depression than the control group (female, adjusted HR: 2.09, 95% CI = 1.24–3.54; male, adjusted HR: 1.87, 95% CI = 0.97–3.60). People with HTN, hyperlipidemia, asthma/COPD, and chronic liver disease were respectively 1.73, 2.3, 2.2, and 1.69 times more likely to suffer from depression than those without these comorbidities (HTN, adjusted HR: 0.75, 95% CI = 0.41–1.42; hyperlipidemia, adjusted HR: 1.48, 95% CI = 0.78–2.82; asthma/COPD, adjusted HR: 1.4, 95% CI = 0.72–2.69; and chronic liver disease, adjusted HR: 1.61, 95% CI = 1.07–2.43). There was a significant association between pemphigus and increased risk of depression. Female patients had a higher incidence of depression.

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Prevalence of culture negative ascitic fluid infection among patients with chronic liver disease.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.05.4074 ◽

2020 ◽

Vol 27 (05) ◽

pp. 999-1003

Author(s):

Muhammad Ayub ◽

Sagheer Hussain ◽

Salman Ahmed ◽

Muhammad Adnan Iqbal

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Ascitic Fluid ◽

Total Duration ◽

Positive Culture ◽

Chronic Liver ◽

Cross Sectional ◽

Male Patients ◽

Culture Positive ◽

Culture Negative

Objectives: To determine prevalence of patients with chronic liver disease having culture negative ascitic fluid infection. Study Design: Cross sectional study. Setting: Gastroenterology and medicine ward of DHQ Teaching Hospital Gujranwala. Period: January 2018 August 2018 having total duration of 8 months. Material & Methods: All patients irrespective of age and gender, having ascites due to chronic liver disease and showing signs and symptoms of ascitic fluid infection like fever, abdominal pain and tenderness, admitted in the medical unit of study hospital underwent ascitic tap and fluid was sent for culture examination to the hospital laboratory. Patients with chronic liver disease having no bacterial growth found on culture of ascitic fluid were placed in one group and who had culture positive ascites were placed in separate group. Patients who have taken any antibiotic in last one month or having any intra abdominal source of infection were excluded from the study. All cases in study group were already diagnosed with CLD. Results: There were 160 cases included in this study having chronic liver disease and ascitic fluid infection with 62.5% male and 37.5% female cases. Out of 160 cases, 22.5% were having culture positive ascites while 77.5% cases were having culture negative ascites among them 61% were male and 39% were female in positive group and 62.9% were male and 37.1% were female cases in negative group. Age range of patients was 25-75 years with mean age of 50±25 years. Mean duration of chronic liver disease was 9.5±2.4 months with minimum duration of 6 months and maximum duration of 15 months. There were 72.6% cases with culture negative ascites and 69.4% with positive culture were having age above 45 years. There was majority of male patients (62.9%) having culture negative ascites due to CLD. Conclusion: Ascitic fluid infection among patients with chronic liver disease is usually culture negative. In our study prevalence of culture negative ascitic flud infection was 77.5%, more common among male patients having age above 45 years.

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