Stereoelectroencephalographic language mapping of the basal temporal cortex predicts postoperative naming outcome

2021 ◽  
pp. 1-11
Author(s):  
Chifaou Abdallah ◽  
Hélène Brissart ◽  
Sophie Colnat-Coulbois ◽  
Ludovic Pierson ◽  
Olivier Aron ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Verbal Fluency ◽  
Temporal Cortex ◽  
Visual Object ◽  
Drug Resistant ◽  
Language Mapping ◽  
Individual Level ◽  
Language Outcome ◽  
Temporal Lobe Resection ◽  
The Individual

OBJECTIVEIn drug-resistant temporal lobe epilepsy (TLE) patients, the authors evaluated early and late outcomes for decline in visual object naming after dominant temporal lobe resection (TLR) according to the resection status of the basal temporal language area (BTLA) identified by cortical stimulation during stereoelectroencephalography (SEEG).METHODSTwenty patients who underwent SEEG for drug-resistant TLE met the inclusion criteria. During language mapping, a site was considered positive when stimulation of two contiguous contacts elicited at least one naming impairment during two remote sessions. After TLR ipsilateral to their BTLA, patients were classified as BTLA+ when at least one positive language site was resected and as BTLA− when all positive language sites were preserved. Outcomes in naming and verbal fluency tests were assessed using pre- and postoperative (means of 7 and 25 months after surgery) scores at the group level and reliable change indices (RCIs) for clinically meaningful changes at the individual level.RESULTSBTLA+ patients (n = 7) had significantly worse naming scores than BTLA− patients (n = 13) within 1 year after surgery but not at the long-term evaluation. No difference in verbal fluency tests was observed. When RCIs were used, 5 of 18 patients (28%) had naming decline within 1 year postoperatively (corresponding to 57% of BTLA+ and 9% of BTLA− patients). A significant correlation was found between BTLA resection and naming decline.CONCLUSIONSBTLA resection is associated with a specific and early naming decline. Even if this decline is transient, naming scores in BTLA+ patients tend to remain lower compared to their baseline. SEEG mapping helps to predict postoperative language outcome after dominant TLR.

scholarly journals Interactional synchrony: signals, mechanisms and benefits

2020 ◽  
Author(s):  
Stefanie Hoehl ◽  
Merle Fairhurst ◽  
Annett Schirmer
Keyword(s):  
Temporal Cortex ◽  
Group Living ◽  
High Temporal Resolution ◽  
Emotional Information ◽  
Interactional Synchrony ◽  
Individual Level ◽  
Temporal Regularity ◽  
Superior Temporal Cortex ◽  
Interval Sequence ◽  
The Individual

Abstract Many group-living animals, humans included, occasionally synchronize their behavior with that of conspecifics. Social psychology and neuroscience have attempted to explain this phenomenon. Here we sought to integrate results around three themes: the stimuli, the mechanisms and the benefits of interactional synchrony. As regards stimuli, we asked what characteristics, apart from temporal regularity, prompt synchronization and found that stimulus modality and complexity are important. The high temporal resolution of the auditory system and the relevance of socio-emotional information endow auditory, multimodal, emotional and somewhat variable and adaptive sequences with particular synchronizing power. Looking at the mechanisms revealed that traditional perspectives emphasizing beat-based representations of others’ signals conflict with more recent work investigating the perception of temporal regularity. Timing processes supported by striato-cortical loops represent any kind of repetitive interval sequence fairly automatically. Additionally, socio-emotional processes supported by posterior superior temporal cortex help endow such sequences with value motivating the extent of synchronizing. Synchronizing benefits arise from an increased predictability of incoming signals and include many positive outcomes ranging from basic information processing at the individual level to the bonding of dyads and larger groups.

scholarly journals Decision-making impairments following insular and medial temporal lobe resection for drug-resistant epilepsy

2016 ◽  
pp. nsw152 ◽  
Author(s):  
Zorina Von Siebenthal ◽  
Olivier Boucher ◽  
Isabelle Rouleau ◽  
Maryse Lassonde ◽  
Franco Lepore ◽  
...  
Keyword(s):  
Decision Making ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Drug Resistant ◽  
Temporal Lobe Resection ◽  
Drug Resistant Epilepsy

The temporal cortex

2020 ◽  
pp. 253-259
Author(s):  
Edmund T. Rolls
Keyword(s):  
Temporal Lobe ◽  
Language Production ◽  
Inferior Frontal Gyrus ◽  
Temporal Cortex ◽  
Visual Object ◽  
Broca’S Area ◽  
Semantic Representations ◽  
Broca's Area ◽  
Anterior Temporal Lobe ◽  
Face Expression

