Abstract TP323: Does Serum Level Of Sex Hormones Before Rehabilitation Predict Functional Recovery In Elderly Post-stroke Patients?

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Ryo Momosaki ◽  
Masahiro Abo ◽  
Wataru Kakuda
Keyword(s):  
Serum Level ◽  
Sex Hormones ◽  
Functional Recovery ◽  
Testosterone Level ◽  
Free Testosterone ◽  
Serum Levels ◽  
Stroke Patients ◽  
Post Stroke ◽  
Male Patients ◽  
Free Testosterone Level

Background: Sex hormone is recognized as a critical factor affecting physical function in the elderly. However, the influence of these hormones on functional recovery after stroke has not been studied in elderly patients. The objective of the study was to examine whether serum level of sex hormones before rehabilitation can predict clinical outcome in elderly post-stroke patients. Subjects and Methods: Seventy-on post-stroke hemiparetic patients who were hospitalized to our rehabilitation ward in their subacute-chronic phase, were subjected (age: 78 ± 6 years, period between onset and admission: 47 ± 31 days). On their admission, serum levels of dehydroepiandrosterone sulfate (DHEA-S) and free testosterone (only in male patients) were measured after an overnight fast. As functional measures, NIHSS and functional Independence Measure (FIM) were evaluated at their admission and discharge. We assessed the correlation between changes in serum levels of measured hormones and functional changes during hospitalization. Results: Neither DHEA-S nor free testosterone levels at admission correlated with the severity of stroke at admission. In male patients, significant positive correlation was found between free testosterone level at admission and FIM at discharge (r=0.31, p<0.05), although there was not significant correlation between DHEA-S level at admission and FIM change. Furthermore, the results of multivariate analysis showed that free testosterone level at admission significantly predicted the rate of FIM change during hospitalization in male patients. Conclusions: Serum level of free testosterone at the admission to rehabilitation ward can be a predictor of functional recovery in elderly male patients after stroke.

scholarly journals How COVID-19 Infection can Alter the Sex Hormones in Hospitalized Patients? A Longitudinal Study in Iran

2021 ◽  
Author(s):  
Poorandokht Afshari ◽  
Mehrnoosh Zakerkish ◽  
Parvin Abedi ◽  
Maryam Beheshtinasab ◽  
Elham Maraghi ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Severe Disease ◽  
Free Testosterone ◽  
Serum Levels ◽  
Total Testosterone ◽  
Demographic Questionnaire ◽  
Moderate Disease ◽  
Male Patients ◽  
Primary Assessment

Abstract Background: There is some evidence about alteration of sex hormones in patients with COVID-19 infection. This study aimed to evaluate the levels of sex hormones in female and male patients with COVID-19 during hospitalization and one month after discharge. Methods: The levels of sex hormones including estradiol, progesterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone, and free testosterone were measured in 162 female and male patients with COVID-19 infection during hospitalization and one month after discharge. A demographic questionnaire and a checklist were used to collect the data. The ANCOVA test was used to compare the level of hormones in patients with severe and moderate disease. Results: In the primary assessment, 162 patients were assessed for serum levels of sex hormones, while a month after discharge, only 69 patients provided consent for assessment, and nine had passed away. During hospitalization, female patients with severe disease had an elevated level of estradiol (407.70±623.37 pg/mL) in comparison to those with a moderate disease (213.78±407.17 pg/mL). The levels of progesterone and LH were high during hospitalization, but there was a decrease in these levels after discharge. The reduction in the level of FSH in patients with severe disease was greater than in patients with moderate disease, which increased after discharge. While the level of testosterone decreased during hospitalization, the alteration of free testosterone was negligible in male patients.Conclusion: In this study, we observed alteration in sex hormones (increased level of estrogen, progesterone, LH and reduction in the level of FSH and total testosterone) in female and male patients, with the alteration being greater in the latter. Due to the attrition of patients in follow-up period, more studies are needed to confirm these results.

scholarly journals Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Marta Sacchetti ◽  
Alessandro Lambiase ◽  
Costanzo Moretti ◽  
Flavio Mantelli ◽  
Stefano Bonini
Keyword(s):  
Children And Adolescents ◽  
Sex Hormones ◽  
Free Testosterone ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Vernal Keratoconjunctivitis ◽  
Total Testosterone ◽  
Male Patients ◽  
Remission Phase

Purpose.Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed.Methods.12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated.Results.Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P<0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P=0.007andP=0.028, resp.) and SHBG (P=0.01andP=0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P=0.007).Conclusions and Relevance.VKC patients have different circulating sex hormone levels in different phases of the disease and when compared to nonallergic subjects. These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC.

