scholarly journals Influence of antianginal therapy and L-arginine on serum essential aminoacids spectrum among patients with unstable angina

2019 ◽  
pp. 63-68
Author(s):  
T. V. Zavalskaya ◽  
V. V. Bogdan
Keyword(s):  
Amino Acids ◽  
Ion Exchange ◽  
Myocardial Ischemia ◽  
Glutamic Acid ◽  
Acetylsalicylic Acid ◽  
Blood Serum ◽  
Unstable Angina ◽  
Liquid Column Chromatography ◽  
Group I ◽  
Intracellular Metabolism

The patients with unstable angina (UA) were examined using the method of ion exchange liquid-column chromatography. The content of the substitutable amino acids (AA) in blood serum was determined: ornithine, taurine, aspartic acid, serine, glutamic acid, proline, glycine, alanine, cysteine, tyrosine, glutamine. The patients were divided into two groups: І – 37 people who received cardicet, bisoprolol, atoris, enap, acetylsalicylic acid, clopidogrel; ІІ – 38 people, the therapy of which, in addition to the mentioned drugs, included L-arginine (100 ml intravenous for 10 days). The results of the study indicate a different dynamics of changes in the level of substitute AK in serum in patients with NA, who received anti-anginal therapy and anti-anginal therapy with L-arginine. Attention is drawn to the fact that in patients with Group I after treatment, the total amount of replacement AA significantly decreased in comparison with the II group in 1,2 times, but remained unchanged compared with the indicator before treatment. In patients of the ІІ group, the total amount of substitute AK in serum is significantly reduced in comparison with kontrol group in 1.4 times, and compared with the indicator before treatment – in 1.2 times. That is, the inclusion of L-arginine in anti-anginal therapy promotes the enhancement of their intracellular metabolism in conditions of coronary circulatory destabilization. In patients with UA, antianginal therapy which included L-arginine, there was a normalization of such alternating AAs as ornithine, taurine and glycine, which can be considered as compensatory, protective reactions in myocardial ischemia. Thus, L-arginine effectively affects the balance of substitute AA blood plasma in patients with UA.

ENDOCRINE CONTROL OF FREE AMINO ACIDS CONTENT IN UTERINE FLUID IN PREGNANT RABBITS

1972 ◽  
Vol 70 (2) ◽  
pp. 409-416 ◽  
Author(s):  
S. Jaszczak ◽  
E. S. E. Hafez
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Blood Serum ◽  
Aspartic Acid ◽  
Free Amino Acids ◽  
Free Amino ◽  
Amino Acid Content ◽  
Endocrine Control ◽  
Uterine Fluid

ABSTRACT Free amino acid content was measured in the uterine fluid and blood serum in the following groups of rabbits 168 h post copulation: intact; intact progesterone-treated; ovariectomized progesterone-treated; ovariectomized progesterone-oestradiol-treated; and ovariectomized without hormonal treatment. At implantation, concentration of the majority of amino acid in uterine fluid exceeded greatly that of blood serum; the difference in concentration being maximal for glycine, taurine, alanine, glutamic acid, aspartic acid, serine and threonine. Glutamine-asparagine and arginine were found in comparable quantities or were even higher in blood serum. Glycine, alanine, taurine, glutamic acid, serine and glutamine-asparagine were found in highest concentration in the uterine fluid. The level of ammonia in uterine fluid was also relatively high. Exogenous progesterone and oestradiol caused significant changes in the concentration of some amino acid. The concentration of glycine, taurine, alanine, serine, glutamic acid, aspartic acid, threonine, ½ cystine and histidine seems to be especially hormonally dependent. The results are discussed in relation to hormonal activity of corpora lutea during early pregnancy, physiological significance of free amino acids in uterine fluid and nourishment of an early embryo.

scholarly journals Relationship between the level of blood plasma amino acids with daily amount of group ventricular extrasystoles and the duration of pain or painless myocardial ischemia in patients with stable and unstable angina

2020 ◽  
pp. 100-103
Author(s):  
T.V. Bogdan ◽  
Keyword(s):  
Amino Acids ◽  
Heart Disease ◽  
Myocardial Ischemia ◽  
Blood Plasma ◽  
Unstable Angina ◽  
Prognostic Indicators ◽  
Ventricular Extrasystoles ◽  
Sulfur Containing ◽  
Amino Acid Spectrum

