Epidemiology of craniosynostosis in Norway

OBJECTIVEThe authors present population-based epidemiological data for craniosynostosis regarding incidence, age at diagnosis, sex differences, and frequency of syndromic and familial cases.METHODSThe prospective registry of the Norwegian National Unit for Craniofacial Surgery was used to retrieve data on all individuals with craniosynostosis treated between 2003 and 2017. The cohort was divided into three 5-year groups based on year of birth: 2003–2007, 2008–2012, and 2013–2017.RESULTSThe authors identified 386 individuals with craniosynostosis. Of these, 328 (85%) consented to be registered with further information. The incidence increased significantly during the study period and was 5.5 per 10,000 live births (1/1800) in the last 5-year period. The increase was seen almost exclusively in the nonsyndromic group. Syndromic craniosynostosis accounted for 27% of the cases, and the incidence remained stable throughout the three 5-year periods. Both syndromic and nonsyndromic craniosynostosis were highly suture specific. There was a male preponderance (male/female ratio 2:1), and males accounted for 75% of the individuals with midline synostosis. Overall, 9.5% were index individuals in families with more than one affected member; of these, 73% were nonsyndromic cases.CONCLUSIONSThe incidence of craniosynostosis increased during the study period, and the observed incidence is among the highest reported. The authors attribute this to increasing awareness among healthcare professionals. The number of syndromic cases was high, likely due to a broader definition compared to the majority of earlier reports. The study revealed a high number of familial cases in both syndromic and nonsyndromic craniosynostosis, thus highlighting the importance of genetics as an underlying cause of craniosynostosis.

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Epidemiology Data of Patients with Chronic Lymphocytic Leukemia in West Central Mexico

Blood ◽

10.1182/blood.v126.23.5269.5269 ◽

2015 ◽

Vol 126 (23) ◽

pp. 5269-5269

Author(s):

Virgina Campos-Cabrera ◽

Gregorio Campos-Cabrera ◽

Salvador Campos-Cabrera ◽

Alicia Rivera-Trujillo ◽

Sonia Hernandez-Rodriguez ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Conflicts Of Interest ◽

Low Frequency ◽

Epidemiological Data ◽

Lymphocytic Leukemia ◽

Female Ratio ◽

Specific Protocol ◽

Male Female Ratio ◽

Epidemiology Data ◽

International Data

Abstract Background: chronic lymphocytic leukemia (CLL) is a rare disease in Mexican mestizos (Br J Haematol 2015;169:909-911 and Int J Hematol 1999;69:253-255). No significant data on epidemiology is available. Methods: epidemiological data from samples referred to Laboratorios Fatima de Michoacan for flow cytometry immunophenotyping for neoplastic hematological disease. Results: 229 samples were received, 52 were diagnosed as CLL (22.7 %). Male 32 and female 20, ratio 1.6 a 1. Age from 33 to 89 years, average 66; 31 to 40 one, 41 to 50 two, 51 to 60 eleven, 61 to 70 twenty four, 71 to 80 ten, more than 81 four. Expression of CD 38 and ZAP-70 in three; only CD38 in 2, only ZAP-70 in three. Conclusions: similar results in male female ratio and age of presentation are noted as compared with international data. Low frequency of expression in CD38 and ZAP-70 may be due pre-analytic phase in the management of the sample. As a regional group we are trying to have epidemiology data in non-malignant and malignant hematological diseases to form specific protocol treatments. Figure 1. Figure 1. Disclosures No relevant conflicts of interest to declare.

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Stroke prevalence among the Turkish population in a rural area of Istanbul: A community-based study

SAGE Open Medicine ◽

10.1177/2050312118797565 ◽

2018 ◽

Vol 6 ◽

pp. 205031211879756 ◽

Cited By ~ 1

Author(s):

Ülkü Türk Börü ◽

Ahmet Şükrü Kulualp ◽

Ömer Faruk Tarhan ◽

Cem Bölük ◽

Arda Duman ◽

...

