Characterization of functional outcome and quality of life following subarachnoid hemorrhage in patients treated with and without nicardipine prolonged-release implants

Object The use of nicardipine prolonged-release implants (NPRIs) is associated with a significant improvement in the therapy of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) regarding the occurrence and severity of cerebral vasospasm, new infarcts, and functional outcome (FO). Because quality of life (QOL) measurements more reliably seem to describe the patient's true condition, the present study was conducted to assess FO and QOL 1 year after aneurysm rupture in patients with and without NPRIs. Methods From the initial series of 32 patients, 18 were assessed 1 year after aSAH (7 of the control and 11 of the NPRI group). The patients underwent neurological investigation, a structured interview followed by a measurement of QOL (Mini-Mental State Examination [MMSE]; 36-Item Short Form Health Survey [SF-36]; and the Hamilton Depression Rating Scale). There were no intergroup differences in the patient characteristics (that is, localization of aneurysm, initial Hunt and Hess grade, or age). Results In addition to the previously reported improvement of the National Institutes of Health Stroke Scale and modified Rankin Scale scores, the NPRI group's Karnofsky Performance Scale and the MMSE scores were markedly to significantly improved (p < 0.05 [Karnofsky Performance Scale] and p = 0.053 [MMSE]). In contrast, anxiety, oblivion, and mild symptoms of depression were equally present in both study groups (p = 0.607 [anxiety]; p = 0.732 [oblivion]; and p = 0.509 [Hamilton Depression Rating Scale]). Furthermore, no intergroup differences were observed in any of the SF-36 domains. The scores in the SF-36 domains of Role-Physical, Vitality, and Role-Emotional were significantly reduced in the NRPI group compared with those observed in an age-matched control population (p < 0.001 [Role-Physical]; p = 0.001 [vitality]; and p = 0.01 [Role-Emotional]). Considering consequent costs, no difference was detectable regarding the duration of in- and outpatient rehabilitation (p = 0.135 and 0.171, respectively) or the Prolo score (p = 0.094). Conclusions Despite FO improvement in terms of a lower incidence of cerebral vasospasm, new infarcts, morbidity in the treatment of aSAH in patients with NPRIs, a patient's QOL seems to be related to the severity of the aSAH itself.

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Adult quality of life in congenital hydrocephalus operated cases. A twenty years retrospective study

Romanian Neurosurgery ◽

10.1515/romneu-2015-0031 ◽

2015 ◽

Vol 29 (3) ◽

pp. 235-238

Author(s):

A. Tascu ◽

A. Iliescu ◽

R.E. Rizea ◽

Irina Tudose ◽

St.M. Iencean

Keyword(s):

Quality Of Life ◽

Retrospective Study ◽

Functional Outcome ◽

Congenital Hydrocephalus ◽

Karnofsky Performance Scale ◽

Outcome Questionnaire ◽

Neurosurgical Department ◽

Emergency Hospital ◽

Performance Scale

Abstract Congenital hydrocephalus is a health problem in many countries and in Romania the pediatric neurosurgical department of the Emergency Hospital “Bagdasar-Arseni” has a large number of such patients. This is a retrospective study and it includes the patients with congenital hydrocephalus operated between 1992 and 2012 in the pediatric neurosurgical department of the Emergency Hospital “Bagdasar-Arseni”. The functional outcome was assessed using Karnofsky Performance Scale, Hydrocephalus Outcome Questionnaire and Glasgow outcome scale. The total number of the patients was 372, with a predominance of boys (212 boys versus 160 girls) and at the time of our study 168 patients were over 16 years old. Functional outcome of the children over 16 years old assessed using Karnofsky Performance Scale, showed that 73 patients were above 80 and leading independent lives, and 95 were less than 80 points. The results would be better if all these patients would benefit from schooling for children with special needs.