It is now known that the human body suffering from coronary heart disease is trying to adapt to new working conditions through biochemical rearrangements, one of which is to increase the involvement of amino acids in car diomyocyte metabolism. Amino acids are metabolized in the myocardium under normal conditions, myocardial ischemia leads to a major restructuring of biochemical reactions, which increases the use of amino acids as metabolites. It is proved that myocardial ischemia, painless myocardial ischemia, and group ventricular extrasystoles are prognostic indicators of the adverse course of ischemic heart disease. According to the results of the study, in patients with stable (SA) or unstable angina (UA), the reliable correlations between the frequency of group ventricular extrasystoles and painless or painful myocardial ischemia with the levels of arginine, the amount of sulfur-containing amino acids and amino acids with branched lateral chain are formed. This indicates the pathogenetic role of the imbalance of the amino acid spectrum of blood plasma in the development of atherosclerosis, destabilization of coronary circulation, and the emergence of cardiac arrhythmia.

ChemInform Abstract: Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors.

ChemInform ◽  
2010 ◽  
Vol 32 (27) ◽  
pp. no-no
Author(s):  
Ulf Madsen ◽  
Hans Braeuner-Osborne ◽  
Karla Frydenvang ◽  
Lise Hvene ◽  
Tommy N. Johansen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
Selective Antagonists ◽  
Group I

Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors

2001 ◽  
Vol 44 (7) ◽  
pp. 1051-1059 ◽  
Author(s):  
Ulf Madsen ◽  
Hans Bräuner-Osborne ◽  
Karla Frydenvang ◽  
Lise Hvene ◽  
Tommy N. Johansen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
Selective Antagonists ◽  
Group I

Amino-acids and peptides. XI. A new synthesis of peptides of glutamic acid

1954 ◽  
Vol 19 (2) ◽  
pp. 375-385 ◽  
Author(s):  
J. Rudinger
Keyword(s):  
Amino Acids ◽  
Glutamic Acid ◽  
New Synthesis

scholarly journals Mitigative effect of Momordica cymbalaria fruit extract against sodium fluoride induced hepatotoxicity in Wistar male albino rats

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Raghavendra Mitta ◽  
Sushmitha Duddu ◽  
Raghuveer Yadav Pulala ◽  
Pradeepkumar Bhupalam ◽  
Venkatakirankumar Mandlem ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Sodium Fluoride ◽  
Total Protein ◽  
Reduced Glutathione ◽  
Serum Biomarkers ◽  
Albino Rats ◽  
Serum Total Protein ◽  
Treatment Groups ◽  
Group I

AbstractObjectivesThe main objective of the present study is to evaluate the mitigative effect of hydroalcoholic extract of Momordica cymbalaria fruits against sodium fluoride (NaF) induced hepatotoxicity.MethodsIn this study, Wistar male albino rats were randomly divided into five groups of six rats each. Group I and II served as normal and toxic controls. Group III as plant control received extract at a dose of 400 mg/kg b. wt, p.o and Groups IV and V as treatment groups received extract at a dose 200 and 400 mg/kg b. wt, p.o for 30 days. All groups except Groups I and III received 100 ppm of NaF through drinking water. After completion of the study, blood collected for the estimation of liver blood serum biomarkers such as aspartate aminotransferases (AST), alanine aminotransferases (ALT), alkaline Phosphatase (ALP), direct and total bilirubin, total protein and albumin. The liver tissue homogenate was for estimation of lipid peroxidation, catalase, and reduced glutathione levels.ResultsThe results showed that NaF intoxication caused elevation of liver blood serum levels and lipid peroxidation; decreased levels of serum total protein, albumin and liver reduced glutathione, and catalase observed. The treatment groups showed decreased elevated serum biomarkers (ALT, AST, and ALP), liver lipid peroxidation and increased serum total protein and albumin, liver reduced glutathione and catalase levels in a dose-dependent manner. Histopathological studies also further strongly supported for mitigative effects of the plant.ConclusionsIn conclusion, our findings of the study indicated that M. cymbalaria fruits were a potential drug candidate in the treatment of NaF induced hepatotoxicity.

scholarly journals THE INFLUENCE OF ETHER ANESTHESIA ON AMINO-ACIDS OF BLOOD SERUM

1916 ◽  
Vol 27 (1) ◽  
pp. 45-50
Author(s):  
Ellison L. Ross
Keyword(s):  
Amino Acids ◽  
Blood Serum ◽  
Ether Anesthesia
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