Keyword(s):

Rural Area ◽

Rural Areas ◽

Turkish Population ◽

Population Based ◽

World Health ◽

Cross Sectional ◽

Female Ratio ◽

Middle East Countries ◽

Stroke Prevalence ◽

Male Female Ratio

Background: The population-based information on the prevalence of stroke from rural areas of Middle East countries including Turkey is unknown. Our aim is to evaluate the prevalence of stroke in those ⩾18 years in the Turkish population in a rural area of Istanbul. Methods: A cross-sectional door-to-door study was conducted in a rural area of Istanbul between 1 March and 30 March 2013. A research protocol recommended by World Health Organization for developing countries was used. Each screening teams consisted of one neurologist, one local nurse, and five surveyors. Teams were trained about the survey and questionnaire. The patients, who claimed to have suffered a stroke, were examined, and the diagnosis was confirmed by a neurologist on site. The findings and medical records were documented. Results: In total, 2906 people ⩾18 years were screened. 50 stroke cases were detected. 80% of those were found to have had an ischemic stroke, 14% of those were hemorrhagic cases, and 6% of those had an unclassified stroke type. The overall prevalence rate in those ⩾ 18 years was 1.7%. The male/female ratio was 0.92. Young (<45) stroke prevalence was found to be 0.6%. Conclusion: This study was the first of its kind to show the stroke prevalence among Turkish population ⩾ 18 years in a rural area of Istanbul. When compared to other studies which investigate people ⩾45 years from Turkey, the result (in the same age group) was moderate high. The male/female ratio was low compared to many other studies.

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Migrainous Disorder and its Relation to Migraine Without Aura and Migraine with Aura. A Genetic Epidemiological Study

Cephalalgia ◽

10.1046/j.1468-2982.1996.1606431.x ◽

1996 ◽

Vol 16 (6) ◽

pp. 431-435 ◽

Cited By ~ 31

Author(s):

MB Russell ◽

J Olesen

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura ◽

International Headache Society ◽

Large Population ◽

Population Based ◽

Population Based Study ◽

Female Ratio ◽

First Degree Relatives ◽

Increased Risk ◽

Male Female Ratio

Migrainous disorder was analysed in a large population-based study of 4000 forty-year-old males and females. All interviews were conducted by one physician and the diagnostic criteria of the International Headache Society were used. Of the 48 people with migrainous disorder, 40 had migrainous disorder without aura and 9 had migrainous disorder with aura One person had co-occurrence of migrainous disorder with and without aura. The lifetime prevalence of migrainous disorder was 2.5% with a male: female ratio of 1:1.2. The first-degree relatives of probands with migrainous disorder were blindly interviewed. Compared with the general population, first-degree relatives of probands with migrainous disorder without aura had a slightly but less increased risk of migraine without aura than first-degree relatives of probands with migraine without aura. First-degree relatives of probands with migrainous disorder with aura had no increased risk of migraine with aura. We conclude that migrainous disorder without aura in some people is a type of migraine without aura and in other people not. Migrainous disorder with aura may be unrelated to migraine with aura. œ

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Age at Onset and Sex Ratio in Cluster Headache: Observations Over Three Decades

Cephalalgia ◽

10.1046/j.1468-2982.2002.00318.x ◽

2002 ◽

Vol 22 (2) ◽

pp. 94-100 ◽

Cited By ~ 105

Author(s):

K Ekbom ◽

DA Svensson ◽

H Träff ◽

E Waldenlind

Keyword(s):

Cluster Headache ◽

Age At Onset ◽

Chronic Cluster Headache ◽

Hormone Regulation ◽

Female Ratio ◽

Age Related ◽

Episodic Cluster Headache ◽

Headache Onset ◽

Male Female Ratio ◽

Male Preponderance

Five hundred and fifty-four patients with episodic cluster headache (ECH) and chronic cluster headache (CCH) were examined between 1963 and 1997. Mean age at onset was significantly higher in women with CCH compared with women with ECH and in men with ECH or CCH. In women with CCH age at onset was evenly distributed from 10 to 69 years, whereas in men with CCH and in both sexes with ECH, there was a peak when they were in their 20s. In women with ECH a second peak of onset occurred in their 50s. Although not statistically significant, primary CCH started later in women (mean 50.8 years) than secondary CCH (mean 35.5 years). There was a significant variation in the male : female ratio with respect to age at onset, being largest between 30 and 49 years of age (ECH 7.2 : 1; CCH 11.0 : 1) and lowest after 50 (ECH 2.3 : 1; CCH 0.6 : 1). During the observation period of more than 30 years there was a trend towards a decreasing male preponderance; the male: female ratio was significantly higher among patients with onset before rather than after 1970. The proportion of episodic vs. chronic CH did not change during the study period. The nature of the sex- and age-related pattern of cluster headache onset remains to be elucidated but mechanisms associated with sex hormone regulation, perhaps of hypothalamic origin, may be involved, as well as environmental factors related to lifestyle.