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Changes in functional outcome and quality of life in patients and caregivers after aneurysmal subarachnoid hemorrhage

Journal of Neurosurgery ◽

10.3171/jns.2001.95.6.0957 ◽

2001 ◽

Vol 95 (6) ◽

pp. 957-963 ◽

Cited By ~ 87

Author(s):

Jeannette W. Hop ◽

Gabriel J. E. Rinkel ◽

Ale Algra ◽

Jan van Gijn

Keyword(s):

Quality Of Life ◽

Subarachnoid Hemorrhage ◽

Functional Outcome ◽

Case Fatality ◽

Time Interval ◽

Consecutive Series ◽

Content Type ◽

Sf 36 ◽

Fine Print

Object. Although the case-fatality rate after subarachnoid hemorrhage (SAH) does not change considerably after the first 4 weeks, functional outcome and the quality of life (QOL) may. To assess the extent of changes in functional outcome and QOL after SAH, the authors conducted a follow-up study at 18 months in patients and caregivers who had participated in a previous study of QOL 4 months after SAH. Methods. In a consecutive series of 98 patients admitted with SAH, 68 had survived until 4 months postbleed, at which time an initial outcome assessment had been performed in 64 of them. This series of 64 patients was contacted again at a median of 18 months after SAH. In all patients, functional outcome was assessed by means of the modified Rankin Scale (mRS). In 48 patients and 35 caregivers QOL was assessed using the SF-36, the Sickness Impact Profile (SIP), and a visual analog scale. The results were compared with the scores that had been obtained at 4 months after SAH. Thirty-two patients (50%) had improved at least one point on the mRS, in 23 patients functional outcome had remained unchanged, six patients had deteriorated one point on the mRS, and three had died. No major changes in the QOL of patients and caregivers could be found on the SIP, but on the SF-36 an improved QOL was detected in patients with better Rankin grades. On both instruments, the QOL at 18 months was still reduced compared with the reference population in all patients. Conclusions. Functional outcome improves significantly between 4 months and 18 months post-SAH; studies on functional outcome after SAH can be compared only if outcome is assessed at the same time interval. The improved functional outcome seems to be accompanied by an improved QOL.

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Quality of life in individuals with cervical dystonia before botulinum toxin injection in a Brazilian tertiary care hospital

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2011000700010 ◽

2011 ◽

Vol 69 (6) ◽

pp. 900-904 ◽

Cited By ~ 9

Author(s):

Mariana Ribeiro Queiroz ◽

Hsin Fen Chien ◽

Egberto Reis Barbosa

Keyword(s):

Quality Of Life ◽

Botulinum Toxin ◽

Cervical Dystonia ◽

Rating Scale ◽

Short Form ◽

Tertiary Care ◽

Residual Effect ◽

Care Hospital ◽

Sf 36

OBJECTIVE: The purpose of this study was to evaluate quality of life (QoL) in a Brazilian population of individuals with cervical dystonia (CD) without effect of botulinum toxin (BTx) or with only residual effect of BTx, and identify possible physical and social aspects that affect their QoL. METHOD: Sixty five out of sixty seven consecutive patients with CD were assessed with two instruments: Short-form Health Survey with 36 questions (SF-36) and Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). RESULTS: Severity of CD (TWSTRS) correlated moderately with two SF-36 subscale: role-physical (r= -0.42) and body pain (r= -0.43). Women also scored worse in two subscale of SF-36: vitality (p<0.05) and mental-health (p<0.005). CONCLUSION: Severity of CD and gender (female) were the main factors related to a worse QoL perception. These findings may help health professionals to predict which characteristics could lead to worse QoL, and therefore, better target their interventions to lessen the burden caused by CD.

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Determinants of health-related quality of life in patients with celiac disease: a structural equation modeling

10.21203/rs.3.rs-263666/v1 ◽

2021 ◽

Author(s):

Zeinab Nikniaz ◽

Mohammad Asghari Jafarabadi ◽

Mahdieh Abbasalizad Farhangi ◽

Masood Shirmohammadi ◽

Leila Nikniaz

Keyword(s):