The inferior and middle temporal gyri are involved visual object recognition, with the more dorsal areas involved in face expression, gesture, and motion representation that is useful in social behaviour. The superior temporal cortex is involved in auditory processing. The anterior temporal lobe is involved in semantic representations, for example information about objects, people, and places. Network mechanisms involved in semantic representations are described. The output of this system reaches the inferior frontal gyrus, which on the left is Broca’s area, involved in language production. The concept that the semantics for language are computed in the anterior temporal lobe, and communicates with Broca’s area for speech production, is introduced.

scholarly journals fNIRS Evaluation of Frontal and Temporal Cortex Activation by Verbal Fluency Task and High-Level Cognition Task for Detecting Anxiety and Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuenan Lang ◽  
Dan Wen ◽  
Qiqi Li ◽  
Qin Yin ◽  
Mingyu Wang ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Verbal Fluency ◽  
Healthy Subjects ◽  
Temporal Cortex ◽  
Anxiety And Depression ◽  
Cerebral Oxygen ◽  
Verbal Fluency Task ◽  
The Subject ◽  
High Level ◽  
Fluency Task

Anxiety and depression are widespread psychosis which are believed to affect cerebral metabolism, especially in frontal and temporal cortex. The comorbidity patients of anxiety and depression (A&D) have more serious clinical symptoms. Functional near-infrared spectroscopy (fNIRS) is a noninvasive modality used to monitor human brain oxygenation, and it could be considered as a potential tool to detect psychosis which may lead to abnormal cerebral oxygen status when the brain is activated. However, how sensitive the cerebral oxygenation response to the cortex activation and whether these responses are consistent at different stages of A&D or different regions still remains unclear. In this study, a conventional physiological paradigm for cortex activation, i.e., verbal fluency task (VFT), and a relatively new paradigm, i.e., high-level cognition task (HCT), were compared to detect A&D through a longitudinal measurement of cerebral oxygen status by fNIRS. The A&D patients at the acute, consolidation and maintenance stages as well as the healthy subjects participated in the VFT and HCT paradigms, respectively. For the VTF paradigm, the subject was instructed to answer questions of phrase constructions within 60 s. For the HCT paradigm, the subject was instructed to categorize items, logical reasoning, and comprehensive judgment and write down the answers within 60 s. For most of the subjects, the oxy-Hb is found to increase remarkably, accompanied with a relatively small reduction in deoxy-Hb when subject to both paradigms. The statistical analyses show a relatively large variability within any group, leading to the significant difference that was only found between A&D at the acute stage and healthy subjects in the temporal lobe region (p < 0.001). Nevertheless, HCT would activate more oxygen increment when compared with the VFT, with a large integral value in oxy-Hb. On average, the oxy-Hb integral value of the A&D patients differs substantially at different stages when subject to HCT paradigm. Moreover, the prefrontal lobe and temporal lobe responses were more consistent to the HCT paradigm rather than the VFT paradigm. Under the VFT paradigm, however, no remarkable difference in integral value was found among the three stages, either at the prefrontal lobe or at the temporal lobe. This study indicated that HCT, which is intensively involved in brain function, would activate more oxygenation changes in the cerebral cortex. Additionally, with good performance at distinguishing different stages according to the oxy-Hb criterion, the HCT has the potential to evaluate the therapeutic effects for A&D patients.

scholarly journals The critical role of the ventral temporal lobe in word retrieval

2021 ◽  
Author(s):  
Kathryn M Snyder ◽  
Kiefer James Forseth ◽  
Cristian Donos ◽  
Patrick S Rollo ◽  
Simon Fischer-Baum ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Critical Role ◽  
Temporal Cortex ◽  
Intractable Epilepsy ◽  
Significant Decline ◽  
Word Retrieval ◽  
Visual Object ◽  
Confrontation Naming

Deficits in word retrieval are a hallmark of a variety of neurological illnesses spanning from dementia to traumatic injuries. The role of the dominant temporal lobe in fluent naming has been characterized by lesional analyses, functional imaging, and intracranial recordings, but limitations of each of these measures preclude a clear assessment of which specific constituent of the temporal lobe is critical for naming. We studied a large cohort of patients undergoing surgical resections or laser ablations of the dominant temporal lobe for medically intractable epilepsy (n=95). These techniques are exceedingly effective for seizure control but often result in language declines, particularly in confrontation naming, which can be socio-economically disabling. We used a multivariate voxel-based lesion symptom mapping analysis to localize brain regions significantly associated with visual object naming deficits. We observed that posterior inferior temporal regions, centered around the middle fusiform gyrus, were significantly associated with a decline in confrontation naming. Furthermore, we found that the posterior margin of anterior temporal lobectomies was linearly correlated to a decline in visual naming with a clinically significant decline occurring once the resection extended 6 cm from the anterior tip of the temporal lobe. We integrated these findings with electrocorticography during naming in a subset of this population and found that the majority of cortical regions whose resection was associated with a significant decline overlapped with regions that were functionally most active prior to articulation. Importantly, these loci coincide with the sites of susceptibility artifacts during echo-planar imaging, which explains why this region has not previously been implicated. Taken together, these data highlight the crucial contribution of the posterior ventral temporal cortex in lexical access and its important role in the pathophysiology of anomia following temporal lobe resections. Surgical strategies, including the use of laser ablation to target the medial temporal lobe as well as microsurgical approaches, should attempt to preserve this region to mitigate postoperative language deficits.