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Study of glottic lesions in patients undergoing microlaryngeal surgery

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200072 ◽

2020 ◽

Vol 6 (2) ◽

pp. 277

Author(s):

Vikrant Mittal ◽

Manish Munjal ◽

Rohit Verma ◽

Parth Chopra ◽

Hemant Chopra

Keyword(s):

Clinical Diagnosis ◽

Histopathological Examination ◽

Detailed Examination ◽

Histopathological Diagnosis ◽

Female Ratio ◽

Histopathological Correlation ◽

Male Female Ratio ◽

Male Preponderance ◽

Vocal Nodules ◽

Microlaryngeal Surgery

Background: Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.Methods: 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed. Results: There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.Conclusions: In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.

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Younger Patients with CLL/SLL Are Less Frequent and Have Favorable Survival in a Canadian Population Based Study: The Manitoba Cohort.

Blood ◽

10.1182/blood.v108.11.3335.3335 ◽

2006 ◽

Vol 108 (11) ◽

pp. 3335-3335

Author(s):

Versha Banerji ◽

Alain Demers ◽

James B. Johnston ◽

Marshall W. Pitz ◽

Zoanne Nugent ◽

...

Keyword(s):

Flow Cytometry ◽

Cancer Registry ◽

Clinical Characteristics ◽

Cox Regression ◽

Population Based ◽

Lymphocytic Leukemia ◽

Female Ratio ◽

Canadian Population ◽

Male Female Ratio ◽

And Gender

Abstract Background: Detailed population-based clinical characteristics and outcomes of chronic lymphocytic leukemia (CLL) and small lymphocytic leukemia (SLL) are scarce. We have previously demonstrated in the province of Manitoba that by combining population-based sources of a cancer registry and a centralized flow cytometry database, the incidence of CLL/SLL is much higher than previously reported. We have now examined the clinical characteristics of this large and well defined patient group. We hypothesized that the clinical features of these patients (pts) may differ from previous studies where data was obtained from referral centers. Methods: All pts from the Manitoba Cancer Registry with ICD codes 9 & 10 for CLL or SLL from 01/01/1998 to 12/31/2003 were identified. Pts from the flow cytometry database during this time period with a diagnosis of CLL/SLL were also identified. A retrospective electronic chart review was conducted. The two databases were compared and analyzed. Results: 715 pts with CLL were identified. 358 pts were identified from the cancer registry alone, 136 pts by the flow cytometry database, and 221 pts in both datasets. Overall, the age-adjusted annual incidence rate of CLL/SLL in Manitoba was 10.5/105 (95% C.I. 9.4–12.7/105). Median age of all pts was 72yrs (19–101). Only 71 pts (9.9%) were aged <55 and 212 pts (29.6) were <65. The Male: Female ratio was identical in the age<55 and >55 categories (1.33). Median follow-up of living pts is 6.6 years (range 2.0–8.0). The Cox regression model was used to evaluate the significance of prognostic factors including age at diagnosis and gender. Older cases (>55 years) had significantly higher risk of dying (HR: 4.0, 95%CI: 1.23–13.1) than younger pts. Women had a slightly lower risk of dying (HR: 0.78, 95%CI: 0.40–1.50) than men. For the 136 pts for whom accurate Rai staging was available, estimated median survival has not been reached in stage 0 patients, while it was 7.2 years in stage I–II cases and 4.5 years in stage III–IV patients. Cause specific mortality and complete survival according to Rai stage for all pts will be presented at the meeting. Conclusions: In this population-based CLL/SLL cohort, clinical presentation and outcomes appear to differ from previously reported studies. Specifically, (1) there are fewer younger pts, (2) the male: female ratio is similar amongst all ages, (3) older pts have a significantly poorer survival, (4) pts with advanced Rai stages appear to live longer than previously reported. This has important implications for treatment and counseling of pts, as well as for resource allocation for this common hematological malignancy.