Quality Of Life ◽

Celiac Disease ◽

Goodness Of Fit ◽

Rating Scale ◽

Education Level ◽

Equation Modeling ◽

Adherence To Diet ◽

Sf 36 ◽

Related Quality

Abstract Purpose We employed the structure equation modeling (SEM) for investigating the determinants of Helath-related quality of life (HRQOL) in Iranian patients with celiac disease (CD). Methods In the present cross-sectional study, a total of 170 patients with CD were recruited. The information regarding adherence to diet, symptom severity and HRQOL were collected using celiac disease adherence test (CDAT), gastrointestinal symptom rating scale (GSRS) and SF-36 questionnaire respectively. Association between various studied variables and HRQOL was assessed using SEM. The standardized regression weights was used to assess total, direct and indirect effects. The model fit was assessed to determine the “goodness of fit” between the hypothesized model. Results The mean age of participants was 37.57 ± 9.59 years. The results of SEM indicated that the overall fit of our model was acceptable. Adherence to the diet, GSRS score, occupation, and education level were significantly related to PCS of SF-36; and adherence to the diet, GSRS score, and education level were significantly correlated to MCS of SF-36. The analysis of indirect effect indicated that only adherence to diet indirectly via GSRS score was significantly associated with PCS and MCS of SF-36. There were significant differences between males and females regarding the relationship between education and adherence to diet (p<0.001) and education level and MCS of SF-36 (p=0.03). Conclusion In adult patients with celiac disease, HRQoL was affected by age, education level, adherence to GFD, and GSRS score. Additionally, occupation and disease duration were associated with HRQoL only in women and men respectively.

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Gender difference in relation to depression and quality of life among patients with a primary brain tumor

European Psychiatry ◽

10.1016/j.eurpsy.2005.05.008 ◽

2006 ◽

Vol 21 (3) ◽

pp. 194-199 ◽

Cited By ~ 54

Author(s):

Arja Mainio ◽

Helinä Hakko ◽

Asko Niemelä ◽

John Koivukangas ◽

Pirkko Räsänen

Keyword(s):

Quality Of Life ◽

Brain Tumor ◽

Functional Status ◽

Primary Brain Tumor ◽

Karnofsky Performance Scale ◽

Tumor Patients ◽

The Relationship ◽

Depressive Patients ◽

Performance Scale

AbstractObjective. –We studied the relationship between depressive symptoms and quality of life (QOL) as well as functional status in primary brain tumor patients at recurrent measurements. Differences in QOL between depressive and non-depressive samples by gender were controlled for tumor characteristics and patients' psychosocial factors.Materials and methods. –The data consisted of 77 patients with a primary brain tumor, 30 males and 47 females. Depression of the patients was assessed by Beck Depression Inventory (BDI) and Crown-Crisp Experiential Index (CCEI), functional status by Karnofsky Performance scale (KPS) and QOL by Sintonen's 15D before tumor operation as well as at 3 months and at 1 year from surgical operation of the tumor.Results.The level of QOL in females was lower compared to that of males. Depression was the main predictor for worse QOL in the patients at all measurements. Depressive patients with a benign brain tumor had significantly worse QOL versus non-depressive ones.Discussion and conclusion. –Decreased QOL was strongly related to depression, especially among patients with a benign brain tumor. Further studies are needed to find whether sufficient depression therapy improves the QOL of patients.

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Influence of reduction quality on functional outcome and quality of life in treatment of tibial plafond fractures: a retrospective cohort study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-019-2932-2 ◽

2019 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Maxim Privalov ◽

Finn Euler ◽

Holger Keil ◽

Benedict Swartman ◽

Nils Beisemann ◽

...

Keyword(s):

Quality Of Life ◽

Functional Outcome ◽

Joint Surface ◽

Intraoperative 3D Imaging ◽

Tibial Plafond ◽

Sf 36 ◽

Surface Irregularities ◽

Tibial Plafond Fractures

Abstract Background The aim of the study was to evaluate the impact of reduction quality, using intraoperative 3D imaging, on quality of life and functional outcome in the operative treatment of tibial plafond fractures. Methods A group of patients with tibial plafond fractures was re-examined. The operative treatment was performed between September 2001 and October 2011. The follow-up examination was at least 2 years after the final surgical procedure. Final reduction result was assessed intraoperatively using a mobile 3D C-arm. A categorization with regard to descriptive parameters as well as type and size of joint surface irregularities was performed. Follow-up results were evaluated using: Olerud and Molander (O & M) score, Short-Form-36 (SF-36) score, movement deficit, Kellgren and Lawrence grade of osteoarthritis, and pain intensity. Results 34 patients with operatively treated tibial plafond fracture could be re-examined. Reduction quality had the greatest influence on functional result measured by the O & M score (p = 0.001) and the PCS domain of the SF-36 score (p = 0.018). Significant differences with regard to O & M score (p = 0.000), SF-36 score (p = 0.001 to p = 0.02; without MCS domain), movement deficit (p = 0.001), grade of osteoarthritis (p = 0.005) and pain (p = 0.001) could be verified under consideration of the reduction quality. The group with the anatomically more accurate reduction also showed a better result for clinical follow-up and quality of life. Furthermore, it is not the type of joint surface irregularity that is always decisive, but rather the size. Conclusions Despite other relevant factors, it appears that reduction quality –which can be analyzed with intraoperative 3D imaging– plays the most important role in postoperative quality of life and functional outcome. Corrections should therefore be performed on joint surface irregularities with a size above 2 mm.