Free Testosterone Level And Quality of Cauda Epididymis Sperm of Local Rabbit That Given Commercial Feed Supplemented By Cod Fish Liver Oil

2016 ◽  
Vol 2 (3) ◽  
pp. 1
Author(s):  
Ni Gusti Ayu Manik Ermayanti ◽  
I Gusti Lanang Oka ◽  
I Gede Mahardika ◽  
I Putu Suyadnya
Keyword(s):  
Testosterone Level ◽  
Sperm Quality ◽  
Free Testosterone ◽  
Fish Liver ◽  
Testosterone Levels ◽  
Commercial Feed ◽  
One Way Anova ◽  
Free Testosterone Level ◽  
Range Test

This study was intended to determine the free testosterone levels and sperm quality of local rabbit that was given commercial feed supplemented cod fish liver oil.  The experiment design that was used in this research was Complete Random Design (CRD) with four experiments of feed, i.e. commercial feed without cod fish liver oil (R-0) as control, commercial feed + 1,5% cod fish liver oil (R-1), commercial feed + cod fish liver oil 3% (R-2), commercial feed + cod fish liver oil 4,5% (R-3). The each experiment included eight rabbits and feed experiment was given starting by 13 weeks to 26 weeks years old. The variable that observed was free testosterone level and sperm quality of local rabbit. The data that was obtained to be analyzed with One Way Anova and if its contrast was done more test with Duncan’s Multiple Range Test (DMRT). The result of this research was to show that supplementation of cod fish liver oil in commercial feed was to show the result that a real distinction of (P<0, 05) towards free testosterone level and sperm quality of local rabbit.

Low Free Testosterone Level Predicts Frailty in Older Men. The Health in Men Study.

2010 ◽  
pp. OR17-3-OR17-3
Author(s):  
Z Hyde ◽  
L Flicker ◽  
OP Almeida ◽  
GJ Hankey ◽  
K McCaul ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Free Testosterone ◽  
Older Men ◽  
Free Testosterone Level

Benefits of antidepressant treatment after a stroke

2017 ◽  
Vol 41 (S1) ◽  
pp. S315-S315 ◽  
Author(s):  
O. Zerriaa ◽  
O. Moula ◽  
S. Ben Saadi ◽  
I. Jelalia ◽  
R. Ghachem
Keyword(s):  
Functional Recovery ◽  
Cognitive Skills ◽  
Antidepressant Treatment ◽  
Antidepressant Drugs ◽  
Antidepressant Therapy ◽  
Motor Deficit ◽  
Stroke Patients ◽  
Double Blind ◽  
Post Stroke ◽  
Post Stroke Depression

IntroductionStroke is an important cause of morbidity and is responsible for 9% of all deaths worldwide. The most frequent neuropsychiatric consequence of stroke is post-stroke depression (PSD). It has been shown to be associated with both impaired recovery and increased mortality. The aim of our study is to determine the benefits of antidepressant prescription after a stroke.MethodThe databases from Medline and PubMed were reviewed for articles related to post-stroke depression (PSD), antidepressant treatment and stroke, post-stroke depression and functional recovery, stroke related impairment.ResultsAntidepressant drugs have been shown to be effective in treating PSD in six double blind randomized studies. Patients treated with antidepressants had better recovery from disability than patients who did not receive antidepressant therapy: it was proved that antidepressant drugs cause an improvement in cognitive skills and functional recovery in PSD patients. In patients with ischemic stroke and moderate to severe motor deficit, the early prescription of fluoxetine with physiotherapy enhanced motor recovery after 3 months. Some studies showed that PSD can be effectively prevented: nortriptyline, fluoxetine, milnacipran and sertraline appeared to be efficacious in preventing depression after stroke and are to use without significant adverse effects in stroke patients.ConclusionAntidepressant treatment plays an increasing role in the management of patients with acute stroke. Therefore, early initiation of antidepressant therapy, in non-depressed stroke patients, may reduce the odds for development of PSD, and improve cognitive and functional recovery.Disclosure of interestThe authors have not supplied their declaration of competing interest.

P–050 The effectiveness of the platelet-rich plasma treatment of men with severe oligoasthenoteratozoospermia

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
O Somova ◽  
H Ivanova ◽  
N Sotnyk ◽  
K Kovalenko ◽  
I Feskova
Keyword(s):  
Male Infertility ◽  
Sperm Motility ◽  
Testosterone Level ◽  
Assisted Reproductive Technologies ◽  
Platelet Rich Plasma ◽  
Sperm Concentration ◽  
Free Testosterone ◽  
Reproductive Technologies ◽  
Positive Effects ◽  
Free Testosterone Level