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Gender-Age Distribution of Patients with COVID-19 at Different Stages of Epidemic in Moscow

Problems of Particularly Dangerous Infections ◽

10.21055/0370-1069-2020-3-27-35 ◽

2020 ◽

pp. 27-35

Author(s):

V. G. Akimkin ◽

S. N. Kuzin ◽

T. A. Semenenko ◽

A. A. Ploskireva ◽

D. V. Dubodelov ◽

...

Keyword(s):

Age Distribution ◽

Age Groups ◽

Population Based ◽

Epidemiological Surveillance ◽

Age Group ◽

Female Ratio ◽

The World ◽

Male Female Ratio ◽

Male Cohort ◽

Epidemiological Characteristics

The ongoing COVID-19 pandemic around the world and in Russia remains a major event of 2020. All over the world, research is being conducted to comprehensively study the patterns and manifestations of the epidemic process. The main quantitative characteristics of SARS-CoV-2 transmission dynamics among the population, based on the data of official monitoring over the current situation, play an important role in the development of the epidemiological surveillance system.The aim of this study is to explore the peculiarities of age-gender distribution of COVID-19 patients in Moscow.Material and methods. The data related to the epidemiological characteristics of age-gender structure of COVID-19 patients in Moscow between March 19, 2020 and April 15, 2020, at different stages of the epidemic were retrospectively analyzed.Results and discussion. The mean age of COVID-19 patients in Moscow was 46,41±20,58 years. The gender ratio (male/female) among the patients was 52.7/47.3 %, wherein the indicators varied depending upon the age. Male/female ratio in the age group “under 39” stood at 53.7/46.3 %, and “over 40 years of age” – at 39.3/60.7 %. The predominant age range among male cases was 19 to 39 years old – 35.4 %, while among female patients – 40–59 years (36.5 %). The age distribution of patients in Moscow is indicative of the fact that COVID-19 is a disease that primarily affects older age groups. The age structure of all COVID-19 cases during the observation period is characterized by predominance of adult patients over 19 years of age – 92,7 % (92,6–92,8 %), the share of patients aged 40–59 years is 35,7% (35,5–35,9 %). The differences in the age distribution in males and females are as follows: in the male cohort, the age groups 19–39 years old and 40–59 years old prevail – 35.4 % (35.1–35.7 %) and 34.9 % (34.6–35.2 %), respectively. The age group 40–59 years old – 36.5 % (36.3–36.8%) dominates in the female cohort.

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Epidemiology of idiopathic inflammatory myopathy in Hungary

Orvosi Hetilap ◽

10.1556/oh.2014.29993 ◽

2014 ◽

Vol 155 (41) ◽

pp. 1643-1646 ◽

Cited By ~ 1

Author(s):

Melinda Nagy-Vincze ◽

Levente Bodoki ◽

Zoltán Griger ◽

Katalin Dankó

Keyword(s):

Inflammatory Myopathy ◽

Idiopathic Inflammatory Myopathy ◽

Epidemiological Data ◽

Systemic Autoimmune Disease ◽

Insurance Fund ◽

Proximal Muscle Weakness ◽

Health Insurance Fund ◽

Proximal Muscle ◽

Female Ratio ◽

Male Female Ratio

Introduction: Idiopathic inflammatory myopathy (called also myositis) is a systemic autoimmune disease mainly characterised with proximal muscle weakness. The most frequent subsets are polymyositis and dermatomyositis. The epidemiology of these diseases is not entirely explored. There is a need to build national and international registries which may help to obtain more data. The Myositis Team at the Department of Clinical Immunology, University of Debrecen, has been established in 1975. Aim: The aim of the authors was to obtain epidemiological data on this disease. Method: The authors analysed the database of the National Health Insurance Fund Administration of Hungary which included 1119 patients with myositis, of which 289 patients were followed up by the authors. Results: The average incidence of the disease was found to be 0.95/100.000/year. The male/female ratio was 1/2. Dermatomyositis occurred both in children and adult, but polymyositis was found mainly in adults. These epidemiological data partly correlate with those published in the international literature. Conclusions: The authors propose to establish a National Myositis Registry in the frame of multicentric collaboration in order to have more information about the disease. Orv. Hetil., 2014, 155(41), 1643–1646.