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The Menopause Rating Scale (MRS): comparison with Kupperman index and quality-of-life scale SF-36

Climacteric ◽

10.3109/13697130009167599 ◽

2000 ◽

Vol 3 (1) ◽

pp. 50-58 ◽

Cited By ~ 78

Author(s):

H. P. G. Schneider ◽

L. A. J. Heinemann ◽

H.-P. Rosemeier ◽

P. Potthoff ◽

H. M. Behre

Keyword(s):

Quality Of Life ◽

Rating Scale ◽

Kupperman Index ◽

Sf 36 ◽

Quality Of Life Scale ◽

Life Scale ◽

Menopause Rating Scale

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Neoplastic pulmonary lymphangitis: Symptomatic treatment and quality-of-life evaluation in a prospective palliative care series

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.19536 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 19536-19536

Author(s):

A. A. Dettino ◽

T. Pagano ◽

C. Jardim ◽

T. Takagaki ◽

D. Deheinzelin ◽

...

Keyword(s):

Quality Of Life ◽

Palliative Care ◽

Short Form ◽

Bone Cancer ◽

Symptomatic Treatment ◽

Symptom Improvement ◽

Karnofsky Performance Scale ◽

Sf 36 ◽

Lymphangitis Carcinomatosa

19536 Background: Neoplastic lymphangitis, or lymphangitis carcinomatosa, is a rare and distressing form of lung metastasis, for which symptom improvement is strongly necessary. Since measuring quality of life is an important step toward improving symptom management in cancer patients, and dyspnea in pulmonary lymphangitis is a complex syndrome in end-of-life care, we focused on evaluating a cohort of those individuals. Methods: 52 consecutive patients with neoplastic pulmonary lymphangitis (NPL) were prospectivelly followed in 3 services, with quality of life (QoL) evaluation also, using Medical Outcomes Study 36-item Short-Form Health Survey (SF- 36) and Saint George's Respiratory Questionnaire (SGRQ). Results: 65% (34) of patients were female; age ranged from 37 to 84 years (median: 60). Primary tumor sites were: 28 lung (54%), 18 breast (35%), 5 digestive (9%) and 1 bone cancer. Histological findings were of adenocarcinoma in most cases (71%). Karnofsky performance scale ranged from 10 to 90% (median: 60%); 52% (27) patients had other comorbidities (Charlson index ranged from 6–10; median 7); 48% (25) were previous smokers; hemoglobin levels ranged from 4.9 to 16.7 g/dL (median: 12). We also evaluated 33 patients with echocardiography, and 13 (43%) of them had signs of associated pulmonary hypertension; ejection fraction ranged from 46 to 83% (median: 69%); diastolic dysfunction was present in 22 and pericardial effusion in 10 patients. At accrual, median QoL scores were of: 32% (range: 0–84%) for SF-36 (scale with 0 worst) and 66% (range: 0–100%) for SGRQ (scale with 100% worst). Treatment is showed in a table below. Median survival was of 4 months (range: 0.2–40+ months); 22 (42%) of the patients had an unusual longer survival of more than 6 months, still showing good QoL scores. Conclusions: Despite the fact that QoL is generally poor and survival is short for patients with NPL, some patients may have longer survival time and some improvement is possible with active palliative care. [Table: see text] No significant financial relationships to disclose.

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Association of Functional Outcome and Post Stroke Depression amongAssociation of Functional Outcome and Post Stroke Depression among Stroke Survivor after Three Months Onset: A Preliminary Study

Jurnal Keperawatan Soedirman ◽

10.20884/1.jks.2019.14.1.888 ◽

2019 ◽

Vol 14 (1) ◽

pp. 31

Author(s):

Fitria Handayani ◽

Setyowati Setyowati ◽

Dwi Pudjonarko ◽

Dian Ratna Sawitri ◽

Hastaning Sakti ◽

...