Narrative and procedural discourse in temporal lobe epilepsy

2003 ◽  
Vol 9 (5) ◽  
pp. 733-739 ◽  
Author(s):  
BRIAN BELL ◽  
CHRISTIAN DOW ◽  
E. RYANN WATSON ◽  
AUSTIN WOODARD ◽  
BRUCE HERMANN ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Early Onset ◽  
Narrative Discourse ◽  
Cognitive Domain ◽  
Control Group ◽  
Individual Level ◽  
Procedural Discourse ◽  
Language Measures ◽  
The Individual

It is well established that some individuals with temporal lobe epilepsy (TLE) demonstrate language deficits at the single word level. However, discourse production rarely has been examined quantitatively within this group. This study compared adult TLE patients with an early seizure onset (≤ age 14 years, n = 27) to a control group (n = 28) on narrative and procedural discourse tasks. As a group, the TLE patients performed normally on the procedural discourse task, but differed significantly from the controls on several narrative discourse variables. At the individual level, 30% of the TLE patients versus 4% of the controls demonstrated impaired discourse ability (p < .01). Within this early onset TLE group, discourse performance was not associated with demographic or seizure history variables. Considering the cognitive domain, discourse performance correlated significantly with working memory. In summary, mild discourse dysfunction was present in a significant minority of early onset TLE patients, but this deficit was not closely associated with other language measures. Discourse ability and its neuropsychological, neuroanatomical and conversational speech correlates deserve further study in TLE patients. (JINS, 2003, 9, 733–739.)

scholarly journals Resective, Ablative and Radiosurgical Interventions for Drug Resistant Mesial Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis of Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Kajol Marathe ◽  
Ali Alim-Marvasti ◽  
Karan Dahele ◽  
Fenglai Xiao ◽  
Sarah Buck ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Focal Epilepsy ◽  
Meta Analysis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Seizure Freedom ◽  
Drug Resistant ◽  
Selective Amygdalohippocampectomy ◽  
Temporal Lobe Resection ◽  
Mesial Temporal Lobe

Objectives: One-third of individuals with focal epilepsy do not achieve seizure freedom despite best medical therapy. Mesial temporal lobe epilepsy (MTLE) is the most common form of drug resistant focal epilepsy. Surgery may lead to long-term seizure remission if the epileptogenic zone can be defined and safely removed or disconnected. We compare published outcomes following open surgical techniques, radiosurgery (SRS), laser interstitial thermal therapy (LITT) and radiofrequency ablation (RF-TC).Methods: PRISMA systematic review was performed through structured searches of PubMed, Embase and Cochrane databases. Inclusion criteria encompassed studies of MTLE reporting seizure-free outcomes in ≥10 patients with ≥12 months follow-up. Due to variability in open surgical approaches, only comparative studies were included to minimize the risk of bias. Random effects meta-analysis was performed to calculate effects sizes and a pooled estimate of the probability of seizure freedom per person-year. A mixed effects linear regression model was performed to compare effect sizes between interventions.Results: From 1,801 screened articles, 41 articles were included in the quantitative analysis. Open surgery included anterior temporal lobe resection as well as transcortical and trans-sylvian selective amygdalohippocampectomy. The pooled seizure-free rate per person-year was 0.72 (95% CI 0.66–0.79) with trans-sylvian selective amygdalohippocampectomy, 0.59 (95% CI 0.53–0.65) with LITT, 0.70 (95% CI 0.64–0.77) with anterior temporal lobe resection, 0.60 (95% CI 0.49–0.73) with transcortical selective amygdalohippocampectomy, 0.38 (95% CI 0.14–1.00) with RF-TC and 0.50 (95% CI 0.34–0.73) with SRS. Follow up duration and study sizes were limited with LITT and RF-TC. A mixed-effects linear regression model suggests significant differences between interventions, with LITT, ATLR and SAH demonstrating the largest effects estimates and RF-TC the lowest.Conclusions: Overall, novel “minimally invasive” approaches are still comparatively less efficacious than open surgery. LITT shows promising seizure effectiveness, however follow-up durations are shorter for minimally invasive approaches so the durability of the outcomes cannot yet be assessed. Secondary outcome measures such as Neurological complications, neuropsychological outcome and interventional morbidity are poorly reported but are important considerations when deciding on first-line treatments.

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