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Colonic Gastrointestinal Stromal Tumor: A Population-Based Analysis of Incidence and Survival

Gastroenterology Research and Practice ◽

10.1155/2019/3849850 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Zhiqiang Liu ◽

Yan Sun ◽

Yongfeng Li ◽

Jingyuan Zhao ◽

Shihong Wu ◽

...

Keyword(s):

Survival Rate ◽

Case Reports ◽

Statistical Significance ◽

Population Based ◽

Percentage Change ◽

Tumor Characteristics ◽

Annual Percentage Change ◽

Female Ratio ◽

Male Female Ratio ◽

Age Of Diagnosis

Objectives. The incidence of gastrointestinal stromal tumors (GISTs) located in the colon is rare. Current studies mainly focus on case reports for colonic GISTs. Therefore, a population-based analysis was useful to guide the clinical treatment strategy. Methods. The patients were selected from 2000 to 2015 based on Surveillance, Epidemiology, and End Results (SEER) database. Patients’ demographics, tumor characteristics, incidence, treatment, and survival were retrieved for analysis. Results. 249 cases of colonic GISTs were collected. The male-female ratio was close to 1 : 1 (male 51.41%, female 48.59%). Most cases were Caucasians (70.28%), and African Americans accounted for 19.68%. Age of diagnosis ranged from 21 to 93 years with a median (mean) age of 67.5 (65.56). The incidence was rare, only 0.018 per 100,000. It had an annual percentage change (APC=−0.7728) without statistical significance (P=0.5127) while the incidence of other GISTs increased from 2000 to 2015, with an annual percentage change of 3.9% (P=0.0001). Surgery was associated with better prognosis whereas chemotherapy did not impact the survival rate. Conclusion. Colonic GIST is a rare solid tumor, and the incidence is stable. The entity has a poorer prognosis than other GISTs. Surgery improved the survival rate, while chemotherapy did not.

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Reduced transmission ofMycobacterium africanumcompared toM. tuberculosisin urban West Africa

10.1101/206136 ◽

2017 ◽

Author(s):

Prince Asare ◽

Adwoa Asante-Poku ◽

Diana Ahu Prah ◽

Sonia Borrell ◽

Stephen Osei-Wusu ◽

...

Keyword(s):

West Africa ◽

Transmission Rate ◽

Population Based ◽

Female Ratio ◽

Recent Transmission ◽

Significant Difference ◽

Male Female Ratio ◽

Continuous Presence ◽

Associated Risk Factors ◽

Mycobacterium Africanum

AbstractBackgroundUnderstanding transmission dynamics is useful for tuberculosis (TB) control. We conducted a population-based molecular epidemiological study to understand TB transmission in Ghana.MethodsMycobacterium tuberculosiscomplex (MTBC) isolates obtained from prospectively-sampled pulmonary TB patients between July, 2012 and December, 2015 were confirmed as MTBC using IS6110PCR. MTBC lineages were identified by large sequence polymorphism and single nucleotide polymorphism assays and further characterized using spoligotyping and standard 15-loci MIRU-VNTR typing. We used the n-1 method to estimate recent TB transmission and identified associated risk factors using logistic regression analysis.FindingsOut of 2,309 MTBC isolates, we identified 1,082 (46·9%) single cases with 1,227 (53·1%) isolates belonging to one of 276 clustered cases (clustering range; 2-35). Recent TB transmission rate was estimated to be 41·2%. While we see no significant difference in the recent transmission rates between lineages ofMycobacterium africanum(lineage-5 (31·8%); lineage-6 (24·7%), p=0·118), we found that lineage-4 belonging to theM. tuberculosistransmitted significantly higher (44·9%, p<0·001). Finally, apart from age being significantly associated with recent TB transmission (p=0·007), we additionally identified a significant departure in the male/female ratio among very large clustered cases compared to the general TB patient population (3:1 vs. 2:1, p=0·022).InterpretationsOur findings indicate high recent TB transmission suggesting occurrences of unsuspected outbreaks. The observed reduced transmission rate ofM. africanumsuggests other factor(s) may be responsible for its continuous presence in West Africa.FundingWellcome Trust Intermediate Fellowship Grant 097134/Z/11/Z to Dorothy Yeboah-Manu.

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