Keyword(s):

Quality Of Life ◽

Functional Outcome ◽

Barthel Index ◽

Rating Scale ◽

Stroke Survivor ◽

Nursing Intervention ◽

Research Committee ◽

Post Stroke ◽

Post Stroke Depression

Background The Post Stroke Depression (PSD) prevalence of stroke survivor after three months onset was ranged from 17% to 37%. Depression led to fatigue, low quality of life, severe morbidity, and mortality. Functional Outcome influence depression on stroke survivor. However, correlation between functional state level and depression among stroke survivor after three months onset has not been established. ObjectiveThis study was aimed to investigate the correlation of executive functional outcome and PSD among stroke survivor after three months onset. MethodThis study was a correlation study. The participants were 44 stroke ischemic patients after three months onset. Participants were recruited in an outpatient unit. PSD was measured using The GRID-Hamilton Rating Scale for Depression 17 (GRID-HAMD 17) and Functional Outcome was measured using Barthel Index (BI). The reliability of GRID-HAMD 17 was .776. Both instruments were conducted on backward translation in to bahasa. Data was examined using simple linier regression analyses. The ethical approval was obtained from the Ethical Research Committee of the Medical Faculty Diponegoro University and Tugurejo Semarang Hospital. ResultsThe presence of PSD were 56.82. The median of HAMD-GRID-17 was 10.38 ± 7.58, and Barthel Index was 69.56 ± 21.69. The Barthel Index showed positive correlation with HAMD-GRID-17 (?= -.41 ?=.006). The Functional Outcome determined PSD as much as 16.8 %. ConclusionModerate association demonstrated the correlation between Functional Outcome and PSD. Nursing intervention should consider these two variables for an optimum quality of life among stroke survivors.

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Unicompartmental Knee Arthroplasty: Short-Term Results

Traumatology and Orthopedics of Russia ◽

10.21823/2311-2905-2021-27-1-153-165 ◽

2021 ◽

Vol 27 (1) ◽

pp. 153-165

Author(s):

V. Yu. Murylev ◽

N. E. Erokhin ◽

P. M. Elizarov ◽

G. A. Kukovenko ◽

A. V. Muzychenkov ◽

...

Keyword(s):

Quality Of Life ◽

Functional Outcome ◽

Postoperative Period ◽

Functional Results ◽

Early Postoperative Period ◽

X Rays ◽

Operating Technique ◽

Sf 36 ◽

The Face

Background. Among the methods of surgical treatment of early stages medial knee osteoarthritis in the partial knee replacement (PKR) becomes more and more relevant. The relevance and increasing number of PKR are confirmed by data from various national registers.The aim of the study was to research the early functional results of PKR and to analyze the complications at various stages of the postoperative period.Material and Methods. Study design: a single-center prospective study. The results of 90 operations of PKR in the period from March 2018 to April 2020 are presented. Assessment of knee function and quality of life of patients was performed according to three scalesquestionnaires: KOOS, WOMAC, SF-36, which were filled in preoperatively and then at 3, 6, 9, 12, 18 months. after surgery. Patients within the reporting period provided X-rays and filled in the scales at the face-to-face examination and at remote contact.Results. The most significant improvement of quality of life and median values of the functional results observed after 3 months, and after 18 months. After replacement the best median functional outcome scales KOOS, WOMAC, SF-36 — 79,4 (73,6–84,3); 27,1 (24,8–30,6); 89,1 (85,3–92,6) compared with the functional results obtained before surgery 32,3 (22,8–38,4); 73,6 (63,6–78,8); 35,2 (31,3–42,1); p = 0,027; p = 0.023; p = 0,028, respectively. A negative correlation was obtained between BMI and functional outcome (p = 0.027, R = -0.7).Conclusion. PKR allowed us to achieve an improvement in the quality of life and functional results already in the early postoperative period (from 3 to 18 months after the operation). The improvement of the operating technique, the analysis of errors and the regularity of the performed PKR will improve the results of PKR and minimize the number of complications.

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