Abstract Study question To evaluate the effect of platelet-rich plasma (PRP) testicular injections on spermogram parameters of men with severe oligoasthenoteratozoospermia (OAT). Summary answer The PRP testicular injections have beneficial effects on spermatogenesis and enhance sperm concentration and motility in infertile men with OAT. What is known already The use of PRP therapy in assisted reproductive technologies is debatable. Despite the recent evidence of its positive effects in promoting endometrial and follicular growth, data from clinical studies are limited. There are only a few papers on the effectiveness of PRP therapy in the treatment of male infertility and sexual dysfunction. In more detail, the influence of PRP on spermatogenesis was carried out only on experimental animals. Although the mechanisms of its action have not yet been clarified, it is assumed that PRP, containing many biologically active molecules, realizes its effect through the tissue regeneration and cell proliferation. Study design, size, duration This prospective study included 68 men (34.6±5.2) years old with severe OAT (≤4 million/ml, motility ≤30%, normal sperm morphology ≤1%) receiving hormonal and antioxidant (AO) therapy during 6 months before in vitro fertilization cycles. 33 of them were injected once with autologous PRP (0.5 ml in each testicle). Spermogram and testosterone level were analyzed before the treatment and in 3, 4 and 6 months after it. Participants/materials, setting, methods: Sperm concentration, motility and morphology in ejaculate of 33 men of PRP group were compared with those in the group of 35 men without PRP within 6 months of starting the treatment. Total and free testosterone level were measured in blood serum. PRP was prepared by centrifuging the patient’s own blood in the anticoagulant-containing tubes. The final concentration of platelets in the obtained sample was 950.000 – 1.250 000 cells in 1 ml. Main results and the role of chance 4 months after the PRP injection, sperm concentration and motility increased in 18 of 33 men of the PRP group compared with the baseline (before the treatment) – 4.2 (1.0; 6.9) vs 1.4 (0.1; 3.4) mln/ml (p &lt; 0.05) and 36.7 (30.6; 45.8) vs 17.7 (6.7; 28.2)% respectively (p &lt; 0.05).The maximum increase in sperm motility (but not in sperm concentration!) was observed in 24 men in 6 months – 49.6 (39.6; 56.4)% (p &lt; 0.05). Percent of morphologically normal spermatozoa in ejaculate slightly increased only in 12 men in that time period from 0–1% to 1–2%. The total testosterone level was 2.4 times higher than the baseline (31.6±7.2 vs 13.2±4.3 nmol/l, p &lt; 0.05), the free testosterone level was 1.8 times higher (14.5±3.5 vs 7.9±3.0 pgl/ml, p &lt; 0.05). Unlike the PRP group, in the group of men without PRP treatment, the sperm parameters did not changed compared with the baseline in 4 months after the starting hormonal and AO treatment. A significant increase of sperin concentration was observed only in 17 of 35 patients in 6 months. Sperm motility and percent of morphologically normal spermatozoa after the treatment did not differ from the baseline. Changes in the testosterone levels were similar to changes in PRP group. Limitations, reasons for caution Only young and middle-aged men were considered in the study. Large randomized controlled studies are required to confirm the PRP therapy efficacy and safety of f various fertility disorders. There are also no standardized protocols for PRP preparation. Wider implications of the findings: PRP therapy may have great potential for the treatment of male infertility and improving spermatogenesis. Optimization of methods of PRP preparation and dosage of testicular injections can enhance reproductive outcomes in assisted reproductive technologies. Trial registration number Not applicable

TESTOSTERONE DECREASE AND OESTROGEN INCREASE IN MALE PATIENTS WITH OBESITY

1979 ◽  
Vol 91 (3) ◽  
pp. 553-563 ◽  
Author(s):  
H. K. Kley ◽  
H. G. Solbach ◽  
J. C. McKinnan ◽  
H. L. Krüskemper
Keyword(s):  
Body Weight ◽  
Sex Hormones ◽  
Plasma Concentrations ◽  
Clinical Signs ◽  
Free Testosterone ◽  
Control Group ◽  
Obese Patients ◽  
Group Iii ◽  
Group I ◽  
Male Patients

ABSTRACT The concentration of sex hormones and their binding in the plasma were measured in male patients (20–40 years old), who weighed 140–170 % (I), 170–200 % (II) and > 200 % (III) of their ideal weight. Correlated to body weight, there is a reduction in the total concentration of testosterone, which, in the very obese patients, amounts to 41 % (in group I: 85 % in group II: 68 % P < 0.001) of that found in an age-matched healthy control group of subjects of "normal" body weight (90–115 % of the ideal body weight; n: 20). Androstenedione values show only a trend downwards (from 0.94 to 0.72 ng/ml plasma), while the oestrogen values increase significantly; oestrone increases by a factor of 1.09 (I), 1.43 (II; P < 0.001) and 1.69 (III; P < 0.001) and oestradiol by 1.13, 1.43 P < 0.001) and 1.76 (P < 0.001), respectively. Despite the fall in testosterone there are no clinical signs of hypogonadism, as SHBG (from 5.1 ± 0.8 in the controls to 2.4 ± 0.6 ×10−8 Mol/l in the very obese patients of group III) and the protein-bound fraction of testosterone also decrease. As a result the concentration of free testosterone remains constant (120 pg/ml), except in the very obese (93 pg/ml). Because of the different affinity of the binding proteins for testosterone and oestradiol the ratio of free oestradiol: free testosterone shifts less strongly in favour of the feminizing hormone (11.1 × 10−3 in group III as compared to 4.1 × 10−3 in the controls), than is suggested by the total hormone concentrations. A disturbance in the gonadal function of the pituitary gland or the testes is not present, since the concentration of LH is normal and the testicular response to HCG in very obese patients adequate (increase of testosterone by a factor of 3.11 as compared to 2.23 in the controls). The cause of the decrease in testosterone and SHBG is unknown, while the increase of plasma oestrogens is likely to be due to the increased conversion of androgens to oestrogens in the adipose tissue, which clearly plays an important role for plasma concentrations of sex hormones in obese patients.

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